Emergent pharmacology of conscious experience: New perspectives in substance addiction

FASEB Journal

Volumn 25, Issue 7, 2011, Pages 2098-2108

  Changeux, Jean Pierre ^a,b   Lou, Hans C ^c  

^a l'alimentation et l'Environnement   (France)

^b INSTITUT PASTEUR   (France)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Acetylcholine; Dopamine; GABA; Global neuronal workspace; Interneurons; Self awareness; Self regulation

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; ACETYLCHOLINE; ANESTHETIC AGENT; APOMORPHINE; BACLOFEN; BENZODIAZEPINE; BICUCULLINE; BROMOCRIPTINE; CHOLINERGIC RECEPTOR; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; ETOMIDATE; LEVODOPA; MUSCARINIC AGENT; NICOTINE; PERGOLIDE; SEVOFLURANE; ZOLPIDEM;

ADDICTION; AUTISM; AWARENESS; BRAIN; CANNABIS ADDICTION; COGNITIVE DEFECT; COMA; CONSCIOUSNESS; CONSCIOUSNESS DISORDER; DOPAMINE RELEASE; DRUG BINDING SITE; ELECTROENCEPHALOGRAPHY; HALLUCINATION; HUMAN; INFORMATION PROCESSING; INTERNEURON; LIMBIC SYSTEM; MAGNETOENCEPHALOGRAPHY; MOLECULAR MODEL; NERVE CELL NETWORK; NEUROTRANSMISSION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SELF CONTROL; SLEEP WAKING CYCLE; SPASTICITY; SPINAL CORD INJURY; SUBSTANCE ABUSE; TRANSCRANIAL MAGNETIC STIMULATION; TRAUMATIC BRAIN INJURY; YOGA;

ANIMALS; BRAIN; CONSCIOUSNESS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; HUMANS; MODELS, NEUROLOGICAL; NERVE NET; NEURONS; SUBSTANCE-RELATED DISORDERS;

EID: 79960155728     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-0702ufm     Document Type: Review

References (108)

