Impact of indium-111 oxine labelling on viability of human mesenchymal stem cells in vitro, and 3D cell-tracking using SPECT/CT in vivo

Molecular Imaging and Biology

Volumn 13, Issue 6, 2011, Pages 1204-1214

  Gildehaus, Franz Josef ^a   Haasters, Florian ^a   Drosse, Inga ^a   Wagner, Erika ^a   Zach, Christian ^a   Mutschler, Wolf ^a   Cumming, Paul ^a   Bartenstein, Peter ^a   Schieker, Matthias ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

111In oxine; Cell tracking; Computed tomography; Cytotoxicity; Mesenchymal stem cells (MSC); Radiolabelling

Indexed keywords

INDIUM 111;

ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CELL LABELING; CELL MIGRATION; CELL SURVIVAL; CELL VIABILITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MESENCHYMAL STEM CELL; MOLECULAR IMAGING; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THREE DIMENSIONAL IMAGING;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CELL SURVIVAL; CELL TRACKING; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELLS; ORGANOMETALLIC COMPOUNDS; OXYQUINOLINE; RATS, NUDE; STAINING AND LABELING; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED;

RATTUS;

EID: 84855643247     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-010-0439-1     Document Type: Article

References (45)

1. Drosse I, Volkmer E, Capanna R et al (2008) Tissue engineering for bone defect healing: An update on a multi-component approach. Injury 39(Suppl 2):S9-S20
2. Zimmermann WH, Melnychenko I, Wasmeier G et al (2006) Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nat Med 12:452-458
3. Petite H, Viateau V, Bensaid W et al (2000) Tissue-engineered bone regeneration. Nat Biotechnol 18:959-963 (Pubitemid 32977376)
4. Wang C, Wang Z, Li A et al (2009) Repair of segmental bone-defect of goat's tibia using a dynamic perfusion culture tissue engineering bone. J Biomed Mater Res A 92A:1145-1153
5. Zhou XZ, Leung VY, Dong QR et al (2008) Mesenchymal stem cellbased repair of articular cartilage with polyglycolic acid-hydroxyapatite biphasic scaffold. Int J Artif Organs 31:480-489
6. Badorff C, Brandes RP, Popp R et al (2003) Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation 107:1024-1032 (Pubitemid 36258727)
7. Kassem M (2006) Stem cells: Potential therapy for age-related diseases. Ann NY Acad Sci 1067:436-442 (Pubitemid 43810011)
8. Liechty KW, MacKenzie TC, Shaaban AF et al (2000) Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 6:1282-1286
9. Pittenger MF, Mackay AM, Beck SC et al (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147 (Pubitemid 29282067)
10. Bruder SP, Jaiswal N, Ricalton NS et al (1998) Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin Orthop Relat Res 355:S247-S256
11. Schantz JT, Hutmacher DW, Lam CX et al (2003) Repair of calvarial defects with customised tissue-engineered bone grafts II. Evaluation of cellular efficiency and efficacy in vivo. Tissue Eng 9(Suppl 1): S127-S139 (Pubitemid 37046612)
12. Xian CJ, Foster BK (2006) Repair of injured articular and growth plate cartilage using mesenchymal stem cells and chondrogenic gene therapy. Curr Stem Cell Res Ther 1:213-229
13. Saldanha KJ, Piper SL, Ainslie KM, Kim HT, Majumdar S (2008) Magnetic resonance imaging of iron oxide labelled stem cells: Applications to tissue engineering based regeneration of the intervertebral disc. Eur Cell Mater 16:17-25
14. Puppi J, Modo M (2009) Use of magnetic resonance imaging contrast agents to detect transplanted liver cells. Top Magn Reson Imaging 20:113-120
15. Choi HO, Hwang KJ (1987) Mechanism of ionophoric transport of indium-111 cations through a lipid bilayer membrane. J Nucl Med 28:91-96 (Pubitemid 17008815)
16. Bindslev L, Haack-Sorensen M, Bisgaard K et al (2006) Labelling of human mesenchymal stem cells with indium-111 for SPECT imaging: Effect on cell proliferation and differentiation. Eur J Nucl Med Mol Imaging 33:1171-1177 (Pubitemid 44484473)
17. Nowak B, Weber C, Schober A et al (2007) Indium-111 oxine labelling affects the cellular integrity of haematopoietic progenitor cells. Eur J Nucl Med Mol Imaging 34:715-721 (Pubitemid 46669358)
18. + hematopoietic progenitor cells in a rat myocardial infarction model. J Nucl Med 45:512-518 (Pubitemid 47618629)
19. Acton PD, Zhou R (2005) Imaging reporter genes for cell tracking with PET and SPECT. Q J Nucl Med Mol Imaging 49:349-360 (Pubitemid 43246284)
20. Böcker W, Yin Z, Drosse I et al (2008) Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer. J Cell Mol Med 12:1347-1359
