Cardiac β-adrenergic responsiveness with exercise

European Journal of Applied Physiology

Volumn 111, Issue 11, 2011, Pages 2735-2741

  Libonati, Joseph R ^a   MacDonnell, Scott M ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Aerobic; Fitness; Heart; Hypertrophy; Left ventricle

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCINEURIN; ISOPRENALINE; ONCOPROTEIN;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; FEMALE; GENETICS; HEART; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; METABOLISM; PHYSIOLOGY; RANDOMIZATION; RAT; WISTAR KYOTO RAT;

ADRENERGIC BETA-AGONISTS; ANIMALS; ATRIAL NATRIURETIC FACTOR; CALCINEURIN; FEMALE; HEART; ISOPROTERENOL; MYOCARDIUM; ONCOGENE PROTEIN V-AKT; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; RATS; RATS, INBRED WKY; RECEPTORS, ADRENERGIC, BETA; VENTRICULAR FUNCTION, LEFT;

EID: 84855697486     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-011-1909-0     Document Type: Article

References (34)

1. Barbier J, Rannou-Bekono F, Marchais J, Berthon PM, Delamarche P, Carre F (2004) Effect of training on beta1 beta2 beta3 adrenergic and M2 muscarinic receptors in rat heart. Med Sci Sports Exerc 36(6):949-954. doi:00005768- 200406000-00006[pii]
2. Barbier J, Reland S, Ville N, Rannou-Bekono F, Wong S, Carre F (2006) The effects of exercise training on myocardial adrenergic and muscarinic receptors. Clin Auton Res 16(1):61-65. doi: 10.1007/s10286-006-0312-0 (Pubitemid 43237905)
3. Billman GE, Kukielka M, Kelley R, Moustafa-Bayoumi M, Altschuld RA (2006) Endurance exercise training attenuates cardiac ß2-adrenoceptor responsiveness and prevents ventricular fibrillation in animals susceptible to sudden death. Am J Physiol Heart Circ Physiol 290(6):H2590-H2599. doi:10.1152/ajpheart.01220.2005 (Pubitemid 43846090)
4. Bohm M, Dorner H, Htun P, Lensche H, Platt D, Erdmann E (1993) Effects of exercise on myocardial adenylate cyclase and Gi alpha expression in senescence. Am J Physiol 264(3 Pt 2):H805-H814 (Pubitemid 23109872)
5. Crews J, Aldinger EE (1967) Effect of chronic exercise on myocardial function. Am Heart J 74(4):536-542
6. Davidson WR Jr, Banerjee SP, Liang CS (1986) Dobutamine-induced cardiac adaptations: comparison with exercise-trained and seden-tary rats. Am J Physiol 250(5 Pt 2):H725-H730
7. Dohm GL, Pennington SN, Barakat H (1976) Effect of exercise train-ing on adenyl cyclase and phosphodiesterase in skeletal muscle, heart, and liver. Biochem Med 16(2):138-142
8. Ekblom B, Kilbom A, Malmfors T, Sigvardsson K, Svanfeldt E (1973) Sympathectomy and pharmacological blockade in trained rats. Acta Physiol Scand 89(2):283-285
9. Holycross BJ, Kukielka M, Nishijima Y, Altschuld RA, Carnes CA, Billman GE (2007) Exercise training normalizes beta-adrenoceptor expression in dogs susceptible to ventricular fibrillation. Am J Physiol Heart Circ Physiol 293(5):H2702-H2709. doi:10.1152/ ajpheart.00763.2007 (Pubitemid 350106493)
10. Hopkins MG, Spina RJ, Ehsani AA (1996) Enhanced beta-adrenergic- mediated cardiovascular responses in endurance athletes. J Appl Physiol 80(2):516-521 (Pubitemid 26061456)
11. Houle MS, Altschuld RA, Billman GE (2001) Enhanced in vivo and in vitro contractile responses to beta(2)-adrenergic receptor stimula- tion in dogs susceptible to lethal arrhythmias. J Appl Physiol 91(4):1627-1637 (Pubitemid 32900353)
12. Kolwicz SC, Kubo H, Mac Donnell SM, Houser SR, Libonati JR (2007) Effects of forskolin on inotropic performance and phos- pholamban phosphorylation in exercise-trained hypertensive myocardium. J Appl Physiol 102(2):628-633. doi:10.1152/ japplphysiol.00449.2006 (Pubitemid 46220892)
13. Leosco D, Rengo G, Iaccarino G, Filippelli A, Lymperopoulos A, Zincarelli C, Fortunato F, Golino L, Marchese M, Esposito G, Rapacciuolo A, Rinaldi B, Ferrara N, Koch WJ, Rengo F (2007) Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation. Am J Physiol Heart Circ Physiol 293(3):H1596-H1603. doi:10.1152/ ajpheart.00308.2007 (Pubitemid 47367205)
14. Leosco D, Rengo G, Iaccarino G, Golino L, Marchese M, Fortunato F, Zincarelli C, Sanzari E, Ciccarelli M, Galasso G, Altobelli GG, Conti V, Matrone G, Cimini V, Ferrara N, Filippelli A, Koch WJ, Rengo F (2008) Exercise promotes angiogenesis and improves beta-adrener- gic receptor signalling in the post-ischaemic failing rat heart. Cardio- vasc Res 78(2):385-394. doi:10.1093/cvr/cvm109 (Pubitemid 351556096)
