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Volumn 8, Issue , 2012, Pages

Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn

Author keywords

Ampa; GluA1; Inflammatory pain; NK1 receptor; P Akt; Pi 3K; Receptor trafficking; Spinal sensitization

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CARRAGEENAN; GLUTAMATE RECEPTOR 1; NEUROKININ 1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SAPORIN; SUBSTANCE P; AMPA RECEPTOR; DRUG DERIVATIVE; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1; RIBOSOME INACTIVATING PROTEIN 1; SUBSTANCE P SAPORIN; SUBSTANCE P-SAPORIN;

EID: 84855741978     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-8-4     Document Type: Article
Times cited : (28)

References (38)
  • 1
    • 79951538149 scopus 로고    scopus 로고
    • Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia
    • 10.1523/JNEUROSCI.2139-10.2011, 3097059, 21307248
    • Xu Q, Fitzsimmons B, Steinauer J, Neill AO, Newton AC, Hua XY, Yaksh TL. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci 2011, 31:2113-2124. 10.1523/JNEUROSCI.2139-10.2011, 3097059, 21307248.
    • (2011) J Neurosci , vol.31 , pp. 2113-2124
    • Xu, Q.1    Fitzsimmons, B.2    Steinauer, J.3    Neill, A.O.4    Newton, A.C.5    Hua, X.Y.6    Yaksh, T.L.7
  • 2
    • 30444439079 scopus 로고    scopus 로고
    • Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin
    • 10.1016/j.pain.2005.10.017, 16360265
    • Sun RQ, Tu YJ, Yan JY, Willis WD. Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin. Pain 2006, 120:86-96. 10.1016/j.pain.2005.10.017, 16360265.
    • (2006) Pain , vol.120 , pp. 86-96
    • Sun, R.Q.1    Tu, Y.J.2    Yan, J.Y.3    Willis, W.D.4
  • 3
    • 77951767621 scopus 로고    scopus 로고
    • Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior
    • 10.1016/j.pain.2010.02.008, 2860679, 20202754
    • Choi JI, Svensson CI, Koehrn FJ, Bhuskute A, Sorkin LS. Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior. Pain 2010, 149:243-253. 10.1016/j.pain.2010.02.008, 2860679, 20202754.
    • (2010) Pain , vol.149 , pp. 243-253
    • Choi, J.I.1    Svensson, C.I.2    Koehrn, F.J.3    Bhuskute, A.4    Sorkin, L.S.5
  • 4
    • 34447623212 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats
    • 10.1016/j.expneurol.2007.05.029, 17628541
    • Xu JT, Tu HY, Xin WJ, Liu XG, Zhang GH, Zhai CH. Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats. Exp Neurol 2007, 206:269-279. 10.1016/j.expneurol.2007.05.029, 17628541.
    • (2007) Exp Neurol , vol.206 , pp. 269-279
    • Xu, J.T.1    Tu, H.Y.2    Xin, W.J.3    Liu, X.G.4    Zhang, G.H.5    Zhai, C.H.6
  • 5
    • 42949128674 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions
    • 10.1523/JNEUROSCI.5392-07.2008, 2935680, 18417706
    • Pezet S, Marchand F, D'Mello R, Grist J, Clark AK, Malcangio M, Dickenson AH, Williams RJ, McMahon SB. Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions. J Neurosci 2008, 28:4261-4270. 10.1523/JNEUROSCI.5392-07.2008, 2935680, 18417706.
    • (2008) J Neurosci , vol.28 , pp. 4261-4270
    • Pezet, S.1    Marchand, F.2    D'Mello, R.3    Grist, J.4    Clark, A.K.5    Malcangio, M.6    Dickenson, A.H.7    Williams, R.J.8    McMahon, S.B.9
  • 6
    • 18844366186 scopus 로고    scopus 로고
    • Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons
    • 10.1111/j.1460-9568.2005.04011.x, 15869474
    • Pezet S, Spyropoulos A, Williams RJ, McMahon SB. Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons. Eur J Neurosci 2005, 21:1785-1797. 10.1111/j.1460-9568.2005.04011.x, 15869474.
    • (2005) Eur J Neurosci , vol.21 , pp. 1785-1797
    • Pezet, S.1    Spyropoulos, A.2    Williams, R.J.3    McMahon, S.B.4
  • 7
    • 34248160137 scopus 로고    scopus 로고
    • Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9,Met(O2)11]-substance P-saporin: behavioral and anatomical analyses
    • 10.1016/j.neuroscience.2007.01.066, 17418497
    • Wiley RG, Kline R, Vierck CJ. Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9,Met(O2)11]-substance P-saporin: behavioral and anatomical analyses. Neuroscience 2007, 146:1333-1345. 10.1016/j.neuroscience.2007.01.066, 17418497.
