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Volumn 120, Issue 2, 2010, Pages 379-389

Combined therapeutic effect of a monoclonal anti-idiotype tumor vaccine against NeuGc-containing gangliosides with chemotherapy in a breast carcinoma model

Author keywords

Angiogenesis; Anti idiotype monoclonal antibody; Breast cancer; Cancer vaccine; Chemotherapy; Combinatorial therapy; Myeloid cells gr1+ cd11b+ apoptosis; Neugc containing ganglioside

Indexed keywords

ALUMINUM POTASSIUM SULFATE; CANCER VACCINE; CD11B ANTIGEN; CYCLOPHOSPHAMIDE; DOXORUBICIN; GANGLIOSIDE; RACOTUMOMAB; UNCLASSIFIED DRUG;

EID: 77950690146     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-009-0399-9     Document Type: Article
Times cited : (26)

References (52)
  • 1
    • 0034022716 scopus 로고    scopus 로고
    • Tumor-specific immunotherapy based on dominant models of natural tolerance
    • DOI 10.1054/mehy.1999.0892
    • 1. Montero E, Amador JF, Perez R, Lage A (2000) Tumor-specific immunotherapy based on dominant models of natural tolerance. Med Hypotheses 54:531-536. doi:10.1054/mehy.1999.0892 (Pubitemid 30311541)
    • (2000) Medical Hypotheses , vol.54 , Issue.4 , pp. 531-536
    • Montero, E.1    Amador, J.F.2    Perez, R.3    Lage, A.4
  • 4
    • 0032412454 scopus 로고    scopus 로고
    • Syngeneic anti-idiotypic monoclonal antibodies to an anti-NeuGc- Containing ganglioside monoclonal antibody
    • 4. Vazquez AM, Perez A, Hernandez AM, Macias A, Alfonso M, Bombino G, Perez R (1998) Syngeneic anti-idiotypic monoclonal antibodies to an anti.-NeuGc-containing ganglioside monoclonal antibody. Hybridoma 17:527-534 (Pubitemid 29024638)
    • (1998) Hybridoma , vol.17 , Issue.6 , pp. 527-534
    • Vazquez, A.M.1    Perez, A.2    Hernandez, A.M.3    Macias, A.4    Alfonso, M.5    Bombino, G.6    Perez, R.7
  • 5
    • 0034219460 scopus 로고    scopus 로고
    • Antitumor properties of an anti-idiotypic monoclonal antibody in relation to N-glycolyl-containing gangliosides
    • Vazquez AM, Gabri MR, Hernandez AM, Alonso DF, Beausoleil I, Gomez DE, Perez R (2000) Antitumor properties of an anti-idiotypic monoclonal antibody in relation to N-glycolyl-containing gangliosides. Oncol Rep 7:751-756
    • (2000) Oncol Rep , vol.7 , pp. 751-756
    • Vazquez, A.M.1    Gabri, M.R.2    Hernandez, A.M.3    Alonso, D.F.4    Beausoleil, I.5    Gomez, D.E.6    Perez, R.7
  • 6
    • 77950689203 scopus 로고    scopus 로고
    • Anti-ganglioside anti-idiotypic monoclonal antibodybased cancer vaccine induces apoptosis and antiangiogenic effect in a metastatic lung carcinoma
    • Diaz Y, Gonzalez A, Lopez A, Perez R, Vazquez AM, Montero E (2008) Anti-ganglioside anti-idiotypic monoclonal antibodybased cancer vaccine induces apoptosis and antiangiogenic effect in a metastatic lung carcinoma. Cancer Immunol Immunother
    • (2008) Cancer Immunol Immunother
    • Diaz, Y.1    Gonzalez, A.2    Lopez, A.3    Perez, R.4    Vazquez, A.M.5    Montero, E.6
  • 9
    • 33847197174 scopus 로고    scopus 로고
    • Evidence accumulating in support of cancer vaccines combined with chemotherapy: A pragmatic review of past and present efforts
