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Volumn 45, Issue 2, 1999, Pages 95-108

Mycobacteria: Genetics of resistance and implications for treatment

Author keywords

Drug resistance; Mycobacteria

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ETHAMBUTOL; ISONIAZID; MACROLIDE; PYRAZINAMIDE; RIFAMPICIN; STREPTOMYCIN; TUBERCULOSTATIC AGENT;

EID: 0033060224     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007171     Document Type: Review
Times cited : (30)

References (73)
  • 2
    • 0026706708 scopus 로고
    • Multidrug resistant Mycobacterium tuberculosis in patients with human immunodeficiency virus infection
    • Busillo CP, Lessnau KD, Sanjana V, Sounakis S, Davidson M, Mullen MP, Talavera W: Multidrug resistant Mycobacterium tuberculosis in patients with human immunodeficiency virus infection. Chest 1992; 102:791-801.
    • (1992) Chest , vol.102 , pp. 791-801
    • Busillo, C.P.1    Lessnau, K.D.2    Sanjana, V.3    Sounakis, S.4    Davidson, M.5    Mullen, M.P.6    Talavera, W.7
  • 3
    • 0027473496 scopus 로고
    • Treatment of 171 patients with pulmonary tuberculosis resistant to isoniazid and rifampin
    • Goble M, Iseman MD, Madsen LA, Waite D, Ackerson L, Horsburgh CR: Treatment of 171 patients with pulmonary tuberculosis resistant to isoniazid and rifampin. N Engl J Med 1993;328:527-532.
    • (1993) N Engl J Med , vol.328 , pp. 527-532
    • Goble, M.1    Iseman, M.D.2    Madsen, L.A.3    Waite, D.4    Ackerson, L.5    Horsburgh, C.R.6
  • 8
    • 0027489149 scopus 로고
    • Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: Alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot
    • Finken M, Kirschner P, Meier A, Wrede A, Böttger EC: Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: Alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot. Mol Microbiol 1993;9: 1239-1246.
    • (1993) Mol Microbiol , vol.9 , pp. 1239-1246
    • Finken, M.1    Kirschner, P.2    Meier, A.3    Wrede, A.4    Böttger, E.C.5
  • 10
    • 0029988593 scopus 로고    scopus 로고
    • The genetic of multiple drug resistance in Mycobacterium tuberculosis and the mycobacterium avium complex
    • Morris SL, Rouse DA: The genetic of multiple drug resistance in Mycobacterium tuberculosis and the Mycobacterium avium complex. Res Microbiol 1996;147:68-73.
    • (1996) Res Microbiol , vol.147 , pp. 68-73
    • Morris, S.L.1    Rouse, D.A.2
  • 11
    • 0027231020 scopus 로고
    • Molecular mechanisms of isoniazid: A drug at the front line of tuberculosis control
    • Zhang Y, Young DB: Molecular mechanisms of isoniazid: A drug at the front line of tuberculosis control. Trends Microbiol 1993;1:109-113.
    • (1993) Trends Microbiol , vol.1 , pp. 109-113
    • Zhang, Y.1    Young, D.B.2
  • 12
    • 0028100019 scopus 로고
    • Resistance to drugs targeting protein synthesis in mycobacteria
    • Böttger EC: Resistance to drugs targeting protein synthesis in mycobacteria. Trends Microbiol 1994;2: 416-421.
    • (1994) Trends Microbiol , vol.2 , pp. 416-421
    • Böttger, E.C.1
  • 13
    • 0028839319 scopus 로고
    • Antimicrobial agent resistance in mycobacteria: Molecular genetic insights
    • Musser JM: Antimicrobial agent resistance in mycobacteria: Molecular genetic insights. Clin Microbiol Rev 1995;8:496-514.
    • (1995) Clin Microbiol Rev , vol.8 , pp. 496-514
    • Musser, J.M.1
  • 14
    • 0029874191 scopus 로고    scopus 로고
    • Ribosomal drug resistance in mycobacteria
    • Sander P, Meier A, Böttger EC: Ribosomal drug resistance in mycobacteria. Res Microbiol 1996;147: 59-67.
