Paradigm shift in consciousness research: The child's self-awareness and abnormalities in autism, ADHD and schizophrenia

Acta Paediatrica, International Journal of Paediatrics

Volumn 101, Issue 2, 2012, Pages 112-119

  Lou, Hans C ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

ADHD; Autism; Conscious experience; Development; Schizophrenia; Self awareness; Self regulation

Indexed keywords

4 AMINOBUTYRIC ACID; DOPAMINE; NEUROTRANSMITTER;

ATTENTION DEFICIT DISORDER; AUTISM; AUTOREGULATION; CONSCIOUSNESS; HUMAN; INTERNEURON; ONTOGENY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SELF CONCEPT; SELF CONTROL;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; AUTISTIC DISORDER; BIOMEDICAL RESEARCH; CHILD; CONSCIOUSNESS; HUMANS; RESEARCH DESIGN; SCHIZOPHRENIA;

EID: 84855725112     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2011.02456.x     Document Type: Review

References (56)

1. Tononi G, Koch C,. The neural correlates of consciousness, an update. Ann NY Acad Sci 2008; 1124: 239-61.
2. Chalmers DJ,. The conscious mind: in search of a fundamental theory. New York: Oxford University Press, 1996.
3. Libet B,. Brain stimulation in the study of neuronal functions for consciousness. Hum Neurobiol 1982; 1: 235-42. (Pubitemid 13187656)
4. Lou HC, Skewes JC, Thomsen KR, Overgaard M, Lau HC, Mouridsen K, et al., Dopaminergic stimulation enhances confidence and accuracy in seeing rapidly presented words. J Vis 2011; 11: 1-6.
5. Kjaer TW, Nowak M, Kjaer KW, Lou AR, Lou HC,. Precuneus-prefrontal activity during awareness of visual verbal stimuli. Conscious Cogn 2001; 10: 356-65. (Pubitemid 32868444)
6. Edelman GM,. The remembered present: a biological theory of consciousness. New York: Basic Book, 1989.
7. Lou HC, Joensson M, Biermann-Ruben K, Schnitzler A, Østergaard L, Kjaer TW, et al., Recurrent activity in higher order, modality non-specific brain regions: a granger causality analysis of autobiographic memory retrieval. PLoS ONE 2011; 6: e22286.
8. Gallagher S,. Philosophical conceptions of the self: implications for cognitive science. Trends Cogn Sci 2000; 4: 14-21. (Pubitemid 30066503)
9. Blackmore S,. Conversations on consciousness. Oxford: Oxford University Press, 2005: 187.
10. Kjaer TW, Nowak M, Lou HC,. Reflective self-awareness and conscious states: PET evidence for a common midline parietofrontal core. Neuroimage 2002; 17: 1080-6. (Pubitemid 35317039)
11. Northoff G, Bernpohl F,. Cortical midline structures and the self. Trends Cogn Sci 2004; 8: 102-7. (Pubitemid 38299319)
12. Lou HC, Luber B, Crupain M, Keenan JP, Nowak M, Kjaer TW, et al., Parietal cortex and representation of the mental self. Proc Natl Acad Sci USA 2004; 101: 6827-32. (Pubitemid 38586059)
13. Lou HC, Luber B, Stanford A, Lisanby HS,. Self-specific processing in the default network: a single pulse TMS study. Exp Brain Res 2010; 207: 27-38.
14. Kwan VS, Barrios V, Ganis G, Gorman J, Lange C, Kumar M, et al., Assessing the neural correlates of self-enhancement bias: a transcranial magnetic stimulation study. Exp Brain Res 2007; 182: 379-85. (Pubitemid 47396467)
15. Damasio H,. Damasio AR investigating the biology of consciousness. Philos Trans R Soc Lond B 1998; 353: 1879-82.
16. 2O PET study of meditation and the resting state of normal consciousness. Hum Brain Mapp 1999; 7: 98-105. (Pubitemid 29055288)
