Manifestation and outcome of severe malaria in children in northern Ghana

American Journal of Tropical Medicine and Hygiene

Volumn 71, Issue 2, 2004, Pages 167-172

  Mockenhaupt, Frank P ^a   Ehrhardt, Stephan ^b   Burkhardt, Jana ^a   Bosomtwe, Samuel Y ^c   Laryea, Stephen ^c   Anemana, Sylvester D ^d   Otchwemah, Rowland N ^e   Cramer, Jakob P ^a   Dietz, Ekkehart ^f   Gellert, Sabine ^c   Bienzle, Ulrich ^a  

^a Institute of Tropical Medicine   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c Tamale Central Hospital   (Ghana)

^d MINISTRY OF HEALTH   (Ghana)

^e UNIVERSITY FOR DEVELOPMENT STUDIES   (Ghana)

^f Haus 562   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; DIAZEPAM; GLUCOSE; PARACETAMOL; PHENOBARBITAL;

ANEMIA; ARTICLE; CHILD; CLINICAL FEATURE; CONSCIOUSNESS DISORDER; CONVULSION; DISEASE SEVERITY; FATALITY; FEMALE; GHANA; HUMAN; HYPOGLYCEMIA; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MALNUTRITION; MORTALITY; OUTCOMES RESEARCH; RESPIRATORY DISTRESS; RISK ASSESSMENT; RISK FACTOR; SHOCK;

PROTOZOA;

EID: 4243084365     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2004.71.167     Document Type: Article

References (30)