1. Cabanac, M., Cabanac, A. J., and Parent, A. (2009) The emergence of consciousness in phylogeny. Behav. Brain Res. 198, 267-272
2. Baars, B. J. (1989) A Cognitive Theory of Consciousness, Cambridge University Press, Cambridge, MA, USA
3. Dehaene, S., Kerszberg, M., and Changeux, J. P. (1998) A neuronal model of a global workspace in effortful cognitive tasks. Proc. Natl. Acad. Sci. U. S. A. 95, 14529-14534
4. Dehaene, S., and Changeux, JP. (2011) Experimental and theoretical approaches to the study of conscious processing Neuron 70, 200-227
5. Dehaene, S., Changeux, J. P., Naccache, L., Sackur, J., and Sergent, C. (2006) Conscious, preconscious, and subliminal processing: a testable taxonomy. Trends Cogn. Sci. 10, 204-211
6. Werner, G. (2007) Brain dynamics across levels of organization. J. Physiol. (Paris) 101, 273-279
7. Gaillard, R., Dehaene, S., Adam, C., Clémenceau, S., Hasboun, D., Baulac, M., Cohen, L., and Naccache, L. (2009) Converging intracranial markers of conscious accesss. PLoS Biol. 7, e61
8. Rodriguez, E., George, N., Lachaux, J. P., Martinerie, J., Renault, B., and Varela, F. J. (1999) Perception's shadow: long-distance synchronization of human brain activity. Nature 397, 430-433
9. Dehaene, S., Sergent, C., and Changeux, J. P. (2003) A neuronal network model linking subjective reports and objective physiological data during conscious perception. Proc. Natl. Acad. Sci. U. S. A. 100, 8520-8525
10. Sohal, V.S., Zhang, F., Yizhar, O., and Deisseroth, K. (2009). Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature 459, 698-702
11. Gross, D. W., and Gorman, J. (1999) Correlation of high-frequency oscillations with the sleep-wake cycle and cognitive activity in humans. Neuroscience 94, 1005-1018 (Pubitemid 29509668)
12. Melloni, N., Schwiedrzik, C., Müller, N., Rodriguez, E. and Singer, W. (2011) Expectations change the signatures and timing of electrophysiological correlates of perceptual awareness. J. Neurosci. 31, 1386-1396
13. Fisch, L., Privman, E., Ramot, M., Harel, M., Nir, Y., Kipervasser. S., Andelman, F., Neufeld, M. Y., Kramer, U., Fried, I., and Malach, R. (2009) Neural "ignition": enhanced activation linked to perceptual awareness in human ventral stream visual cortex. Neuron 64, 562-574
14. Gonzalez-Burgos, G., and Lewis, D. A. (2008) GABA neurons and the mechanism of network oscillations: implications for understanding cortical dysfunction in schizophrenia. Schizophr. Bull. 34, 944-961
15. Blakemore, S.-J., Rees, G., and Frith, C. D. (1998) How do we predict the consequences of our actions? A functional imaging study. Neuropsychologia 36, 521-529
16. Damasio, A. R. (1998) Investigating the biology of consciousness. Phil. Trans. R. Soc. Lond. B 353, 1879-1882
17. Gallagher, I. (2000) Philosophical conceptions of the self: implications for cognitive science. Trends Cogn. Sci. 4, 14-21
18. Gardiner, J. M. (2001) Episodic memory and autonoetic consciousness: a first-person approach. Philos. Trans. R. Soc. Lond. B Biol. Sci. 356, 351-361
19. Kjaer, T. W., Nowak, M., and Lou, H. C. (2002) reflective self-awareness and conscious states: PET evidence for a common midline parietofrontal core. Neuroimage 17, 1080-1086
20. Lou, H. C., Luber, B., Crupain, M., Keenan, J. P., Nowak, M., Kjaer, T. W., Sackeim, H. A., and Lisanby, S. H. (2004) Parietal cortex and representation of the mental self. Proc. Natl. Acad. Sci. U. S. A. 101, 6827-6832
21. Northoff, G., and Bermpohl, F. (2004) Cortical midline structures and the self. Trends Cogn. Sci. 8, 102-107
22. Vogeley, K., May, M., Ritzl, A., Falkai, P., Zilles, K., and Fink, G. R. (2004) Neural correlates of first-person perspective as a constituent of human self-consciousness. J. Cogn. Neurosci. 16, 817-827
23. Ehrsson, H. H., Wiech, K., Weiskopf, N., Dolan, R. J., and Passingham, R. E. (2007) Threatening a rubber hand that you feel is yours elicits a cortical anxiety response. Proc. Natl. Acad. Sci. 104, 9828-9833
24. Lou, H. C., Luber, B., Stanford, A., and Lisanby, S. H. (2010) Self-specific processing in the default network: a single pulse TMS study. Exp. Brain Res. 207, 27-38