    • (1996) Res Microbiol , vol.147 , pp. 59-67
    • Sander, P.1    Meier, A.2    Böttger, E.C.3
  • 15
    • 0013573281 scopus 로고    scopus 로고
    • Molecular basis of drug resistance in M. tuberculosis
    • Zhang Y: Molecular basis of drug resistance in M. tuberculosis. J Med Microbiol 1996;44:5-7.
    • (1996) J Med Microbiol , vol.44 , pp. 5-7
    • Zhang, Y.1
  • 16
    • 0029943128 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance in Mycobacterium tuberculosis
    • Blanchard JS: Molecular mechanisms of drug resistance in Mycobacterium tuberculosis. Annu Rev Biochem 1996;65:215-239.
    • (1996) Annu Rev Biochem , vol.65 , pp. 215-239
    • Blanchard, J.S.1
  • 17
    • 84958294760 scopus 로고
    • Chemotherapy of experimental tuberculosis. Isonicotinic acid hydrazide (nydrazid) and related compounds
    • Bernstein J, Lott WA, Steinberg BA, Yale HL: Chemotherapy of experimental tuberculosis. Isonicotinic acid hydrazide (nydrazid) and related compounds. Am Rev Tuberc 1952;65:357-364.
    • (1952) Am Rev Tuberc , vol.65 , pp. 357-364
    • Bernstein, J.1    Lott, W.A.2    Steinberg, B.A.3    Yale, H.L.4
  • 18
    • 0029968681 scopus 로고    scopus 로고
    • The structure and function of the isoniazid target in M. tuberculosis
    • Sacchettini JC, Blanchard JS: The structure and function of the isoniazid target in M. tuberculosis. Res Microbiol 1996;147:36-43.
    • (1996) Res Microbiol , vol.147 , pp. 36-43
    • Sacchettini, J.C.1    Blanchard, J.S.2
  • 19
    • 0028090438 scopus 로고
    • Strain variation in the katG region of Mycobacterium tuberculosis
    • Zhang Y, Young D: Strain variation in the katG region of Mycobacterium tuberculosis. Mol Microbiol 1994;14:301-308.
    • (1994) Mol Microbiol , vol.14 , pp. 301-308
    • Zhang, Y.1    Young, D.2
  • 20
    • 0027248433 scopus 로고
    • Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis
    • Heym B, Zhang Y, Poulet S, Young D, Cole ST: Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis. J Bacteriol 1993;175: 4255-4259.
    • (1993) J Bacteriol , vol.175 , pp. 4255-4259
    • Heym, B.1    Zhang, Y.2    Poulet, S.3    Young, D.4    Cole, S.T.5
  • 21
    • 0026705772 scopus 로고
    • The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
    • Zhang Y, Heym B, Allen B, Young D, Cole S: The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature 1992;358:591-593.
    • (1992) Nature , vol.358 , pp. 591-593
    • Zhang, Y.1    Heym, B.2    Allen, B.3    Young, D.4    Cole, S.5
  • 22
    • 0027211111 scopus 로고
    • Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations
    • Zhang Y, Garbe T, Young D: Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations. Mol Microbiol 1994;8:521-524.
    • (1994) Mol Microbiol , vol.8 , pp. 521-524
    • Zhang, Y.1    Garbe, T.2    Young, D.3
  • 23
  • 24
    • 0029833576 scopus 로고    scopus 로고
    • Presence of katG gene in resistant Mycobacterium tuberculosis
    • Jaber M, Rattan A, Kumar R: Presence of katG gene in resistant Mycobacterium tuberculosis. J Clin Pathol 1996;9:945-947.
    • (1996) J Clin Pathol , vol.9 , pp. 945-947
    • Jaber, M.1    Rattan, A.2    Kumar, R.3
  • 25
    • 0028851341 scopus 로고
    • Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase peroxidase (katG) gene associated with isoniazid resistance
    • Cockerill FR, Uhl JR, Temesgen Z, Zhang Y, Stockman L, Roberts GD, Williams DL, Kline BC: Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase peroxidase (katG) gene associated with isoniazid resistance. J Infect Dis 1995;171:1240-1245.