    • (2007) Neuroscience , vol.146 , pp. 1333-1345
    • Wiley, R.G.1    Kline, R.2    Vierck, C.J.3
  • 9
    • 0034052838 scopus 로고    scopus 로고
    • Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem
    • 10.1046/j.1460-9568.2000.00950.x, 10712649
    • Todd AJ, McGill MM, Shehab SA. Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem. Eur J Neurosci 2000, 12:689-700. 10.1046/j.1460-9568.2000.00950.x, 10712649.
    • (2000) Eur J Neurosci , vol.12 , pp. 689-700
    • Todd, A.J.1    McGill, M.M.2    Shehab, S.A.3
  • 10
    • 0036899904 scopus 로고    scopus 로고
    • Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
    • 10.1038/nn966, 12402039
    • Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH. Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 2002, 5:1319-1326. 10.1038/nn966, 12402039.
    • (2002) Nat Neurosci , vol.5 , pp. 1319-1326
    • Suzuki, R.1    Morcuende, S.2    Webber, M.3    Hunt, S.P.4    Dickenson, A.H.5
  • 11
    • 34047271295 scopus 로고    scopus 로고
    • Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways
    • 10.1016/j.pain.2006.09.033, 17123731
    • Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F. Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain 2007, 129:35-45. 10.1016/j.pain.2006.09.033, 17123731.
    • (2007) Pain , vol.129 , pp. 35-45
    • Vera-Portocarrero, L.P.1    Zhang, E.T.2    King, T.3    Ossipov, M.H.4    Vanderah, T.W.5    Lai, J.6    Porreca, F.7
  • 12
    • 77954566628 scopus 로고    scopus 로고
    • Local axon collaterals of lamina I projection neurons in the spinal cord of young rats
    • Szucs P, Luz LL, Lima D, Safronov BV. Local axon collaterals of lamina I projection neurons in the spinal cord of young rats. J Comp Neurol 2010, 518:2645-2665.
    • (2010) J Comp Neurol , vol.518 , pp. 2645-2665
    • Szucs, P.1    Luz, L.L.2    Lima, D.3    Safronov, B.V.4
  • 13
    • 0030612064 scopus 로고    scopus 로고
    • Tachykinin NK1 receptor antagonist RP67580 attenuates progressive hypersensitivity of flexor reflex during experimental inflammation in rats
    • 10.1016/S0014-2999(97)00014-9, 9098683
    • Ma QP, Woolf CJ. Tachykinin NK1 receptor antagonist RP67580 attenuates progressive hypersensitivity of flexor reflex during experimental inflammation in rats. Eur J Pharmacol 1997, 322:165-171. 10.1016/S0014-2999(97)00014-9, 9098683.
    • (1997) Eur J Pharmacol , vol.322 , pp. 165-171
    • Ma, Q.P.1    Woolf, C.J.2
  • 14
    • 0029098297 scopus 로고
    • Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones
    • 1156564, 7473237
    • Ma QP, Woolf CJ. Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones. J Physiol 1995, 486(Pt 3):769-777. 1156564, 7473237.
    • (1995) J Physiol , vol.486 , Issue.PART 3 , pp. 769-777
    • Ma, Q.P.1    Woolf, C.J.2
  • 15
    • 9244250346 scopus 로고    scopus 로고
    • In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons
    • 10.1016/j.pain.2004.09.011, 15561387
    • Galan A, Laird JM, Cervero F. In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons. Pain 2004, 112:315-323. 10.1016/j.pain.2004.09.011, 15561387.
    • (2004) Pain , vol.112 , pp. 315-323
    • Galan, A.1    Laird, J.M.2    Cervero, F.3
  • 16
    • 0028999428 scopus 로고
    • Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis
    • 10.1002/cne.903560302, 7642798
    • Brown JL, Liu H, Maggio JE, Vigna SR, Mantyh PW, Basbaum AI. Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis. J Comp Neurol 1995, 356:327-344. 10.1002/cne.903560302, 7642798.
    • (1995) J Comp Neurol , vol.356 , pp. 327-344
    • Brown, J.L.1    Liu, H.2    Maggio, J.E.3    Vigna, S.R.4    Mantyh, P.W.5    Basbaum, A.I.6
  • 18
    • 0029655582 scopus 로고    scopus 로고
    • Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain
    • 10.1016/0306-4522(95)00343-H, 8848125
    • Abbadie C, Brown JL, Mantyh PW, Basbaum AI. Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain. Neuroscience 1996, 70:201-209. 10.1016/0306-4522(95)00343-H, 8848125.
    • (1996) Neuroscience , vol.70 , pp. 201-209
