Towards PET imaging of intact pancreatic beta cell mass: A transgenic strategy

Molecular Imaging and Biology

Volumn 13, Issue 5, 2011, Pages 962-972

  McGirr, Rebecca ^a   Hu, Shirley ^c   Yee, Siu Pok ^b,c   Kovacs, Michael S ^a,c   Lee, Ting Yim ^a,c   Dhanvantari, Savita ^a,b,c  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b LONDON REGIONAL CANCER PROGRAM   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Beta cell mass; Diabetes; PET; Reporter gene; Transgenic

Indexed keywords

FLUOROHYDROXYMETHYL BUTYLGUANINE F 18; INSULIN; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL VOLUME; CONTROLLED STUDY; DOWN REGULATION; DRUG DISTRIBUTION; DRUG RETENTION; DRUG UPTAKE; EX VIVO STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULINOMA; MALE; MOUSE; NONHUMAN; PANCREAS ISLET CELL FUNCTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STREPTOZOCIN DIABETES; TRANSGENE; TRANSGENIC MOUSE; TRANSGENICS; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; DNA PRIMERS; GLUCOSE TOLERANCE TEST; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; POSITRON-EMISSION TOMOGRAPHY; TISSUE DISTRIBUTION;

MUS; MUS MUSCULUS;

EID: 84855643931     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-010-0435-5     Document Type: Article

References (41)

