Novel immune-modulator identified by a rapid, functional screen of the parapoxvirus ovis (Orf virus) genome

Proteome Science

Volumn 10, Issue 1, 2012, Pages

  McGuire, Michael J ^b   Johnston, Stephen A ^a   Sykes, Kathryn F ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adjuvant; Functional screen; Genetic immunization; Immunomodulator; Orf virus; Parapox

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B2L GENE; CELL AGGREGATION; CONTROLLED STUDY; FEMALE; GENE CASSETTE; GENE EXPRESSION SYSTEM; GENE LIBRARY; GENE SEQUENCE; GENOME ANALYSIS; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; POXVIRUS; VIRAL GENE DELIVERY SYSTEM; VIRUS GENE; VIRUS GENOME;

ANIMALIA; MURINAE; MUS; ORF VIRUS; OVIS; PARAPOXVIRUS; POXVIRIDAE;

EID: 84855747374     PISSN: None     EISSN: 14775956     Source Type: Journal    
DOI: 10.1186/1477-5956-10-4     Document Type: Article

References (45)

1. Rappuoli R. Reverse vaccinology, a genome-based approach to vaccine development. Vaccine 2001, 19:2688-2691. 10.1016/S0264-410X(00)00554-5, 11257410.
2. Cui J, Han LY, Cai CZ, Zheng CJ, Ji ZL, Chen YZ. Prediction of functional class of novel bacterial proteins without the use of sequence similarity by a statistical learning method. J Mol Microbiol Biotechnol 2005, 9:86-100. 10.1159/000088839, 16319498.
3. Weinstock GM, Smajs D, Hardham J, Norris SJ. From microbial genome sequence to applications. Res Microbiol 2000, 151:151-158. 10.1016/S0923-2508(00)00115-7, 10865961.
4. Davies DH, Liang X, Hernandez JE, Randall A, Hirst S, Mu Y, Romero KM, Nguyen TT, Kalantari-Dehaghi M, Crotty S, et al. Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery. Proc Natl Acad Sci USA 2005, 102:547-552. 10.1073/pnas.0408782102, 545576, 15647345.
5. Ketela T, Heisler L, Brown K, Ammar R, Kasimer D, Surendra A, Ericson E, Blakely K, Karamboulas D, Smith A, et al. A comprehensive platform for highly multiplexed mammalian functional genetic screens. BMC Genomics 2011, 12:213. 10.1186/1471-2164-12-213, 3115879, 21548937.
6. Barry MA, Lai WC, Johnston SA. Protection against mycoplasma infection using expression-library immunization. Nature 1995, 377:632-635. 10.1038/377632a0, 7566175.
7. Borovkov A, Magee DM, Loskutov A, Cano JA, Selinsky C, Zsemlye J, Lyons CR, Sykes K. New classes of orthopoxvirus vaccine candidates by functionally screening a synthetic library for protective antigens. Virology 2009, 395:97-113. 10.1016/j.virol.2009.09.008, 2784938, 19800089.
8. Li D, Borovkov A, Vaglenov A, Wang C, Kim T, Gao D, Sykes KF, Kaltenboeck B. Mouse model of respiratory Chlamydia pneumoniae infection for a genomic screen of subunit vaccine candidates. Vaccine 2006, 24:2917-2927. 10.1016/j.vaccine.2005.12.035, 16434129.
9. Whitlock GC, Robida MD, Judy BM, Qazi O, Brown KA, Deeraksa A, Taylor K, Massey S, Loskutov A, Borovkov AY, et al. Protective antigens against glanders identified by expression library immunization. Front Microbiol 2011, 2:227. 3221416, 22125550.
10. Johnston JB, McFadden G. Poxvirus Immunomodulatory Strategies: Current Perspectives. J Virol 2003, 77:6093-6100. 10.1128/JVI.77.11.6093-6100.2003, 155018, 12743266.
11. Johannessen JV, Krogh HK, Solberg I, Dalen A, van Wijngaarden H, Johansen B. Human orf. J Cutan Pathol 1975, 2:265-283. 10.1111/j.1600-0560.1975.tb00179.x, 1219046.
12. Haig DM, Mercer AA. Ovine diseases. Orf. Vet Res 1998, 29:311-326.
