Crystal Structure of Carbapenam Synthetase (CarA)

Journal of Biological Chemistry

Volumn 278, Issue 42, 2003, Pages 40996-41002

  Miller, Matthew T ^a   Gerratana, Barbara ^b   Stapon, Anthony ^b   Townsend, Craig A ^b   Rosenzweig, Amy C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CATALYSIS; CRYSTAL STRUCTURE; SUBSTRATES; SYNTHESIS (CHEMICAL);

ADENYLATION;

ENZYMES;

5 CARBOXYMETHYLPROLINE; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; ASPARAGINE; BETA LACTAM; CARBAPENAM SYNTHETASE; CARBAPENEM; CLAVULANIC ACID; GLUTAMINASE; MAGNESIUM; PROLINE DERIVATIVE; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BINDING SITES; CARBAPENEMS; CARBON-NITROGEN LIGASES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GLUTAMINASE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 0142071777     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307901200     Document Type: Article

References (36)

1. Neu, H. C. (1994) Curr. Opin. Infect. Dis. 7, S3-S10
2. McGowan, S. J., Bycroft, B. W., and Salmond, G. P. C. (1998) Trends Microbiol. 6, 203-208
3. McGowan, S. J., Holden, M. T. G., Bycroft, B. W., and Salmond, G. P. C. (1999) Antonie Leeuwenhoek 75, 135-141
4. Coulton, S., and Hunt, E. (1996) Prog. Med. Chem. 33, 99-145
5. Clifton, I. J., Doan, L. X., Sleeman, M. C., Topf, M., Suzuki, H., Wilmouth, R. C., and Schofield, C. J. (2003) J. Biol. Chem. 278, 20843-20850
6. McGowan, S. J., Sebaihia, M., Porter, L. E., Stewart, G. S. A. B., Williams, P., Bycroft, B. W., and Salmond, G. P. C. (1996) Mol. Microbiol. 22, 415-426
7. Thomson, N. R., Crow, M. A., McGowan, S. J., Cox, A., and Salmond, G. P. C. (2000) Mol. Microbiol. 36, 539-556
8. Parker, W. L., Rathnum, M. L., Wells, J. S., Trejo, W. H., Principe, P. A., and Sykes, R. B. (1982) J. Antibiot. 35, 653-660
9. McGowan, S. J., Sebaihia, M., O'Leary, S., Hardie, K. R., Williams, P., Stewart, G. S. A. B., Bycroft, B. W., and Salmond, G. P. C. (1997) Mol. Microbiol. 26, 545-556
10. Li, R., Stapon, A., Blanchfield, J. T., and Townsend, C. A. (2000) J. Am. Chem. Soc. 122, 9296-9297
11. Stapon, A., Li, R., and Townsend, C. A. (2003) J. Am. Chem. Soc. 125, 8486-8493
12. Gerratana, B., Stapon, A., and Townsend, C. A. (2003) Biochemistry 42, 7836-7847
13. Salowe, S. P., Marsh, E. N., and Townsend, C. A. (1990) Biochemistry 29, 6499-6508
14. Zhang, Z., Ren, J., Stammers, D. K., Baldwin, J. E., Harlos, K., and Schofield, C. J. (2000) Nat. Struct. Biol. 7, 127-133
15. Bachmann, B. O., Li, R., and Townsend, C. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9082-9086
16. McNaughton, H. J., Thirkettle, J. E., Zhang, Z., Schofield, C. J., Jensen, S. E., Barton, B., and Greaves, P. (1998) Chem. Commun. 21, 2325-2326
17. Bachmann, B. O., and Townsend, C. A. (2000) Biochemistry 39, 11187-11193
18. Miller, M. T., Bachmann, B. O., Townsend, C. A., and Rosenzweig, A. C. (2001) Nat. Struct. Biol. 8, 684-689
19. Miller, M. T., Bachmann, B. O., Townsend, C. A., and Rosenzweig, A. C. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 14752-14757
20. Richards, N. G. J., and Schuster, S. M. (1998) Adv. Enzymol. Relat. Areas Mol. Biol. 72, 145-198
21. Larsen, T. M., Boehlein, S. K., Schuster, S. M., Richards, N. G. J., Thoden, J. B., Holden, H. M., and Rayment, I. (1999) Biochemistry 38, 16146-16157
22. Doublié, S. (1997) Methods Enzymol. 276, 523-530
23. Powell, H. R. (1999) Acta Crystallogr. Sect. D Biol. Crystallogr. 55, 1690-1695
24. Collaborative Computational Project Number 4 (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
25. Terwilliger, T. C., and Berendzen, J. (1999) Acta Crystallogr. Sect. D Biol. Crystallogr. 55, 849-861
26. McRee, D. E. (1999) J. Struct. Biol. 125, 156-165
27. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
28. Kleywegt, G. J., and Jones, T. A. (1994) CCP4/ESF-EACBM Newslett. Protein Crystallogr. 31, 9-14
29. Laskowski, R. A. (1993) J. Appl. Crystallogr. 26, 283-291
30. Vagin, A., and Teplyakov, A. (1997) J. Appl. Crystallogr. 30, 1022-1025
31. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
32. Delano, W. L. (2002) The PyMOL Molecular Graphics System, DeLano Scientific, San Carlos, CA
33. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
34. Jones, S., and Thornton, J. M. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 13-20
35. Haynie, D. T. (2001) Biological Thermodynamics, p. 127, Cambridge University Press, Cambridge, UK
36. Boehlein, S. K., Stewart, J. D., Walworth, E. S., Thirumoorthy, R., Richards, N. G. J., and Schuster, S. M. (1998) Biochemistry 37, 13230-13238