The initial prodrome in schizophrenia: Searching for naturalistic core dimensions of experience and behavior

Schizophrenia Bulletin

Volumn 26, Issue 1, 2000, Pages 217-232

  Møller, Paul ^a   Husby, Ragnhild ^b  

^a Buskerud Central Hospital   (Norway)

^b DIAKONHJEMMET HOSPITAL   (Norway)

Author keywords

First episode schizophrenia; Illness onset; Prodromal behaviors; Prodromal experiences; Qualitative methods; Self experience

Indexed keywords

ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTIVATION; ONSET AGE; PERSONALITY; PRIORITY JOURNAL; RISK ASSESSMENT; SCHIZOPHRENIA; SELF CONCEPT; SOCIAL ISOLATION;

EID: 0034113110     PISSN: 05867614     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.schbul.a033442     Document Type: Article

References (101)

1. à Campo, J.; Frederikx, M.; Nijman, H.; and Merckelbach, H. Schizophrenia and changes in physical appearance. [Letter]. Journal of Clinical Psychiatry, 59(4): 197, 1998.
2. Altheide, D.L., and Johnson, J.M. Criteria for assessing interpretive validity in qualitative research. In: Denzin, N.K., and Lincoln, Y.S., eds. Handbook of Qualitative Research. Thousand Oaks, CA; London, U.K.; and New Delhi, India: Sage Publications, 1994. pp. 485-499.
3. American Psychiatric Association. DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders. 3rd ed., revised. Washington, DC: The Association, 1987.
4. American Psychiatric Association. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: The Association, 1994.
5. Beiser, M.; Erickson, D.; Fleming, J.A.F.; and Iacono, W.G. Establishing the onset of psychotic illness. American Journal of Psychiatry, 150(9):1349-1354, 1993.
6. Berner, P. Delusional atmosphere. British Journal of Psychiatry, 159(Suppl 14):88-93, 1991.
7. Birchwood, M.; McGorry, P.D.; and Jackson, H.J. Early intervention in schizophrenia. British Journal of Psychiatry, 170:2-5, 1997.
8. Bleuler, E. Textbook of Psychiatry. Translated by A.A. Brill. New York, NY: The Macmillan Company, 1924.
9. Bleuler, E. Dementia Praecox or the Group of Schizophrenias. Translated by J. Zinkin. New York, NY: International Universities Press, 1950.
10. Bovet, P., and Parnas, J. Schizophrenic delusions: A phenomenological approach. Schizophrenia Bulletin, 19(3):579-597, 1993.
11. Brannen, J. Combining qualitative and quantitative approaches: An overview. In: Brannen, J., ed. Mixing Methods: Qualitative and Quantitative Research. Hants, U.K.: Avebury Ashgate Publishing, 1992. pp. 3-37.
12. Bustillo, J.; Buchanan, R.W.; and Carpenter, W.T. Prodromal symptoms vs. early warning signs and clinical action in schizophrenia. Schizophrenia Bulletin, 21(4):553-559, 1995.
13. Cameron, D.E. Early schizophrenia. American Journal of Psychiatry, 95:567-582, 1938.
14. Carpenter, W.T., and Heinrichs, D.W. Early intervention, time-limited, targeted pharmacotherapy of schizophrenia. Schizophrenia Bulletin, 9:533-542, 1983.
15. Chapman, J. The early symptoms of schizophrenia. British Journal of Psychiatry, 112:225-251, 1966.
16. Chapman, L.J., and Chapman, J.P. The search for symptoms predictive of schizophrenia. Schizophrenia Bulletin, 13(3):497-503, 1987.
17. Conrad, K. Die beginnende Schizophrenie:Versuch einer Gestaltanalyse des Wahns. Stuttgart, Germany: Georg Thieme Verlag, 1958.
18. Cornblatt, B.; Obuchowski, M.; Ditkowsky, K.; Singer, A.; Malhotra, A.; Becker, J.; Shah, M.; and Pappadopulos, E. The Hillside RAPP clinic: A research/early intervention center for the schizophrenia prodrome. [Abstract]. Schizophrenia Research, 36:6, 1999.
19. Crow, T.J.; MacMillan, J.F.; Johnson, A.L.; and Johnstone, F.C. A randomised controlled trial of prophylactic neuroleptic treatment. British Journal of Psychiatry, 148:120-127, 1986.
