Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality

Infection and Immunity

Volumn 79, Issue 12, 2011, Pages 4923-4932

  Anyona, Samuel B ^a,b   Kempaiah, Prakasha ^c   Raballah, Evans ^a   Ouma, Collins ^a,d   Were, Tom ^a,b   Davenport, Gregory C ^c   Konah, Stephen N ^a   Vulule, John M ^a   Hittner, James B ^e   Gichuki, Charity W ^b   Ong'echa, John M ^a   Perkins, Douglas J ^a,c  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b KENYATTA UNIVERSITY   (Kenya)

^c UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^d MASENO UNIVERSITY   (Kenya)

^e School of Business   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; INTERLEUKIN 18;

ALLELE; ANEMIA; ARTICLE; BACTEREMIA; CHILDHOOD MORTALITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE PRODUCT; GENETIC VARIABILITY; GENOTYPE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HAPLOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; INFANT; KENYA; MAJOR CLINICAL STUDY; MALARIA; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; GENE EXPRESSION REGULATION; GENETIC SCREENING; GENETICS; INFANT MORTALITY; MALARIA FALCIPARUM; MORTALITY; PHYSIOLOGY; PROMOTER REGION; RISK; RISK FACTOR;

ANEMIA; FEMALE; GENE EXPRESSION REGULATION; GENETIC TESTING; GENETIC VARIATION; HAPLOTYPES; HUMANS; INFANT; INFANT MORTALITY; INTERLEUKIN-18; KENYA; LINKAGE DISEQUILIBRIUM; MALARIA, FALCIPARUM; MALE; ODDS RATIO; PROMOTER REGIONS, GENETIC; RISK FACTORS;

EID: 84855750776     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05601-11     Document Type: Article

References (54)

