Synthesis, antimicrobial, antimycobacterial and structure-activity relationship of substituted pyrazolo-, isoxazolo-, pyrimido- and mercaptopyrimidocyclohepta[b]indoles

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 228-238

  Yamuna, Ezhumalai ^a   Kumar, R Ajay ^b   Zeller, Matthias ^c   Rajendra Prasad, Karnam Jayarampillai ^a  

^a BHARATHIAR UNIVERSITY   (India)

^b RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

^c YOUNGSTOWN STATE UNIVERSITY   (United States)

Author keywords

Antimicrobial; Antimycobacterial; Cyclohepta b indoles; In silico drug relevant properties; Structure activity relationship

Indexed keywords

1 PHENYL 4,5,6,11 TETRAHYDRO PYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 10 METHYL 1 PHENYL 4,5,6,11 TETRAHYDRO PYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 10 METHYL 4,5,6,11 TETRAHYDROISOXAZOLO[40,30:6,7] CYCLOHEPTA[B]INDOLE; 10 METHYL 4,5,6,11 TETRAHYDROPYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 2 CHLORO 7 (HYDROXYMETHYLENE) 7,8,9,10 TETRAHYDROCYCLOHEPTA[B]INDOL 6 (5H)ONE; 2 HYDROXY 10 METHYL 5,6,7,12 TETRAHYDROPYRIMIDO[50,60:6,7]CYCLOHEPTA[B]INDOLE; 2 HYDROXY 11 METHYL 5,6,7,12 TETRAHYDROPYRIMIDO[50,60:6,7]CYCLOHEPTA[B]INDOLE; 2 HYDROXY 5,6,7,12 TETRAHYDROPYRIMIDO[50,60:6,7]CYCLOHEPTA[B]INDOLE; 2 HYDROXY 9 METHYL 5,6,7,12 TETRAHYDROPYRIMIDO[50,60:6,7]CYCLOHEPTA[B]INDOLE; 2 MERCAPTO 10 METHYL 5,6,7,12 TETRAHYDROPYRIMIDO[50,60:6,7]CYCLOHEPTA[B]INDOLE; 2 MERCAPTO 9 METHYL 5,6,7,12 TETRAHYDROPYRIMIDO[50,60:6,7]CYCLOHEPTA[B]INDOLE; 4,5,6,11 TETRAHYDROISOXAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 4,5,6,11 TETRAHYDROPYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 7 (HYDROXYMETHYLENE) 2 METHYL 7,8,9,10 TETRAHYDROCYCLOHEPTA[B]INDOL 6 (5H)ONE; 7 (HYDROXYMETHYLENE) 3 METHYL 7,8,9,10 TETRAHYDROCYCLOHEPTA[B]INDOL 6 (5H)ONE; 7 (HYDROXYMETHYLENE) 4 METHYL 7,8,9,10 TETRAHYDROCYCLOHEPTA[B]INDOL 6 (5H)ONE; 7 (HYDROXYMETHYLENE) 7,8,9,10 TETRAHYDROCYCLOHEPTA[B]INDOL ONE; 8 CHLORO 1 PHENYL 4,5,6,11 TETRAHYDRO PYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 8 CHLORO 4,5,6,11 TETRAHYDROISOXAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 8 CHLORO 4,5,6,11 TETRAHYDROPYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 8 METHYL 1 PHENYL 4,5,6,11 TETRAHYDRO PYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 8 METHYL 4,5,6,11 TETRAHYDROISOXAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 8 METHYL 4,5,6,11 TETRAHYDROPYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 9 CHLORO 2 HYDROXY 5,6,7,12 TETRAHYDROPYRIMIDO[50,60:6,7]CYCLOHEPTA[B]INDOLE; 9 METHYL 1 PHENYL 4,5,6,11 TETRAHYDRO PYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 9 METHYL 4,5,6,11 TETRAHYDROISOXAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; 9 METHYL 4,5,6,11 TETRAHYDROPYRAZOLO[40,30:6,7]CYCLOHEPTA[B]INDOLE; ANTIINFECTIVE AGENT; INDOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER MODEL; CURVULARIA LUNATA; DRUG STRUCTURE; DRUG SYNTHESIS; FUSARIUM SOLANI; HYDROGEN BOND; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; PROTEUS VULGARIS; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY DIFFRACTION;

ANTI-BACTERIAL AGENTS; HYDROGEN BONDING; INDOLES; ISOXAZOLES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; PYRAZOLES; PYRIMIDINES; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855809318     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.046     Document Type: Article

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