    • Sinkovics JG, Horvath JC (2006) Evidence accumulating in support of cancer vaccines combined with chemotherapy: a pragmatic review of past and present efforts. Int J Oncol. 29: 765-777
    • (2006) Int J Oncol. , vol.29 , pp. 765-777
    • Sinkovics, J.G.1    Horvath, J.C.2
  • 10
    • 0034048358 scopus 로고    scopus 로고
    • Less is, more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • 10. Hanahan D, Bergers G, Bergsland E (2000) Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest 1.05:1045-1047. doi:10.1172/JCI9872 (Pubitemid 30217688)
    • (2000) Journal of Clinical Investigation , vol.105 , Issue.8 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 12
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • 12. Browder T, Butterfield CE, Kraling BM, Shi B, Marshall B, O'Reilly MS, Folkman J (2000) Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60:1878-1886 (Pubitemid 30207647)
    • (2000) Cancer Research , vol.60 , Issue.7 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3    Shi, B.4    Marshall, B.5    O'Reilly, M.S.6    Folkman, J.7
  • 13
    • 20444467321 scopus 로고    scopus 로고
    • Immunostimulatory effects of low-dose cyclophosphamide are controlled by inducible nitric oxide synthase
    • DOI 10.1158/0008-5472.CAN-05-0646
    • 13. Loeffler M, Kruger JA, Reisfeld RA (2005) Immunostimulatory effects of low-dose cyclophosphamide are controlled by inducible nitric oxide synthase. Cancer Res 65:5027-5030, doi:10.1158/0008-5472.CAN-05-0646 (Pubitemid 40827309)
    • (2005) Cancer Research , vol.65 , Issue.12 , pp. 5027-5030
    • Loeffler, M.1    Kruger, J.A.2    Reisfeld, R.A.3
  • 14
    • 0029785179 scopus 로고    scopus 로고
    • Characterization of F3II, a sarcomatoid mammary carcinoma cell line originated from a clonal subpopulation of a mouse adenocarcinoma
    • DOI 10.1002/(SICI)1096-9098(199608)62:4<288::AID-JSO14>3.0.CO;2-1
    • 14. Alonso DF, Farias EF, Urtreger A, Ladeda V, Vidal MC, Bal De Kier Joffe E (1996) Characterization of F3II, a sarcomatoid mammary carcinoma cell line originated from a clonal subpopulation of a mouse adenocarcinoma. J Surg Oncol 62:288-297. doi:10.1002/(SICI)1096-9098(199608)62:4<288::AID-JSO14> 3.0.CO;2-1 (Pubitemid 26262354)
    • (1996) Journal of Surgical Oncology , vol.62 , Issue.4 , pp. 288-297
    • Alonso, D.F.1    Farias, E.F.2    Urtreger, A.3    Ladeda, V.4    Vidal, M.C.5    Bal De Kier Joffe, E.6
  • 15
    • 0031784485 scopus 로고    scopus 로고
    • Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis
    • DOI 10.1023/A:1006058409974
    • 15. Alonso DF, Farina HG, Skilton G, Gabri MR, De Lorenzo MS, Gomez DE (1998) Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis. Breast Cancer Res Treat 50: 83-93. doi:10.1023/A:1006058409974 (Pubitemid 28438864)
    • (1998) Breast Cancer Research and Treatment , vol.50 , Issue.1 , pp. 83-93
    • Alonso, D.F.1    Farina, H.G.2    Skilton, G.3    Gabri, M.R.4    De Lorenzo, M.S.5    Gomez, D.E.6
  • 17
    • 0013528330 scopus 로고    scopus 로고
    • DIGIPAT. un sistema cubano para morfometría de imágenes
    • Coro RM, Borrajero I (1996) DIGIPAT. Un sistema cubano para morfometría de imágenes. Rev Latinoam Patol 34:9-10
    • (1996) Rev Latinoam Patol , vol.34 , pp. 9-10