20. Cutting, J. Gestalt theory and psychiatry: Discussion paper. Journal of the Royal Society of Medicine, 82:429-431, 1989.
21. Cutting, J., and Dunne, F. The nature of the abnormal perceptual experiences at the onset of schizophrenia. Psychopathology, 19:347-352, 1986.
22. Docherty, J.P.; van Kammen, D.P.; Siris, S.G.; and Marder, S.R. Stages of onset of schizophrenic psychosis. American Journal of Psychiatry, 135:420-426, 1978.
23. Falloon, I.R. Early interventions for first episodes of schizophrenia: A preliminary exploration. Psychiatry, 55:4-15, 1992.
24. Falloon, I.R.; Coverdale, J.H.; Laidlaw, T.M.; Merry, S.; Kydd, R.R.; and Morosini, P. Early intervention for schizophrenic disorders. British Journal of Psychiatry, 172(Suppl 33):33-38, 1998.
25. Fenning, S.; Craig, T.; Lavelle, J.; Kovasznay, B.; and Bromet, E.J. Best-estimate versus structured interview-based diagnosis in first-admission psychosis. Comprehensive Psychiatry, 35(5):341-348, 1994.
26. Fish, F. Fish's Schizophrenia. Bristol, U.K.: John Wright and Sons, 1976.
27. Gillies, H. The clinical diagnosis of early schizophrenia. In: Rodger, T.F.; Mowbray, R.M.; and Roy, J.R., eds. Topics in Psychiatry. London, U.K.: Cassell, 1958. pp. 47-56.
28. Gross, G. The onset of schizophrenia. Schizophrenia Research, 28:187-198, 1997.
29. Gross, G.; Huber, G.; and Klosterkötter, J. Early diagnosis of schizophrenia. Neurology, Psychiatry and Brain Research, 1:17-22, 1992.
30. Gross, G.; Huber, G.; Klosterkötter, J.; and Linz, M. BSABS Bonner Skala für die Beurteilung von Basissymptomen. [Bonn Scale for the Assessment of Basic Symptoms.] Heidelberg, Germany: Springer Verlag, 1987.
31. Haas, G.L.; Garratt, L.S.; and Sweeney, J.A. Delay to first antipsychotic medication in schizophrenia: Impact on symptomatology and clinical course of illness. Journal of Psychiatric Research, 32(3-4):151-159, 1998.
32. Häfner, H.; Maurer, K.; Löffler, W.; and Riecher-Rössler, A. The influence of age and sex on the onset and early course of schizophrenia. British Journal of Psychiatry, 162:80-86, 1993.
33. Häfner, H.; Nowotny, B.; Löffler, W.; [v]an der Heiden, W.; and Maurer, K. When and how does schizophrenia produce social deficits? European Archives of Psychiatry and Clinical Neuroscience, 246(1):17-28, 1995.
34. Häfner, H.; Riecher-Rössler, A.; Hambrecht, M.; Maurer, K.; Meissner, S.; Schmidtke, A.; Fätkenheuer, B.; Löffler, W.; and van der Heiden, W. IRAOS: An instrument for the assessment of onset and early course of schizophrenia. Schizophrenia Research, 6:209-223, 1992.
35. Hambrecht, M., and Häfner, H. Sensitivity and specificity of relatives' reports on the early course of schizophrenia. Psychopathology, 30:12-19, 1997.
36. Hambrecht, M.; Häfner, H.; and Löffler, W. Beginning schizophrenia observed by significant others. Social Psychiatry and Psychiatric Epidemiology, 29:53-60, 1994.
37. Hans, S.L.; Marcus, J.; Henson, L.; Auerbach, J.G.; and Mirsky, A.F. Interpersonal behavior of children at risk for schizophrenia. Psychiatry, 55:314-335, 1992.
38. Helgason, L. Twenty years' follow-up of first psychiatric presentation for schizophrenia: What could have been prevented? Acta Psychiatrica Scandinavica, 81:231-235, 1990.
39. Herz, M.I., and Melville, C. Relapse in schizophrenia. American Journal of Psychiatry, 137(7):801-805, 1980.
40. Huber, G. Prodrome der schizophrenie. [Prodromes of schizophrenia.] Fortschritte der Neurologie-Psychiatrie, 63(4):131-138, 1995.
41. Huber, G. Reine defektsyndrome und basisstadien endogener psychosen. [Pure deficit syndromes and basic stages of endogenous psychoses.] Fortschritte der Neurologie-Psychiatrie, 34:409-426, 1966.