13. Fleming SB, Mercer AA, Schmidt A, Weber O. Genus Parapoxvirus. Poxviruses. Birkhaeuser Advances in Infectious Diseases 2007, 127-165. Birkhaeuser Verlag, Basel, Schmidt A, Wolff M, Kaufmann S.
14. McKeever DJ, Jenkinson DM, Hutchison G, Reid HW. Studies of the pathogenesis of orf virus infection in sheep. J Comp Pathol 1988, 99:317-328. 10.1016/0021-9975(88)90052-7, 3204166.
15. Schütze N, Raue R, Büttner M, Köhler G, McInnes CJ, Alber G. Specific antibodies induced by inactivated parapoxvirus ovis potently enhance oxidative burst in canine blood polymorphonuclear leukocytes and monocytes. Veterinary Microbiology 2010, 140:81-91. 10.1016/j.vetmic.2009.07.027, 19748192.
16. Ziebell KL, Steinmann H, Kretzdorn D, Schlapp T, Failing K, Schmeer N. The use of Baypamun N in crowding associated infectious respiratory disease: efficacy of Baypamun N (freeze dried product) in 4-10 month old horses. Zentralbl Veterinarmed B 1997, 44:529-536. 10.1111/j.1439-0450.1997.tb01004.x, 9451942.
17. Weber O, Siegling A, Friebe A, Limmer A, Schlapp T, Knolle P, Mercer A, Schaller H, Volk H-D. Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus. J Gen Virol 2003, 84:1843-1852. 10.1099/vir.0.19138-0, 12810878.
18. Friebe A, Siegling A, Friederichs S, Volk H-D, Weber O. Immunomodulatory Effects of Inactivated Parapoxvirus Ovis (Orf Virus) on Human Peripheral Immune Cells: Induction of Cytokine Secretion in Monocytes and Th1-Like Cells. J Virol 2004, 78:9400-9411. 10.1128/JVI.78.17.9400-9411.2004, 506965, 15308734.
19. Fachinger V, Schlapp T, Strube W, Schmeer N, Saalmuller A. Poxvirus-induced immunostimulating effects on porcine leukocytes. J Virol 2000, 74:7943-7951. 10.1128/JVI.74.17.7943-7951.2000, 112325, 10933702.
20. Castrucci G, Osburn BI, Frigeri F, Ferrari M, Salvatori D, Lo Dico M, Barreca F. The use of immunomodulators in the control of infectious bovine rhinotracheitis. Comparative Immunology, Microbiology and Infectious Diseases 2000, 23:163-173. 10.1016/S0147-9571(99)00069-7, 10855662.
21. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu Y-J, Pulendran B, Palucka K. Immunobiology of Dendritic Cells. Annual Review of Immunology 2000, 18:767-811. 10.1146/annurev.immunol.18.1.767, 10837075.
22. Igyarto BZ, Kaplan DH. The evolving function of Langerhans cells in adaptive skin immunity. Immunol Cell Biol 88:361-365.
23. Haig DM, McInnes C, Deane D, Reid H, Mercer A. The immune and inflammatory response to orf virus. Comp Immunol Microbiol Infect Dis 1997, 20:197-204. 10.1016/S0147-9571(96)00045-8, 9280386.
24. Sykes KF, Johnston SA. Linear expression elements: a rapid, in vivo, method to screen for gene functions. Nat Biotechnol 1999, 17:355-359. 10.1038/7908, 10207883.
25. Romani N, Thurnher M, Idoyaga J, Steinman RM, Flacher V. Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy. Immunol Cell Biol 2010, 88:424-430. 10.1038/icb.2010.39, 2907485, 20368713.
26. Sullivan JT, Mercer AA, Fleming SB, Robinson AJ. Identification and characterization of an orf virus homologue of the vaccinia virus gene encoding the major envelope antigen p37K. Virology 1994, 202:968-973. 10.1006/viro.1994.1420, 8030257.
27. Dupasquier M, Stoitzner P, van Oudenaren A, Romani N, Leenen PJ. Macrophages and dendritic cells constitute a major subpopulation of cells in the mouse dermis. J Invest Dermatol 2004, 123:876-879. 10.1111/j.0022-202X.2004.23427.x, 15482474.
