Novel thiopyrano[3,2-b] and cycloalkeno[1,2-b]indole derivatives with high inhibitory properties in LTB4 production

European Journal of Medicinal Chemistry

Volumn 34, Issue 1, 1999, Pages 51-61

  Kuehm Caubère, Catherine ^a   Caubère, Paul ^b   Jamart Grégoire, Brigitte ^b   Pfeiffer, Bruno ^a   Guardiola Lemaître, Béatrice ^c   Manechez, Dominique ^c   Renard, Pierre ^a  

^a ADIR   (France)

^b Univ H   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

5 lipoxygenase inhibition; 5 lipoxygenase activating protein (FLAP); Antiinflammatory properties; Antipsoriatic properties; Cycloalkanoindoles; LTB4 production inhibition; Thiopyranoindoles

Indexed keywords

ANTIPSORIASIS AGENT; ARACHIDONATE 5 LIPOXYGENASE; CYCLOALKANE DERIVATIVE; INDOLE DERIVATIVE; LEUKOTRIENE B4;

ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CATALYSIS; DEMETHYLATION; DERIVATIZATION; ENZYME ACTIVATION; ENZYME METABOLISM; GRANULOCYTE; LIGAND BINDING; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; STRUCTURE ANALYSIS;

EID: 0345044906     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80040-3     Document Type: Article

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