Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 97-103

  Vijaya Bhaskar Reddy, M ^a   Shen, Yuh Chiang ^b   Ohkoshi, Emika ^c   Bastow, Kenneth F ^c   Qian, Keduo ^c   Lee, Kuo Hsiung ^c,d   Wu, Tian Shung ^a,d  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c University of North Carolina   (United States)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bis chalcones; Cytotoxicity; NO production inhibition; Structure activity relationships

Indexed keywords

(2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS(3 PHENYLPROP 2 EN 1 ONE); (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (2,3 DIMETHOXYPHENYL)PROP 2 EN 1 ONE]; (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (2,3,4 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE]; (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (2,5 DIMETHOXYPHENYL)PROP 2 EN 1 ONE]; (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (3 METHOXYPHENYL)PROP 2 EN 1 ONE]; (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (3 METHYLFURAN 2 YL)PROP 2 EN 1 ONE]; (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (3,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE]; (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE]; (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE]; (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (FURAN 2 YL)PROP 2 EN 1 ONE]; (2, 2') 1,1' (4,6 DIHYDROXY 1,3 PHENYLENE)BIS[3 (PYRIDIN 2 YL)PROP 2 EN 1 ONE]; ALDEHYDE DERIVATIVE; CHALCONE DERIVATIVE; CYTOTOXIC AGENT; DIACETYLRESORCINOL; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; RESORCINOL DERIVATIVE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MICROGLIA; ONE STEP CLAISEN SCHMIDT CONDENSATION; POLYMERIZATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHALCONE; HUMANS; I-KAPPA B KINASE; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; TRANSCRIPTION FACTOR RELA;

EID: 84855778053     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.026     Document Type: Article

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