25. Kwan, V.S., Barrios, V., Garnis, G., Gorman, J., Kumar, M., Shepard, A., and Keenan, J. P. (2007) Assessing the neural correlates of self-enhancement bias: a transcranial magnetic stimulation study. Exp. Brain Res. 182, 379-385
26. Lou, H. C., Kjaer, T. W., Friberg, L., Wildschiodtz, G., Holm, S., and Nowak, M. (1999) A 15O-H2O PET study of meditation and the resting state of normal consciousness. Hum. Brain Mapp. 7, 98-105
27. Kjaer, T. W., and Lou, H. C. (2000) Interaction between precuneus and dorsolateral prefrontal cortex may play a unitary role in consciousness: a principal component analysis of rCBF. Consc. Cogn. 9, S59
28. Maguire, E. A., Frith, C. D., and Morris, R. G. (1999) The functional neuroanatomy of comprehension and memory: the importance of prior knowledge. Brain 122, 1839-1850
29. Lou, H.C., Gross, J., Biermann-Ruben, K., Kjaer. T.W., and Schnitzler, A. (2010) Coherence in consciousness: paralimbic gamma synchrony of self-reference links experience. Hum. Brain Mapp. 31, 185-192
30. Kjaer, T. W., Nowak, M., Kjaer, K. W., Lou, A. R., and Lou, H. C. (2001) Precuneus- prefrontal activity during awareness of visual verbal stimuli. Conscious. Cogn. 10, 356-365
31. Vohs, K. D., Baumeister, R. F., Schmeichel, B. J., Twenge, J. M., Nelson, N. M., and Tice, (2008) Making choices impairs subsequent self-control: a limited-resourse account of decisionmaking self-regulation, and active initiative. J. Pers. Soc. Psychol. 94, 883-898
32. Williams, L. M., Sidis, A., Gordon, E., and Meares, R. A. (2006) "Missing links" in borderline personality disorder: loss of neural synchrony relates to lack of emotion regulation and impulse control. J. Psychiatry Neurosci. 31, 181-188
33. Williams, L. M., Whitford, T. J., Gordon, E., Gomes, L., Brown, K. J., and Harris, A. W. (2009) Neural synchrony in patients with a first episode of schizophrenia: tracking relations with grey matter and symptom profile. J. Psychiatry Neurosci. 34, 21-29
34. Fuchs, E. C., Zivkovic, A. R., Cunningham, M. O., Middleton, S., Lebeau, F. E., Bannerman, D. M., Rozov, A., Whittington, M. A., Traub, R. D., Rawlins, J. N., and Monyer, H. (2007) Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behaviour. Neuron 53, 591-604
35. Galarreta, M., and Hestrin, S. (2001) Electrical synapses between GABA-releasing interneurons. Nat. Rev. Neurosci. 2, 425-433
36. George O., and Koob, G. F. (2010) Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci. Biobehav. Rev. 35, 232-247
37. Simeone, T. A., Donavan, S. D., and Rho, J. M. (2003) Activation of GABA(A) receptors in immature neurons causes depolarization. J. Child Neurol. 18, 39-48
38. Uhlhaas, P. J., Roux, F., Rodriguez, E., Rotarska-Jagiela, A., and Singer, W. (2010) Neural synchrony and the development of cortical networks. Trends Cogn. Neurosci. 14, 72-80
39. Rochat, P. (1998) Self-perception and action in infancy. Exp. Brain Res. 123, 102-109
40. Li, G. D., Chiara, D. C., Sawyer, G. W., Husain, S. S., Olsen, R. W., and Cohen, J. B. (2006) Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog. J. Neurosci. 26, 11599-11605
41. Olsen, R. W., and Li, G. D. (2011) GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation. Can. J. Anaesth. 58, 206-215
42. Kröner, S., Krimer, L. S., Lewis, D. A., and Barrionuevo (2007) Dopamine increases inhibition in the monkey dorsolateral prefrontal cortex through cell type-specific modulation of interneurons. Cereb. Cortex 17, 2020-2032
43. Fisahn, A., Pike, F. G., Buhl, E. H., and Paulsen, O. (1998) Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro. Nature 394, 186-189 (Pubitemid 28325972)
44. Franks, N. P., and Zecharia, A. Y. (2011) Sleep and general anesthesia. Can. J. Anaesth. 58, 139-148
45. Nury, H., Van Renterghem, C., Weng, Y., Tran, A., Baaden, M., Dufresne, V., Changeux, J. P., Sonner, J. M., Delarue, M., and Corringer, P. J. (2011) X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature 469, 428-431
46. Bocquet, N., Prado de Carvalho, L., Cartaud, J., Neyton, J., Le Poupon, C., Taly, A., Grutter, T., Changeux, J. P., Corringer, P. J. (2007) A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature 445, 116-119 (Pubitemid 46067312)
47. Faulkner, H. J., Traub, R. D., and Wittington, M. A. (1998) Disruption of synchronous gamma oscillations in the rat hippocampal slice: a common mechanism of anaesthetic drug action. Br. J. Pharmacol. 125, 483-492
