Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Murray, Sarah S ^a   Smith, Erin N ^h   Villarasa, Nikki ^a   Nahey, Tara ^c   Lande, Jeff ^c   Goldberg, Harold ^c   Shaw, Marian ⁱ   Rosenthal, Lawrence ^d   Ramza, Brian ^e   Alaeddini, Jamshid ^f   Han, Xinqiang ^g   Damani, Samir ^a   Soykan, Orhan ^c   Kowal, Robert C ^b   Topol, Eric J ^a  

^a SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE   (United States)

^b BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^c MEDTRONIC INC   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e SAINT LUKE S MID AMERICA HEART INSTITUTE   (United States)

^f Inland Cardiology Associates   (United States)

^g Richmond Cardiology Associates   (United States)

^h RADY CHILDREN'S HOSPITAL   (United States)

ⁱ SEQUENOM INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT;

AGED; ARTICLE; CHROMOSOME 13; COHORT ANALYSIS; CONTROLLED STUDY; DEFIBRILLATION; DEFIBRILLATOR; ELECTROCARDIOGRAM; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEART ARRHYTHMIA; HEREDITY; HUMAN; LIFE THREATENING ARRHYTHMIA; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; QT INTERVAL; RETROSPECTIVE STUDY; CASE CONTROL STUDY; COMPARATIVE STUDY; COPY NUMBER VARIATION; GENETICS; MORTALITY; SURVIVAL RATE;

AGED; ARRHYTHMIAS, CARDIAC; CASE-CONTROL STUDIES; COHORT STUDIES; DEFIBRILLATORS, IMPLANTABLE; DNA COPY NUMBER VARIATIONS; FEMALE; FOLLOW-UP STUDIES; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; SURVIVAL RATE;

EID: 84855703380     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025387     Document Type: Article

References (37)

1. Sen-Chowdhry S, McKenna WJ, (2007) Sudden cardiac death in the young: the impact of inherited cardiovascular disease. Textbook of Cardiovascular Medicine. CD/online content ed Philadelphia, PA Lippincott Williams and Wilkins Press.
2. Jouven X, Desnos M, Guerot C, Ducimetiere P, (1999) Predicting sudden death in population: Paris prospective study I. Circulation 99: 1978-1983.
3. Dekker L, Bezzina CR, Henriques JP, Tanck MW, Koch KT, et al. (2006) Familial Sudden Death Is an Important Risk Factor for Primary Ventricular Fibrillation. Circulation 114: 1140-1145.
4. Friedlander Y, Siscovick DS, Weinmann S, Austin MA, Psaty BM, et al. (1998) Family History as a Risk Factor for Primary Cardiac Arrest. Circulation 97: 155-160.
5. Knollmann BC, Roden DM, (2008) A genetic framework for improving arrhythmia therapy. Nature 451: 929-936.
6. Noseworthy PA, Newton-Cheh C, (2008) Genetic determinants of sudden cardiac death. Circulation 118: 1854-1863.
7. Albert CM, MacRae CA, Chasman DI, VanDenburgh M, Buring JE, et al. (2010) Common variants in cardiac ion channel genes are associated with sudden cardiac death. Circ Arrhythm Electrophysiol 3: 222-229.
8. Kao WH, Arking DE, Post W, Rea TD, Sotoodehnia N, et al. (2009) Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation 119: 940-951.
9. Bezzina CR, Pazoki R, Bardai A, Marsman RF, de Jong JS, et al. (2010) Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Nat Genet 42: 688-691.
10. Newton-Cheh C, Eijgelsheim M, Rice KM, de Bakker PI, Yin X, et al. (2009) Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet 41: 399-406.
11. Pfeufer A, Sanna S, Arking DE, Muller M, Gateva V, et al. (2009) Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet 41: 407-414.
12. Myerburg RJ, (2008) Implantable cardioverter-defibrillators after myocardial infarction. N Engl J Med 359: 2245-2253.
13. Desai H, Aronow WS, Ahn C, Gandhi K, Hussain S, et al. (2010) Risk factors for appropriate cardioverter-defibrillator shocks, inappropriate cardioverter-defibrillator shocks, and time to mortality in 549 patients with heart failure. Am J Cardiol 105: 1336-1338.
14. Kruger A, Aronow WS, Lai H, Desai H, Singla A, et al. (2009) Prevalence of appropriate cardioverter-defibrillator shocks in 1038 consecutive patients with implantable cardioverter-defibrillators. Am J Ther 16: 323-325.
15. Otmani A, Trinquart L, Marijon E, Lavergne T, Waintraub X, et al. (2009) Rates and predictors of appropriate implantable cardioverter-defibrillator therapy delivery: results from the EVADEF cohort study. Am Heart J 158: 230-237 e1.
16. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, et al. (2007) A common allele on chromosome 9 associated with coronary heart disease. Science 316: 1488-1491.
17. Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, et al. (2007) Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 448: 353-357.
18. Arking DE, Pfeufer A, Post W, Kao WH, Newton-Chew C, et al. (2006) A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet 38: 644-651.
19. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
20. Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR, (2010) MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34: 816-834.
21. Shen Y, Liu Z, Ott J, (2010) Systematic removal of outliers to reduce heterogeneity in case-control association studies. Hum Hered 70: 227-231.
22. R Development Core Team (2008) R: A language and environment for statistical computing Vienna, Austria R Foundation for Statistical Computing.
23. Therneau T, Lumley T, (2008) survival: Survival analysis, including penalised likelihood; S original; R package version 2.34-1.
24. Skol AD, Scott LJ, Abecasis GR, Boehnke M, (2007) Optimal designs for two-stage genome-wide association studies. Genet Epidemiol 31: 776-788.
25. Wang K, Li M, Hadley D, Liu R, Glessner J, et al. (2007) PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res 17: 1665-1674.
26. Colella S, Yau C, Taylor JM, Mirza G, Butler H, et al. (2007) QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data. Nucleic Acids Res 35: 2013-2025.
27. Chambers JC, Zhao J, Terracciano CM, Bezzina CR, Zhang W, et al. (2010) Genetic variation in SCN10A influences cardiac conduction. Nat Genet 42: 149-152.
28. Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, et al. (2010) Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet 42: 240-244.
29. Holm H, Gudbjartsson DF, Arnar DO, Thorleifsson G, Thorgeirsson G, et al. (2010) Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet 42: 117-122.
30. Pfeufer A, van Noord C, Marciante KD, Arking DE, Larson MG, et al. (2010) Genome-wide association study of PR interval. Nat Genet 42: 153-159.
31. Eberle MA, Ng PC, Kuhn K, Zhou L, Peiffer DA, et al. (2007) Power to detect risk alleles using genome-wide tag SNP panels. PLoS Genet 3: 1827-1837.
32. Eichler EE, Lu F, Shen Y, Antonacci R, Jurecic V, et al. (1996) Duplication of a gene-rich cluster between 16p11.1 and Xq28: a novel pericentromeric-directed mechanism for paralogous genome evolution. Hum Mol Genet 5: 899-912.
33. Johansen CT, Wang J, Lanktree MB, Cao H, McIntyre AD, et al. (2010) Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet 42: 684-687.
34. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA, (2009) Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324: 387-389.
35. Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, et al. (2010) A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature 463: 671-675.
36. Ezekowitz JA, Rowe BH, Dryden DM, Hooton N, Vandermeer B, et al. (2007) Systematic review: implantable cardioverter defibrillators for adults with left ventricular systolic dysfunction. Ann Intern Med 147: 251-262.
37. Manolio TA, (2010) Genomewide association studies and assessment of the risk of disease. N Engl J Med 363: 166-176.