Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression

Journal of Neuroscience

Volumn 21, Issue 16, 2001, Pages 6170-6180

  Fariñas, Isabel ^a,b   Jones, Kevin R ^c   Tessarollo, Lino ^e   Vigers, Allison J ^c   Huang, Eric ^a   Kirstein, Martina ^b   De Caprona, Dominique C ^d   Coppola, Vincenzo ^e   Backus, Carey ^a   Reichardt, Louis F ^a   Fritzsch, Bernd ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSITY OF COLORADO   (United States)

^d CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Development of ear innervation; Ear and neurotrophin expression; Ear innervation; Neurotrophins; NT 3; Sensory neuron survival

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; NEUROTROPHIN; NEUROTROPHIN 3; PROTEIN TRKC; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; COCHLEA; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; IMMUNOCYTOCHEMISTRY; INNERVATION; MITOSIS; MOUSE; MOUSE MUTANT; NERVE FIBER GROWTH; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; SENSORY NERVE CELL; SPIRAL GANGLION;

EID: 0035882477     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-16-06170.2001     Document Type: Article

References (48)

1. Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: Parallel with Drosophila sense-organ development
2. Development of the cranial nerve ganglia and related nuclei in the rat
3. Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye
4. Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice
5. Studies on cell migration and axon guidance in the developing distal auditory system of the mouse
6. Dissection of NT-3 functions in vivo by gene replacement strategy
7. Contribution of placode and neural crest cells to avian cranial peripheral ganglia
8. Complementary roles of BDNF and NT-3 in vestibular and auditory development
9. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
10. Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors
11. Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: Direct NT-3 activation of TrkB neurons in vivo
12. Structure and function in sound discrimination among vertebrates
13. DiI reveals a prenatal arrival of efferents at the differentiating otocyst of mice
14. Reduction and loss of inner ear innervation in trkB and trkC receptor knockout mice: A whole mount DiI and scanning electron microscopic analysis
15. The role of neurotrophic factors in regulating inner ear innervation
16. Neurotrophins, neurotrophin receptors and the maintenance of the afferent inner ear innervation
17. Lack of NT-3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion
18. The development of NT-3 expression as revealed with a Lac-Z reporter and of innervation deficits in NT-3 mutant mice
19. Early embryology of the vertebrate ear
20. The combined effects of trkB and trkC mutations on the innervation of the inner ear
21. Making and breaking the innervation of the ear: Neurotrophic support during ear development and its clinical implications
22. The spatio-temporal expression of BDNF and NT-3 causes topological restricted spiral ganglion loss: No hair cell specificity in sight
23. Dynamics of placodal lineage development revealed by targeted transgene expression
24. Expression of Trk receptors in the developing mouse trigeminal ganglion: In vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC
25. GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear
26. NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development
27. Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin3-, and trkC-deficient embryonic mice
28. Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation
29. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
30. The role of FGF-3 in early inner ear development: An analysis in normal and Kreisler mutant mice
31. Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear
32. Development of the mouse inner ear and origin of its sensory organs
33. Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: The role of Wnt factors
34. Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia
35. Coordinated expression and function of neurotrophins and their receptors in the rat inner ear during target innervation
36. Expression of neurotrophins and Trk receptors in the developing, adult, and regenerating avian cochlea
37. FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis
38. Development of sensory and neural structures in the mammalian cochlea
39. Development of the inner ear of the mouse, a radio-autographic study of terminal mitosis
40. The auditory nerve: Peripheral innervation, cell body morphology, and central projections
41. Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear
42. Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets
43. Survival of inner ear sensory neurons in trk mutants
44. Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors
45. The development of innervation in the organ of Corti
46. Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis
47. Expression of neurotrophin-3 in the mouse forebrain: Insights from a targeted LacZ reporter
48. Expression of BDNF and NT-3 mRNA in hair cells of the organ of Corti: Quantitative analysis in developing rats