48. Fox, J. E., and Jefferys, J. G. (1998) Frequency and synchrony of tetanically-induced, gamma-frequency population discharges in the rat hippocampal slice: the effect of diazepam and propofol. Neurosci. Lett. 257, 101-104
49. Ferrarelli, F., Massimini, M., Sarasso, S., Casali, A., Riedner, B. A., Angelini, G., Tononi, G., and Pearce, R. A. (2010) Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness. Proc. Natl. Assoc. Sci. U. S. A. 107, 2681-2686
50. Clayton, T., Chen, J. L., Ernst, M., Richter,. L, Cromer, B. A, Morton, C. J., Ng, H., Kaczorowski, C. C., Helmstetter, F.J., Furtmüller, R., Ecker, G., Parker, M. W., Sieghart, W., and Cook, J. M. (2007) An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid (a) receptors: correlation with comparative models. Curr. Med. Chem.14, 2755-2775
51. Clauss, R. P. (2010) Neurotransmitters in coma, vegetative and minimally conscious states, pharmacological interventions. Med. Hypotheses 75, 287-290
52. Nyakale, N. E., Clauss, R. P., Nel, W., and Sathekge, M. (2010) Clinical and brain SPECT scan response to zolpidem in patients after brain damage. Arzneimittelforschung 60, 177-181
53. Camacho-Arroyo, I., Alvarado, R., Manjarrez, J., and Tapia, R. (1991) Microinjections of muscinol and bicuculline into the pontine reticular formation modify the sleep-waking cycle in the rat. Neurosci. Lett. 129, 95-97
54. Flint, R. R., Chang, T., Lydic, R., and Baghdoyan, H. A. (2010) GABA(A) receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioural phenotypes of wakefulness. J. Neurosci. 30, 12301-12309
55. Marks, G. A., Sachs, O. W., and Birabil, C. G. (2008) Blockade of GABA, type A, receptors in the rat pontine reticular formation induces rapid eye movements sleep that is dependent upon the cholinergic system. Neuroscience 156, 1-10
56. Vanini, G., Watson, C. J., Lydic, R., and Baghdoyan, H. A. (2008) Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isolurane anesthesia. Anesthesiology 109, 978-988
57. Vazquez, J., and Baghdoyan, H. A., (2004) GABAA receptors inhibit acetylcholine release in cat pontine reticular formation: implications for REM sleep regulation. J. Neurophysiol. 92, 2198-2206
58. Schiff, N. D. (20100 Recovery of consciousness after severe brain inhury. The role of arousal regulation mechanisms and some speculations on the heart-brain interface. Cleve. Clin. J. Med. 77(Suppl 3), S27-S33
59. Yamasaki, M., Matsui, M., and Watanabe, M. (2010) Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission. J. Neurosci. 30, 4408-4418
60. Jeon, J., Dencker, D., Wörtwein, G., Woldbye, D. P., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C. X., Fink-Jensen, A., and Wess, J. (2010) A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviours. J. Neurosci. 30, 2396-2405
61. Taly, A., Corringer, P. J., Guedin, D., Lestage, P., and Changeux, J. P. (2009) Nicotinic receptors. Allosteric transitions and therapeutic targets in the nervous system. Nat. Rev. Drug Discov. 8, 733-750
62. Gotti, C., Clementi, F., Fornari, A., Gaimarri, A., Guiducci, S., Manfredi, I., Moretti, M., Pedrazzi, P., Pucci, L., and Zoli, M. (2009) Structural and functional diversity of native brain neuronal nicotinic receptors. Biochem. Pharmacol. 78, 703-711
63. Vidal, C., Changeux, J. P. (1993) Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortex in vitro. Neuroscience 56, 23-32 (Pubitemid 23261800)
64. MacDermott, A. B., Role, L. W., and Siegelbaum, S. A. (1999) Presynaptic ionotropic receptors and the control of transmitter release. Annu. Rev. Neurosci. 22, 443-485
65. Rodriguez, R., Kallenbach, U., Singer, W., and Munk, M. H. (2004) Short- and long-term effects of cholinergic modulation on gamma oscillations and response synchronization in the visual cortex. J. Neurosci. 24. 103, 69-78
66. Lena, C., Changeux, J. P. and Mulle, C. (1993) Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus. J. Neurosci. 13, 2680-2688
67. Lambe, E.K., Picciotto, M. R., and Aghajanian, G.K. (2003) Nicotine induces glutamate release from thalamocortical terminals in cortex. Neuropsychopharmacology 28, 216-225