17. Kjaer TW, Lou HC,. Interaction between precuneus and dorsolateral prefrontal cortex may play a unitary role in consciousness. A principal component analysis of rCBF. Conscious Cogn 2000; 9: S59.
18. Vogeley K, May M, Ritzl A, Falkai P, Zilles K, Fink GR,. Neural correlates of first-person perspective as a constituent of human self-consciousness. J Cogn Neurosci 2004; 16: 817-27. (Pubitemid 38757247)
19. Maguire EA, Frith CD, Morris RG,. The functional neuroanatomy of prior knowledge. Brain 1999; 122: 1839-50.
20. Cavanna AE, Trimble MR,. The precuneus: a review of its functional anatomy and behavioural correlates. Brain 2006; 129: 564-83. (Pubitemid 43278220)
21. Lou HC, Gross J, Biermann-Ruben K, Kjaer TW, Schnitzler A,. Coherence in consciousness: paralimbic gamma synchrony of self-reference links experiences. Hum Brain Mapp 2010; 31: 185-92.
22. He BJ, Raichle ME,. The fMRI signal, slow potential and consciousness. Trends Cogn Sci 2009; 13: 302-9.
23. Changeux J-P, Lou HC,. Emergent pharmacology of conscious experience: new perspectives in drug addiction. FASEB J 2011; 25: 2098-108.
24. Sohal VS, Zhang F, Yizhar O, Deisseroth K,. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature 2009; 459: 698-702.
25. Gross DW, Gotman J,. Correlation of high-frequency oscillations with the sleep-wake cycle and cognitive activity in humans. Neuroscience 1999; 94: 1005-18. (Pubitemid 29509668)
26. Rodriguez E, George N, Lachaux JP, Martinerie J, Renault B, Varela FJ,. Perception's shadow: long-distance synchronization of human brain activity. Nature 1999; 397: 430-3.
27. Rochat P,. Self-perception and action in infancy. Exp Brain Res 1998; 123: 102-9. (Pubitemid 28495302)
28. McAdams DP, Olson BD,. Personality development: continuity and change over the life course. Annu Rev Psychol 2010; 61: 517-42.
29. Fivush R,. The development of autobiographical memory. Ann Rev Psychol 2011; 62: 559-82.
30. Kostovic I, Judas M,. The development of the subplate and thalamocortical connections in the human foetal brain. Acta Paediatr 2010; 99: 1119-27.
31. Fransson P, Skiöld B, Horsch S, Nordell A, Blennow M, Lagercrantz H, et al., Resting-state networks in the infant brain. Proc Natl Acad Sci USA 2007; 104: 15531-6. (Pubitemid 47502951)
32. Holmboe K, Nemoda Z, Fearon RM, Csibra G, Sasvari-Szekely M, Johnson MH,. Polymorphisms in dopamine system genes are associated with individual differences in attention in infancy. Dev Psychol 2010; 46: 404-16.
33. Lagercrantz H, Changeux J-P,. The emergence of human consciousness: from fetal to neonatal life. Pediatr Res 2009; 65: 255-60.
34. Csibra G, Davis G, Spratling MW, Johnson MH,. Gamma oscillations and object processing in the infant brain. Science 2000; 290: 1582-5.
35. Hashimoto T, Nguyen QL, Rotaru D, Keenan T, Arion D, Beneyto M, et al., Protracted development of GABAA alpha 1 and alpha 2 subunit expression in primate prefrontal cortex. Biol Psychiatry 2009; 65: 1015-23.
36. Tseng KY, O'Donnell P,. Dopamine modulation of prefrontal cortical interneurons changes during adolescence. Cereb Cortex 2007; 17: 1235-40. (Pubitemid 46598865)
37. Uhlhaas PJ, Singer W,. The development of neural synchrony and large-scale cortical networks during adolescence: relevance for pathophysiology of schizophrenia and neurodevelopmental hypothesis. Schizophr Bull 2011; 37: 514-23.
38. Lind SE,. Memory and the self in autism: a review and theoretical framework. Autism 2010; 14: 430-56.
