Inscuteable regulates the pins-mud spindle orientation pathway

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Mauser, Jonathon F ^a   Prehoda, Kenneth E ^a  

^a UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL PROTEIN; DISC LARGE PROTEIN; INSCUTEABLE; MUSHROOM BODY DEFECT PROTEIN; PARTNER OF INSCUTEABLE PROTEIN; UNCLASSIFIED DRUG; CYTOSKELETON PROTEIN; DISCS LARGE 1 PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INSC PROTEIN, DROSOPHILA; MEMBRANE PROTEIN; MUD PROTEIN, DROSOPHILA; MULTIPROTEIN COMPLEX; NERVE PROTEIN; PINS PROTEIN, DROSOPHILA; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; IN VITRO STUDY; MITOSIS SPINDLE; NONHUMAN; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; REGULATORY MECHANISM; ANIMAL; BINDING COMPETITION; CELL POLARITY; CHEMISTRY; CYTOLOGY; DROSOPHILA MELANOGASTER; METABOLISM; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

BASIDIOMYCOTA; MAMMALIA;

ANIMALS; BINDING, COMPETITIVE; CELL POLARITY; CYTOSKELETAL PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; MEMBRANE PROTEINS; MITOTIC SPINDLE APPARATUS; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84855573224     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029611     Document Type: Article

References (31)

1. Cabernard C, Doe CQ, (2009) Apical/basal spindle orientation is required for neuroblast homeostasis and neuronal differentiation in Drosophila. Dev Cell 17: 134-141.
2. Baena-López LA, Baonza A, García-Bellido A, (2005) The orientation of cell divisions determines the shape of Drosophila organs. Curr Biol 15: 1640-1644.
3. Siller KH, Doe CQ, (2009) Spindle orientation during asymmetric cell division. Nature Cell Biol 11: 365-374.
4. Knoblich JA, (2010) Asymmetric cell division: recent developments and their implications for tumour biology. Nat Rev Mol Cell Biol 11: 849-860.
5. Prehoda KE, (2009) Polarization of Drosophila neuroblasts during asymmetric division. Cold Spring Harb Perspect Biol 1: a001388.
6. Chia W, Somers WG, Wang H, (2008) Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis. J Cell Biol 180: 267-272.
7. Glotzer M, (2004) Cleavage furrow positioning. J Cell Biol 164 (3): 347-351.
8. Cabernard C, Prehoda KE, Doe CQ, (2010) A spindle-independent cleavage furrow positioning pathway. Nature 467: 91-94.
9. Schober M, Schaefer M, Knoblich JA, (1999) Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature 402: 548-551.
10. Wodarz A, Ramrath A, Kuchinke U, Knust E, (1999) Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature 402: 544-547.
11. Yu F, Morin X, Cai Y, Yang X, Chia W, (2000) Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell 100: 399-409.
12. Schaefer M, Shevchenko A, Shevchenko A, Knoblich JA, (2000) A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila. Current Biol 10: 353-362.
13. Kraut R, Chia W, Jan LY, Jan YN, Knoblich JA, (1996) Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383: 50-55.
14. Siegrist SE, Doe CQ, (2005) Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Cell 123: 1323-1335.
15. Siller KH, Cabernard C, Doe CQ, (2006) The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nature Cell Biol 8: 594-600.
16. Siller KH, Doe CQ, (2008) Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts. Dev Biol 319: 1-9.
17. Johnston CA, Hirono K, Prehoda KE, Doe CQ, (2009) Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells. Cell 138: 1150-1163.
18. Tio M, Zavortink M, Yang X, Chia W, (1999) A functional analysis of inscuteable and its roles during Drosophila asymmetric cell divisions. J Cell Sci 112: 1541-1551.
19. Nipper RW, Siller KH, Smith NR, Doe CQ, Prehoda KE, (2007) Galphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts. Proc Natl Acad Sci U S A 104: 14306-14311.
20. Du Q, Macara IG, (2004) Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell 119: 503-516.
21. Moore JK, Cooper JA, (2010) Coordinating mitosis with cell polarity: Molecular motors at the cell cortex. Semin Cell Dev Biol 21: 283-289.
22. Lechler T, Fuchs E, (2005) Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature 437: 275-280.
23. Reinsch S, Karsenti E, (1994) Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells. J Cell Biol 126: 1509-1526.
24. Gray RS, Cheung KJ, Ewald AJ, (2010) Cellular mechanisms regulating epithelial morphogenesis and cancer invasion. Curr Opin Cell Biol 22: 640-650.
25. Pease JC, Tirnauer JS, (2011) Mitotic spindle misorientation in cancer-out of alignment and into the fire. J Cell Sci 124: 1007-1016.
26. Egger B, Boone JQ, Stevens NR, Brand AH, Doe CQ, (2007) Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe. Neural Dev 2: 1.
27. Poulson N, Lechler T, (2010) Robust control of mitotic spindle orientation in the developing epidermis. J Cell Biol 191: 915-922.
28. Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, et al. (2011) LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gai/LGN/NuMA pathways. Mol Cell 43: 418-431.
29. Yu F, Ong CT, Chia W, Yang X, (2000) Membrane targeting and asymmetric localization of Drosophila partner of inscuteable are discrete steps controlled by distinct regions of the protein. Mol Cell Biol 22: 4230-4240.
30. Du Q, Stukenberg PT, Macara IG, (2001) A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Nature Cell Biol 3: 1069-1075.
31. Kisurina-Evgenieva O, Mack G, Du Q, Macara I, Khodjakov A, et al. (2004) Multiple mechanisms regulate NuMA dynamics at spindle poles. J Cell Sci 117: 6391-6400.