28. Angel CE, George E, Ostrovsky LL, Dunbar PR. Comprehensive analysis of MHC-II expression in healthy human skin. Immunol Cell Biol 2007, 85:363-369. 10.1038/sj.icb.7100047, 2262850, 17342064.
29. Payne LG. Characterization of vaccinia virus glycoproteins by monoclonal antibody precipitation. Virology 1992, 187:251-260. 10.1016/0042-6822(92)90313-E, 1736527.
30. Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991, 9:271-296. 10.1146/annurev.iy.09.040191.001415, 1910679.
31. Narbutt J, Lesiak A, Sysa-Jedrzejowska A, Smolewski P, Robak T, Zalewska A. The number and distribution of blood dendritic cells in the epidermis and dermis of healthy human subjects. Folia Histochem Cytobiol 2006, 44:61-63.
32. Timares L, Safer KM, Qu B, Takashima A, Johnston SA. Drug-inducible, dendritic cell-based genetic immunization. J Immunol 2003, 170:5483-5490.
33. Timares L, Takashima A, Johnston SA. Quantitative analysis of the immunopotency of genetically transfected dendritic cells. Proc Natl Acad Sci USA 1998, 95:13147-13152. 10.1073/pnas.95.22.13147, 23740, 9789056.
34. Barratt-Boyes SM, Zimmer MI, Harshyne LA, Meyer EM, Watkins SC, Capuano S, Murphey-Corb M, Falo LD, Donnenberg AD. Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. J Immunol 2000, 164:2487-2495.
35. Celluzzi CM, Falo LD. Epidermal dendritic cells induce potent antigen-specific CTL-mediated immunity. J Invest Dermatol 1997, 108:716-720. 10.1111/1523-1747.ep12292095, 9129221.
36. Honeychurch KM, Yang G, Jordan R, Hruby DE. The Vaccinia Virus F13L YPPL Motif Is Required for Efficient Release of Extracellular Enveloped Virus. J Virol 2007, 81:7310-7315. 10.1128/JVI.00034-07, 1933313, 17475658.
37. Husain M, Moss B. Vaccinia Virus F13L Protein with a Conserved Phospholipase Catalytic Motif Induces Colocalization of the B5R Envelope Glycoprotein in Post-Golgi Vesicles. J Virol 2001, 75:7528-7542. 10.1128/JVI.75.16.7528-7542.2001, 114988, 11462025.
38. Hooper JW, Custer DM, Thompson E. Four-gene-combination DNA vaccine protects mice against a lethal vaccinia virus challenge and elicits appropriate antibody responses in nonhuman primates. Virology 2003, 306:181-195. 10.1016/S0042-6822(02)00038-7, 12620810.
39. Perdiguero B, Blasco R. Interaction between Vaccinia Virus Extracellular Virus Envelope A33 and B5 Glycoproteins. J Virol 2006, 80:8763-8777. 10.1128/JVI.00598-06, 1563889, 16912323.
40. Sung TC, Roper RL, Zhang Y, Rudge SA, Temel R, Hammond SM, Morris AJ, Moss B, Engebrecht J, Frohman MA. Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J 1997, 16:4519-4530. 10.1093/emboj/16.15.4519, 1170078, 9303296.
41. Vitale JJ, Broitman SA. Lipids and immune function. Cancer Res 1981, 41:3706-3710.
42. Rayner S, Brignac S, Bumeister R, Belosludtsev Y, Ward T, Grant O, O'Brien K, Evans GA, Garner HR. MerMade: an oligodeoxyribonucleotide synthesizer for high throughput oligonucleotide production in dual 96-well plates. Genome Res 1998, 8:741-747. 310754, 9685322.
43. Nisson PE, Rashtchian A, Watkins PC. Rapid and efficient cloning of Alu-PCR products using uracil DNA glycosylase. PCR Methods Appl 1991, 1:120-123.
44. Vieira J, Messing J. Production of single-stranded plasmid DNA. Methods Enzymol 1987, 153:3-11.
45. Talaat AM, Lyons R, Johnston SA. A combination vaccine confers full protection against co-infections with influenza, herpes simplex and respiratory syncytial viruses. Vaccine 2001, 20:538-544. 10.1016/S0264-410X(01)00352-8, 11672920.