39. Assaf M, Jagannnathan K, Calhoun VD, Miller L, Stephens MC, Sahl R, et al., Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. Neuroimage 2010; 53: 247-56.
40. Wilson TW, Rojas DC, Reite ML, Rogers SJ,. Children and adolescents with autism exhibit reduced MEG steady-state gamma responses. Biol Psychiatry 2007; 62: 192-7. (Pubitemid 47042016)
41. Oblak AL, Gibbs TT, Blatt GJ,. Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism Res 2009; 2: 205-19.
42. Baskerville TA, Douglas AJ,. Dopamine and oxytocin interactions underlying behaviors: potential contributions to behavioral disorders. CNS Neurosci Ther 2010; 16: e92-123.
43. Neuhaus E, Beauchaine TP, Bernier R,. Neurobiological correlates of social functioning in autism. Clin Psychol Rev 2010; 30: 733-48.
44. Plessen KJ, Peterson BS,. The neurobiology of impulsivity and self-regulatory control in children with attention-deficit/hyperactivity disorder. In:, Charney DS, Nestler EJ, editors. Neurobiology of mental illness. 3rd ed. New York: Oxford University Press, 2008: 1129-52.
45. Lou HC,. Etiology and pathogenesis of attention deficit hyperactivity disorder (ADHD: significance of prematurity and perinatal hypoxic-haemodynamic encephalopathy. Acta Paediatr 1996; 85: 1266-71. (Pubitemid 26382370)
46. Castellanos FX, Marguelis DS, Kelly C, Uddin LQ, Gharaffi M, Kirsch A, et al., Cingulate-precuneus interactions: a new locus of dysfunction in adult attention deficit/hyperactivity disorder. Biol Psychiatry 2008; 63: 332-7.
47. Barry RJ, Clarke AR, Hajos M, McCarthy R, Selikowitz M, Dupuy FE,. Resting state EEG gamma activity in children with ADHD. Clin Neurophysiol 2011; Epub ahead of print.
48. English BA, Hahn MK, Gizer IR, Mazei-Robison M, Steele A, Kurnik DM, et al., Choline transporter gene variation is associated with attention-deficit hyperactivity disorder. J Neurodev Disord 2009; 1: 252-63.
49. Møller P, Husby R,. The initial prodrome in schizophrenia: searching for naturalistic core dimensions of experience and behavior. Schizophr Bull 2000; 26: 217-32. (Pubitemid 30317707)
50. Whitfield-Gabrieli S, Thermenos HW, Milanovic S, Tsuang MT, Faraone SV, McCarley RW, et al., Hyperactivity and hyperconnectivity of the default network in schizophrenia and first-degree relatives of patients with schizophrenia. Proc Natl Acad Sci USA 2009; 106: 1279-84.
51. Nejad AB, Ebdrup BH, Siebner HR, Rasmussen H, Aggernßs B, Glenthøj BY, et al., Impaired temporo-parietal deactivation with working memory loading of antipsychotic-naïve patients with first episode schizophrenia. World J Biol Psychiatry 2011; 12: 271-81.
52. Gallinat J, Winterer G, Herrmann CS, Senkowski D,. Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing. Clin Neurophysiol 2004; 115: 1863-74. (Pubitemid 38952954)
53. Minzenberg MJ, Firl AJ, Yoon JH, Gomes GC, Reinking C, Carter CS,. Gamma oscillatory power is impaired during cognitive control independent of medication status in first-episode schizophrenia. Neuropsychopharmacology 2010; 35: 2590-9.
54. Hashimoto T, Volk DW, Eggan SM, Mirnics K, Pierri JN, Sun Z, et al., Gene suppression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci 2003; 23: 6315-26. (Pubitemid 36875633)
55. Ishikawa M, Hashimoto K,. alpha7 nicotinic acetylcholine receptor as a potential therapeutic target for schizophrenia. Curr Pharm Des 2011; 17: 121-9.
56. Gonzales-Burgos G, Lewis DA,. GABA neurons and the network of oscillations for understanding cortical dysfunction in schizophrenia. Schizophr Bull 2008; 34: 944-61.