    • Coro, R.M.1    Borrajero, I.2
  • 18
    • 0343851552 scopus 로고    scopus 로고
    • Role of tumor-derived granulocyte-macrophage colonystimulating factor in mice bearing a highly invasive and metastatic mammary carcinoma
    • doi:10.1159/000028070
    • Gabri MR, Menna PL, Scursoni AM, Gomez DE, Alonso DF (1999) Role of tumor-derived granulocyte-macrophage colonystimulating factor in mice bearing a highly invasive and metastatic mammary carcinoma. Pathobiology 67:180-185. doi:10.1159/000028070
    • (1999) Pathobiology , vol.67 , pp. 180-185
    • Gabri, M.R.1    Menna, P.L.2    Scursoni, A.M.3    Gomez, D.E.4    Alonso, D.F.5
  • 19
    • 0034551670 scopus 로고    scopus 로고
    • Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
    • Bronte V, Apolloni E, Cabrelle A, Ronca R, Serafini P, Zamboni P, Restiro NP, Zanovello P (2000) Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood 96:3838-3846
    • (2000) Blood , vol.96 , pp. 3838-3846
    • Bronte, V.1    Apolloni, E.2    Cabrelle, A.3    Ronca, R.4    Serafini, P.5    Zamboni, P.6    Restiro, N.P.7    Zanovello, P.8
  • 20
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • doi:10.101.6/S0092-8674(00)81683-9
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70. doi:10.101.6/S0092-8674(00)81683-9
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 24
    • 33645237406 scopus 로고    scopus 로고
    • Clinical evidences of GM3 (NeuGc) ganglioside expression in human breast cancer using the 14F7 monoclonal antibody labelled with (99 m)Tc
    • doi:10.1007/s10549-005-9064-0
    • Oliva JP, Valdes Z, Casaco A, Pimentel G, Gonzalez J, Alvarez I, Osorio M, Velazco M, Figueroa M, Ortiz R et al (2006) Clinical evidences of GM3 (NeuGc) ganglioside expression in human breast cancer using the 14F7 monoclonal antibody labelled with (99 m)Tc. Breast Cancer Res Treat 96:115-121. doi:10.1007/s10549-005-9064-0
    • (2006) Breast Cancer Res Treat , vol.96 , pp. 115-121
    • Oliva, J.P.1    Valdes, Z.2    Casaco, A.3    Pimentel, G.4    Gonzalez, J.5    Alvarez, I.6    Osorio, M.7    Velazco, M.8    Figueroa, M.9    Ortiz, R.10
  • 26
    • 18344375283 scopus 로고    scopus 로고
    • Immunotherapy and chemotherapy-a practical partnership
    • doi:10.1038/nrc1613
    • Lake RA, Robinson BW (2005) Immunotherapy and chemotherapy-a practical partnership. Nat Rev Cancer 5:397-405. doi:10.1038/nrc1613
    • (2005) Nat Rev Cancer , vol.5 , pp. 397-405
    • Lake, R.A.1    Robinson, B.W.2
  • 28
    • 33645984249 scopus 로고    scopus 로고
    • Spindle cell (sarcomatoid) carcinoma of the breast: A clinicopathologic and immunohistochemical analysis of 29 cases
    • DOI 10.1097/01.pas.0000184809.27735.a1, PII 0000047820060300000002
    • 28. Carter MR, Hornick JL, Lester S, Fletcher CD (2006) Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases. Am J Surg Pathol 30:300-309 (Pubitemid 43740161)
    • (2006) American Journal of Surgical Pathology , vol.30 , Issue.3 , pp. 300-309
    • Carter, M.R.1    Hornick, J.L.2    Lester, S.3    Fletcher, C.D.M.4
  • 29
    • 33751209215 scopus 로고    scopus 로고
    • Combined chemoimmunotherapy of solid tumours: Improving vaccines?