68. Heath, C. J., King, S. L., Gotti, C., Marks, M. J., and Picciotto, M. R. (2010) Cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through alpha4/beta2/ alpha5 nicotinic acetylcholine receptors. Neuropsychopharmacology 25, 2324-2338
69. Granon, S., Poucet, B., Thinus-Blanc, C., Changeux, J. P., and Vidal, C. (1995) Nicotinic and muscarinic receptors in the rat prefrontal cortex: differential roles in working memory, response selection, and effortful processing. Psychopharmacology (Berl.) 119, 139-144
70. Changeux, J. P. (2010) Nicotine addiction and nicotinic receptors: lessons from genetically modified mice. Nat. Rev. Neurosci. 11, 389-401
71. Granon, S., Faure, P., and Changeux, J. P. (2003) Executive and social behaviors under nicotinic receptor regulation. Proc. Natl. Acad. Sci. U. S. A. 100, 9596-9601
72. Léna, C., Popa, D., Grailhe, R., Escourrou, P., Changeux, J. P., and Adrien, J. (2004) Beta2-containing nicotinic receptors contribute to the organization of sleep and regulate putative micro-arousals in mice. J. Neurosci. 24, 5711-5718 (Pubitemid 38857225)
73. Changeux, J. P. (2006) The Ferrier Lecture 1998. The molecular biology of consciousness investigated with genetically modified mice. Philos. Trans. R. Soc. Lond. B Biol. Sci. 361, 2239-2259
74. Wiklund, A., Granon, S., Cloëz-Tayarani, I., Faure, P., le Sourd, A. M., Sundman, E., Changeux, J. P., and Eriksson, L. I. (2008) Sevoflurane anesthesia alters exploratory and anxiety-like behaviour in mice lacking the beta2 nicotinic acetylcholine receptor subunit. Anesthesiology 109, 790-798
75. Mameli-Engvall, M., Evrard, A., Pons, S., Maskos, U., Svensson, T. H., Changeux, J. P., and Faure, P. (2006) Hierarchial control of dopamine neuron-firing patterns by nicotinic receptors. Neuron 50, 911-921 (Pubitemid 43850688)
76. Wong, J. Y., Clifford, J. J., Massalas, J. S., Finkelstein, D. I., Horne, M. K., Waddington, J. L., and Drago, J. (2003) Neurochemical changes in dopamine D1, D, and D1/D3 receptor knockout mice. Eur. J. Pharmacol. 472, 39-47
77. Yuen, E, Y, and Yan, Z. (2009) Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex. J. Neurosci. 29, 550-562
78. Demiralp, T., Herrmann, C. S., Erdal, M. E., Ergenoglu, T., Keskin, Y. H., Ergen, M., and Beydagi, H. (2007) DRD4 and DAT1 polymorphisms modulate human gamma band responses. Cereb. Cortex 17, 1007-1019 (Pubitemid 46598842)
79. Schmitt, G. J., Frodl, T., Dresel, S., la Fougère, C., Bottlender, R., Koutsouleris, N., Hahn, K., Möller, H. J., and Meisenzahl, E. M. (2006) Striatal dopamine transporter availability is associated with the productive psychotic state in first episode, drug-naïve schizophrenic patients. Eur. Arch. Psychiatry Clin. Neurosci. 256, 115-121
80. Matsuda, W., Komatsu, Y., Yanaka, K., and Matsumura, A. (2005) Levodopa treatment for patients in persistent vegetative or minimally conscious states. Neuropsychol. Rehabil. 15, 414-427
81. Passler, M. A., and Riggs, R. V. (2001) Positive outcomes in traumatic brain injury-vegetative state: patients treated with bromocriptine. Arch. Phys. Med. Rehabil. 82, 311-315
82. Fridman, E. A., Calvar, J., Bonetto, M., Gamzu, E., Krimchansky, B. Z., Meli, F., Leiguarda, R. C., and Zafonte, R. (2009) Fast awakening from minimally conscious states with apomorphine. Brain Inj. 23, 172-177
83. Kjaer, T. W., Bertelsen, C., Piccini, P., Brooks, D., Alving, J., Lou, H. C. (2002) Increased dopamine tone during meditation- induced change of consciousness. Brain Res. Cogn. Brain Res. 13, 255-259
84. Lou, H. C., Skewes, J. C., Thomsen, K. R., Overgaard, M., Lau, H. C., Mouridsen, K., and Roepstorff, A. (2011) Dopaminergic stimulation enhances confidence and accuracy in seeing rapidly presented words. J. Vis. 11(2), pii 15
85. Pessiglione, M., Seymour, B., Flandin, G., Dolan, R. J., and Frith, C. D. (2006) Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature 442, 1042-1045
86. Comoli, E., Coizet, V., Boyes, J., Bolam, J. P., Canteras, N. S., Quirk, R. H., Overton, P. G., and Redgrave, P. (2003) A direct projection from superior colliculus to substantia nigra for detecting salient visual events. Nat. Neurosci. 6, 974-980