    • Abbadie, C.1    Brown, J.L.2    Mantyh, P.W.3    Basbaum, A.I.4
  • 19
    • 0029880285 scopus 로고    scopus 로고
    • Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat
    • 10.1016/0306-4522(95)00558-7, 8730722
    • Marshall GE, Shehab SA, Spike RC, Todd AJ. Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat. Neuroscience 1996, 72:255-263. 10.1016/0306-4522(95)00558-7, 8730722.
    • (1996) Neuroscience , vol.72 , pp. 255-263
    • Marshall, G.E.1    Shehab, S.A.2    Spike, R.C.3    Todd, A.J.4
  • 20
    • 0034253658 scopus 로고    scopus 로고
    • Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat
    • 10.1016/S0304-3959(00)00290-6, 10963906
    • Kovelowski CJ, Ossipov MH, Sun H, Lai J, Malan TP, Porreca F. Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. Pain 2000, 87:265-273. 10.1016/S0304-3959(00)00290-6, 10963906.
    • (2000) Pain , vol.87 , pp. 265-273
    • Kovelowski, C.J.1    Ossipov, M.H.2    Sun, H.3    Lai, J.4    Malan, T.P.5    Porreca, F.6
  • 21
    • 70449529722 scopus 로고    scopus 로고
    • Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal horn
    • 10.1016/j.neuroscience.2009.09.071, 2784948, 19800942
    • Al Ghamdi KS, Polgar E, Todd AJ. Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal horn. Neuroscience 2009, 164:1794-1804. 10.1016/j.neuroscience.2009.09.071, 2784948, 19800942.
    • (2009) Neuroscience , vol.164 , pp. 1794-1804
    • Al Ghamdi, K.S.1    Polgar, E.2    Todd, A.J.3
  • 23
    • 77952547627 scopus 로고    scopus 로고
    • Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input
    • Polgar E, Al Ghamdi KS, Todd AJ. Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input. Neuroscience 167:1192-1204.
    • Neuroscience , vol.167 , pp. 1192-1204
    • Polgar, E.1    Al Ghamdi, K.S.2    Todd, A.J.3
  • 24
    • 0029012284 scopus 로고
    • The types of neuron in spinal dorsal horn which possess neurokinin-1 receptors
    • 10.1016/0306-4522(95)00039-L, 7543982
    • Littlewood NK, Todd AJ, Spike RC, Watt C, Shehab SA. The types of neuron in spinal dorsal horn which possess neurokinin-1 receptors. Neuroscience 1995, 66:597-608. 10.1016/0306-4522(95)00039-L, 7543982.
    • (1995) Neuroscience , vol.66 , pp. 597-608
    • Littlewood, N.K.1    Todd, A.J.2    Spike, R.C.3    Watt, C.4    Shehab, S.A.5
  • 25
    • 34248226218 scopus 로고    scopus 로고
    • Descending serotonergic facilitation of spinal ERK activation and pain behavior
    • 10.1016/j.febslet.2006.11.012, 2291024, 17113581
    • Svensson CI, Tran TK, Fitzsimmons B, Yaksh TL, Hua XY. Descending serotonergic facilitation of spinal ERK activation and pain behavior. FEBS Lett 2006, 580:6629-6634. 10.1016/j.febslet.2006.11.012, 2291024, 17113581.
    • (2006) FEBS Lett , vol.580 , pp. 6629-6634
    • Svensson, C.I.1    Tran, T.K.2    Fitzsimmons, B.3    Yaksh, T.L.4    Hua, X.Y.5
  • 26
    • 25644445926 scopus 로고    scopus 로고
    • Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin
    • 10.1016/j.pain.2005.06.015, 16150546
    • Suzuki R, Rahman W, Rygh LJ, Webber M, Hunt SP, Dickenson AH. Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Pain 2005, 117:292-303. 10.1016/j.pain.2005.06.015, 16150546.
    • (2005) Pain , vol.117 , pp. 292-303
    • Suzuki, R.1    Rahman, W.2    Rygh, L.J.3    Webber, M.4    Hunt, S.P.5    Dickenson, A.H.6
  • 27
    • 0037109674 scopus 로고    scopus 로고
    • Spinal neurons that possess the substance P receptor are required for the development of central sensitization
    • Khasabov SG, Rogers SD, Ghilardi JR, Peters CM, Mantyh PW, Simone DA. Spinal neurons that possess the substance P receptor are required for the development of central sensitization. J Neurosci 2002, 22:9086-9098.
    • (2002) J Neurosci , vol.22 , pp. 9086-9098
    • Khasabov, S.G.1    Rogers, S.D.2    Ghilardi, J.R.3    Peters, C.M.4    Mantyh, P.W.5    Simone, D.A.6
  • 28
    • 0023227670 scopus 로고
    • The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the rat
    • 10.1016/0304-3959(87)90051-0, 3614971
