Involvement of the retinoid X receptor ligand in the anti-inflammatory effect induced by peroxisome proliferator-activated receptor agonist in vivo

PPAR Research

Volumn , Issue , 2011, Pages

  Yamamoto, Atsuki ^a   Kakuta, Hiroki ^a   Miyachi, Hiroyuki ^a   Sugimoto, Yukio ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 3' [[2 FLUORO 4 (TRIFLUOROMETHYL)BENZAMIDO]METHYL] 4' PROPOXYBIPHENYL 4 CARBOXYLIC ACID; 6 [N ETHYL N(3 ISOPROPIXY 4 ISOPROPYLPHENYL)AMINO]NICOTINIC ACID; ANTIINFLAMMATORY AGENT; CARRAGEENAN; DACTINOMYCIN; N[2 [[1 METHYL 3 OXO 3 [[4 (TRIFLUOROMETHYL)PHENYL]PROP 1 ENYL]AMINO] 3 [4 [2 (5 METHYL 2 PHENYL 1,3 OXAZOL 4 YL)ETHOXY]PHENYL]PROPYL]PROPANAMIDE; NICOTINIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG RECEPTOR BINDING; DRUG RESPONSE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PAW EDEMA;

EID: 84855583379     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2011/840194     Document Type: Article

References (44)