87. Dommett, E., Coizet, V., Blaha, C. D., Martindale, J., Lefebvre, V., Walton, N., Mayhew, J. E., Overton, P. G., and Redgrave, P. (2005) How visual stimuli activate dopaminergic neurons at short latency. Science 307, 1476-1479 (Pubitemid 40321947)
88. Libet, B. (1982) Brain stimulation in the study of neuronal functions for conscious experiences. Hum. Neurobiol. 2, 35-42
89. Verdejo-García, A., Bechara, A., Recknor, E. C., and Pérez-García, M. (2007) Negative emotion-driven impulsivity predicts substance dependence problems. Drug Alcohol Depend. 91, 213-219
90. Glass, J. M., Buu, A., Adams, K. M., Nigg, J. T., Puttler, L. I., Jester, J. M., and Zucker, R. A. (2009) Effects of alcoholism severity and smoking on executive neurocognitive function. Addiction 104, 38-48
91. Salo, R., Ursu, S., Buonocore, M. H., Leamon, M. H., and Carter, C. (2009) Impaired prefrontal cortical function and disrupted adaptive cognitive control in methamphetamine abusers. A functional magnetic resonance imaging study. Biol. Psychiatry. 65, 706-709
92. Cumyn, L., French, L., and Hechtman, L. (2009) Comorbidity in adults with attention-deficit hyperactivity disorder. Can. J. Psychiatry. 54, 673-683
93. Bechara, A., and Van der Linden, M. (2005) Decision-making and impulse control after frontal lobe injuries. Curr. Opin. Neurol. 18, 734-739
94. Naqvi, N. H., Rudrauf, D., Damasio, H., and Bechara, A. (2007) Damage to the insula disrupts addiction to cigarette smoking. Science 315, 531-534 (Pubitemid 46175760)
95. Raichle, M. E., and Snyder, A. Z. (2007) A default mode of brain function: a brief history of an evolving idea. Neuroimage 37, 1083-1090
96. Everitt, B. J., and Robbins, T. W. (2005) Neural systems of reinforcement for drug addictions to habits to compulsion. Nat. Neurosci. 8, 1481-1489; erratum: 9, 979
97. Volkow, N. D., Hitzemann. R., Wang, G. J., Fowler, J. S., Wolf, A. P., Dewey, S. L., and Handlesman, L. (1992) Long-term frontal brain metabolic changes in cocaine abusers. Synapse 11, 184-190; erratum: 12, 86
98. Hester, R., and Garavan, H. (2004) Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity. J. Neurosci. 24, 11017-11022 (Pubitemid 40012960)
99. Hartley, A. A., and Speer, N. K. (2000) Locating and fractionating working memory using functional neuroimaging: storage, maintenance, and executive functions. Microsc. Res. Tech. 51, 45-53
100. Bechara, A., Damasio, H., and Damasio, A. R. (2000) Emotion, decision making, and the orbitofrontal cortex. Cereb. Cortex 10, 295-307
101. Salo, R., Nordahl, T. E., Buonocore, M. H., Natsuaki, Y., Waters, C., Moore, C. D., Galloway, G. P., and Leamon, M. H. (2009) Cognitive control and white matter callosal microstructure in methamphetamine-dependent subjects: a diffusion tensor imaging study. Biol. Psychiatry 65, 122-128
102. Wang, J. J., Durazzo, T. C., Gazdzinski, S., Yeh, P. H., Mon, A., and Meyerhoff, D. J. (2009) MRSI and DTI: a multimodal approach for improved detection of white matter abnormalities in alcohol and nicotine dependence. NMR Biomed. 22, 516-522
103. Yeh, P. H., Simpson, K., Durazzo, T. C., Gazdzinski, S., and Meyerhoff, D. J. (2009) Tract-based spatial statistics (TBSS) of diffusion tensor imaging data in alcohol dependence: abnormalities of the motivational circuitry. Psychiatry Res. 173, 22-30
104. Liu, H., Li, L., Hao, Y., Cao, D., Xu, L., Rohrbaugh, R., Xue, Z., Hao, W., Shan, B., and Liu, Z. (2008) Disrupted white matter integrity in heroin dependence: a controlled study utilizing diffusion tensor imaging. Am. J. Drug Alcohol Abuse 34, 562-575
105. Ashtari, M., Cervellione, K., Cottone, J., Ardekani, B. A., Sevy, S., and Kumra, S. (2009) Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use. J. Psychiatr. Res. 43, 189-204
106. Jacobsen, L. K., Picciotto, M. R., Heath, C. J., Frost, S. J., Tsou, K. A., Dwan, R. A., Jackowski, M. P., Constable, R. T., and Menci, W. E. (2007) Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure. J. Neurosci. 27, 13491-13498
107. Kawai, H., Lazar, R., and Metherate, R. (2007) Nicotinic control of axon excitability regulates thalamocortical transmission. Nat. Neurosci. 10, 1168-1175
108. Lagercrantz, H., and Changeux, J. P. (2009) The emergence of human consciousness: from fetal to neonatal life. Pediatr. Res. 65, 255-260