An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis

International Journal of Antimicrobial Agents

Volumn 39, Issue 2, 2012, Pages 124-129

  Osman, Khadijo ^a,b   Evangelopoulos, Dimitrios ^b,c   Basavannacharya, Chandrakala ^b   Gupta, Antima ^b   McHugh, Timothy D ^c   Bhakta, Sanjib ^b   Gibbons, Simon ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Hypercalin B; Hyperenone A; Hypericum acmosepalum; MurE ligase; Peptidoglycan; Staphylococcus aureus; Tuberculosis

Indexed keywords

ATP DEPENDENT LIGASE; BACTERIAL ENZYME; CHLOROFORM; CIPROFLOXACIN; ERYTHROMYCIN; HEXANE; HYPERCALIN B; HYPERENONE A; NORFLOXACIN; PLANT MEDICINAL PRODUCT; PROTEIN MURE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CELL CULTURE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; HYPERICUM; HYPERICUM ACMOSEPALUM; MACROPHAGE; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; ENZYME INHIBITORS; ESCHERICHIA COLI; HYPERICUM; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; PLANT EXTRACTS; STAPHYLOCOCCUS AUREUS;

EID: 84855500645     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.09.018     Document Type: Article

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