1. Kliewer S. A., Forman B. M., Blumberg B., Ong E. S., Borgmeyer U., Mangelsdorf D. J., Umesono K., Evans R. M., Differential expression and activation of a family of murine peroxisome proliferator-activated receptors Proceedings of the National Academy of Sciences of the United States of America 1994 91 15 7355 7359 (Pubitemid 24226862)
2. Mangelsdorf D. J., Thummel C., Beato M., Herrlich P., Schtz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R. M., The nuclear receptor super-family: the second decade Cell 1995 83 6 835 839
3. Ricote M., Li A. C., Willson T. M., Kelly C. J., Glass C. K., The peroxisome proliferator-activated receptor- is a negative regulator of macrophage activation Nature 1998 391 6662 79 82 (Pubitemid 28079218)
4. Moraes L. A., Piqueras L., Bishop-Bailey D., Peroxisome proliferator-activated receptors and inflammation Pharmacology and Therapeutics 2006 110 3 371 385
5. Xu J., Barger S. W., Drew P. D., The PPAR- agonist 15-deoxy- 12, 14 -prostaglandin J 2 attenuates microglial production of IL-12 family cytokines: potential relevance to Alzheimer's disease PPAR Research 2008 2008
6. Yang X. Y., Wang L. H., Farrar W. L., A role for PPAR in the regulation of cytokines in immune cells and cancer PPAR Research 2008 2008
7. Nakajima A., Wada K., Miki H., Kubota N., Nakajima N., Terauchi Y., Ohnishi S., Saubermann L. J., Kadowaki T., Blumberg R. S., Nagai R., Matsuhashi N., Endogenous PPAR mediates anti-inflammatory activity in murine ischemia-reperfusion injury Gastroenterology 2001 120 2 460 469 (Pubitemid 32147643)
8. Shiojiri T., Wada K., Nakajima A., Katayama K., Shibuya A., Kudo C., Kadowaki T., Mayumi T., Yura Y., Kamisaki Y., PPAR ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice European Journal of Pharmacology 2002 448 2-3 231 238 (Pubitemid 34874592)
9. Belvisi M. G., Mitchell J. A., Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease British Journal of Pharmacology 2009 158 4 994 1003
10. Jeon E. J., Lee S. K., Park Y. S., Kim D. H., Yum J. H., Park C. S., The effects of Peroxisome Proliferator-Activated Receptor- agonist on a murine model of experimental allergic rhinitis OtolaryngologyHead and Neck Surgery 2008 139 1 124 130 (Pubitemid 351862347)
11. Mangelsdorf D. J., Borgmeyer U., Heyman R. A., Yang Zhou J., Ong E. S., Oro A. E., Kakizuka A., Evans R. M., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid Genes and Development 1992 6 3 329 344
12. Kizaki M., Ikeda Y., Tanosaki R., Nakajima H., Morikawa M., Sakashita A., Koeffler H. P., Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor- and retinoid X receptor- RNA by HL-60 cells Blood 1993 82 12 3592 3599 (Pubitemid 24006039)
13. Mangelsdorf D. J., Evans R. M., The RXR heterodimers and orphan receptors Cell 1995 83 6 841 850 (Pubitemid 26006526)
14. Manzano V. M., Muoz J. C. S., Jiménez J. R., Puyol M. R., Puyol D. R., Kitamura M., Caza F. J. L., Human renal mesangial cells are a target for the anti-inflammatory action of 9-cis retinoic acid British Journal of Pharmacology 2000 131 8 1673 1683 (Pubitemid 32056434)
15. Diab A., Hussain R. Z., Lovett-Racke A. E., Chavis J. A., Drew P. D., Racke M. K., Ligands for the peroxisome proliferator-activated receptor- and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis Journal of Neuroimmunology 2004 148 1-2 116 126 (Pubitemid 38229564)
16. Motomura K., Sakai H., Isobe H., Nawata H., Effects of retinoids on the production of tumour necrosis factor- and nitric oxide by lipopolysaccharide stimulated rat Kupffer cells in vitro: evidence for participation of retinoid X receptor signalling pathway Cell Biochemistry and Function 1997 15 2 95 101 (Pubitemid 27344605)
17. Benson S., Padmanabhan S., Kurtz T. W., Pershadsingh H. A., Ligands for the peroxisome proliferator-activated receptor- and the retinoid X receptor- exert synergistic antiproliferative effects on human coronary artery smooth muscle cells Molecular Cell Biology Research Communications 2000 3 3 159 164 (Pubitemid 30430016)
18. Cha B. S., Ciaraldi T. P., Carter L., Nikoulina S. E., Mudaliar S., Mukherjee R., Paterniti J. R., Henry R. R., Peroxisome proliferator-activated receptor (PPAR) and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle Diabetologia 2001 44 4 444 452 (Pubitemid 32324355)
19. Wan Y. J., Badr M. Z., Inhibition of carrageenan-induced cutaneous inflammation by PPAR agonists is dependent on hepatocyte-specific retinoid X receptor PPAR Research 2006 2006 1 6
20. Cuzzocrea S., Pisano B., Dugo L., Ianaro A., Maffia P., Patel N. S. A., Di Paola R., Ialenti A., Genovese T., Chatterjee P. K., Di Rosa M., Caputi A. P., Thiemermann C., Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-, reduces acute inflammation European Journal of Pharmacology 2004 483 1 79 93 (Pubitemid 38056607)
21. Posadas I., Bucci M., Roviezzo F., Rossi A., Parente L., Sautebin L., Cirino G., Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression British Journal of Pharmacology 2004 142 2 331 338 (Pubitemid 38746169)
22. Ramos G. C., Fernandes D., Charo C. T., Souza D. G., Teixeira M. M., Assreuy J., Apoptotic mimicry: phosphatidylserine liposomes reduce inflammation through activation of peroxisome proliferator-activated receptors (PPARs) in vivo British Journal of Pharmacology 2007 151 6 844 850 (Pubitemid 47075330)