    • doi:10.1016/j.addr.2006.04.002
    • Nowak AK, Lake RA, Robinson BW (2006) Combined chemoimmunotherapy of solid tumours: improving vaccines? Adv Drug Deliv Rev 58:975-990. doi:10.1016/j.addr.2006.04.002
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 975-990
    • Nowak, A.K.1    Lake, R.A.2    Robinson, B.W.3
  • 30
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • 30. Klement G, Baruchel S, Rak J, Man S, Clark K, Hicklin DJ, Bohlen P, Kerbel RS (2000) Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 105:R15-R24. doi:10.1172/JCI8829 (Pubitemid 30217701)
    • (2000) Journal of Clinical Investigation , vol.105 , Issue.8
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.J.6    Bohlen, P.7    Kerbel, R.S.8
  • 31
    • 0038577172 scopus 로고    scopus 로고
    • Immune responses in breast cancer patients immunized with an anti-idiotype antibody mimicking NeuGc-containing gangliosides
    • DOI 10.1016/S1521-6616(03)00036-6
    • 31. Diaz A, Alfonso M, Alonso R, Saurez G, Troche M, Catala M, Diaz RM, Perez R, Vazquez AM (2003) Immune responses in breast cancer patients immunized with an anti-idiotype antibody mimicking NeuGc-containing gangliosides. Clin Immunol 107:80-89. doi:10.1016/S1521-6616(03)00036-6 (Pubitemid 36579371)
    • (2003) Clinical Immunology , vol.107 , Issue.2 , pp. 80-89
    • Diaz, A.1    Alfonso, M.2    Alonso, R.3    Saurez, G.4    Troche, M.5    Catala, M.6    Diaz, R.M.7    Perez, R.8    Vazquez, A.M.9
  • 32
    • 33646768654 scopus 로고    scopus 로고
    • Cellular and humoral immune response to N-glycolyl-GM3 elicited by prolonged immunotherapy with an anti-idiotypic vaccine in high-risk and metastatic breast cancer patients
    • DOI 10.1097/01.cji.0000188502.11348.34, PII 0000237120060300000011
    • 32. Guthmann MD, Castro MA, Cinat G, Venier C, Koliren L, Bitton RJ, Vazquez AM, Fainboim L (2006) Cellular and humoral immune response to N-glycolyl-GM3 elicited by prolonged immunotherapy with an anti-idiotypic vaccine in high-risk and metastatic breast cancer patients. J Immunother 29:215-223. doi:10.1097/01.cji.0000188502.11348.34 (Pubitemid 43756097)
    • (2006) Journal of Immunotherapy , vol.29 , Issue.2 , pp. 215-223
    • Guthmann, M.D.1    Castro, M.A.2    Cinat, G.3    Venier, C.4    Koliren, L.5    Bitton, R.J.6    Vazquez, A.M.7    Fainboim, L.8
  • 34
    • 0035266136 scopus 로고    scopus 로고
    • Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci
    • 34. Kanwar JR, Kanwar RK, Pandey S, Ching LM, Krissansen GW (2001) Vascular attack by 5, 6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci. Cancer Res 61:1948-1956 (Pubitemid 32692012)
    • (2001) Cancer Research , vol.61 , Issue.5 , pp. 1948-1956
    • Kanwar, J.R.1    Kanwar, R.K.2    Pandey, S.3    Ching, L.-M.4    Krissansen, G.W.5
  • 35
    • 0035328683 scopus 로고    scopus 로고
    • Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice
    • 35. Machieis JP, Reilly RT, Emens LA, Ercolini AM, Lei RY, Weintraub D, Okoye FI, Jaffee EM (2001) Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factorsecreting whole-cell vaccines in HER-2/neu tolerized mice. Cancer Res 61:3689-3697 (Pubitemid 32694981)
    • (2001) Cancer Research , vol.61 , Issue.9 , pp. 3689-3697
    • Machiels, J.-P.H.1    Todd Reilly, R.2    Emens, L.A.3    Ercolini, A.M.4    Lei, R.Y.5    Weintraub, D.6    Okoye, F.I.7    Jaffee, E.M.8
  • 36
    • 7044231363 scopus 로고    scopus 로고
    • Doxorubicin and paclitaxel enhance the antitumor efficacy of vaccines directed against HER 2/neu in a murine mammary carcinoma model
    • doi:10.1186/bcr787
    • Eralp Y, Wang X, Wang JP, Maughan MF, Polo JM, Lachman LB (2004) Doxorubicin and paclitaxel enhance the antitumor efficacy of vaccines directed against HER 2/neu in a murine mammary carcinoma model. Breast Cancer Res 6:R275-R283. doi:10.1186/bcr787