    • (1995) J Infect Dis , vol.171 , pp. 1240-1245
    • Cockerill, F.R.1    Uhl, J.R.2    Temesgen, Z.3    Zhang, Y.4    Stockman, L.5    Roberts, G.D.6    Williams, D.L.7    Kline, B.C.8
  • 26
    • 0028886398 scopus 로고
    • Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis
    • Rouse DA, Li Z, Bai GH, Morris SL: Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother 1995;39:2472-2477.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2472-2477
    • Rouse, D.A.1    Li, Z.2    Bai, G.H.3    Morris, S.L.4
  • 27
    • 0029836553 scopus 로고    scopus 로고
    • Site directed mutagenesis of the katG gene of Mycobacterium tuberculosis: Effects on catalase-peroxidase activities and isoniazid resistance
    • Rouse DA, DeVito JA, Li Z, Byer H, Morris SL: Site directed mutagenesis of the katG gene of Mycobacterium tuberculosis: Effects on catalase-peroxidase activities and isoniazid resistance. Mol Microbiol 1996;22:583-592.
    • (1996) Mol Microbiol , vol.22 , pp. 583-592
    • Rouse, D.A.1    DeVito, J.A.2    Li, Z.3    Byer, H.4    Morris, S.L.5
  • 30
    • 0031057723 scopus 로고    scopus 로고
    • Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: A blind study at reference laboratory level
    • Telenti A, Honoré N, Bernasconi C, March J, Ortega A, Heym B, Takiff HE, Cole ST: Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: A blind study at reference laboratory level. J Clin Microbiol 1997;35: 719-723.
    • (1997) J Clin Microbiol , vol.35 , pp. 719-723
    • Telenti, A.1    Honoré, N.2    Bernasconi, C.3    March, J.4    Ortega, A.5    Heym, B.6    Takiff, H.E.7    Cole, S.T.8
  • 31
    • 0029888258 scopus 로고    scopus 로고
    • Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: Characterization and inducibility of ahpc by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis
    • Dhandayuthapani S, Zhang Y, Mudd MH, Deretic V: Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: Characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis. J Bacteriol 1996;178:3641-3649.
    • (1996) J Bacteriol , vol.178 , pp. 3641-3649
    • Dhandayuthapani, S.1    Zhang, Y.2    Mudd, M.H.3    Deretic, V.4
  • 32
    • 0029915633 scopus 로고    scopus 로고
    • AhpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex
    • Wilson TM, Collins DM: ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex. Mol Microbiol 1996;19: 1025-1034.
    • (1996) Mol Microbiol , vol.19 , pp. 1025-1034
    • Wilson, T.M.1    Collins, D.M.2
  • 33
    • 0029959745 scopus 로고    scopus 로고
    • The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid
    • Deretic V, Pagan-Ramos E, Zhang Y, Dhandayuthapani S, Via LE: The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid. Nat Biotechnol 1996;14:1557-1561.
    • (1996) Nat Biotechnol , vol.14 , pp. 1557-1561
    • Deretic, V.1    Pagan-Ramos, E.2    Zhang, Y.3    Dhandayuthapani, S.4    Via, L.E.5
  • 34
    • 0029830769 scopus 로고    scopus 로고
    • Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid
    • Zhang Y, Dhandayuthapani S, Deretic V: Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid. Proc Natl Acad Sci USA 1996;93:13212-13216.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13212-13216
    • Zhang, Y.1    Dhandayuthapani, S.2    Deretic, V.3
  • 35
    • 0028882958 scopus 로고
    • Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: Implications for sensitivity to isoniazid
    • Deretic V, Philipp W, Dhandayuthapani S, Mudd MH, Curcic R, Garbe T, Heym B, Via LE, Cole ST: Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: Implications for sensitivity to isoniazid. Mol Microbiol 1995;17:889-900.
