Secretion of human latent TGF-β-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-β

Journal of Cell Science

Volumn 115, Issue 17, 2002, Pages 3457-3468

  Penttinen, Carita ^a   Saharinen, Juha ^a   Weikkolainen, Krista ^a   Hyytiäinen, Marko ^a   Keski Oja, Jorma ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Alternative splicing; Latent TGF ; LTBP

Indexed keywords

ANTIBODY; BINDING PROTEIN; COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; LATENT TRANSFORMING GROWTH FACTOR BETA; MESSENGER RNA; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; COVALENT BOND; EXON; EXTRACELLULAR MATRIX; FIBROBLAST CULTURE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HEART; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA CELL; OVARY; PRIORITY JOURNAL; PROSTATE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN SECRETION; SKELETAL MUSCLE;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; CLONING, MOLECULAR; EXONS; HUMANS; INTRONS; LATENT TGF-BETA BINDING PROTEINS; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; TISSUE DISTRIBUTION; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0036711805     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Role of transforming growth factor-beta in bone remodeling
2. A new DNA sequence assembly program
3. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
4. Bone abnormalities in latent TGF-beta binding protein (Ltbp-3)-3-null mice indicate a role for Ltbp-3 in modultaing TGF-beta bioavailability
5. Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo
6. Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein
7. The many faces of epidermal growth factor repeats
8. Processing of transforming growth factor beta 1 precursor by human furin convertase
9. Lack of the latent transforming growth factor beta binding protein in malignant, but not benign prostatic tissue
10. Bovine latent transforming growth factor beta 1-binding protein 2: Molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils
11. Sequence and expression of a novel member (LTBP-4) of the family of latent transforming growth factor-beta binding proteins
12. Isoforms and splice variant of transforming growth factor beta-binding protein in rat hepatic stellate cells
13. Recombinant latent transforming growth factor beta-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release
14. TGF-beta 1 binding protein: A component of the large latent complex of TGF-beta 1 with multiple repeat sequences
15. Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition
16. Latency, activation, and binding proteins of TGF-β
17. Independent promoters regulate the expression of two amino terminally distinct forms of latent transforming growth factor-beta binding protein-1 (LTBP-1) in a cell type-specific manner
18. An analysis of vertebrate mRNA sequences: Intimations of translational control
19. Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes
20. Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2)
21. Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region
22. A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1
23. Retention of the transforming growth factor-beta 1 precursor in the Golgi complex in a latent endoglycosidase H-sensitive form
24. Immunoelectron microscopic localization of transforming growth factor beta 1 and latent transforming growth factor beta 1 binding protein in human gastrointestinal carcinomas: Qualitative difference between cancer cells
25. Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein
26. Regulation of differentiation by TGF-beta
27. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
28. Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes
29. Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix
30. Transforming growth factor-beta
31. Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta
32. Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP- 1
33. Identification and characterization of a new latent transforming growth factor-beta-binding protein, LTBP-4
34. Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microtibrils
35. Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development
36. Disruption of the gene encoding the latent transforming growth factor-β binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy and colorectal cancer
37. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells
38. Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta inding protein
39. Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils
40. Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains
41. Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3)
42. Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices