메뉴 건너뛰기




Volumn 167, Issue 2, 2012, Pages 356-365

Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: Differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice

Author keywords

Butyrate; Clostridium tyrobutyricum; Confocal fluorimetry; Dextran sodium sulphate induced colitis; SCID mice

Indexed keywords

BUTYRIC ACID; CD11B ANTIGEN; DEXTRAN SULFATE; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; INTERLEUKIN 18; MUCIN 2; PROBIOTIC AGENT; PROTEIN ZO1; TUMOR NECROSIS FACTOR ALPHA;

EID: 84855768263     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04498.x     Document Type: Article
Times cited : (49)

References (52)
  • 1
    • 25444461358 scopus 로고    scopus 로고
    • Involvement of innate immunity in the development of inflammatory and autoimmune diseases
    • Tlaskalova-Hogenova H, Tuckova L, Stepankova R etal. Involvement of innate immunity in the development of inflammatory and autoimmune diseases. Ann NY Acad Sci 2005; 1051:787-98.
    • (2005) Ann NY Acad Sci , vol.1051 , pp. 787-798
    • Tlaskalova-Hogenova, H.1    Tuckova, L.2    Stepankova, R.3
  • 2
    • 39449127013 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis
    • Frolova L, Drastich P, Rossmann P, Klimesova K, Tlaskalova-Hogenova H. Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. J Histochem Cytochem 2008; 56:267-74.
    • (2008) J Histochem Cytochem , vol.56 , pp. 267-274
    • Frolova, L.1    Drastich, P.2    Rossmann, P.3    Klimesova, K.4    Tlaskalova-Hogenova, H.5
  • 3
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 1993; 69:238-49.
    • (1993) Lab Invest , vol.69 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.2    Shah, R.S.3    Sedergran, D.J.4
  • 5
    • 35348945960 scopus 로고    scopus 로고
    • Segmented filamentous bacteria in a defined bacterial cocktail induces intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells
    • Stepankova R, Powrie F, Kofronova O etal. Segmented filamentous bacteria in a defined bacterial cocktail induces intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells. Inflamm Bowel Dis 2007; 13:1202-11.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 1202-1211
    • Stepankova, R.1    Powrie, F.2    Kofronova, O.3
  • 6
    • 0035757522 scopus 로고    scopus 로고
    • The role of microflora in the development of intestinal inflammation: acute and chronic colitis induced by dextran sulfate in germ-free and conventionally reared immunocompetent and immunodeficient mice
    • Hudcovic T, Stepankova R, Cebra J, Tlaskalova-Hogenova H. The role of microflora in the development of intestinal inflammation: acute and chronic colitis induced by dextran sulfate in germ-free and conventionally reared immunocompetent and immunodeficient mice. Folia Microbiol 2001; 46:565-72.
    • (2001) Folia Microbiol , vol.46 , pp. 565-572
    • Hudcovic, T.1    Stepankova, R.2    Cebra, J.3    Tlaskalova-Hogenova, H.4
  • 7
    • 77957906400 scopus 로고    scopus 로고
    • Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model
    • Johansson ME, Gustafsson JK, Sjoberg KE etal. Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLoS ONE 2010; 5:e12238.
    • (2010) PLoS ONE , vol.5
    • Johansson, M.E.1    Gustafsson, J.K.2    Sjoberg, K.E.3
  • 8
    • 0025181580 scopus 로고
    • A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
    • Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990; 98:694-702.
    • (1990) Gastroenterology , vol.98 , pp. 694-702
    • Okayasu, I.1    Hatakeyama, S.2    Yamada, M.3    Ohkusa, T.4    Inagaki, Y.5    Nakaya, R.6
  • 10
    • 0036080443 scopus 로고    scopus 로고
    • Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitis
    • Renes IB, Boshuizen JA, Van Nispen DJ etal. Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitis. Am J Physiol 2002; 282:G382-9.
