Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats

Food and Chemical Toxicology

Volumn 47, Issue 11, 2009, Pages 2735-2741

  El Sharaky, A S ^a   Wahby, M M ^a   Bader El Dein, M M ^a   Fawzy, R A ^a   El Shahawy, I N ^b  

^a Alexandria University Faculty Of Science   (Egypt)

^b Alexandria Soap and Oil Co   (Egypt)

Author keywords

Antioxidants; Gossypol acetic acid; Gossypol iron complex; Hepatotoxicity; Lipid peroxydation

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DNA; FATTY ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GOSSYPOL ACETIC ACID; GOSSYPOL DERIVATIVE; GOSSYPOL IRON COMPLEX; HYDROXYL RADICAL; MALONALDEHYDE; PHENOL; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; FATTY ACID ANALYSIS; INHIBITION KINETICS; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; DRUG-INDUCED LIVER INJURY; GOSSYPOL; IRON; LIPID PEROXIDATION; LIVER; MALE; RATS;

ANIMALIA; RATTUS;

EID: 70350200877     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.08.001     Document Type: Article

References (53)

1. 14C-gossypol in laying hens. Toxicol. Appl. Phrmacol. 17 (1970) 4473
2. Achedume A.C., Nwoha P.U., Adepoju A.Y., and Abu K.A. Gossypol profound influence on the regulation of cholesterol level in the liver. Contraception 50 4 (1994) 391
3. Akingbemi B.T., and Aire T.A. Hematological and serum biochemical changes in the rat due to protein malnutrition and gossypol-ethanol interactions. J. Comp. Pathol. 111 4 (1994) 413
4. Aletor V.A., and Aturamu O.A. Use of oyster shell as calcium supplement part 2. An assessment of the responses of hepatic and serum enzymes, relative organ weights, and bone minerals in the broiler chicken fed gossypol containing cottonseed cake supplementation with oyster shell. Nahrung 34 4 (1990) 319
5. Ali S.F., and El Sewedy S.M. Effect of gossypol on liver metabolic enzymes in male rats. Toxicol. Lett. 23 (1984) 299-306
6. Armstrong D., and Browne R. The analysis of free radicals, lipid peroxides, antioxidant enzymes and compounds related to oxidative stress as applied to clinical chemistry. Lab. Free Rad. Diag. Med. 366 (1994) 49
7. Bender H.S., Derolf S.Z., and Misra H.P. Effects of gossypol on the antioxidant defense system of the rat testis. Arch. Androl. 21 1 (1988) 59
8. Braham J.E., and Bressani R. Effect of different levels of gossypol on transaminase activity, on nonessential to essential amino acid ratio, and on iron and nitrogen retention in rats. J. Nutr. 105 3 (1975) 348
9. Campbell K.N., Morris R.C., and Adams R. The structure of gossypol. J. Am. Chem. Soc. 59 (1937) 1723
10. Chalvardjian A.M. Fatty acids of brown and yellow fat in rats. Biochem. J. 90 (1964) 518
11. Coutinho E.M. Gossypol. A contraceptive for men. Contraception 65 4 (2002) 259
12. Dao V.T., Dowd M.K., Gaspard C., Martin M.T., Hémez J., Laprévote O., Mayer M., and Michelot R.J. New thioderivatives of gossypol and gossypolone, as pro-drugs of cytotoxic agents. Bioorg. Med. Chem. 11 (2003) 2001
13. Deng H.L., and Zhang J.T. Anti-lipid peroxidative effect of ginsenoside Rb1 and Rg1. Chin. Med. J. 104 5 (1991) 395
14. Dou S., and Fu Y. Effects of GAA on heart mitochondrial membranes ATPase. Zhongguo Yaoli Xuebao 9 3 (1988) 233
15. El-Sharaky A.S., El-Sewedy S.M., El-Sayed M.M., and El-Shahawy I.N. Effect of gossypol, apogossypol and gossypolone on fertility of male rats and in vitro sperm mobility. Qatar Univ. Sci. J. 13 2 (1993) 214-218
16. El-Sharaky A.S., El-Sewedy S.M., El-Sayed M.M., and El-Shahawy I.N. The effect of gossypol, gossypolone and apogossypol on the lipids of male rat serum and seminal fluids. Qatar Univ. Sci. J. 14 C (1994) 32-38
17. Folch J., Less M., and Sloane-Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226 (1957) 497
18. {radical dot}OH scavengers, motile stimulators and MDA production. Biochem. Biophys. Res. Commun. 195 3 (1993) 1289
19. Fossati P., and Prencipe L. Serum triglycerides determined calorimetrically with an enzyme that produces hydrogen peroxide. Clin. Chem. 28 10 (1982) 2077
20. Gutteridge J.M.C., and Xia-Chang F. Enhancement of belomycin-iron free radical damage to DNA by antioxidants and their inhibition of lipid per oxidation. FEBS Lett. 123 (1981) 71
21. Halliwell B., and Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am. J. Clin. Nutr. 57 Suppl. (1993) 715S-725S
22. Hamasaki Y., and Tai H.H. Gossypol: a potent inhibitor of arachidonate 5- and 12- lipoxygenases. Biochim. Biophys. Acta 34 1 (1985) 37
23. Jonassen H.B., and Demint R.J. Interaction of gossypol with ferrous ion. J. Am. Oil Chem. Soc. 32 (1955) 424
