Crotonase catalysis enables flexible production of functionalized prolines and carbapenams

Journal of the American Chemical Society

Volumn 134, Issue 1, 2012, Pages 471-479

  Hamed, Refaat B ^a,b   Henry, Luc ^a   Gomez Castellanos, J Ruben ^a   Mecinović, Jasmin ^a   Ducho, Christian ^a   Sorensen, John L ^a   Claridge, Timothy D W ^a   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b University of Assiut   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCATALYSIS; BIOSYNTHESIS PATHWAYS; CARBAPENEMS; FLEXIBLE PRODUCTION; FUNCTIONALIZED; QUATERNARY CENTERS; STEREO-SELECTIVE; SYNTHASES; SYNTHETASES; WILD TYPES;

ALDEHYDES; AMIDES; BIOCHEMISTRY; ENZYMES; STEREOSELECTIVITY;

AMINO ACIDS;

1BETA METHYL CARBAPENEM; 5 CARBOXYMETHYL PROLINE; ALDEHYDE; AMINO ACID; BETA LACTAM; CARBAPENEM DERIVATIVE; CARBOXYMETHYLPROLINE SYNTHASE; ENOYL COENZYME A HYDRATASE; MALONYL COENZYME A; PROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BIOCATALYSIS; BIOCATALYST; CONTROLLED STUDY; HYDROLYSIS; SIGNAL TRANSDUCTION; STEREOCHEMISTRY;

BIOCATALYSIS; CARBAPENEMS; CARBON-CARBON LYASES; METHYLATION; MODELS, MOLECULAR; PROLINE; PROTEIN CONFORMATION; PROTEIN ENGINEERING;

EID: 84855668128     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja208318d     Document Type: Article

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