A new approach with less damage: Intranasal delivery of tetracycline-inducible replication-defective herpes simplex virus type-1 vector to brain

Neuroscience

Volumn 201, Issue , 2012, Pages 96-104

  Jiang, Y ^a   Wei, N ^a   Zhu, J ^a   Zhai, D ^a,b   Wu, L ^a   Chen, M ^a   Xu, G ^a   Liu, X ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Brain; HSV 1; Intranasal; Tetracycline; Trigeminal; Vector

Indexed keywords

BETA GALACTOSIDASE; HERPESVIRUS VECTOR; INTERLEUKIN 6; TETRACYCLINE; TETRACYCLINE INDUCIBLE REPLICATION DEFECTIVE HERPES SIMPLEX VIRUS 1 VECTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN VENTRICLE; CELL STRUCTURE; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFICACY; DRUG SAFETY; GENE; GENE EXPRESSION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; LACZ GENE; MALE; MEDULLA OBLONGATA; NONHUMAN; NOSE SEPTUM; OLFACTORY BULB; PRIORITY JOURNAL; RAT; REPORTER GENE; VIRAL GENE DELIVERY SYSTEM;

ANALYSIS OF VARIANCE; ANIMALS; BETA-GALACTOSIDASE; BRAIN; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, VIRAL; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; IN SITU NICK-END LABELING; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TETRACYCLINE; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; TRANSFECTION;

EID: 84855550892     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.10.043     Document Type: Article

References (33)