    • (2002) Am J Physiol , vol.282
    • Renes, I.B.1    Boshuizen, J.A.2    Van Nispen, D.J.3
  • 11
    • 0033769165 scopus 로고    scopus 로고
    • The dietary combination of germinated barley foodstuff plus Clostridium butyricum suppresses the dextran sulfate sodium-induced experimental colitis in rats
    • Araki Y, Fujiyama Y, Andoh A, Koyama S, Kanauchi O, Bamba T. The dietary combination of germinated barley foodstuff plus Clostridium butyricum suppresses the dextran sulfate sodium-induced experimental colitis in rats. Scand J Gastroenterol 2000; 35:1060-7.
    • (2000) Scand J Gastroenterol , vol.35 , pp. 1060-1067
    • Araki, Y.1    Fujiyama, Y.2    Andoh, A.3    Koyama, S.4    Kanauchi, O.5    Bamba, T.6
  • 12
    • 66549123465 scopus 로고    scopus 로고
    • Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon
    • Gaudier E, Rival M, Buisine MP, Robineau I, Hoebler C. Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon. Physiol Res 2009; 58:111-19.
    • (2009) Physiol Res , vol.58 , pp. 111-119
    • Gaudier, E.1    Rival, M.2    Buisine, M.P.3    Robineau, I.4    Hoebler, C.5
  • 13
    • 0033773235 scopus 로고    scopus 로고
    • Increased permeability in dextran sulphate colitis in rats: time course of development and effect of butyrate
    • Venkatraman A, Ramakrishna BS, Pulimood AB, Patra S, Murthy S. Increased permeability in dextran sulphate colitis in rats: time course of development and effect of butyrate. Scand J Gastroenterol 2000; 35:1053-9.
    • (2000) Scand J Gastroenterol , vol.35 , pp. 1053-1059
    • Venkatraman, A.1    Ramakrishna, B.S.2    Pulimood, A.B.3    Patra, S.4    Murthy, S.5
  • 14
  • 15
    • 77952682071 scopus 로고    scopus 로고
    • Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier
    • Karczewski J, Troost FJ, Konings I etal. Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier. Am J Physiol 2010; 298:G851-9.
    • (2010) Am J Physiol , vol.298
    • Karczewski, J.1    Troost, F.J.2    Konings, I.3
  • 16
    • 33846894974 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair
    • Zyrek AA, Cichon C, Helms S, Enders C, Sonnenborn U, Schmidt MA. Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair. Cell Microbiol 2007; 9:804-16.
    • (2007) Cell Microbiol , vol.9 , pp. 804-816
    • Zyrek, A.A.1    Cichon, C.2    Helms, S.3    Enders, C.4    Sonnenborn, U.5    Schmidt, M.A.6
  • 17
    • 0034810346 scopus 로고    scopus 로고
    • Intestinal microflora and chronic inflammatory bowel diseases
    • Desreumaux P, Colombel JF. Intestinal microflora and chronic inflammatory bowel diseases. Gastroenterol Clin Biol 2001; 25:C89-93.
    • (2001) Gastroenterol Clin Biol , vol.25
    • Desreumaux, P.1    Colombel, J.F.2
  • 19
    • 34848858207 scopus 로고    scopus 로고
    • A comparative study of the preventative effects exerted by three probiotics, Bifidobacterium lactis, Lactobacillus casei and Lactobacillus acidophilus, in the TNBS model of rat colitis
    • Peran L, Camuesco D, Comalada M etal. A comparative study of the preventative effects exerted by three probiotics, Bifidobacterium lactis, Lactobacillus casei and Lactobacillus acidophilus, in the TNBS model of rat colitis. J Appl Microbiol 2007; 103:836-44.
    • (2007) J Appl Microbiol , vol.103 , pp. 836-844
    • Peran, L.1    Camuesco, D.2    Comalada, M.3
  • 21
    • 0034091384 scopus 로고    scopus 로고
    • Preventive efficacy of butyrate enemas and oral administration of Clostridium butyricum M588 in dextran sodium sulfate-induced colitis in rats
    • Okamoto T, Sasaki M, Tsujikawa T, Fujiyama Y, Bamba T, Kusunoki M. Preventive efficacy of butyrate enemas and oral administration of Clostridium butyricum M588 in dextran sodium sulfate-induced colitis in rats. J Gastroenterol 2000; 35:341-6.