    • (1995) Mol Microbiol , vol.17 , pp. 889-900
    • Deretic, V.1    Philipp, W.2    Dhandayuthapani, S.3    Mudd, M.H.4    Curcic, R.5    Garbe, T.6    Heym, B.7    Via, L.E.8    Cole, S.T.9
  • 37
    • 0026794683 scopus 로고
    • Pyrazinamide sterilizing activity in vitro against semidormant Mycobacterium tuberculosis bacterial populations
    • Heifets L, Lindholm-Levy P: Pyrazinamide sterilizing activity in vitro against semidormant Mycobacterium tuberculosis bacterial populations. Am Rev Respir Dis 1992;145: 1223-1225.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 1223-1225
    • Heifets, L.1    Lindholm-Levy, P.2
  • 38
    • 0029954860 scopus 로고    scopus 로고
    • Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to antituberculous drug pyrazinamide in tubercle bacillus
    • Scorpio A, Zhang Y: Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to antituberculous drug pyrazinamide in tubercle bacillus. Nat Med 1996;2:1-6.
    • (1996) Nat Med , vol.2 , pp. 1-6
    • Scorpio, A.1    Zhang, Y.2
  • 40
    • 0031029455 scopus 로고    scopus 로고
    • Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms
    • Sreevatsan S, Pan X, Zhang Y, Kreiswirth BN, Musser JM: Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms. Antimicrob Agents Chemother 1997;41:636-640.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 636-640
    • Sreevatsan, S.1    Pan, X.2    Zhang, Y.3    Kreiswirth, B.N.4    Musser, J.M.5
  • 41
    • 0027262433 scopus 로고
    • Mycobacterium smegmatis RNA polymerase: DNA supercoiling, action of rifampicin and mechanism of rifampicin resistance
    • Levin ME, Hatfull GF: Mycobacterium smegmatis RNA polymerase: DNA supercoiling, action of rifampicin and mechanism of rifampicin resistance. Mol Microbiol 1993;8: 277-285.
    • (1993) Mol Microbiol , vol.8 , pp. 277-285
    • Levin, M.E.1    Hatfull, G.F.2
  • 44
    • 0028961224 scopus 로고
    • Mutation position and type of substitution in the β-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant M. tuberculosis
    • Bodmer T, Zürcher G, Imboden P, Telenti A: Mutation position and type of substitution in the β-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant M. tuberculosis. J Antimicrob Chemother 1995;35: 345-348.
    • (1995) J Antimicrob Chemother , vol.35 , pp. 345-348
    • Bodmer, T.1    Zürcher, G.2    Imboden, P.3    Telenti, A.4
  • 47
    • 0029908204 scopus 로고    scopus 로고
    • The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol
    • Belanger AE, Besra GS, Ford ME, Mikosuva K, Belisle T, Brennan PJ, Inamine JM: The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc Natl Acad Sci USA 1996;93:11919-11924.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11919-11924
    • Belanger, A.E.1    Besra, G.S.2    Ford, M.E.3    Mikosuva, K.4    Belisle, T.5    Brennan, P.J.6    Inamine, J.M.7
  • 49
    • 0028082028 scopus 로고
    • Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: Mapping of mutations conferring resistance
    • Meier A, Kirschner P, Bange FC, Vogel U, Böttger EC: Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: mapping of mutations conferring resistance. Antimicrob Agents Chemother 1994;38:228-233.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 228-233
    • Meier, A.1    Kirschner, P.2    Bange, F.C.3    Vogel, U.4    Böttger, E.C.5
  • 51
    • 0029978270 scopus 로고    scopus 로고
    • Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities
    • Sreevatsan S, Pan X, Stockbauer KE, Williams DL, Kreis-Wirth BN, Musser JM: Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities. Antimicrob Agents Chemother 1996;40:1024-1026.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 1024-1026
    • Sreevatsan, S.1    Pan, X.2    Stockbauer, K.E.3    Williams, D.L.4    Kreis-Wirth, B.N.5    Musser, J.M.6
  • 52
    • 0023238983 scopus 로고
    • Interaction of antibiotics with functional sites in 16s ribosomal RNA
    • Moazed D, Noller HF: Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature 1987; 327:389-394.
