Synergistic antinociceptive actions and tolerance development produced by morphine-fentanyl coadministration: Correlation with μ-opioid receptor internalization

European Journal of Pharmacology

Volumn 674, Issue 2-3, 2012, Pages 239-247

  Silva Moreno, Arturo ^a   Gonzalez Espinosa, Claudia ^a   León Olea, Martha ^b   Cruz, Silvia L ^a,b  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ   (Mexico)

Author keywords

Opioid receptor internalization; Fentanyl; Isobologram; Morphine; Synergism; Tolerance

Indexed keywords

BETA ARRESTIN 2; FENTANYL; MORPHINE; MU OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CONCENTRATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG TOLERANCE; INTERNALIZATION; LOCUS CERULEUS; LOW DRUG DOSE; MALE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; RECEPTOR INTERNALIZATION;

ANALGESICS, OPIOID; ANIMALS; ARRESTINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG TOLERANCE; ENDOCYTOSIS; FENTANYL; LOCUS COERULEUS; MALE; MORPHINE; NOCICEPTION; PERIAQUEDUCTAL GRAY; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU;

EID: 84855538252     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.10.034     Document Type: Article

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