Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas

Journal of Molecular Histology

Volumn 39, Issue 5, 2008, Pages 543-551

  Saisho, Yoshifumi ^a   Harris, Paul E ^b   Butler, Alexandra E ^a   Galasso, Ryan ^a   Gurlo, Tatyana ^a   Rizza, Robert A ^c   Butler, Peter C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Beta cell mass; Insulin; Pancreatic polypeptide; Type 1 diabetes; Type 2 diabetes; Vesicular monoamine transporter

Indexed keywords

INSULIN; PANCREAS POLYPEPTIDE; VESICULAR MONOAMINE TRANSPORTER 2;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 53149109681     PISSN: 15672379     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10735-008-9195-9     Document Type: Article

References (19)

1. B Ahren 2000 Autonomic regulation of islet hormone secretion-implications for health and disease Diabetologia 43 393 410 10.1007/s001250051322
2. M Anlauf R Eissele MK Schafer LE Eiden R Arnold U Pauser 2003 Expression of the two isoforms of the vesicular monoamine transporter (VMAT1 and VMAT2) in the endocrine pancreas and pancreatic endocrine tumors J Histochem Cytochem 51 1027 1040
3. M Anlauf MK Schafer T Schwark N von Wurmb-Schwark V Brand B Sipos 2006 Vesicular monoamine transporter 2 (VMAT2) expression in hematopoietic cells and in patients with systemic mastocytosis J Histochem Cytochem 54 201 213 10.1369/jhc.5A6739.2005
4. FC Brunicardi DM Shavelle DK Andersen 1995 Neural regulation of the endocrine pancreas Int J Pancreatol 18 177 195
5. AE Butler J Janson S Bonner-Weir R Ritzel RA Rizza PC Butler 2003 Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes Diabetes 52 102 110 10.2337/diabetes.52.1.102
6. AE Butler R Galasso JJ Meier R Basu RA Rizza PC Butler 2007 Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis Diabetologia 50 2323 2331 10.1007/s00125-007-0794-x
7. LE Eiden 2000 The vesicular neurotransmitter transporters: current perspectives and future prospects FASEB J 14 2396 2400 10.1096/fj.00-0817rev
8. JD Erickson MK Schafer TI Bonner LE Eiden E Weihe 1996 Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter Proc Natl Acad Sci USA 93 5166 5171 10.1073/pnas.93.10.5166
9. M Freeby N Simpson C Saxena S Dashnaw J Hirsch M Prince 2007 Non-invasive pancreatic beta cell imaging using 11C dihydrotetrabenazine and positron emission tomography Diabetes 56 A84 (Abstract)
10. KA Frey RA Koeppe MR Kilbourn 2001 Imaging the vesicular monoamine transporter Adv Neurol 86 237 247
11. EH Liu P Herscovitch C Barker M Channing E Geras-Raaka K Pechihold 2007 11C-DTBZ PET scanning: its potential for measuring beta cell mass in vivo Diabetes 56 A83 (Abstract)
12. A Maffei Z Liu P Witkowski F Moschella G Del Pozzo E Liu 2004 Identification of tissue-restricted transcripts in human islets Endocrinology 145 4513 4521 10.1210/en.2004-0691
13. JJ Meier A Bhushan AE Butler RA Rizza PC Butler 2005 Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48 2221 2228 10.1007/s00125-005-1949-2
14. JJ Meier JC Lin AE Butler R Galasso DS Martinez PC Butler 2006 Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes Diabetologia 49 1838 1844 10.1007/s00125-006-0308-2
15. RA Ritzel AE Butler RA Rizza JD Veldhuis PC Butler 2006 Relationship between beta-cell mass and fasting blood glucose concentration in humans Diabetes Care 29 717 718 10.2337/diacare.29.03.06.dc05-1538
16. NR Simpson F Souza P Witkowski A Maffei A Raffo A Herron 2006 Visualizing pancreatic beta-cell mass with [11C]DTBZ Nucl Med Biol 33 855 864 10.1016/j.nucmedbio.2006.07.002
17. F Souza N Simpson A Raffo C Saxena A Maffei M Hardy 2006 Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model J Clin Invest 116 1506 1513 10.1172/JCI27645
18. E Weihe LE Eiden 2000 Chemical neuroanatomy of the vesicular amine transporters FASEB J 14 2435 2449 10.1096/fj.00-0202rev
19. E Weihe MK Schafer JD Erickson LE Eiden 1994 Localization of vesicular monoamine transporter isoforms (VMAT1 and VMAT2) to endocrine cells and neurons in rat J Mol Neurosci 5 149 164 10.1007/BF02736730