Comprehensive analysis of MHC-II expression in healthy human skin

Immunology and Cell Biology

Volumn 85, Issue 5, 2007, Pages 363-369

  Angel, Catherine E ^a   George, Elizabeth ^b   Ostrovsky, Lena L ^a   Dunbar, P Rod ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Antigen presenting cells; Human; Major histocompatibility complex; Skin; T lymphocytes

Indexed keywords

LANGERIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T6 ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CELL SUBPOPULATION; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LANGERHANS CELL; LYMPH VESSEL ENDOTHELIUM; NORMAL HUMAN; PHENOTYPE; SKIN CELL; T LYMPHOCYTE SUBPOPULATION;

ANTIGEN-PRESENTING CELLS; DERMIS; HEALTH; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LYMPHOCYTE ACTIVATION; SKIN; T-LYMPHOCYTES;

EID: 34447120213     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/sj.icb.7100047     Document Type: Article

References (33)

1. Klenerman P, Cerundolo V, Dunbar PR. Tracking T cells with tetramers: new tales from new tools. Nat Rev Immunol 2002; 2: 263-272.
2. Pober JS. Immunobiology of human vascular endothelium. Immunol Res 1999; 19: 225-232.
3. Choi J, Enis DR, Koh KP, Shiao SL, Pober JS. T lymphocyte-endothelial cell interactions. Annu Rev Immunol 2004; 22: 683-709.
4. Sidhu S, Deacock S, Bal V, Batchelor JR, Lombardi G, Lechler RI. Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells. J Exp Med 1992; 176: 875-880.
5. Nakada M, Nishizaki K, Yoshino T, Okano M, Yamamoto T, Masuda Y et al. CD80 (B7-1) and CD86 (B7-2) antigens on house dust mite-specific T cells in atopic disease function through T-T cell interactions. J Allergy Clin Immunol 1999; 104: 222-227.
6. Barnaba V, Watts C, de Boer M, Lane P, Lanzavecchia A. Professional presentation of antigen by activated human T cells. Eur J Immunol 1994; 24: 71-75.
7. Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol 2004; 65: 282-290.
8. Valladeau J, Saeland S. Cutaneous dendritic cells. Semin Immunol 2005; 17: 273-283.
9. Romani N, Holzmann S, Tripp CH, Koch F, Stoitzner P. Langerhans cells - dendritic cells of the epidermis. Apmis 2003; 111: 725-740.
10. Turville SG, Cameron PU, Handley A, Lin G, Pohlmann S, Doms RW et al. Diversity of receptors binding HIV on dendritic cell subsets. Nat Immunol 2002; 3: 975-983.
11. Nestle FO, Nickoloff BJ. A fresh morphological and functional look at dermal dendritic cells. J Cutan Pathol 1995; 22: 385-393.
12. Larregina AT, Morelli AE, Spencer LA, Logar AJ, Watkins SC, Thomson AW et al. Dermal-resident CD14+ cells differentiate into Langerhans cells. Nat Immunol 2001; 2: 1151-1158.
13. Angel CE, George E, Brooks AE, Ostrovsky LL, Brown TL, Dunbar PR. Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. J Immunol 2006; 176: 5730-5734.
14. Stoitzner P, Holzmann S, McLellan AD, Ivarsson L, Stossel H, Kapp M et al. Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207. J Invest Dermatol 2003; 120: 266-274.
15. Mayerova D, Parke EA, Bursch LS, Odumade OA, Hogquist KA. Langerhans cells activate naive self-antigen-specific CD8 Tcells in the steady state. Immunity 2004; 21: 391-400.
16. Geissmann F, Dieu-Nosjean MC, Dezutter C, Valladeau J, Kayal S, Leborgne M et al. Accumulation of immature Langerhans cells in human lymph nodes draining chronically inflamed skin. J Exp Med 2002; 196: 417-430.
17. Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 2000; 12: 71-81.
18. Numahara T, Tanemura M, Nakagawa T, Takaiwa T. Spatial data analysis by epidermal Langerhans cells reveals an elegant system. J Dermatol Sci 2001; 25: 219-228.
19. Bauer J, Bahmer FA, Worl J, Neuhuber W, Schuler G, Fartasch M. A strikingly constant ratio exists between Langerhans cells and other epidermal cells in human skin. A stereologic study using the optical disector method and the confocal laser scanning microscope. J Invest Dermatol 2001; 116: 313-318.
20. Romani N, Lenz A, Glassel H, Stossel H, Stanzl U, Majdic O et al. Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function. J Invest Dermatol 1989; 93: 600-609.
21. Lampugnani MG, Resnati M, Raiteri M, Pigott R, Pisacane A, Houen G et al. A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J Cell Biol 1992; 118: 1511-1522.
22. Breiteneder-Geleff S, Soleiman A, Horvat R, Amann G, Kowalski H, Kerjaschki D. Podoplanin - a specific marker for lymphatic endothelium expressed in angiosarcoma. Verh Dtsch Ges Pathol 1999; 83: 270-275.
23. Oliver G. Lymphatic vasculature development. Nat Rev Immunol 2004; 4: 35-45.
24. Pober JS, Kluger MS, Schechner JS. Human endothelial cell presentation of antigen and the homing of memory/effector T cells to skin. Ann NY Acad Sci 2001; 941: 12-25.
25. Pope M, Betjes MG, Hirmand H, Hoffman L, Steinman RM. Both dendritic cells and memory T lymphocytes emigrate from organ cultures of human skin and form distinctive dendritic-T-cell conjugates. J Invest Dermatol 1995; 104: 11-17.
26. McLellan AD, Heiser A, Sorg RV, Fearnley DB, Hart DN. Dermal dendritic cells associated with T lymphocytes in normal human skin display an activated phenotype. J Invest Dermatol 1998; 111: 841-849.
27. Katou F, Ohtani H, Saaristo A, Nagura H, Motegi K. Immunological activation of dermal Langerhans cells in contact with lymphocytes in a model of human inflamed skin. Am J Pathol 2000; 156: 519-527.
28. Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka K, Dowgiert RK et al. The vast majority of CLA+ T cells are resident in normal skin. J Immunol 2006; 176: 4431-4439.
29. LaSalle JM, Tolentino PJ, Freeman GJ, Nadler LM, Hafler DA. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J Exp Med 1992; 176: 177-186.
30. LaSalle JM, Ota K, Hafler DA. Presentation of autoantigen by human T cells. J Immunol 1991; 147: 774-780.
31. Lamb JR, Fledmann M. A human suppressor T cell clone which recognizes an autologous helper T cell clone. Nature 1982; 300: 456-458.
32. Muczynski KA, Ekle DM, Coder DM, Anderson SK. Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression. J Am Soc Nephrol 2003; 14: 1336-1348.
33. Ebner S, Ehammer Z, Holzmann S, Schwingshackl P, Forstner M, Stoitzner P et al. Expression of C-type lectin receptors by subsets of dendritic cells in human skin. Int Immunol 2004; 16: 877-887.