    • (2000) J Gastroenterol , vol.35 , pp. 341-346
    • Okamoto, T.1    Sasaki, M.2    Tsujikawa, T.3    Fujiyama, Y.4    Bamba, T.5    Kusunoki, M.6
  • 22
    • 0023836427 scopus 로고
    • Morphological changes in human embryonic lung fibroblasts caused by cytotoxins of various Clostridium species
    • Schallehn G, Wolff MH. Morphological changes in human embryonic lung fibroblasts caused by cytotoxins of various Clostridium species. Zentralbl Bakteriol Mikrobiol Hyg 1988; 267:367-78.
    • (1988) Zentralbl Bakteriol Mikrobiol Hyg , vol.267 , pp. 367-378
    • Schallehn, G.1    Wolff, M.H.2
  • 23
    • 78650833595 scopus 로고    scopus 로고
    • Therapeutic transplantation of the distal gut microbiota
    • Khoruts A, Sadowsky MJ. Therapeutic transplantation of the distal gut microbiota. Mucosal Immunol 2011; 4:4-7.
    • (2011) Mucosal Immunol , vol.4 , pp. 4-7
    • Khoruts, A.1    Sadowsky, M.J.2
  • 24
    • 0034959553 scopus 로고    scopus 로고
    • Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides
    • Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 2001; 81:1031-64.
    • (2001) Physiol Rev , vol.81 , pp. 1031-1064
    • Topping, D.L.1    Clifton, P.M.2
  • 25
    • 19644386689 scopus 로고    scopus 로고
    • Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation
    • Melgar S, Karlsson A, Michaelsson E. Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation. Am J Physiol 2005; 288:G1328-38.
    • (2005) Am J Physiol , vol.288
    • Melgar, S.1    Karlsson, A.2    Michaelsson, E.3
  • 26
    • 34249913692 scopus 로고    scopus 로고
    • The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression
    • Bauer C, Loher F, Dauer M etal. The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression. Dig Dis Sci 2007; 52:1642-52.
    • (2007) Dig Dis Sci , vol.52 , pp. 1642-1652
    • Bauer, C.1    Loher, F.2    Dauer, M.3
  • 27
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav E, Strowig T, Kau AL etal. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011; 145:745-57.
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1    Strowig, T.2    Kau, A.L.3
  • 28
    • 0021911773 scopus 로고
    • Regional distribution and alterations of lectin binding to colorectal mucin in mucosal biopsies from controls and subjects with inflammatory bowel diseases
    • Jacobs LR, Huber PW. Regional distribution and alterations of lectin binding to colorectal mucin in mucosal biopsies from controls and subjects with inflammatory bowel diseases. J Clin Invest 1985; 75:112-18.
    • (1985) J Clin Invest , vol.75 , pp. 112-118
    • Jacobs, L.R.1    Huber, P.W.2
  • 29
    • 33745746660 scopus 로고    scopus 로고
    • Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
    • Van der Sluis M, De Koning BA, De Bruijn AC etal. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 2006; 131:117-29.
    • (2006) Gastroenterology , vol.131 , pp. 117-129
    • Van der Sluis, M.1    De Koning, B.A.2    De Bruijn, A.C.3
  • 30
    • 34047172442 scopus 로고    scopus 로고
    • Mucosal function in rat jejunum and ileum is altered by induction of colitis
    • Amit-Romach E, Reifen R, Uni Z. Mucosal function in rat jejunum and ileum is altered by induction of colitis. Int J Molecular Med 2006; 18:721-7.