    • (2004) Breast Cancer Res , vol.6
    • Eralp, Y.1    Wang, X.2    Wang, J.P.3    Maughan, M.F.4    Polo, J.M.5    Lachman, L.B.6
  • 37
    • 33745699557 scopus 로고    scopus 로고
    • Evaluating strategies to enhance the anti-tumor immune response to a carbohydrate mimetic peptide vaccine
    • Monzavi-Karbassi B, Pashov A, Jousheghany F, Artaud C, Kieber-Emmons T (2006) Evaluating strategies to enhance the anti-tumor immune response to a carbohydrate mimetic peptide vaccine. Int J Mol Med 17:1045-1052
    • (2006) Int J Mol Med , vol.17 , pp. 1045-1052
    • Monzavi-Karbassi, B.1    Pashov, A.2    Jousheghany, F.3    Artaud, C.4    Kieber-Emmons, T.5
  • 38
    • 33744935272 scopus 로고    scopus 로고
    • + T cells against human leukemia-associated minor histocompatibility antigens
    • DOI 10.1158/0008-5472.CAN-05-3130
    • 38. Rice J, Dunn S, Piper K, Buchan SL, Moss PA, Stevenson FK (2006) DNA fusion vaccines induce epitope-specific cytotoxic CD8(+) T cells against human leukemia-associated minor histocompatibility antigens. Cancer Res 66:5436-5442. doi:10.1158/0008-5472.CAN-05-3130 (Pubitemid 43844971)
    • (2006) Cancer Research , vol.66 , Issue.10 , pp. 5436-5442
    • Rice, J.1    Dunn, S.2    Piper, K.3    Buchan, S.L.4    Moss, P.A.5    Stevenson, F.K.6
  • 39
    • 24944478531 scopus 로고    scopus 로고
    • Leveraging the activity of tumor vaccines with cytotoxic chemotherapy
    • DOI 10.1158/0008-5472.CAN-05-1797
    • 39. Emens LA, Jaffee EM (2005) Leveraging the activity of tumor vaccines with cytotoxic chemotherapy. Cancer Res 65:8059-8064. doi:10.1158/0008-5472.CAN- 05-1797 (Pubitemid 41330564)
    • (2005) Cancer Research , vol.65 , Issue.18 , pp. 8059-8064
    • Emens, L.A.1    Jaffee, E.M.2
  • 40
    • 34648847075 scopus 로고    scopus 로고
    • Interleukin-2 mastering regulation in cancer and autoimmunity
    • DOI 10.1196/annals.1381.026, Autoimmunity, Part C The Mosaic of Autoimmunity
    • 40. Montero E, Alonso L, Perez R, Lage A (2007) Interleukin-2 mastering regulation in cancer and autoimmunity. Ann N Y Acad Sci 1107:239-250. doi:10.1196/annals. 1381.026 (Pubitemid 47528801)
    • (2007) Annals of the New York Academy of Sciences , vol.1107 , pp. 239-250
    • Montero, E.1    Alonso, L.2    Perez, R.3    Lage, A.4
  • 41
    • 48649107126 scopus 로고    scopus 로고
    • Refractoriness to antivascular endothelial growth factor treatment: Role of myeloid cells
    • doi:10.1158/0008-5472.CAN-08-0925
    • Shojaei F, Ferrara N (2008) Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells. Cancer Res 68:5501-5504. doi:10.1158/0008-5472.CAN-08-0925
    • (2008) Cancer Res , vol.68 , pp. 5501-5504
    • Shojaei, F.1    Ferrara, N.2
  • 42
    • 40449105940 scopus 로고    scopus 로고
    • Equilibrium between host and cancer caused by effector T cells killing tumor stroma
    • DOI 10.1158/0008-5472.CAN-07-5324
    • 42. Zhang B, Zhang Y, Bowerman NA, Schietinger A, Fu YX, Kranz DM, Rowley DA, Schreiber H (2008) Equilibrium between host and cancer caused by effector T cells killing tumor stroma. Cancer Res 68:1563-1571. doi:10.11.58/0008-5472. CAN-07-5324 (Pubitemid 351346866)
    • (2008) Cancer Research , vol.68 , Issue.5 , pp. 1563-1571
    • Zhang, B.1    Zhang, Y.2    Bowerman, N.A.3    Schietinger, A.4    Fu, Y.-X.5    Kranz, D.M.6    Rowley, D.A.7    Schreiber, H.8
  • 44
    • 44449147036 scopus 로고    scopus 로고
    • Tumor cell metabolism: Cancer's Achilles' heel
    • DOI 10.1016/j.ccr.2008.05.005, PII S1535610808001608
    • 44. Kroemer G, Pouyssegur J (2008) Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13:472-482. doi:1.0.10.16/j.ccr.2008.05.005 (Pubitemid 351766797)
    • (2008) Cancer Cell , vol.13 , Issue.6 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 45
    • 45749134564 scopus 로고    scopus 로고
    • The anticancer immune response: Indispensable for therapeutic success?