42. Huberman, A.M., and Miles, M.B. Methods of collecting and analyzing empirical materials: Data management and analysis methods. In: Denzin, N.K., and Lincoln, Y.S., eds. Handbook of Qualitative Research. Thousand Oaks, CA; London, U.K.; and New Delhi, India: Sage Publications, 1994. pp. 428-444.
43. Jackson, H.J.; McGorry, P.D.; Dakis, J.; Harrigan, S.; Henry, L.; and Mihalopoulos, C. The inter-rater and test-retest reliabilities of prodromal symptoms in first-episode psychosis. Australian and New Zealand Journal of Psychiatry, 30:498-504, 1996.
44. Jackson, H.J.; McGorry, P.D.; and Dudgeon, P. Prodromal symptoms of schizophrenia in first-episode psychosis: Prevalence and specificity. Comprehensive Psychiatry, 36(4):241-250, 1995.
45. Jackson, H.J.; McGorry, P.D.; and McKenzie, D. The reliability of DSM-III prodromal symptoms in first-episode psychotic patients. Acta Psychiatrica Scandinavica, 90:375-378, 1994.
46. Jaspers, K. Allgemeine Psychopathologie. Berlin, Germany: Springer, 1913.
47. Johnstone, E.G.; Crow, T.J.; Johnson, A.L.; and MacMillan, J.F. The Northwick Park study of first episodes of schizophrenia: I. Presentation of the illness and problems ralating to admission. British Journal of Psychiatry, 148:115-120, 1986.
48. Keith, S.J., and Matthews, S.M. The diagnosis of schizophrenia: A review of onset and duration issues. Schizophrenia Bulletin, 17(1):51-67, 1991.
49. Keshavan, M.S., and Schooler, N.R. First-episode studies in schizophrenia: Criteria and characterization. Schizophrenia Bulletin, 18(3):491-513, 1992.
50. Kim, Y.; Takemoto, K.; Mayahara, K.; Sumida, K.; and Shiba, S. An analysis of the subjective experience of schizophrenia. Comprehensive Psychiatry, 35(6):430-436, 1994.
51. Klosterkötter, J.; Gross, G.; Huber, G.; Wieneke, A.; Steinmeyer, E.M.; and Schultze-Lutter, F. Evaluation of the "Bonn Scale for the Assessment of Basic Symptoms - BSABS" as an instrument for the assessment of schizophrenia proneness: A review of recent findings. Neurology, Psychiatry and Brain Research, 5:137-150, 1997a.
52. Klosterkötter, J.; Schultze-Lutter, F.; Gross, G.; Huber, G.; and Steinmeyer, E.M. Early self-experienced neuropsychological deficits and subsequent schizophrenic diseases: An 8-year average follow-up prospective study. Acta Psychiatrica Scandinavica, 95:396-404, 1997b.
53. Kvale, S. Validity in the qualitative research interview. Methods, 1(2):37-72, 1987.
54. Larsen, T.K.; Johannessen, J.O.; and Opjordsmoen, S. First-episode schizophrenia with long duration of untreated psychosis. Pathways to care. British Journal of Psychiatry, 172(Suppl 33):45-52, 1998.
55. Lieberman, J.A.; Alvir, J.M.; Koreen, A.; Geisler, S.H.; Chakos, M.; Sheitman, B.; and Woerner, M. Psychobiologic correlates of treatment response in schizophrenia. Neuropsychopharmacology, 14(3S):13S-21S, 1996.
56. Loebel, A.D.; Lieberman, J.A.; Alvir, J.M.; Mayerhoff, D.I.; Geisler, S.H.; and Szymanski, S.R. Duration of psychosis and outcome in first-episode schizophrenia. American Journal of Psychiatry, 149:1183-1188, 1992.
57. May, P.R.; Tuma, A.H.; and Dixon, W. Schizophrenia: A follow-up study of the results of the five forms of treatment. Archives of General Psychiatry, 38:776-784, 1981.
58. McEvoy, J.P.; Schooler, N.R.; and Wilson, W.H. Predictors of therapeutic response to haloperidol in acute schizophrenia. Psychopharmacology Bulletin, 27:97-101, 1991.
59. McGlashan, T.H. Early detection and intervention in schizophrenia: Research. Schizophrenia Bulletin, 22(2):327-345, 1996.
60. McGlashan, T.H. Early detection and intervention of schizophrenia: Rationale and research. British Journal of Psychiatry, 172 (Suppl 33):3-6, 1988.
