Selective G-quadruplex DNA stabilizing agents based on bisquinolinium and bispyridinium derivatives of 1,8-naphthyridine

Journal of Organic Chemistry

Volumn 77, Issue 1, 2012, Pages 229-242

  Dhamodharan, V ^a   Harikrishna, S ^a   Jagadeeswaran, C ^a   Halder, K ^a   Pradeepkumar, P I ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING FREE ENERGY; BINDING MODES; DNA STRUCTURE; DUPLEX DNA; G-QUADRUPLEXES; HIGH SELECTIVITY; HUMAN TELOMERIC DNA; LIGAND CONCENTRATION; MOLECULAR DYNAMICS SIMULATIONS; PYRIDINIUM; SIDE-CHAINS; SMALL MOLECULES; STABILIZING AGENTS; TELOMERES; THERAPEUTIC INTERVENTION; THERAPEUTIC POTENTIALS; THERMAL MELTING;

BINDING ENERGY; DNA; GENE EXPRESSION; GENE THERAPY; MOLECULAR DYNAMICS;

LIGANDS;

1,8 NAPHTHYRIDINE DERIVATIVE; 3,3 [1,8 NAPHTHYRIDINEDIYL 2,7 BIS(CARBONYLIMINO)]BIS(1 METHYLQUINOLINIUM)TRIFLATE; 3,3' [1,8 NAPHTHYRIDINEDIYL 2,7 BIS(CARBONYLIMINO)]BIS[1 METHYLPYRIDINIUM]TRIFLATE; 3,3' [2,6 PYRIDINEDIYL BIS(CARBONYLIMINO)]BIS[1 METHYLQUINOLINIUM]TRIFLATE; 6,6' [1,8 NAPHTHYRIDINEDIYL 2,7 BIS(CARBONYLIMINO)]BIS(1 METHYLQUINOLINIUM)TRIFLATE; BIS(PYRIDINIUM OXIME) DERIVATIVE; BISQUINOLINIUM; GUANINE QUADRUPLEX; LIGAND; N,N' DI(QUINOLIN 3 YL) 1,8 NAPHTHYRIDINE 2,7 DICARBOXAMIDE; N,N' DI(QUINOLIN 6 YL) 1,8 NAPHTHYRIDINE 2,7 DICARBOXAMIDE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOPHYSICS; DNA DENATURATION; DNA STRUCTURE; DRUG BINDING; DRUG DNA INTERACTION; DRUG SYNTHESIS; HUMAN; MOLECULAR DYNAMICS; MOLECULAR MODEL; SIMULATION; TELOMERE;

BASE SEQUENCE; EXCIPIENTS; G-QUADRUPLEXES; HETEROCYCLIC COMPOUNDS; LIGANDS; MODELS, MOLECULAR; NAPHTHYRIDINES; PYRIDINIUM COMPOUNDS; QUINOLINIUM COMPOUNDS;

EID: 84855536627     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201816g     Document Type: Article

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