1. Abramoff, M. D., P. J. Magelhaes, and S. J. Ram. 2004. Image processing with ImageJ. Biophotonic Int. 11:36-42.
2. An, P., et al. 2008. Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance. J. Infect. Dis. 198:1159-1165.
3. Arimitsu, J., et al. 2006. IL-18 gene polymorphisms affect IL-18 production capability by monocytes. Biochem. Biophys. Res. Commun. 342:1413-1416.
4. Awandare, G. A., et al. 2009. MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia. J. Infect. Dis. 200:629-637.
5. Beier, J. C., et al. 1994. Plasmodium falciparum incidence relative to entomologic inoculation rates at a site proposed for testing malaria vaccines in western Kenya. Am. J. Trop. Med. Hyg. 50:529-536.
6. Bingle, C. D., B. P. Hackett, M. Moxley, W. Longmore, and J. D. Gitlin. 1995. Role of hepatocyte nuclear factor-3 alpha and hepatocyte nuclear factor-3 beta in Clara cell secretory protein gene expression in the bronchiolar epithelium. Biochem. J. 308(Part 1):197-202.
7. Bloland, P. B., et al. 1999. Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission II. Descriptive epidemiology of malaria infection and disease among children. Am. J. Trop. Med. Hyg. 60:641-648.
8. Chaisavaneeyakorn, S., et al. 2003. Relationship between plasma interleukin-12 (IL-12) and IL-18 levels and severe malarial anemia in an area of holoendemicity in western Kenya. Clin. Diagn. Lab. Immunol. 10:362-366.
9. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
10. Cox-Singh, J., et al. 2008. Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening. Clin. Infect. Dis. 46:165-171.
11. Dzeing-Ella, A., et al. 2005. Severe falciparum malaria in Gabonese children: clinical and laboratory features. Malar. J. 4:1.
12. Gaunt, T. R., S. Rodriguez, C. Zapata, and I. N. Day. 2006. MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers. BMC Bioinformatics 7:227.
13. Giedraitis, V., B. He, W. X. Huang, and J. Hillert. 2001. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J. Neuroimmunol. 112:146-152.
14. Hedrick, P. W. 2011. Population genetics of malaria resistance in humans. Heredity 107:283-304.
15. Hollegaard, M. V., and J. L. Bidwell. 2006. Cytokine gene polymorphism in human disease: on-line databases, supplement 3. Genes Immun. 7:269-276.
16. Huang, M. C., K. K. Li, and B. T. Spear. 2002. The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3 (FOXA). DNA Cell Biol. 21:561-569.
17. International HapMap Consortium. 2003. The International HapMap Project. Nature 426:789-796.
18. Kantele, A., and T. S. Jokiranta. 2011. Review of cases with the emerging fifth human malaria parasite, Plasmodium knowlesi. Clin. Infect. Dis. 52: 1356-1362.
19. Koch, O., et al. 2005. Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region. Genes Immun. 6:312-318.
20. Kojima, S., Y. Nagamine, M. Hayano, S. Looareesuwan, and K. Nakanishi. 2004. A potential role of interleukin 18 in severe falciparum malaria. Acta Trop. 89:279-284.
21. Kwiatkowski, D. P., and G. Luoni. 2006. Host genetic factors in resistance and susceptibility to malaria. Parassitologia 48:450-467.
22. Lee, H. M., et al. 2006. Interleukin-18/-607 gene polymorphism in allergic rhinitis. Int. J. Pediatr. Otorhinolaryngol. 70:1085-1088.
23. Liang, X. H., W. Cheung, C. K. Heng, and D. Y. Wang. 2005. Reduced transcriptional activity in individuals with IL-18 gene variants detected from functional but not association study. Biochem. Biophys. Res. Commun. 338: 736-741.
24. Malaguarnera, L., S. Pignatelli, M. Musumeci, J. Simpore, and S. Musumeci. 2002. Plasma levels of interleukin-18 and interleukin-12 in Plasmodium falciparum malaria. Parasite Immunol. 24:489-492.
25. Marsh, K., et al. 1995. Indicators of life-threatening malaria in African children. N. Engl. J. Med. 332:1399-1404.
26. McElroy, P. D., et al. 1999. Analysis of repeated hemoglobin measures in full-term, normal birth weight Kenyan children between birth and four years of age. III. The Asemobo Bay Cohort Project. Am. J. Trop. Med. Hyg. 61:932-940.
27. McInnes, I. B., J. A. Gracie, B. P. Leung, X. Q. Wei, and F. Y. Liew. 2000. Interleukin 18: a pleiotropic participant in chronic inflammation. Immunol. Today 21:312-315.
28. Mockenhaupt, F. P., et al. 2004. Manifestation and outcome of severe malaria in children in northern Ghana. Am. J. Trop. Med. Hyg. 71:167-172.
29. Nagamine, Y., et al. 2003. Involvement of interleukin-18 in severe Plasmodium falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 97:236-241.
30. Nakanishi, K., T. Yoshimoto, H. Tsutsui, and H. Okamura. 2001. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev. 12:53-72.
31. Nakanishi, K., T. Yoshimoto, H. Tsutsui, and H. Okamura. 2001. Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19:423-474.
32. Obonyo, C. O., J. Vulule, W. S. Akhwale, and D. E. Grobbee. 2007. Inhospital morbidity and mortality due to severe malarial anemia in western Kenya. Am. J. Trop. Med. Hyg. 77:23-28.
33. Okamura, H., H. Tsutsui, S. Kashiwamura, T. Yoshimoto, and K. Nakanishi. 1998. Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv. Immunol. 70:281-312.
34. Okiro, E. A., V. A. Alegana, A. M. Noor, and R. W. Snow. 2010. Changing malaria intervention coverage, transmission and hospitalization in Kenya. Malar. J. 9:285.
35. Ong'echa, J. M., et al. 2006. Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area. Am. J. Trop. Med. Hyg. 74:376-385.
36. Otieno, R. O., et al. 2006. Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria. AIDS 20:275-280.
37. Ouma, C., et al. 2008. Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production. J. Infect. Dis. 198:1219-1226.
38. Ouma, C., et al. 2008. Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production. Hum. Genet. 124:515-524.
39. Shin, H. D., et al. 2005. Association of interleukin 18 (IL18) polymorphisms with specific IgE levels to mite allergens among asthmatic patients. Allergy 60:900-906.
40. Singh, R. P., et al. 2002. The role of IL-18 in blood-stage immunity against murine malaria Plasmodium yoelii 265 and Plasmodium berghei ANKA. J. Immunol. 168:4674-4681.
41. Snow, R. W., et al. 1997. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 349:1650-1654.
42. Sugiura, T., et al. 2006. A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population. Arthritis Res. Ther. 8:R60.
43. Thompson, S. R., and S. E. Humphries. 2007. Interleukin-18 genetics and inflammatory disease susceptibility. Genes Immun. 8:91-99.
44. Torre, D., et al. 2001. Serum levels of interleukin-18 in patients with uncomplicated Plasmodium falciparum malaria. Eur. Cytokine Netw. 12:361-364.
45. Tsutsui, H., et al. 1999. Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. Immunity 11:359-367.
46. Walker, W., M. Aste-Amezaga, R. A. Kastelein, G. Trinchieri, and C. A. Hunter. 1999. IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell production of IL-12-induced IFN-gamma. J. Immunol. 162:5894-5901.
47. Were, T., et al. 2011. Bacteremia in Kenyan children presenting with malaria. J. Clin. Microbiol. 49:671-676.
48. WHO. 2000. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans. R. Soc. Trop. Med. Hyg. 94(Suppl. 1): S1-S90.
49. WHO. 2005. World malaria report 2005. World Health Organization/United Nations Children's Fund, Geneva, Switzerland. http://www.rollbackmalaria .org/wmr2005/pdf/WMReport_lr.pdf.
50. WHO. 2008. World malaria report 2008. World Health Organ. Tech. Rep. Ser. 1:1-80.
51. Wilson, J. N., et al. 2005. Analysis of IL10 haplotypic associations with severe malaria. Genes Immun. 6:462-466.
52. Zheng, W., and R. A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89:587-596.
53. Zhou, Y., E. Yamaguchi, N. Hizawa, and M. Nishimura. 2005. Roles of functional polymorphisms in the interleukin-18 gene promoter in sarcoidosis. Sarcoidosis Vasc. Diffuse Lung Dis. 22:105-113.
54. Zucker, J. R., et al. 1997. Clinical signs for the recognition of children with moderate or severe anaemia in western Kenya. Bull. World Health Organ. 75(Suppl. 1):97-102.