1. Aiuti A., Cattaneo F., Galimberti S., Benninghoff U., Cassani B., Callegaro L., Scaramuzza S., Andolfi G., Mirolo M., Brigida I., Tabucchi A., Carlucci F., Eibl M., Aker M., Slavin S., Al-Mousa H., Al Ghonaium A., Ferster A., Duppenthaler A., Notarangelo L., Wintergerst U., Buckley R.H., Bregni M., Marktel S., Valsecchi M.G., Rossi P., Ciceri F., Miniero R., Bordignon C., Roncarolo M.G. Gene therapy for immunodeficiency due to adenosine deaminase deficiency. N Engl J Med 2009, 360:447-458.
2. Alcalá-Barraza S.R., Lee M.S., Hanson L.R., McDonald A.A., Frey W.H., McLoon L.K. Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS. J Drug Target 2010, 18:179-190.
3. Bitko V., Barik S. Nasal delivery of siRNA. Methods Mol Biol 2008, 442:75-82.
4. Broberg E.K., Peltoniemi J., Nygårdas M., Vahlberg T., Röyttä M., Hukkanen V. Spread and replication of and immune response to gamma134.5-negative herpes simplex virus type 1 vectors in BALB/c mice. J Virol 2004, 78:13139-13152.
5. Cartier N., Hacein-Bey-Abina S., Bartholomae C.C., Veres G., Schmidt M., Kutschera I., Vidaud M., Abel U., Dal-Cortivo L., Caccavelli L., Mahlaoui N., Kiermer V., Mittelstaedt D., Bellesme C., Lahlou N., Lefrère F., Blanche S., Audit M., Payen E., Leboulch P., l'Homme B., Bougnères P., Von Kalle C., Fischer A., Cavazzana-Calvo M., Aubourg P. Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 2009, 326:818-823.
6. Chen Z., Lu T., Yue X., Wei N., Jiang Y., Chen M., Ni G., Liu X., Xu G. Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: with emphasis on autophagy. Neurosci Lett 2010, 482:264-268.
7. Damjanovic D., Zhang X., Mu J., Medina M.F., Xing Z. Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector. Genet Vaccines Ther 2008, 6:5.
8. Danielyan L., Schäfer R., von Ameln-Mayerhofer A., Bernhard F., Verleysdonk S., Buadze M., Lourhmati A., Klopfer T., Schaumann F., Schmid B., Koehle C., Proksch B., Weissert R., Reichardt H.M., van den Brandt J., Buniatian G.H., Schwab M., Gleiter C.H., Frey W.H. Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease. Rejuvenation Res 2011, 14:3-16.
9. Danielyan L., Schäfer R., von Ameln-Mayerhofer A., Buadze M., Geisler J., Klopfer T., Burkhardt U., Proksch B., Verleysdonk S., Ayturan M., Buniatian G.H., Gleiter C.H., Frey W.H. Intranasal delivery of cells to the brain. Eur J Cell Biol 2009, 88:315-324.
10. De Rosa R., Garcia A.A., Braschi C., Capsoni S., Maffei L., Berardi N., Cattaneo A. Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci U S A 2005, 102:3811-3816.
11. Dhuria S.V., Hanson L.R., Frey W.H. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharmacol Sci 2010, 99:1654-1673.
12. Doi K., Nibu K., Ishida H., Okado H., Terashima T. Adenovirus-mediated gene transfer in olfactory epithelium and olfactory bulb: a long-term study. Ann Otol Rhinol Laryngol 2005, 114:629-633.
13. Draghia R., Caillaud C., Manicom R., Pavirani A., Kahn A., Poenaru L. Gene delivery into the central nervous system by nasal instillation in rats. Gene Ther 1995, 2:418-423.
14. Frampton A.R., Goins W.F., Nakano K., Burton E.A., Glorioso J.C. HSV trafficking and development of gene therapy vectors with applications in the nervous system. Gene Ther 2005, 12:891-901.
15. Frenkel D., Solomon B. Filamentous phage as vector-mediated antibody delivery to the brain. Proc Natl Acad Sci U S A 2002, 99:5675-5679.
16. Han I.K., Kim M.Y., Byun H.M., Hwang T.S., Kim J.M., Hwang K.W., Park T.G., Jung W.W., Chun T., Jeong G.J., Oh Y.K. Enhanced brain targeting efficiency of intranasally administered plasmid DNA: an alternative route for brain gene therapy. J Mol Med 2007, 85:75-83.
17. Hashizume R., Ozawa T., Gryaznov S.M., Bollen A.W., Lamborn K.R., Frey W.H., Deen D.F. New therapeutic approach for brain tumors: intranasal delivery of telomerase inhibitor GRN163. Neuro Oncol 2008, 10:112-120.
18. Holtmaat A.J., Hermens W.T., Oestreicher A.B., Gispen W.H., Kaplitt M.G., Verhaagen J. Efficient adenoviral vector-directed expression of a foreign gene to neurons and sustentacular cells in the mouse olfactory neuroepithelium. Brain Res Mol Brain Res 1996, 41:148-156.
19. Jerusalmi A., Morris-Downes M.M., Sheahan B.J., Atkins G.J. Effect of intranasal administration of Semliki Forest virus recombinant particles expressing reporter and cytokine genes on the progression of experimental autoimmune encephalomyelitis. Mol Ther 2003, 8:886-894.
20. Jiang Y., Wei N., Lu T., Zhu J., Xu G., Liu X. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 2011, 172:398-405.
21. Jiang Y., Zhu J., Xu G., Liu X. Intranasal delivery of stem cells to the brain. Expert Opin Drug Deliv 2011, 8:623-632.
22. Laing J.M., Gober M.D., Golembewski E.K., Thompson S.M., Gyure K.A., Yarowsky P.J., Aurelian L. Intranasal administration of the growth-compromised HSV-2 vector DeltaRR prevents kainate-induced seizures and neuronal loss in rats and mice. Mol Ther 2006, 13:870-881.
23. Lu Y., Madu C.O. Viral-based gene delivery and regulated gene expression for targeted cancer therapy. Expert Opin Drug Deliv 2010, 7:19-35.
24. Manservigi R., Argnani R., Marconi P. HSV recombinant vectors for gene therapy. Open Virol J 2010, 4:123-156.
25. Neuwelt E.A., Bauer B., Fahlke C., Fricker G., Iadecola C., Janigro D., Leybaert L., Molnár Z., O'Donnell M.E., Povlishock J.T., Saunders N.R., Sharp F., Stanimirovic D., Watts R.J., Drewes L.R. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci 2011, 12:169-182.
26. Perl D.P., Good P.F. Uptake of aluminium into central nervous system along nasal-olfactory pathways. Lancet 1987, 1:1028.
27. Stieger K., Belbellaa B., Le Guiner C., Moullier P., Rolling F. In vivo gene regulation using tetracycline-regulatable systems. Adv Drug Deliv Rev 2009, 61:527-541.
28. Thorne R.G., Pronk G.J., Padmanabhan V., Frey W.H. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004, 127:481-496.
29. Tucker D. Nonolfactory responses from the nasal cavity: Jacobsen's organ and the trigeminal system. Handbook of sensory physiology 1971, 151-181. Springer-Verlag, New York. 4th ed. L.M. Biedler (Ed.).
30. Yao F., Eriksson E. A novel tetracycline-inducible viral replication switch. Hum Gene Ther 1999, 10:419-427.
31. Yao F., Murakami N., Bleiziffer O., Zhang P., Akhrameyeva N.V., Xu X., Brans R. Development of a regulatable oncolytic herpes simplex virus type 1 recombinant virus for tumor therapy. J Virol 2010, 84:8163-8171.
32. Yao F., Svensjö T., Winkler T., Lu M., Eriksson C., Eriksson E. Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells. Hum Gene Ther 1998, 9:1939-1950.
33. Yao F., Theopold C., Hoeller D., Bleiziffer O., Lu Z. Highly efficient regulation of gene expression by tetracycline in a replication-defective herpes simplex viral vector. Mol Ther 2006, 13:1133-1141.