A butyrolactone derivative suppressed lipopolysaccharide-induced autophagic injury through inhibiting the autoregulatory loop of p8 and p53 in vascular endothelial cells

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 2, 2012, Pages 311-319

  Meng, Ning ^a,b   Zhao, Jing ^a,c   Su, Le ^a,c   Zhao, Baoxiang ^a   Zhang, Yun ^c   Zhang, Shangli ^a,c   Miao, Junying ^a,c  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF JINAN   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

Autophagy; Butyrolactone derivative; Lipopolysaccharide; P53; P8; Vascular endothelial cells

Indexed keywords

3 BENZYL 5[(2 NITROPHENOXY) METHYL] DIHYDROFURAN 2(3H) ONE; ACETYLCYSTEINE; BUTYROLACTONE; LIPOPOLYSACCHARIDE; PROTEIN P53; PROTEIN P8; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; AUTOREGULATION; CELL NUCLEUS; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; RNA INTERFERENCE; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

4-BUTYROLACTONE; ACETYLCYSTEINE; APOPTOSIS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HOMEOSTASIS; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84855595493     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.11.001     Document Type: Article

References (42)

1. K. Buttenschoen, P. Radermacher, and H. Bracht Endotoxin elimination in sepsis: physiology and therapeutic application Langenbecks Arch Surg 395 2010 597 605
2. D.W. Clark, A. Mitra, R.A. Fillmore, W.G. Jiang, R.S. Samant, and O. Fodstad NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress Curr Cancer Drug Targets 8 2008 421 430
3. S.M. Dauphinee, and A. Karsan Lipopolysaccharide signaling in endothelial cells Lab Invest 86 2006 9 22 (Pubitemid 43250964)
4. V. Deretic Autophagy in infection Curr Opin Cell Biol 22 2010 252 262
5. C.J. Feeney, P.S. Pennefather, and A.V. Gyulkhandanyan A cuvette-based fluorometric analysis of mitochondrial membrane potential measured in cultured astrocyte monolayers J Neurosci Methods 125 2003 13 25 (Pubitemid 36579328)
6. K. Fujita, D. Maeda, Q. Xiao, and S.M. Srinivasula Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation Proc Natl Acad Sci U S A 108 2011 1427 1432
7. S. Goruppi, and J.L. Iovanna Stress-inducible protein p8 is involved in several physiological and pathological processes J Biol Chem 285 2010 1577 1581
8. Z.Y. Gu, Y.L. Ling, X.H. Xu, T.N. Zhu, and B. Cong Endogenous peroxynitrite mediates lipopolysaccharide-induced injury in cultured pulmonary artery endothelial cells Sheng Li Xue Bao 55 2003 475 480 (Pubitemid 37101611)
9. S. Hagiwara, H. Iwasaka, H. Koga, A. Hasegawa, K. Kudo, and J. Kusaka Stimulation of autophagy in the liver by lipopolysaccharide-induced systemic inflammation in a rat model of diabetes mellitus Biomed Res 31 2010 263 271
10. A. Hamacher-Brady, N.R. Brady, S.E. Logue, M.R. Sayen, M. Jinno, and L.A. Kirshenbaum Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy Cell Death Differ 14 2007 146 157 (Pubitemid 44911902)
11. D.L. Hickson-Bick, C. Jones, and L.M. Buja Stimulation of mitochondrial biogenesis and autophagy by lipopolysaccharide in the neonatal rat cardiomyocyte protects against programmed cell death J Mol Cell Cardiol 44 2008 411 418
12. +-ATPase activity in vascular endothelial cells Chem Res Toxicol 22 2009 471 475
13. E.A. Jaffe, R.L. Nachman, C.G. Becker, and C.R. Minick Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria J Clin Invest 52 1973 2745 2756
14. Y.F. Jiang, M.I. Vaccaro, F. Fiedler, E.L. Calvo, and J.L. Iovanna Lipopolysaccharides induce p8 mRNA expression in vivo and in vitro Biochem Biophys Res Commun 260 1999 686 690 (Pubitemid 29371112)
15. H.S. Kim, and M.S. Lee Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-activated protein kinase/STAT1/reactive oxygen species pathway Mol Cell Biol 25 2005 6821 6833 (Pubitemid 41023252)
16. D.K. Kong, S.P. Georgescu, C. Cano, M.J. Aronovitz, J.L. Iovanna, and R.D. Patten Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function Mol Biol Cell 21 2010 1335 1349
17. D.K. Kong, S.P. Georgescu, J.M. Kyriakis, and S. Goruppi Deficiency of transcriptional regulator p8 induces autophagy and causes impaired cardiac function Autophagy 6 2010 5