21. Volkmer E, Drosse I, Otto S et al (2008) Hypoxia in static and dynamic 3D culture systems for tissue engineering of bone. Tissue Eng A 14:1331-1340
22. Gholamrezanezhad A, Mirpour S, Ardekani JM et al (2009) Cytotoxicity of 111In-oxine on mesenchymal stem cells: A time-dependent adverse effect. Nucl Med Commun 30:210-216
23. Jin Y, Kong H, Stodilka RZ et al (2005) Determining the minimum number of detectable cardiac-transplanted 111In-tropolone-labelled bone-marrow-derived mesenchymal stem cells by SPECT. Phys Med Biol 50:4445-4455 (Pubitemid 41361509)
24. Bustamante J, Dock L, Vahter M, Fowler B, Orrenius S (1997) The semiconductor elements arsenic and indium induce apoptosis in rat thymocytes. Toxicology 118:129-136 (Pubitemid 27140456)
25. Fjälling M, Andersson P, Forssell-Aronsson E et al (1996) Systemic radionuclide therapy using indium-111-DTPA-D-Phe1-octreotide in midgut carcinoid syndrome. J Nucl Med 37:1519-1521 (Pubitemid 26321635)
26. Martin RF, Bradley TR, Hodgson GS (1979) Cytotoxicity of an 125Ilabeled DNA-binding compound that induces double-stranded DNA breaks. Cancer Res 39:3244-3247 (Pubitemid 9231834)
27. Weaver AS, Su YP, Begun DL et al (2010) The effects of axial displacement on fracture callus morphology and MSC homing depend on the timing of application. Bone 47:41-48
28. Mahmood A, Lu D, Wang L et al (2001) Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurgery 49:1196-1203
29. Orlic D, Kajstura J, Chimenti S et al (2001) Bone marrow cells regenerate infarcted myocardium. Nature 410:701-705 (Pubitemid 32290358)
30. Assis AC, Carvalho JL, Jacoby BA et al (2010) Time-dependent migration of systemically delivered bone marrow mesenchymal stem cells to the infarcted heart. Cell Transplant 19:219-230
31. Haasters F, Prall WC, Anz D et al (2009) Morphological and immunocytochemical characteristics indicate the yield of early progenitors and represent a quality control for human mesenchymal stem cell culturing. J Anat 214:759-767
32. Schieker M, Pautke C, Haasters F et al (2007) Human mesenchymal stem cells at the single-cell level: Simultaneous seven-colour immunofluorescence. J Anat 210:592-599 (Pubitemid 46647827)
33. Jaiswal RK, Jaiswal N, Bruder SP et al (2000) Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 275:9645-9652 (Pubitemid 30185197)
34. Raimondo S, Penna C, Pagliaro P, Geuna S (2006) Morphological characterization of GFP stably transfected adult mesenchymal bone marrow stem cells. J Anat 208:3-12
35. Massoud TF, Gambhir SS (2003) Molecular imaging in living subjects: Seeing fundamental biological processes in a new light. Genes Dev 17:545-580 (Pubitemid 36307540)
36. Agriantonis DJ, Hall L, Wilson MA (2009) Utility of SPECT/CT as an adjunct to planar whole body I-131 imaging: Liver metastasis from papillary thyroid cancer. Clin Nucl Med 34:247-248
37. Keidar Z, Israel O, Krausz Y (2003) SPECT/CT in tumor imaging: Technical aspects and clinical applications. Semin Nucl Med 33:205-218 (Pubitemid 36859499)
38. ten Berge RJ, Natarajan AT, Hardeman MR, van Royen EA, Schellekens PT (1983) Labeling with indium-111 has detrimental effects on human lymphocytes: Concise communication. J Nucl Med 24:615-620 (Pubitemid 13049714)
39. Kraitchman DL, Tatsumi M, Gilson WD et al (2005) Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation 112:1451-1461 (Pubitemid 41291771)
40. Shake JG, Gruber PJ, Baumgartner WA et al (2002) Mesenchymal stem cell implantation in a swine myocardial infarct model: Engraftment and functional effects. Ann Thorac Surg 73:1919-1925
41. Terrovitis JV, Bulte JW, Sarvananthan S et al (2006) Magnetic resonance imaging of ferumoxide-labeledmesenchymal stemcells seeded on collagen scaffolds-relevance to tissue engineering. Tissue Eng 12:2765-2775 (Pubitemid 46141245)
42. +/CD31- cardiac side population cells in a murine myocardial ischemic model. Int J Cardiol 138:40-49
43. Lien CY, Chih-Yuan HK, Lee OK, Blunn GW, Su Y (2009) Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and cbfa-1 co-expressing mesenchymal stem cells. J Bone Miner Res 24:837-848
44. Lan X, Yin X, Wang R, Liu Y, Zhang Y (2009) Comparative study of cellular kinetics of reporter probe [(131)I]FIAU in neonatal cardiac myocytes after transfer of HSV1-tk reporter gene with two vectors. Nucl Med Biol 36:207-213
45. Roelants V, Labar D, de Meester C et al (2008) Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells. J Nucl Med 49:1836-1844