Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus

Journal of General Virology

Volumn 84, Issue 7, 2003, Pages 1843-1852

  Weber, Olaf ^a,e   Siegling, Angela ^a,f   Friebe, Astrid ^b   Limmer, Andreas ^c   Schlapp, Tobias ^a   Knolle, Percy ^c   Mercer, Andrew ^d   Schaller, Heinz ^c   Volk, Hans Dieter ^b  

^a BAYER AG   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF OTAGO   (New Zealand)

^e BAYER CORPORATION   (United States)

^f Faculte de Medicine Necker   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; CONCANAVALIN A; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INACTIVATED VIRUS VACCINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 4; LAMIVUDINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; CYTOKINE RESPONSIVE ELEMENT; DOWN REGULATION; FEMALE; GENITAL HERPES; GUINEA PIG; HELPER CELL; HEPATITIS B; HEPATITIS B VIRUS; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; IMMUNITY; IMMUNOTHERAPY; LEUKOCYTE; LIVER; MALE; MOUSE; NONHUMAN; PARAPOXVIRUS; PRIORITY JOURNAL; TRANSGENIC MOUSE; UPREGULATION; VIRUS INACTIVATION; VIRUS PARTICLE; VIRUS STRAIN;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GUINEA PIGS; HEPATITIS B VIRUS; HERPES GENITALIS; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; ORF VIRUS; VACCINES, INACTIVATED; VIRUS REPLICATION;

ANIMALIA; CAVIA; CAVIA PORCELLUS; DNA VIRUSES; HEPATITIS B VIRUS; HUMAN HERPESVIRUS 1; MUS MUSCULUS; ORF VIRUS; OVIS; PARAPOXVIRUS; SIMPLEXVIRUS; SUS SCROFA;

EID: 0038827428     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.19138-0     Document Type: Article

References (33)