61. McGorry, P.D.; McFarlane, C.; Patton, G.C.; Bell, R.; Hibbert, M.E.; Jackson, H.J.; and Bowes, G. The prevalence of prodromal features of schizophrenia in adolescence: a preliminary survey. Acta Psychiatrica Scandinavica, 92(4):241-249, 1995.
62. McGorry, P.D. "A stitch in time"...the scope for preventive strategies in early psychosis. European Archives of Psychiatry and Clinical Neuroscience, 248:22-31, 1998.
63. McGorry, P.D., and Singh, B.S. Schizophrenia: Risk and possibility of prevention. In: Raphael, B., and Burrows, G.D., eds. Handbook of Studies on Preventive Psychiatry. Amsterdam, The Netherlands: Elsevier Science B.V., 1995. pp. 491-514, 502.
64. Meyer, E., and Covi, L. The experiences of depersonalization: A written report by a patient. Psychiatry, 23:215-217, 1960.
65. Miller, T.J.; McGlashan, T.H.; Woods, S.W.; Stein, K.; Driesen, N.; Corcoran, C.M.; Hoffman, R.; and Davidson, L. Symptom assessment in schizophrenic prodromal states. Psychiatric Quarterly, 70:273-287, 1999.
66. Miller, W.L., and Crabtree, B.F. Strategies of inquiry: Clinical research. In: Denzin, N.K., and Lincoln, Y.S., eds. Handbook of Qualitative Research. Thousand Oaks, CA; London, U.K.; New Delhi, India: Sage Publications, 1994. pp. 340-352.
67. Minkowski, E. La Schizophrénie. [Schizophrenia.] Paris, France: Payot, 1927.
68. Møller, P. First-episode schizophrenia: Do grandiosity, disorganization and acute initial development reduce duration of untreated psychosis? Comprehensive Psychiatry, in press.
69. Myin-Germeys, I.; Delespaul, P.A.E.G.; and deVries, M.W. Schizophrenia patients are more emotionally active than is assumed based on their behavior. Schizophrenia Bulletin, in press.
70. Parnas, J. On defining schizophrenia. In: Sartorius, N., and Maj, M., eds. WPA Series: Evidence and Experience in Psychiatry. Vol. 2. Schizophrenia. New York, NY: John Wiley and Sons, 1999.
71. Parnas, J. Schizophrenia: The concept and the development of the illness (Danish). In: Jörgensen, P.; Larsen, T.K.; and Rosenbaum, B., eds. Early Intervention in Schizophrenia (Danish). Copenhagen, Denmark: FADL, 2000.
72. Parnas, J.; Jansson, L.; Sass, L.A.; and Handest, P. Self-experience in the prodromal phases of schizophrenia: A pilot study of first-admissions. Neurology, Psychiatry and Brain Research, 6:97-106, 1998.
73. Rapoport, J.L.; Giedd, J.N.; Kumra, S.; Jacobsen, L.; Smith, A.; Lee, P.; Nelson, J.; and Hamburger, S. Childhood-onset schizophrenia: Progressive ventricular change during adolescence. Archives of General Psychiatry, 54:897-903, 1997.
74. Rapoport, J.L.; Giedd, J.N.; Blumenthal, J.; Hamburger, S.; Jeffries, N.; Fernandez, T.; Nicolson, R.; Bedwell, J.; Lenane, M.; Zijdenbos, A.; Paus, T.; and Evans, A. Progressive cortical change during adolescence in childhood-onset schizophrenia. Archives of General Psychiatry, 56:649-654, 1999.
75. Roy, M.-A.; Lanctôt, G.; Mérette, C.; Cliche, D.; Fournier, J.-P.; Boutin, P.; Rodrigue, C.; Charron, L.; Turgeon, L.; Hamel, M.; Montgrain, N.; Nicole, L.; Pirès, A.; Wallot, H.; Ponton, A.-M.; Garneau, Y.; Dion, C.; Lavallée, J.-C.; Potvin, A.; Szatmari, P.; and Maziade, M. Clinical and methodological factors related to reliability of the best-estimate diagnostic procedure. American Journal of Psychiatry, 154:1726-1733, 1997.
76. Rümke, H.C. The nuclear symptom of schizophrenia and the praecoxfeeling. Translated by Neeleman, J. History of Psychiatry, 1:331-341, 1990.
77. Sass, L.A. The truth-taking stare. In: Madness and Modernism. Insanity in the Light of Modern Art, Literature, and Thought. New York, NY: Basic Books, 1992. pp. 43-74.
78. Sass, L. A. The Paradoxes of Delusion: Wittgenstein, Schreher and the Schizophrenic Mind. Ithaca, NY, and London, U.K.: Cornell University Press, 1994.
