Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 5, 2009, Pages 1884-1889

  Turk, Samo ^a   Kovač, Andreja ^a   Boniface, Audrey ^b   Bostock, Julieanne M ^c   Chopra, Ian ^c   Blanot, Didier ^b   Gobec, Stanislav ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Antibacterials; Computational methods; Enzyme inhibitors; Mur ligases

Indexed keywords

ALANINE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; GLUTAMINE; LIGASE; MURC PROTEIN; MURD PROTEIN; MURE PROTEIN; MURF PROTEIN; NSC 119889; NSC 209931; PEPTIDOGLYCAN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NATIONAL HEALTH ORGANIZATION; NONHUMAN; PROTEIN TARGETING;

ANTI-BACTERIAL AGENTS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG DISCOVERY; ENZYME INHIBITORS; PEPTIDE SYNTHASES; PEPTIDOGLYCAN;

BACTERIA (MICROORGANISMS);

EID: 61549097473     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.052     Document Type: Article

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