    • doi:10.1172/JCI35180
    • Zitvogel L, Apetoh L, Ghiringhelli F, Andre F, Tesniere A, Kroemer G (2008) The anticancer immune response: indispensable for therapeutic success? J Clin Invest 118:1991-2001. doi:10.1172/JCI35180
    • (2008) J Clin Invest , vol.118 , pp. 1991-2001
    • Zitvogel, L.1    Apetoh, L.2    Ghiringhelli, F.3    Andre, F.4    Tesniere, A.5    Kroemer, G.6
  • 46
    • 0035201127 scopus 로고    scopus 로고
    • Tumor-induced immune dysfunctions caused by myeloid suppressor cells
    • DOI 10.1097/00002371-200111000-00001
    • 46. Bronte V, Serafini P, Apolloni E, Zanovello P (2001) Tumorinduced immune dysfunctions caused by myeloid suppressor cells. J Immunother 24:431-446 (Pubitemid 33104863)
    • (2001) Journal of Immunotherapy , vol.24 , Issue.6 , pp. 431-446
    • Bronte, V.1    Serafini, P.2    Apolloni, E.3    Zanovello, P.4
  • 47
    • 25144466458 scopus 로고    scopus 로고
    • + myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • doi:10.1158/1078-0432.CCR-05-0883
    • + myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res 11:6713-6721. doi:10.1158/1078-0432.CCR-05-0883
    • (2005) Clin Cancer Res , vol.11 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3    Kaiser, L.R.4    Albelda, S.M.5
  • 48
    • 33751531874 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
    • DOI 10.1084/jem.20061104
    • 48. Serafini P, Meckel K, Kelso M, Noonan K, Califano J, Koch W, Dolcetti L, Bronte V, Borrello I (2006) Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med 203:2691-2702. doi:10.1084/jem.20061104 (Pubitemid 44833345)
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.12 , pp. 2691-2702
    • Serafini, P.1    Meckel, K.2    Kelso, M.3    Noonan, K.4    Califano, J.5    Koch, W.6    Dolcetti, L.7    Bronte, V.8    Borrello, I.9
  • 49
    • 45549092607 scopus 로고    scopus 로고
    • Cancer immunology
    • doi:10.1056/NEJMra072739
    • Finn OJ (2008) Cancer immunology. N Engl J Med 358:2704-2715. doi:10.1056/NEJMra072739
    • (2008) N Engl J Med , vol.358 , pp. 2704-2715
    • Finn, O.J.1
  • 50
    • 41149096150 scopus 로고    scopus 로고
    • Tumor immunology top 10 list
    • doi:10.1111/j.1600-065X.2008.00623.x
    • Finn OJ (2008) Tumor immunology top 10 list. Immunol Rev 222:5-8. doi:10.1111/j.1600-065X.2008.00623.x
    • (2008) Immunol Rev , vol.222 , pp. 5-8
    • Finn, O.J.1
  • 51
    • 48849094983 scopus 로고    scopus 로고
    • Priming and boosting determinants on the antibody response to an epidermal growth factor-based cancer vaccine
    • doi:10.1016/j.vaccine.2008.07.003
    • Rodriguez PC, Gonzalez I, Gonzalez A, Avellanet J, Lopez A, Perez R, Lage A, Montero E (2008) Priming and boosting determinants on the antibody response to an epidermal growth factor-based cancer vaccine. Vaccine 26:4647-4654. doi:10.1016/j.vaccine.2008.07.003
    • (2008) Vaccine , vol.26 , pp. 4647-4654
    • Rodriguez, P.C.1    Gonzalez, I.2    Gonzalez, A.3    Avellanet, J.4    Lopez, A.5    Perez, R.6    Lage, A.7    Montero, E.8
  • 52
    • 61849137236 scopus 로고    scopus 로고
    • Chemotherapy induced transient B-cell depletion boosts antibody-forming cells expansion driven by an epidermal growth factor-based cancer vaccine
    • doi:10.1016/j.vaccine.2009.02.018
    • Montero E, Valdes M, Avellanet J, Lopez A, Perez R, Lage A (2009) Chemotherapy induced transient B-cell depletion boosts antibody-forming cells expansion driven by an epidermal growth factor-based cancer vaccine. Vaccine 27:2230-2239. doi:10.1016/j.vaccine.2009.02.018
    • (2009) Vaccine , vol.27 , pp. 2230-2239
    • Montero, E.1    Valdes, M.2    Avellanet, J.3    Lopez, A.4    Perez, R.5    Lage, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.