1. Min JJ, Gambhir SS (2008) Molecular imaging of PET reporter gene expression. Handb Exp Pharmacol 185:277-303
2. Tai JH, Nguyen B, Wells RG, Kovacs MS, McGirr R, Prato FS, Morgan TG, Dhanvantari S (2008) Imaging of gene expression in live pancreatic islet cell lines using dual-isotope SPECT. J Nucl Med 49:94-102
3. Kim SJ, Doudet DJ, Studenov AR, Nian C, Ruth TJ, Gambhir SS, McIntosh CH (2006) Quantitative micro positron emission tomography (PET) imaging for the in vivo determination of pancreatic islet graft survival. Nat Med 12:1423-1428 (Pubitemid 44924502)
4. Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL (2006) Long-term monitoring of transplanted islets using positron emission tomography. Mol Ther 14:851-856 (Pubitemid 44743130)
5. Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB et al (2006) Noninvasive imaging of islet grafts using positron-emission tomography. Proc Natl Acad Sci USA 103:11294-11299 (Pubitemid 44156512)
6. Kim SJ, Nian C, Doudet DJ, McIntosh CH (2008) Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes 57:1331-1339
7. Kim SJ, Nian C, Doudet DJ, McIntosh CH (2009) Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes 58:641-651
8. Simpson NR, Souza F, Witkowski P, Maffei A, Raffo A, Herron A et al (2006) Visualizing pancreatic beta-cell mass with [11C]DTBZ. Nucl Med Biol 33:855-864 (Pubitemid 44512128)
9. Souza F, Simpson N, Raffo A, Saxena C, Maffei A, Hardy M et al (2006) Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest 116:1506-1513
10. Kung MP, Hou C, Lieberman BP, Oya S, Ponde DE, Blankemeyer E, Skovronsky D, Kilbourn MR, Kung HF (2008) In vivo imaging of betacell mass in rats using 18F-FP-(+)-DTBZ: A potential PET ligand for studying diabetes mellitus. J Nucl Med 49:1171-1176 (Pubitemid 351948027)
11. Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N et al (2009) 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med 50:382-389
12. Hara M, Dizon RF, Glick BS, Lee CS, Kaestner KH, Piston DW, Bindokas VP (2006) Imaging pancreatic beta-cells in the intact pancreas. Am J Physiol Endocrinol Metab 290:E1041-E1047
13. Hara M, Wang X, Kawamura T, Bindokas VP, Dizon RF, Alcoser SY, Magnuson MA, Bell GI (2003) Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab 284:E177-E183 (Pubitemid 36082810)
14. Ray P, De A, Min JJ, Tsien RY, Gambhir SS (2004) Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res 64:1323-1330 (Pubitemid 38235600)
15. Black ME, Newcomb TG, Wilson HM, Loeb LA (1996) Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy. Proc Natl Acad Sci USA 93:3525-3529 (Pubitemid 26125654)
16. McGirr R, Ejbick CE, Carter DE, Andrews JD, Nie Y, Friedman TC, Dhanvantari S (2005) Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells. Endocrinology 146:4514-4523 (Pubitemid 41324050)
17. Saisho Y, Harris PE, Butler AE, Galasso R, Gurlo T, Rizza RA, Butler PC (2008) Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas. J Mol Histol 39:543-551
18. Chamson-Reig A, Thyssen SM, Arany E, Hill DJ (2006) Altered pancreatic morphology in the offspring of pregnant rats given reduced dietary protein is time and gender specific. J Endocrinol 191:83-92 (Pubitemid 44756510)
19. Andrikopoulos S, Blair AR, Deluca N, Fam BC, Proietto J (2008) Evaluating the glucose tolerance test in mice. Am J Physiol Endocrinol Metab 295:E1323-E1332
20. Baribault H (2010) Mouse models of type II diabetes mellitus in drug discovery. Methods Mol Biol 602:135-155
21. Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ (2003) Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278:471-478 (Pubitemid 36043598)
22. Li Z, Karlsson FA, Sandler S (2000) Islet loss and alpha cell expansion in type 1 diabetes induced by multiple low-dose streptozotocin administration in mice. J Endocrinol 165:93-99 (Pubitemid 30210569)
23. O'Brien BA, Harmon BV, Cameron DP, Allan DJ (1996) Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. J Pathol 178:176-181 (Pubitemid 26059918)
24. Xie X, Li S, Liu S, Lu Y, Shen P, Ji J (2008) Proteomic analysis of mouse islets after multiple low-dose streptozotocin injection. Biochim Biophys Acta 1784:276-284
25. Penuelas I, Boan JF, Marti-Climent JM, Barajas MA, Narvaiza I, Satyamurthy N, Barrio JR, Richter JA (2002) A fully automated one pot synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl) guanine for gene therapy studies. Mol Imaging Biol 4:415-424 (Pubitemid 36221809)
26. Bergstrom M, Eriksson L, Bohm C, Blomqvist G, Litton J (1983) Correction for scattered radiation in a ring detector positron camera by integral transformation of the projections. J Comput Assist Tomogr 7:42-50 (Pubitemid 13189434)
27. Hoverath H, Kuebler WK, Ostertag HI, Doll J, Ziegler SI, Knopp MV, Lorenz WJ (1993) Scatter correction in the transaxial slices of a whole-body positron emission tomograph. Phys Med Biol 38:717-728 (Pubitemid 23188334)
28. Hudson H, Larkin R (1994) Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imag 13:601-609
29. Thie JA (2004) Understanding the standardized uptake value, its methods, and implications for usage. J Nucl Med 45:1431-1434 (Pubitemid 47618494)
30. Logan J (2000) Graphical analysis of PET data applied to reversible and irreversible tracers. Nucl Med Biol 27:661-670
31. Green LA, Nguyen K, Berenji B, Iyer M, Bauer E, Barrio JR, Namavari M, Satyamurthy N, Gambhir SS (2004) A tracer kinetic model for 18FFHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PET. J Nucl Med 45:1560-1570 (Pubitemid 47618511)
32. Koeppe RA, Frey KA, Kume A, Albin R, Kilbourn MR, Kuhl DE (1997) Equilibrium versus compartmental analysis for assessment of the vesicular monoamine transporter using (+)-alpha-[11C]dihydrotetrabenazine (DTBZ) and positron emission tomography. J Cereb Blood Flow Metab 17:919-931 (Pubitemid 27396580)
33. Salmi E, Aalto S, Hirvonen J, Langsjo JW, Maksimow AT, Oikonen V, Metsahonkala L, Virkkala J, Nagren K, Scheinin H (2008) Measurement of GABAA receptor binding in vivo with [11C]flumazenil: A testretest study in healthy subjects. Neuroimage 41:260-269
34. Egerton A, Demjaha A, McGuire P, Mehta MA, Howes OD (2010) The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function. Neuroimage 50:524-531
35. Goren HJ, Kulkarni RN, Kahn CR (2004) Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology 145:3307-3323 (Pubitemid 38830003)
36. Virostko J, Radhika A, Poffenberger G, Chen Z, Brissova M, Gilchrist J, Coleman B, Gannon M, Jansen ED, Powers AC (2010) Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation. Mol Imaging Biol 12:42-53
37. Silva JP, Kohler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG (2000) Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nat Genet 26:336-340
38. Ruggiero A, Brader P, Serganova I, Zanzonico P, Cai S, Lipman NS, Hricak H, Blasberg RG (2010) Different strategies for reducing intestinal background radioactivity associated with imaging HSV1-tk expression using established radionucleoside probes. Mol Imaging 9:47-58
39. Like AA, Rossini AA (1976) Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus. Science 193:415-417
40. Alanentalo T, Asayesh A, Morrison H, Loren CE, Holmberg D, Sharpe J, Ahlgren U (2007) Tomographic molecular imaging and 3D quantification within adult mouse organs. Nat Methods 4:31-33 (Pubitemid 46029471)
41. Bock T, Pakkenberg B, Buschard K (2005) Genetic background determines the size and structure of the endocrine pancreas. Diabetes 54:133-137 (Pubitemid 40105104)