24. Kanwar U., Kaur R., Chadha S., and Sanyal S. Gossypol-induced inhibition of glucose uptake in human ejaculated spermatozoa may be mediated by lipid per oxidation. Contraception 42 5 (1990) 573
25. Knight J.A., Anderson S., and Rawle J.M. Chemical basis of the sulfophospho-vanillin reaction for estimating total serum lipids. Clin. Chem. 18 3 (1972) 199
26. Kovacic P. Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. Curr. Med. Chem. 10 24 (2003) 2711
27. Laughton M.J., Halliwell B., Evans P.J., and Hoult J.R. Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid per oxidation, hydroxyl radical generation and belomycin-dependent damage to DNA. Biochem. Pharmacol. 38 17 (1989) 2859
28. Lawrence R.A., and Burk R.F. GSH-Px activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71 4 (1976) 952
29. Li A.S., Bandy B., Tsang S.S., and Davison A.J. DNA-breaking versus DNA-protection activity of four phenolic compounds in vitro. Free Rad. Res. 33 5 (2000) 551
30. Manabe S., Nuber D.C., and Lin Y.C. Zone-specific hepatotoxicity of gossypol in perfused rat liver. Toxicon 29 6 (1991) 787
31. Mangold H.K., and Malins D.C. Fractionation of fats, oils, and waxes on thin-layers of silicic acid. J. Am. Soc. 37 (1960) 383
32. Marchlewski L. Gossypol: Ein Bestandtheil der Baumwollsamen. J. Prakt. Chem. 60 (1899) 84
33. McDowell L.R., Velasquez-Pereira J., Risco C.A., Prichard D., Mart F.G., Calhoun M.C., Williams S.N., Wilkinson N.S., and Ogebe P. Effects on performance, tissue integrity, and metabolism of vitamin E supplementation for beff heifers fed a diet that contains gossypol. J. Anim. Sci. 76 11 (1998) 2871
34. Obeidy A., Fities I.A., and Sheriff D.S. The effect of gossypol on serum lipoproteins of adult rats. Horm. Metab. Res. 21 12 (1989) 649
35. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351
36. Ohnishi S.T., and Barr J.K. A simplified method of quantitating protein using the biuret and phenol reagent. Anal. Biochem. 86 (1978) 193
37. Paglia D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte GSH-Px. J. Lab. Clin. Med. 70 1 (1967) 158
38. Peyster A., Quintanilha A., Packer L., and Smith M.T. Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. Biochem. Biophys. Res. Commun. 118 (1984) 573
39. Prichard D., Velasquez-Pereira J., McDowell L.R., Chenoweth P.J., Risco C.A., Staples C.R., Martin F.G., Calhoun M.C., Rojas L.X., Williams S.N., and Wilkinson N.S. Long-term effects of gossypol and vitamin E in the diet of dairy bulls. J. Dairy Sci. 81 9 (1998) 2475
40. Radwan S.S. Coupling of two-dimensional TLC with gas chromatography for the quantitative analysis of lipid classes and their constituent fatty acids. J. Chromatogr. Sci. 16 (1978) 538
41. Reitman S., and Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am. J. Clin. Path. 28 (1957) 56
42. Richardson R.J., and Murphy S.D. Effect of GSH depletion on tissue deposition of methylmercury in rats. Toxicol. Appl. Pharmacol. 31 (1975) 505
43. Richmond W. Preparation and properties of cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin. Chem. 19 2 (1973) 1350
44. Sedlak J., and Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25 (1968) 192
45. Shandilya L.N., and Clarkson T.B. Hypolipidemic effects of gossypol in cynomolgus monkeys (Macaca fascicularis). Lipids 17 4 (1982) 285
46. Sheriff D.S. Gossypol and testicular lipids of adult rats. Horm. Metab. Res. 20 11 (1988) 691
47. Sheriff D.S. Effect of gossypol on tissue levels of GSH and thiobarbituric acid reactive products in rats. Indian J. Exp. Biol. 30 8 (1992) 734
48. Velasquez-Pereira J., McDowell L.R., Risco C.A., Prichard D., Martin F.G., Calhoun M.C., Williams S.N., Wilkinson N.S., and Ogebe P. Effects on performance, tissue integrity, and metabolism of vitamin E supplementation for beef heifers fed a diet that contains gossypol. J. Anim. Sci. 76 11 (1998) 2871
49. Velasquez-Pereira J., Pichard D., McDowell L.R., Chenoweth P.J., Risco C.A., Staples C.R., Martin F.G., Calhoun M.C., Rojas L.X., Williams S.N., and Wilkinson N.S. Long-term effects of gossypol and vitamin E in the diets of dairy bulls. J. Dairy Sci. 81 9 (1998) 2475
50. Wong R.C., Nakagawa Y., and Perlmann G.E. Studies on the nature of the inhibition by gossypol of the transformation of pepsinogen to pepsin. J. Biol. Chem. 247 (1972) 1625
51. Xiao D.M., Wang X.L., Zhang J.B., and Chen H.C. Effects of gossypol on phorbol ester-calcimycin-induced prostaglandin synthesis by macrophages. Clin. Med. J. 104 4 (1991) 321
52. Yang X., and Kulkarni A.P. N-dealkylation of aminopyrine catalyzed by soybean lipoxygenase in the presence of hydrogen peroxide. J. Biochem. Mol. Toxicol. 12 3 (1998) 175
53. Ying W., and Lei H.P. Hepatotoxicity of gossypol in rats. J. Ethnopharmacol. 20 (1987) 53