    • (2006) Int J Molecular Med , vol.18 , pp. 721-727
    • Amit-Romach, E.1    Reifen, R.2    Uni, Z.3
  • 33
    • 0032168626 scopus 로고    scopus 로고
    • Involvement of CD4+ T cells in the development of dextran sulfate sodium-induced experimental colitis and suppressive effect of IgG on their action
    • Shintani N, Nakajima T, Okamoto T, Kondo T, Nakamura N, Mayumi T. Involvement of CD4+ T cells in the development of dextran sulfate sodium-induced experimental colitis and suppressive effect of IgG on their action. Gen Pharmacol 1998; 31:477-81.
    • (1998) Gen Pharmacol , vol.31 , pp. 477-481
    • Shintani, N.1    Nakajima, T.2    Okamoto, T.3    Kondo, T.4    Nakamura, N.5    Mayumi, T.6
  • 34
    • 77957603468 scopus 로고    scopus 로고
    • The role of bacteria in the pathogenesis of inflammatory bowel disease
    • Friswell M, Campbell B, Rhodes J. The role of bacteria in the pathogenesis of inflammatory bowel disease. Gut Liver 2010; 4:295-306.
    • (2010) Gut Liver , vol.4 , pp. 295-306
    • Friswell, M.1    Campbell, B.2    Rhodes, J.3
  • 35
    • 0034795561 scopus 로고    scopus 로고
    • Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
    • Siegmund B, Fantuzzi G, Rieder F etal. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Comp Physiol 2001; 281:R1264-73.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Siegmund, B.1    Fantuzzi, G.2    Rieder, F.3
  • 36
    • 44249091188 scopus 로고    scopus 로고
    • Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment
    • Kolinska J, Lisa V, Clark JA etal. Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment. J Interferon Cytokine Res 2008; 28:287-96.
    • (2008) J Interferon Cytokine Res , vol.28 , pp. 287-296
    • Kolinska, J.1    Lisa, V.2    Clark, J.A.3
  • 37
    • 77956128040 scopus 로고    scopus 로고
    • Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
    • Bauer C, Duewell P, Mayer C etal. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut 2010; 59:1192-9.
    • (2010) Gut , vol.59 , pp. 1192-1199
    • Bauer, C.1    Duewell, P.2    Mayer, C.3
  • 38
    • 77949982382 scopus 로고    scopus 로고
    • Interleukin-18 in intestinal inflammation: friend and foe?
    • Siegmund B. Interleukin-18 in intestinal inflammation: friend and foe? Immunity 2010; 32:300-2.
    • (2010) Immunity , vol.32 , pp. 300-302
    • Siegmund, B.1
  • 39
    • 77950002937 scopus 로고    scopus 로고
    • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010; 32:379-91.
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1    Boyd, K.L.2    Vogel, P.3    Kastan, M.B.4    Lamkanfi, M.5    Kanneganti, T.D.6
  • 40
    • 77949965210 scopus 로고    scopus 로고
    • Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    • Dupaul-Chicoine J, Yeretssian G, Doiron K etal. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 2010; 32:367-78.
    • (2010) Immunity , vol.32 , pp. 367-378
    • Dupaul-Chicoine, J.1    Yeretssian, G.2    Doiron, K.3
  • 41
    • 0034133163 scopus 로고    scopus 로고
    • The key role of macrophages in the immunopathogenesis of inflammatory bowel disease
    • Mahida YR. The key role of macrophages in the immunopathogenesis of inflammatory bowel disease. Inflamm Bowel Dis 2000; 6:21-33.
    • (2000) Inflamm Bowel Dis , vol.6 , pp. 21-33
    • Mahida, Y.R.1
  • 42
    • 0027451455 scopus 로고
    • Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
    • Reinecker HC, Steffen M, Witthoeft T etal. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 1993; 94:174-81.
    • (1993) Clin Exp Immunol , vol.94 , pp. 174-181
    • Reinecker, H.C.1    Steffen, M.2    Witthoeft, T.3
  • 44
    • 78149341679 scopus 로고    scopus 로고
    • Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota
    • Noor SO, Ridgway K, Scovell L etal. Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota. BMC Gastroenterol 2010; 10:134.
