The semiconductor elements arsenic and indium induce apoptosis in rat thymocytes

Toxicology

Volumn 118, Issue 2-3, 1997, Pages 129-136

  Bustamante, Juanita ^a   Dock, Lennart ^b   Vahter, Marie ^b   Fowler, Bruce ^c   Orrenius, Sten ^b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

Apoptosis; Arsenic; Indium; Necrosis; Semiconductors

Indexed keywords

ARSENIC; DNA FRAGMENT; INDIUM;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; FLOW CYTOMETRY; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THYMOCYTE;

ANIMALS; APOPTOSIS; ARSENIC POISONING; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; FLOW CYTOMETRY; INDIUM; MALE; NECROSIS; PROPIDIUM; RATS; RATS, SPRAGUE-DAWLEY; SEMICONDUCTORS; T-LYMPHOCYTES; THYMUS GLAND;

ANIMALIA;

EID: 0031588958     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(96)03607-4     Document Type: Article

References (21)

1. Aposhian, H.V. (1989) Biochemical toxicology of arsenic. In: E. Hodgson, J.R. Bend and R.M. Philpot (Eds.), Reviev of Biochemical Toxicology, Vol. 10, Elsevier, Amsterdam, pp. 265-299.
2. Aw, T.Y., Nicotera, P.L., Manzo, L. and Orrenius, S. (1990) Arch. Biochem. Biophys. 283, 46-50.
3. Burns, L.A., Sikorski, E.E., Saady, J.J. and Munson, A.E. (1991) Evidence for arsenic as the immunosuppressive component of gallium arsenide. Toxicol. Appl. Pharmacol. 110, 157-169.
4. Bustamante, J., Slater, A. and Orrenius, S. (1995) Antioxidant inhibition of thymocyte apoptosis by dihydrolipoic acid. Free Rad. Biol. Med. 19, 339-347.
5. Conner, E.A, Yamauchi, H., Fowler, B.A. and Akkerman, M. (1993) Biological indicators for monitoring exposure/toxicity from III-V semiconductors. J. Expos. Anal. Environ. Epidemiol. 3, 431-440.
6. Conner, E.A., Yamauchi, H. and Fowler, B.A. (1995) Alterations in the heme biosynthetic pathway from the III-V semiconductor metal, indium arsenide (InAs). Chem.-Biol. Interact. 14, 273-285.
7. Harrison, R.J. (1968) Gallium arsenide. State Art Rev. Occup. Med. 1, 49-58.
8. Lopez, S., Yoshihiro, M. and Simons, S.S. Jr. (1990) Structurally based selective interaction of arsenite with steroid receptors. J. Biol. Chem. 265, 16039-16042.
9. 2+-mediated endonuclease activation. Science 242, 256-259.
10. 2+ concentration. Arch. Biochem. Biophys. 269, 365-370.
11. McConkey, D.J., Nicotera, P. and Orrenius, S. (1994) Signalling and chromatin fragmentation in thymocyte apoptosis. Immunol. Rev. 142, 343-363.
12. Migliorati, G., Nicoletti, I., Crocicchio, F., Pagliacci, C., D'Adamio, F. and Riccardi, C. (1992) Heat shock induces apoptosis in mouse thymocytes and protects them from glucocorticoid-induced cell death. Cell. Immunol. 143, 348-356.
13. Nicoletti, I., Migliorati, G., Pagliacci, M.C., Grignani, F. and Riccardi, C. (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139, 271-279.
14. Robinson, A.L. (1983) GaAs readied for high-speed microcircuits. Science 210, 275-277.
15. Sikorski, E.E., McCay, J.A., White, K.L. Jr, Bradley, S.G. and Munson, A.E. (1991a) Immunotoxicity of the semiconductor gallium arsenide in female B6C3F1 mice. Fundam. Appl. Toxicol. 13, 843-858.
16. Sikorski, E.E., Burns, L.A., Stern, M.L., Luster, M.I. and Munson, A.E. (1991b) Splenic cell targets in gallium arsenide-induced suppression of the primary antibody response. Toxicol. Appl. Pharmacol. 110, 129-142.
17. Squibb, K.S. and Fowler, B.A. (1983) The toxicity of arsenic and its compounds. In: B. Fowler (Ed.), Biological and Environmental Effects of Arsenic, Elsevier, Amsterdam, pp. 234-240.
18. Simons, S.S., Jr., Chakraborti, P.K. and Cavanaugh, A.H. (1990) Arsenite and cadmium (II) as probes of glucocorticoid receptor structure and function. J. Biol. Chem. 265, 1938-1945.
19. Webb, D.R., Sipes, I.G. and Carter, D.E. (1984) In vitro solubility and in vivo toxicity of gallium arsenide. Toxicol. Appl. Pharmacol. 76, 96-104.
20. Wyllie, A.H. (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555-556.
21. Yih, L.-H. and Lee, T.C. (1994) A proteolytic activity enhanced by arsenite in Chinese hamster ovary cells: possible involvement in arsenite-induced cell killing. Biochem. Biophys. Res. Commun. 202, 1015-1023.