79. Schultze-Lutter, F.; Steinmeyer, E.M.; and Klosterkötter, J. Early detection of schizophrenia. Schizophrenia Research, in press.
80. Scully, P.J.; Coakley, G.; Kinsella, A.; and Waddington, J.L. Negative symptom severity and general cognitive impairment increase with duration of initially untreated psychosis. Schizophrenia Research, 24(1-2)22, 1997.
81. Simeon, D.; Gross, S.; Guralnik, O.; Stein, D.J.; Schmeidler, J.; and Hollander, E. Feeling unreal: 30 cases of DSM-III-R Depersonalization Disorder. American Journal of Psychiatry, 154:1107-1113, 1997.
82. Spitzer, R.L.; Williams, J.B.W.; Gibbon, M.; and First, M.B. Structured Clinical Interview for DSM-III-R - Patient Version (SCID-P 6/1/88). New York, NY: New York State Psychiatric Institute, Biometrics Research, 1988.
83. Strauss, J.S. Mediating processes in schizophrenia: Towards a new dynamic psychiatry. British Journal of Psychiatry, 155(Suppl 5):22-28, 1989.
84. Strauss, J.S., and Carpenter, W.T. Schizophrenia. New York, NY, and London, U.K.: Plenum Medical Book Company, 1981.
85. Subotnik, K.I., and Nuechterlein, K.H. Prodromal signs and symptoms of schizophrenic relapse. Journal of Abnormal Psychology, 97(4):405-412, 1988.
86. Sullivan, H.S. The onset of schizophrenia. American Journal of Psychiatry, 151(Suppl 6):135-139, 1994.
87. Timbury, G.C., and Mowbray, R.M. The diagnosis of schizophrenia by Scottish psychiatrists. British Journal of Psychiatry, 110:174-180, 1964.
88. Vaglum, P. Earlier detection and intervention in schizophrenia: Unsolved questions. Schizophrenia Bulletin, 22(2):347-351, 1996.
89. Varsamis, J., and Adamson, J.D. Early schizophrenia. Canadian Psychiatric Association Journal, 16:487-497, 1971.
90. Waddington, J.L.; Youssef, H.A.; and Kinsella, A. Sequential cross-sectional and 10-year prospective study of severe negative symptoms in relation to duration of initially untreated psychosis in chronic schizophrenia. Psychological Medicine, 25:849-857, 1995.
91. Weinberger, D. From neuropathology to neurodevelopment. Lancet, 346:552-557, 1995.
92. Weinberger, D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44:660-669, 1987.
93. Wiersma, D.; Nienhuis, F.J.; Slooff, C.J.; and Giel, R. Natural course of schizophrenic disorders: A 15-year followup of a Dutch incidence cohort. Schizophrenia Bulletin, 24(1):75-85, 1998.
94. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders. Geneva, Switzerland: WHO, 1992.
95. Wyatt, R.J. Neuroleptics and the natural course of schizophrenia. Schizophrenia Bulletin, 17(2):325-351, 1991.M
96. Wyatt, R.J. Early intervention for schizophrenia: Can the course of the illness be altered? Biological Psychiatry, 38:1-3, 1995.
97. Wyatt, R.J.; Green, M.F.; and Tuma, A.H. Long-term morbidity associated with delayed treatment of first admission schizophrenic patients: A re-analysis of the Camarillo State Hospital data. Psychological Medicine, 27:261-268, 1997.
98. Yung, A.R., and McGorry, P.D. The initial prodrome in psychosis: Descriptive and qualitative aspects. Australian and New Zealand Journal of Psychiatry, 30:587-599, 1996a.
99. Yung, A.R., and McGorry, P.D. The prodromal phase of first-episode psychosis: Past and current conceptualizations. Schizophrenia Bulletin, 22(2):353-370, 1996b.
100. Yung, A.R.; McGorry, P.D.; McFarlane, C.A.; Jackson, H.J.; Patton, G.C.; and Rakkar, A. Monitoring and care of young people at incipient risk of psychosis. Schizophrenia Bulletin, 22(2):283-303, 1996.
101. Yung, A.R.; Phillips, L.J.; McGorry, P.D.; McFarlane, C.; Francey, F.; Harrigan, S.; Patton, G.C.; and Jackson, H.J. Prediction of psychosis: A step towards indicated prevention of schizophrenia. British Journal of Psychiatry, 172(Suppl 33):14-20, 1998.