18. B. Levine, and J. Yuan Autophagy in cell death: an innocent convict? J Clin Invest 115 2005 2679 2688 (Pubitemid 41434392)
19. Y. Lin, S. Choksi, H.M. Shen, Q.F. Yang, G.M. Hur, and Y.S. Kim Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation J Biol Chem 279 2004 10822 10828 (Pubitemid 38372695)
20. M.C. Maiuri, E. Tasdemir, A. Criollo, E. Morselli, J.M. Vicencio, and R. Carnuccio Control of autophagy by oncogenes and tumor suppressor genes Cell Death Differ 16 2009 87 93
21. W. Martinet, and G.R. De Meyer Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential Circ Res 104 2009 304 317
22. N. Meng, L. Wu, J. Gao, J. Zhao, L. Su, and H. Su Lipopolysaccharide induces autophagy through BIRC2 in human umbilical vein endothelial cells J Cell Physiol 225 2010 174 179
23. N. Meng, J. Zhao, B. Zhao, Y. Cheng, W. Wang, and Y. Zhang A novel butyrolactone derivative inhibited smooth muscle cell migration and proliferation and maintained endothelial cell functions through selectively affecting Na, K-ATPase activity and mitochondria membrane potential during in vitro angiogenesis J Cell Biochem 104 2008 2123 2130
24. N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075 (Pubitemid 351317450)
25. K. Nakahira, J.A. Haspel, V.A. Rathinam, S.J. Lee, T. Dolinay, and H.C. Lam Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome Nat Immunol 12 2011 222 230
26. S.M. Opal Endotoxins and other sepsis triggers Contrib Nephrol 167 2010 14 24
27. S. Pankiv, T.H. Clausen, T. Lamark, A. Brech, J.A. Bruun, and H. Outzen p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy J Biol Chem 282 2007 24131 24145 (Pubitemid 47328003)
28. H.S. Park, H.Y. Jung, E.Y. Park, J. Kim, W.J. Lee, and Y.S. Bae Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B J Immunol 173 2004 3589 3593 (Pubitemid 39280716)
29. M. Salazar, A. Carracedo, I.J. Salanueva, S. Hernandez-Tiedra, M. Lorente, and A. Egia Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells J Clin Invest 119 2009 1359 1372
30. R. Scherz-Shouval, and Z. Elazar ROS, mitochondria and the regulation of autophagy Trends Cell Biol 17 2007 422 427 (Pubitemid 47499043)
31. E. Schulz, J. Dopheide, S. Schuhmacher, S.R. Thomas, K. Chen, and A. Daiber Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction Circulation 118 2008 1347 1357
32. R.C. Scott, G. Juhasz, and T.P. Neufeld Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death Curr Biol 17 2007 1 11 (Pubitemid 46027564)
33. S.T. Smiley, M. Reers, C. Mottola-Hartshorn, M. Lin, A. Chen, and T.W. Smith Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1 Proc Natl Acad Sci U S A 88 1991 3671 3675 (Pubitemid 21916685)
34. L.L. Stoll, G.M. Denning, and N.L. Weintraub Potential role of endotoxin as a proinflammatory mediator of atherosclerosis Arterioscler Thromb Vasc Biol 24 2004 2227 2236 (Pubitemid 39658022)
35. N. Suematsu, H. Tsutsui, J. Wen, D. Kang, M. Ikeuchi, and T. Ide Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes Circulation 107 2003 1418 1423 (Pubitemid 36350742)
36. S. Vasseur, A. Hoffmeister, A. Garcia-Montero, G.V. Mallo, R. Feil, and S. Kuhbandner p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis Oncogene 21 2002 1685 1694 (Pubitemid 34259032)
37. W. Wang, X. Liu, J. Zhao, B. Zhao, S. Zhang, and J. Miao A novel butyrolactone derivative inhibited apoptosis and depressed integrin beta4 expression in vascular endothelial cells Bioorg Med Chem Lett 17 2007 482 485 (Pubitemid 46073740)
38. Y. Xu, C. Jagannath, X.D. Liu, A. Sharafkhaneh, K.E. Kolodziejska, and N.T. Eissa Toll-like receptor 4 is a sensor for autophagy associated with innate immunity Immunity 27 2007 135 144 (Pubitemid 47089027)
39. Y. Xu, S.O. Kim, Y. Li, and J. Han Autophagy contributes to caspase-independent macrophage cell death J Biol Chem 281 2006 19179 19187 (Pubitemid 44035422)
40. H. Yuan, C.N. Perry, C. Huang, E. Iwai-Kanai, R.S. Carreira, and C.C. Glembotski LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection Am J Physiol Heart Circ Physiol 296 2009 H470 H479
41. W.X. Zong, and U. Moll p53 in autophagy control Cell Cycle 7 2008 2947
42. D.B. Zorov, M. Juhaszova, and S.J. Sollott Mitochondrial ROS-induced ROS release: an update and review Biochim Biophys Acta 1757 2006 509 517