    • (1987) Nature , vol.327 , pp. 389-394
    • Moazed, D.1    Noller, H.F.2
  • 53
    • 0029861166 scopus 로고    scopus 로고
    • Correlation of molecular resistance mechanisms and phenotypic resistance level in streptomycin resistant Mycobacterium tuberculosis
    • Meier A, Sander P, Schaper KJ, Scholz M, Böttger EC: Correlation of molecular resistance mechanisms and phenotypic resistance level in streptomycin resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother 1996;40:2452-2454.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2452-2454
    • Meier, A.1    Sander, P.2    Schaper, K.J.3    Scholz, M.4    Böttger, E.C.5
  • 54
    • 0345143010 scopus 로고
    • Synergistic effects of antimycobacterial drugs on Mycobacterium avium complex determined radiometrically in liquid medium
    • Hoffner SE, Svenson SB, Källenius G: Synergistic effects of antimycobacterial drugs on Mycobacterium avium complex determined radiometrically in liquid medium. Eur J Clin Microbiol Infect Dis 1987;6: 530-535.
    • (1987) Eur J Clin Microbiol Infect Dis , vol.6 , pp. 530-535
    • Hoffner, S.E.1    Svenson, S.B.2    Källenius, G.3
  • 56
    • 0026657212 scopus 로고
    • Activities of clarithromycin against eight slowly growing species of non-tuberculous mycobacteria determined by using a broth microdilution MIC system
    • Brown BA, Wallace RJ, Onyi GO: Activities of clarithromycin against eight slowly growing species of non-tuberculous mycobacteria determined by using a broth microdilution MIC system. Antimicrob Agents Chemother 1992;36:1987-1990.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1987-1990
    • Brown, B.A.1    Wallace, R.J.2    Onyi, G.O.3
  • 57
    • 0026541701 scopus 로고
    • Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum. Mycobacterium chelonae, and M. chelonae-like organisms
    • Brown BA, Wallace RJ, Onyi GO, de Rosas V, Wallace RJ: Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum. Mycobacterium chelonae, and M. chelonae-like organisms. Antimicrob Agents Chemother 1992; 36:180-184.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 180-184
    • Brown, B.A.1    Wallace, R.J.2    Onyi, G.O.3    De Rosas, V.4    Wallace, R.J.5
  • 60
    • 0028814739 scopus 로고
    • Rapid development of resistance to clarithromycin following monotherapy for disseminated Mycobacterium chelonae infection in a heart transplant patient
    • Tebas P, Sultan F, Wallace RJ, Fraser V: Rapid development of resistance to clarithromycin following monotherapy for disseminated Mycobacterium chelonae infection in a heart transplant patient. Clin Infect Chemother 1995;20:443-444.
    • (1995) Clin Infect Chemother , vol.20 , pp. 443-444
    • Tebas, P.1    Sultan, F.2    Wallace, R.J.3    Fraser, V.4
  • 61
    • 0028963496 scopus 로고
    • Erythromycin resistance by ribosome modification
    • Weisblum B: Erythromycin resistance by ribosome modification. Antimicrob Agents Chemother 1995;39:577-585.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 577-585
    • Weisblum, B.1
  • 64
    • 0030003258 scopus 로고    scopus 로고
    • Molecular mechanisms of clarithromycin resistance in Mycobacterium avium; observation of multiple 23S r-DNA mutations in a clonal population
    • Meier A, Heifets L, Wallace RJ, Zhang Y, Brown PA, Sander P, Böttger EC: Molecular mechanisms of clarithromycin resistance in Mycobacterium avium; observation of multiple 23S r-DNA mutations in a clonal population. J Infect Dis 1996; 174:354-360.
    • (1996) J Infect Dis , vol.174 , pp. 354-360
    • Meier, A.1    Heifets, L.2    Wallace, R.J.3    Zhang, Y.4    Brown, P.A.5    Sander, P.6    Böttger, E.C.7
  • 66
    • 0030792311 scopus 로고    scopus 로고
    • Bacterial resistance to aminoglycoside antibiotics
    • Davies J, Wright GD: Bacterial resistance to aminoglycoside antibiotics. Trends Microbiol 1997;5:234-240.