15. Mac Donnell SM, Kubo H, Crabbe DL, Renna BF, Reger PO, Mohara J, Smithwick LA, Koch WJ, Houser SR, Libonati JR (2005) Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension. Circulation 111(25):3420-3428. doi:10.1161/CIRCULATIONAHA.104. 505784 (Pubitemid 40923395)
16. Mac Donnell SM, Kubo H, Harris DM, Chen X, Berretta R, Barbe MF, Kolwicz S, Reger PO, Eckhart A, Renna BF, Koch WJ, Houser SR, Libonati JR (2007) Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol 293(5):H3122-H3129. doi: 10.1152/ajpheart.00687.2007 (Pubitemid 350106538)
17. Mazzeo RS, Podolin DA, Henry V (1995) Effects of age and endurance training on beta-adrenergic receptor characteristics in Fischer 344 rats. Mech Ageing Dev 84(2):157-169. doi:0047-6374 (95)01643-0[pii] (Pubitemid 26008048)
18. Mole PA (1978) Increased contractile potential of papillary muscles from exercise-trained rat hearts. Am J Physiol 234(4):H421-H425 (Pubitemid 9125787)
19. Moore RL, Riedy M, Gollnick PD (1982) Effect of training on beta-adrenergic receptor number in rat heart. J Appl Physiol 52(5):1133-1137 (Pubitemid 12055061)
20. Nieto JL, Laviada ID, Guillen A, Haro A (1996) Adenylyl cyclase system is affected differently by endurance physical training in heart and adipose tissue. Biochem Pharmacol 51(10):1321-1329. doi:0006295296000408[pii] (Pubitemid 26142857)
21. Nutter DO, Priest RE, Fuller EO (1981) Endurance training in the rat. I. Myocardial mechanics and biochemistry. J Appl Physiol 51(4):934-940 (Pubitemid 11007464)
22. Paynter DE, Tipton CM, Tcheng TK (1977) Response of immunosym- pathectomized rats to training. J Appl Physiol 42(6):935-940
23. Plourde G, Rousseau-Migneron S, Nadeau A (1991) Beta-adrenoceptor adenylate cyclase system adaptation to physical training in rat ventricular tissue. J Appl Physiol 70(4):1633-1638
24. Reger PO, Barbe MF, Amin M, Renna BF, Hewston LA, Mac Donnell SM, Houser SR, Libonati JR (2006) Myocardial hypoperfusion/ reperfusion tolerance with exercise training in hypertension. J Appl Physiol 100(2):541-547. doi:10.1152/japplphysiol.00350.2005 (Pubitemid 43671606)
25. Roth DA, White CD, Podolin DA, Mazzeo RS (1998) Alterations in myocardial signal transduction due to aging and chronic dynamic exercise. J Appl Physiol 84(1):177-184 (Pubitemid 28065126)
26. Saito K, Torda T, Potter WZ, Saavedra JM (1989) Characterization of ß1 and ß2 adrenoreceptor subtypes in the rat sinoatrial node and stellate ganglia by quantitative autoradiography. Neurosci Lett 96:35-41 (Pubitemid 19003446)
27. Spina RJ, Ogawa T, Coggan AR, Holloszy JO, Ehsani AA (1992) Exercise training improves left ventricular contractile response to beta-adrenergic agonist. J Appl Physiol 72(1):307-311
28. Spina RJ, Turner MJ, Ehsani AA (1998) Beta-adrenergic-mediated improvement in left ventricular function by exercise training in older men. Am J Physiol 274(2 Pt 2):H397-H404
29. Spina RJ, Rashid S, Davila-Roman VG, Ehsani AA (2000) Adapta-tions in beta-adrenergic cardiovascular responses to training in older women. J Appl Physiol 89(6):2300-2305
30. Stones R, Natali A, Billeter R, Harrison S, White E (2008) Voluntary exercise-induced changes in beta2-adrenoceptor signalling in rat ventricular myocytes. Exp Physiol 93(9):1065-1075. doi:10.1113/ expphysiol.2008.042598
31. Suman OE, Hasten D, Turner MJ, Rinder MR, Spina RJ, Ehsani AA (2000) Enhanced inotropic response to dobutamine in strength-trained subjects with left ventricular hypertrophy. J Appl Physiol 88(2):534-539 (Pubitemid 30097096)
32. Takeda N, Dominiak P, Turck D, Rupp H, Jacob R (1985) The influence of endurance training on mechanical catecholamine responsiveness, beta-adrenoceptor density and myosin isoenzyme pattern of rat ventricular myocardium. Basic Res Cardiol 80(1):88-99 (Pubitemid 15125628)
33. Vatner SF, Vatner DE, Homcy CJ (2000) beta-adrenergic receptor signaling: an acute compensatory adjustment-inappropriate for the chronic stress of heart failure? Insights from Gsalpha overex-pression and other genetically engineered animal models. Circ Res 86(5):502-506 (Pubitemid 30165040)
34. Werle EO, Strobel G, Weicker H (1990) Decrease in rat cardiac beta 1- and beta 2-adrenoceptors by training and endurance exercise. Life Sci 46(1):9-17 (Pubitemid 20019508)