Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis

Protein and Cell

Volumn 1, Issue 11, 2010, Pages 1011-1022

  Basavannacharya, Chandrakala ^a,b   Moody, Paul R ^a,b   Munshi, Tulika ^a,b   Cronin, Nora ^a,b   Keep, Nicholas H ^a,b   Bhakta, Sanjib ^a,b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

m DAP; MurE ligase; peptidoglycan; site directed mutagenesis

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALANINE; ARGININE; ASPARAGINE; ASPARTIC ACID; DIAMINOPIMELIC ACID; GLUTAMIC ACID; LYSINE; MURAMIC ACID; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID; BACTERIAL PROTEIN; MURE PROTEIN, MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENE OVEREXPRESSION; GENETIC CONSERVATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN HYDROLYSIS; PROTEIN QUATERNARY STRUCTURE; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS; SPECIES COMPARISON; WILD TYPE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

MYCOBACTERIUM TUBERCULOSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; SEQUENCE ALIGNMENT;

EID: 79952584476     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-010-0132-9     Document Type: Article

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