1. WHO, 2000. Severe falciparum malaria. Trans R Soc Trop Med Hyg 94 (Suppl 1): S1-S90.
2. Trape JF, 2001. The public health impact of chloroquine resistance in Africa. Am J Trop Med Hyg 64: 12-17.
3. Sachs J, Malaney P, 2002. The economic and social burden of malaria. Nature 415: 680-685.
4. Snow RW, Bastos de Azevedo I, Lowe BS, Kabiru EW, Nevill CG, Mwankusye S, Kassiga G, Marsh K, Teuscher T, 1994. Severe childhood malaria in two areas of markedly different falciparum transmission in east Africa. Acta Trop 57: 289-300.
5. Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, Newton C, Winstanley P, Warn P, Peshu N, Pasvol G, Snow R, 1995. Indicators of life-threatening malaria in African children. N Engl J Med 332: 1399-1404.
6. Genton B, al-Yaman F, Alpers MP, Mokela D, 1997. Indicators of fatal outcome in paediatric cerebral malaria: a study of 134 comatose Papua New Guinean children. Int J Epidemiol 26: 670-676.
7. Imbert P, Sartelet I, Rogier C, Ka S, Baujat G, Candito D, 1997. Severe malaria among children in a low seasonal transmission area, Dakar, Senegal: influence of age on clinical presentation. Trans R Soc Trop Med Hyg 91: 22-24.
8. Snow RW, Omumbo JA, Lowe B, Molyneux CS, Obiero JO, Palmer A, Weber MW, Pinder M, Nahlen B, Obonyo C, Newbold C, Gupta S, Marsh K, 1997. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 349: 1650-1654.
9. Schellenberg D, Menendez C, Kahigwa E, Font F, Galindo C, Acosta C, Schellenberg JA, Aponte JJ, Kimario J, Urassa H, Mshinda H, Tanner M, Alonso P, 1999. African children with malaria in an area of intense Plasmodium falciparum transmission: features on admission to the hospital and risk factors for death. Am J Trop Med Hyg 61: 431-438.
10. Imbert P, Gerardin P, Rogier C, Ka AS, Jouvencel P, Brousse V, Guyon P, 2002. Severe falciparum malaria in children: a comparative study of 1990 and 2000 WHO criteria for clinical presentation, prognosis and intensive care in Dakar, Senegal. Trans R Soc Trop Med Hyg 96: 278-281.
11. Maitland K, Levin M, English M, Mithwani S, Peshu N, Marsh K, Newton CR, 2003. Severe P. falciparum malaria in Kenyan children: evidence for hypovolaemia. QJM 96: 427-434.
12. Waller D, Krishna S, Crawley J, Miller K, Nosten F, Chapman D, ter Kuile FO, Craddock C, Berry C, Holloway PA, Brewster D, Greenwood BM, White NJ, 1995. Clinical features and outcome of severe malaria in Gambian children. Clin Infect Dis 21: 577-587.
13. Warrell DA, Molyneux ME, Beales PF, 1990. Severe and complicated malaria. Trans R Soc Trop Med Hyg 84 (Suppl 2): 1-65.
14. Binka FN, Morris SS, Ross DA, Arthur P, Aryeetey ME, 1994. Patterns of malaria morbidity and mortality in children in northern Ghana. Trans R Soc Trop Med Hyg 88: 381-385.
15. Owusu-Agyei S, Smith T, Beck HP, Amenga-Etego L, Felger I, 2002. Molecular epidemiology of Plasmodium falciparum infections among asymptomatic inhabitants of a holoendemic malarious area in northern Ghana. Trop Med Int Health 7: 421-428.
16. Ehrhardt S, Mockenhaupt FP, Agana-Nsiire P, Mathieu A, Anemana SD, Stark K, Otchwemah RN, Bienzle U, 2002. Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana. Ann Trop Med Parasitol 96: 239-247.
17. Ehrhardt S, Mockenhaupt FP, Eggelte TA, Agana-Nsiire P, Stollberg K, Anemana SD, Otchwemah RN, Bienzle U, 2003. Chloroquine blood concentrations and molecular markers of chloroquine-resistant Plasmodium falciparum in febrile children in northern Ghana. Trans R Soc Trop Med Hyg 97: 1-5.
18. Planche T, Krishna S, Kombila M, Engel K, Faucher JF, Ngou-Milama E, Kremsner PG, 2001. Comparison of methods for the rapid laboratory assessment of children with malaria. Am J Trop Med Hyg 65: 599-602.
19. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A, 1989. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. QJM 71: 441-459.
20. Modiano D, Sirima BS, Sawadogo A, Sanou I, Konaté A, Pagnoni F, 1998. Severe malaria in Burkina Faso: influence of age and transmission level on clinical presentation. Am J Trop Med Hyg 59: 539-542.
21. Kahigwa E, Schellenberg D, Sanz S, Aponte JJ, Wigayi J, Mshinda H, Alonso P, Menendez C, 2002. Risk factors for presentation to hospital with severe anaemia in Tanzanian children: a case-control study. Trop Med Int Health 7: 823-830.
22. Müller O, Traore C, Jahn A, Becher H, 2003. Severe anaemia in west African children: malaria or malnutrition? Lancet 361: 86-87.
23. Kurtzhals JA, Helleberg M, Goka BQ, Akanmori BD, 2003. Severe malaria in west African children (letter). Lancet 361: 1393.
24. Koram KA, Owusu-Agyei S, Fryauff DJ, Anto F, Atuguba F, Hodgson A, Hoffman SL, Nkrumah FK, 2003. Seasonal profiles of malaria infection, anaemia, and bednet use among age groups and communities in northern Ghana. Trop Med Int Health 8: 793-802.
25. Schellenberg D, Schellenberg JR, Mushi A, de Savigny D, Mgalula L, Mbuya C, Victora CG, 2003. The silent burden of anaemia in Tanzanian children: a community-based study. Bull World Health Organ 81: 581-590.
26. Taylor TE, Borgstein A, Molyneux ME, 1993. Acid-base status in paediatric Plasmodium falciparum malaria. QJM 86: 99-109.
27. Rice AL, Sacco L, Hyder A, Black RE, 2000. Malnutrition as an underlying cause of childhood deaths associated with infectious diseases in developing countries. Bull World Health Organ 78: 1207-1221.
28. Cao XT, Bethell DB, Pham TP, Ta TT, Tran TN, Nguyen TT, Pham TT, Nguyen TT, Day NP, White NJ, 1997. Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria. Trans R Soc Trop Med Hyg 91: 335-342.
29. Lackritz EM, Campbell CC, Ruebush TK, Hightower AW, Wakube W, Steketee RW, Were JBO, 1992. Effect of transfusion on survival among children in a Kenyan hospital. Lancet 340: 524-528.
30. Schellenberg D, Menendez C, Kahigwa E, Aponte J, Vidal J, Tanner M, Mshinda H, Alonso P, 2001. Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised, placebo-controlled trial. Lancet 357: 1471-1477.