    • Kocher L, Anton F, Reeh PW, Handwerker HO. The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the rat. Pain 1987, 29:363-373. 10.1016/0304-3959(87)90051-0, 3614971.
    • (1987) Pain , vol.29 , pp. 363-373
    • Kocher, L.1    Anton, F.2    Reeh, P.W.3    Handwerker, H.O.4
  • 30
    • 0036305484 scopus 로고    scopus 로고
    • AMPA receptor trafficking and synaptic plasticity
    • 10.1146/annurev.neuro.25.112701.142758, 12052905
    • Malinow R, Malenka RC. AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci 2002, 25:103-126. 10.1146/annurev.neuro.25.112701.142758, 12052905.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 103-126
    • Malinow, R.1    Malenka, R.C.2
  • 31
    • 79957715137 scopus 로고    scopus 로고
    • Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor
    • Makino Y, Johnson RC, Yu Y, Takamiya K, Huganir RL. Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor. Proc Natl Acad Sci USA 108:8450-8455.
    • Proc Natl Acad Sci USA , vol.108 , pp. 8450-8455
    • Makino, Y.1    Johnson, R.C.2    Yu, Y.3    Takamiya, K.4    Huganir, R.L.5
  • 32
    • 0037312605 scopus 로고    scopus 로고
    • PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
    • 10.1038/nn997, 12536214
    • Esteban JA, Shi SH, Wilson C, Nuriya M, Huganir RL, Malinow R. PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nat Neurosci 2003, 6:136-143. 10.1038/nn997, 12536214.
    • (2003) Nat Neurosci , vol.6 , pp. 136-143
    • Esteban, J.A.1    Shi, S.H.2    Wilson, C.3    Nuriya, M.4    Huganir, R.L.5    Malinow, R.6
  • 33
    • 78650702451 scopus 로고    scopus 로고
    • Protein kinase A-dependent spinal alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate-receptor trafficking mediates capsaicin-induced colon-urethra cross-organ reflex sensitization
    • 10.1097/ALN.0b013e3181fe4204, 21169799
    • Peng HY, Chang CH, Tsai SJ, Lai CY, Tung KC, Wu HC, Lin TB. Protein kinase A-dependent spinal alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate-receptor trafficking mediates capsaicin-induced colon-urethra cross-organ reflex sensitization. Anesthesiology 2011, 114:70-83. 10.1097/ALN.0b013e3181fe4204, 21169799.
    • (2011) Anesthesiology , vol.114 , pp. 70-83
    • Peng, H.Y.1    Chang, C.H.2    Tsai, S.J.3    Lai, C.Y.4    Tung, K.C.5    Wu, H.C.6    Lin, T.B.7
  • 34
    • 0034161251 scopus 로고    scopus 로고
    • Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
    • 10.1093/emboj/19.5.979, 305637, 10698939
    • Biondi RM, Cheung PC, Casamayor A, Deak M, Currie RA, Alessi DR. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. Embo J 2000, 19:979-988. 10.1093/emboj/19.5.979, 305637, 10698939.
    • (2000) Embo J , vol.19 , pp. 979-988
    • Biondi, R.M.1    Cheung, P.C.2    Casamayor, A.3    Deak, M.4    Currie, R.A.5    Alessi, D.R.6
  • 35
    • 1342342993 scopus 로고    scopus 로고
    • PDK1, the master regulator of AGC kinase signal transduction
    • 10.1016/j.semcdb.2003.12.022, 15209375
    • Mora A, Komander D, van Aalten DM, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 2004, 15:161-170. 10.1016/j.semcdb.2003.12.022, 15209375.
    • (2004) Semin Cell Dev Biol , vol.15 , pp. 161-170
    • Mora, A.1    Komander, D.2    van Aalten, D.M.3    Alessi, D.R.4
  • 36
    • 0034644523 scopus 로고    scopus 로고
    • Cellular signaling: pivoting around PDK-1
    • 10.1016/S0092-8674(00)00110-0, 11057891
    • Toker A, Newton AC. Cellular signaling: pivoting around PDK-1. Cell 2000, 103:185-188. 10.1016/S0092-8674(00)00110-0, 11057891.
    • (2000) Cell , vol.103 , pp. 185-188
    • Toker, A.1    Newton, A.C.2
  • 37
    • 49049102134 scopus 로고    scopus 로고
    • Translocation of GluR1-containing AMPA receptors to a spinal nociceptive synapse during acute noxious stimulation
    • 10.1523/JNEUROSCI.5749-07.2008, 18614677
    • Larsson M, Broman J. Translocation of GluR1-containing AMPA receptors to a spinal nociceptive synapse during acute noxious stimulation. J Neurosci 2008, 28:7084-7090. 10.1523/JNEUROSCI.5749-07.2008, 18614677.
    • (2008) J Neurosci , vol.28 , pp. 7084-7090
    • Larsson, M.1    Broman, J.2


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