    • (2010) BMC Gastroenterol , vol.10 , pp. 134
    • Noor, S.O.1    Ridgway, K.2    Scovell, L.3
  • 45
    • 66249109643 scopus 로고    scopus 로고
    • Gut microbiology: fitting into the intestinal neighbourhood
    • Willing BP, Finlay BB. Gut microbiology: fitting into the intestinal neighbourhood. Curr Biol 2009; 19:R457-9.
    • (2009) Curr Biol , vol.19
    • Willing, B.P.1    Finlay, B.B.2
  • 46
    • 0033798852 scopus 로고    scopus 로고
    • Rationale for the luminal provision of butyrate in intestinal diseases
    • Wachtershauser A, Stein J. Rationale for the luminal provision of butyrate in intestinal diseases. Eur J Nutr 2000; 39:164-71.
    • (2000) Eur J Nutr , vol.39 , pp. 164-171
    • Wachtershauser, A.1    Stein, J.2
  • 47
    • 77955472405 scopus 로고    scopus 로고
    • Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission
    • Hamer HM, Jonkers DM, Vanhoutvin SA etal. Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission. Clin Nutr 2010; 29:738-44.
    • (2010) Clin Nutr , vol.29 , pp. 738-744
    • Hamer, H.M.1    Jonkers, D.M.2    Vanhoutvin, S.A.3
  • 48
    • 3242692641 scopus 로고    scopus 로고
    • Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C
    • Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 2004; 127:224-38.
    • (2004) Gastroenterology , vol.127 , pp. 224-238
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 49
    • 12844286019 scopus 로고    scopus 로고
    • Short-chain fatty acids induce colonic mucosal injury in rats with various postnatal ages
    • Nafday SM, Chen W, Peng L, Babyatsky MW, Holzman IR, Lin J. Short-chain fatty acids induce colonic mucosal injury in rats with various postnatal ages. Pediatr Res 2005; 57:201-4.
    • (2005) Pediatr Res , vol.57 , pp. 201-204
    • Nafday, S.M.1    Chen, W.2    Peng, L.3    Babyatsky, M.W.4    Holzman, I.R.5    Lin, J.6
  • 50
    • 20444440260 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha reduces butyrate oxidation in vitro in human colonic mucosa: a link from inflammatory process to mucosal damage?
    • Nancey S, Moussata D, Graber I, Claudel S, Saurin JC, Flourie B. Tumor necrosis factor alpha reduces butyrate oxidation in vitro in human colonic mucosa: a link from inflammatory process to mucosal damage? Inflam Bowel Dis 2005; 11:559-66.
    • (2005) Inflam Bowel Dis , vol.11 , pp. 559-566
    • Nancey, S.1    Moussata, D.2    Graber, I.3    Claudel, S.4    Saurin, J.C.5    Flourie, B.6
  • 51
    • 0036737806 scopus 로고    scopus 로고
    • Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region
    • Kalina U, Koyama N, Hosoda T etal. Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region. Eur J Immunol 2002; 32:2635-43.
    • (2002) Eur J Immunol , vol.32 , pp. 2635-2643
    • Kalina, U.1    Koyama, N.2    Hosoda, T.3
  • 52
    • 77955537640 scopus 로고    scopus 로고
    • Effect of nonpathogenic Escherichia coli monoassociation on small intestinal brush-border glycoconjugate moieties and cytokine production after colonization in ex-germ-free rats and piglets
    • Kolinska J, Zakostelecka M, Schwarzer M, Stepankova R, Hudcovic T, Kozakova H. Effect of nonpathogenic Escherichia coli monoassociation on small intestinal brush-border glycoconjugate moieties and cytokine production after colonization in ex-germ-free rats and piglets. Int J Interferon Cytokine Mediat Res 2010; 2:73-84.
    • (2010) Int J Interferon Cytokine Mediat Res , vol.2 , pp. 73-84
    • Kolinska, J.1    Zakostelecka, M.2    Schwarzer, M.3    Stepankova, R.4    Hudcovic, T.5    Kozakova, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.