    • (1997) Trends Microbiol , vol.5 , pp. 234-240
    • Davies, J.1    Wright, G.D.2
  • 67
    • 0030950670 scopus 로고    scopus 로고
    • Aminoglycosie 2′-N-acetyltransferase genes are universally present in mycobacteria: Characterization of the aac(2′)-Ic gene from Mycobacterium tuberculosis and the aac(2′)-Id gene from Mycobacterium smegmatis
    • Ainsa JA, Perez E, Pelicic V, Berthet FX, Gicquel B, Martin C: Aminoglycosie 2′-N-acetyltransferase genes are universally present in mycobacteria: Characterization of the aac(2′)-Ic gene from Mycobacterium tuberculosis and the aac(2′)-Id gene from Mycobacterium smegmatis. Mol Microbiol 1997;24:431-441.
    • (1997) Mol Microbiol , vol.24 , pp. 431-441
    • Ainsa, J.A.1    Perez, E.2    Pelicic, V.3    Berthet, F.X.4    Gicquel, B.5    Martin, C.6
  • 68
    • 0029800114 scopus 로고    scopus 로고
    • Introducing mutations into a chromosomal rRNA gene using a genetically modified eubacterial host with a single rRNA operon
    • Sander P, Prammananan T, Böttger EC: Introducing mutations into a chromosomal rRNA gene using a genetically modified eubacterial host with a single rRNA operon. Mol Microbiol 1996;22:841-848.
    • (1996) Mol Microbiol , vol.22 , pp. 841-848
    • Sander, P.1    Prammananan, T.2    Böttger, E.C.3
  • 69
    • 0031802176 scopus 로고    scopus 로고
    • A single 16S ribosomal RNA substitution is responsible for amikacin and other 2-deoxystreptamine aminoglycoside resistance in Mycobacterium abscessus and Mycobacterium chelonae
    • Prammananan T, Sander P, Brown BA, Frischkorn K, Onyi GO, Zhang Y, Böttger EC, Wallace RJ: A single 16S ribosomal RNA substitution is responsible for amikacin and other 2-deoxystreptamine aminoglycoside resistance in Mycobacterium abscessus and Mycobacterium chelonae. J Infect Dis 1998;177:1573-1581.
    • (1998) J Infect Dis , vol.177 , pp. 1573-1581
    • Prammananan, T.1    Sander, P.2    Brown, B.A.3    Frischkorn, K.4    Onyi, G.O.5    Zhang, Y.6    Böttger, E.C.7    Wallace, R.J.8
  • 71
    • 9344242918 scopus 로고    scopus 로고
    • Propylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both
    • Havlir DV, Dube MP, Sattler FR, Forthal DN, Kemper CA, Dunne MW: Propylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both. N Engl J Med 1996;335:392-398.
    • (1996) N Engl J Med , vol.335 , pp. 392-398
    • Havlir, D.V.1    Dube, M.P.2    Sattler, F.R.3    Forthal, D.N.4    Kemper, C.A.5    Dunne, M.W.6
  • 72
    • 9344235425 scopus 로고    scopus 로고
    • A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome
    • Pierce M, Crampton S, Henry D, Heifets L, La Marca A, Montecalvo M: A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome. N Engl J Med 1996;335:384-391.
    • (1996) N Engl J Med , vol.335 , pp. 384-391
    • Pierce, M.1    Crampton, S.2    Henry, D.3    Heifets, L.4    La Marca, A.5    Montecalvo, M.6
  • 73
    • 0030857664 scopus 로고    scopus 로고
    • Prophylaxis of mycobacterial infection and acquired drug resistance
    • Böttger EC, Böttger O, Stichnoth DO: Prophylaxis of mycobacterial infection and acquired drug resistance. J Antimicrob Chemother 1997;40:145-146.
    • (1997) J Antimicrob Chemother , vol.40 , pp. 145-146
    • Böttger, E.C.1    Böttger, O.2    Stichnoth, D.O.3


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