23. D'Agostino G., La Rana G., Russo R., Sasso O., Iacono A., Esposito E., Raso G. M., Cuzzocrea S., Lo Verme J., Piomelli D., Meli R., Calignano A., Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor- agonist, modulates carrageenan-induced paw edema in mice Journal of Pharmacology and Experimental Therapeutics 2007 322 3 1137 1143 (Pubitemid 47295805)
24. Takamatsu K., Takano A., Yakushiji N., Morohashi K., Morishita K., Matsuura N., Makishima M., Tai A., Sasaki K., Kakuta H., The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXR / -dual agonist) ChemMedChem 2008 3 5 780 787
25. Morishita K. I., Yakushiji N., Ohsawa F., Takamatsu K., Matsuura N., Makishima M., Kawahata M., Yamaguchi K., Tai A., Sasaki K., Kakuta H., Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity Bioorganic and Medicinal Chemistry Letters 2009 19 3 1001 1003
26. Taylor B. K., Dadia N., Yang C. B., Krishnan S., Badr M., Peroxisome proliferator-activated receptor agonists inhibit inflammatory edema and hyperalgesia Inflammation 2002 26 3 121 127 (Pubitemid 34596971)
27. Youssef J., Badr M., Role of peroxisome proliferator-activated receptors in inflammation control Journal of Biomedicine and Biotechnology 2004 2004 3 156 166 (Pubitemid 39287736)
28. Oliveira A. C., Bertollo C. M., Rocha L. T., Nascimento E. B., Costa K. A., Coelho M. M., Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR, and pioglitazone, an agonist of PPAR European Journal of Pharmacology 2007 561 13 194 201 (Pubitemid 46435842)
29. Wan Y. J., Cai Y., Lungo W., Fu P., Locker J., French S., Sucov H. M., Peroxisome proliferator-activated receptor -mediated pathways are altered in hepatocyte-specific retinoid x receptor -deficient mice Journal of Biological Chemistry 2000 275 36 28285 28290
30. Na S. Y., Kang B. Y., Chung S. W., Han S. J., Ma X., Trinchieri G., Im S. Y., Lee J. W., Kim T. S., Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NF B Journal of Biological Chemistry 1999 274 12 7674 7680
31. Uchimura K., Nakamuta M., Enjoji M., Irie T., Sugimoto R., Muta T., Iwamoto H., Nawata H., Activation of retinoic X receptor and peroxisome proliferator-activated receptor- inhibits nitric oxide and tumor necrosis factor- production in rat Kupffer cells Hepatology 2001 33 1 91 99 (Pubitemid 32016891)
32. Shulman A. I., Mangelsdorf D. J., Retinoid X receptor heterodimers in the metabolic syndrome New England Journal of Medicine 2005 353 6 604 615 (Pubitemid 41138942)
33. Chan L. S., Wells R. A., Cross-talk between PPARs and the partners of RXR: a molecular perspective PPAR Research 2009 2009
34. Shimizu M., Moriwaki H., Synergistic effects of PPAR ligands and retinoids in cancer treatment PPAR Research 2008 2008
35. Shulman A. I., Larson C., Mangelsdorf D. J., Ranganathan R., Structural determinants of allosteric ligand activation in RXR heterodimers Cell 2004 116 3 417 429 (Pubitemid 38366318)
36. Ijpenberg A., Tan N. S., Gelman L., Kersten S., Seydoux J., Xu J., Metzger D., Canaple L., Chambon P., Wahli W., Desvergne B., In vivo activation of PPAR target genes by RXR homodimers EMBO Journal 2004 23 10 2083 2091 (Pubitemid 38737735)
37. Kersten S., Desvergne B., Wahli W., Roles of PPARS in health and disease Nature 2000 405 6785 421 424 (Pubitemid 30367411)
38. Wu Y., Guo S. W., Peroxisome proliferator-activated receptor- and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells Fertility and Sterility 2009 91 5 2142 2147
39. Desreumaux P., Dubuquoy L., Nutten S., Peuchmaur M., Englaro W., Schoonjans K., Derijard B., Desvergne B., Wahli W., Chambon P., Leibowitz M. D., Colombel J. F., Auwerx J., Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor (PPAR ) heterodimer. A basis for new therapeutic strategies Journal of Experimental Medicine 2001 193 7 827 838 (Pubitemid 32524532)
40. Burrage P. S., Schmucker A. C., Ren Y., Sporn M. B., Brinckerhoff C. E., Retinoid X receptor and peroxisome proliferator-activated receptor- agonists cooperate to inhibit matrix metalloproteinase gene expression Arthritis Research and Therapy 2008 10 6, article R139
41. Wang Y., Moser A. H., Shigenaga J. K., Grunfeld C., Feingold K. R., Downregulation of liver X receptor- in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines Journal of Lipid Research 2005 46 11 2377 2387 (Pubitemid 41532526)
42. Harada K., Isse K., Kamihira T., Shimoda S., Nakanuma Y., Th1 cytokine-induced downregulation of PPAR in human biliary cells relates to cholangitis in primary biliary cirrhosis Hepatology 2005 41 6 1329 1338 (Pubitemid 40770286)
43. Beigneux A. P., Moser A. H., Shigenaga J. K., Grunfeld C., Feingold K. R., The acute phase response is associated with retinoid X receptor repression in rodent liver Journal of Biological Chemistry 2000 275 21 16390 16399 (Pubitemid 30366957)
44. Wan Y. J., An D., Cai Y., Repa J. J., Chen T. H. P., Flores M., Postic C., Magnuson M. A., Chen J., Chien K. R., French S., Mangelsdorf D. J., Sucov H. M., Hepatocyte-specific mutation establishes retinoid X receptor as a heterodimeric integrator of multiple physiological processes in the liver Molecular and Cellular Biology 2000 20 12 4436 4444 (Pubitemid 30346638)