1. Bahnemann, H. G. (1990). Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine. Vaccine 8, 299-303.
2. Binder, G. K.&Griffin, D. E. (2001). Interferon-γ- mediated site-specific clearance of alphavirus from CNS neurons. Interferon-γ-mediated site-specific clearance of alphavirus from CNS neurons. Science 293, 303-306.
3. Büttner, M., Czerny, C. P., Lehner, K. H.&Wertz K. (1995). Interferon induction in peripheral blood mononuclear leukocytes of man and farm animals by poxvirus vector candidates and some poxvirus constructs. Vet Immunol Immunopathol 46, 237-250.
4. Cavanaugh, V. J., Guidotti, L. G.&Chisari, F. V. (1997). Interleukin-12 inhibits hepatitis B virus replication in transgenic mice. J Virol 71, 3236-3243.
5. Cavanaugh, V. J., Guidotti, L. G.&Chisari, F. V. (1998). Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice. J Virol 72, 2630-2637.
6. Deane, D., McInnes, C. J., Percival, A.&7 other authors (2000). Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2. J Virol 74, 1313-1320.
7. del Val, M., Hengel, H., Häcker, H., Hartlaub, U., Ruppert, T., Lucin, P.&Koszinowski, U. H. (1992). Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment. J Exp Med 176, 729-738.
8. Fleming, S. B., McCaughan, C. A., Andrews, A. E., Nash, A. D. &Mercer, A. A. (1997). A homolog of interleukin-10 is encoded by the poxvirus orf virus. J Virol 71, 4857-4861.
9. Förster, R., Wolf, G.&Mayr, A. (1994). Highly attenuated poxviruses induce functional priming of neutrophils in vitro. Arch Virol 136, 219-226.
10. Grandvaux, N., tenOever, B. R., Servant M. J.&Hiscott, J. (2002). The interferon antiviral response: from viral invasion to evasion. Curr Opin Infect Dis 1, 259-267.
11. Guidotti, L. G.&Chisari, F. V. (1996). Current Opinion in Immunology, vol. 8, pp. 487-483. Edited by R. Zinkernagel&B. Bloom. London: Current Biology.
12. Guidotti, L. G., Borrow, P., Hobbs, M. V., Matzke, B., Gresser, I., Oldstone, M. B. A.&Chisari, F. V. (1996). Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. Proc Natl Acad Sci U S A 93, 4589-4594.
13. Guidotti, L. G., Rochford, R., Chung, J., Shapiro, M., Purcell, R.&Chisari, F. V. (1999). Viral clearance without destruction of infected cells during acute HBV infection. Science 284, 825-829.
14. Haig, D. M.&Mercer, A. A. (1998). Ovine disease. Orf. Vet Res 29, 311-326.
15. Haig, D. M.&McInnes, C. J. (2002). Immunity and counter-immunity during infection with the parapoxvirus orf virus. Virus Res 88, 3-16.
16. Haig, D., McInnes, C., Deane, D.&8 other authors (1996). Cytokines and their inhibitors in orf virus infection. Vet Immunol Immunopathol 54, 261-267.
17. Haig, D., McInnes, C. J., Deane, D., Reid, H. W.&Mercer, A. A. (1997). The immune and inflammatory response to orf virus. Comp Immunol Microbiol Infect Dis 20, 197-204.
18. Haig, D. M., McInnes, C. J., Thomson, J., Wood, A., Bunyan, K.&Mercer, A. A. (1998). The orf virus OV20.01, gene product is involved in interferon resistance and inhibits an interferon-inducible, double stranded RNA-dependent kinase. Immunology 93, 335-340.
19. Kimura, K., Kakimi, K., Wieland, S., Guidotti, L. G. & Chisari, F. V. (2002). Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice. J Virol 76, 10702-10707.
20. Knolle, P. A., Uhrig, A., Hegenbarth, S., Loser, E., Schmitt, E., Gerken, G.&Lohse, A. W. (1998). IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules. Clin Exp Immunol 114, 427-433.
21. Kruse, N.&Weber, O. (2001). Selective induction of apoptosis in antigen-presenting cells in mice by Parapoxvirus ovis. J Virol 75, 4699-4704.
22. Lane, H. C., Dapper, J. M., Greene, W. C., Whalen, G., Waldmann, T. A.&Fauci, A. S. (1985). Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. New Engl J Med 2, 79-84.
23. Leite-de-Moraes, M. C., Hameg, A., Pacilio, M., Koezuka, Y., Taniguchi, M., Van Kaer, L., Schneider, E., Dy, M.&Herbelin A. (2000 . IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells. J Immunol 166, 945-951.
24. Marsig, E.&Stickl, H. (1988). Highly attenuated poxviruses induce functional priming of neutrophils in vitro. Zentralbl Veterinarmed B 35, 601-609 (in German).
25. Mayr, A., Büttner, M., Wolf, G., Meyer, H.&Czerny, C. (1989). Experimental detection of the paraspecific effects of purified and inactivated poxviruses. Zentralbl Veterinarmed B 36, 81-99 (in German).
26. McKeever, D. J., Jenkinson, D. M., Hutchinson, G.&Reid, H. W. (1988). Studies on the pathogenesis of orf virus infection in sheep. J Comp Pathol 99, 317-328.
27. Micallef, M. J., Ohtsuki, T., Kohno, K.&9 other authors (1996). Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur J Immunol 26, 1647-1651.
28. Mocarski, E. S., Jr (2002). Immunomodulation by cytomegaloviruses: manipulative strategies beyond evasion. Trends Microbiol 10, 332-339.
29. Mossman, K. L. (2002). Activation and inhibition of virus and interferon: the herpesvirus story. Viral Immunol 15, 3-15.
30. Schijns, V. E. C. J., Haagmans, B. L., Wierda, C. M. H., Kruithof, B., Heijnen, I. A. F. M., Alber, G.&Horzinek, M. C. (1998). Mice lacking IL-12 develop polarized Thi cells during viral infection. J Immunol 160, 3958-3964.
31. Siegling, A., Lehmann, M., Platzer, C., Emmrich, F.&Volk, H. D. (1994). A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats. J Immunol Methods 177, 23-28.
32. + T cells during T helper (Th)1/Th2 differentiation: critical downregulatory role of IL-4. J Exp Med 194, 143-153.
33. Weber, O., Schlemmer, K. H., Hartmann, E.&10 other authors (2002). Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res 54, 69-75.