Dietary β-conglycinin prevents fatty liver induced by a high-fat diet by a decrease in peroxisome proliferator-activated receptor γ2 protein

Journal of Nutritional Biochemistry

Volumn 23, Issue 2, 2012, Pages 123-132

  Yamazaki, Tomomi ^a   Kishimoto, Kyoko ^a   Miura, Shinji ^a   Ezaki, Osamu ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

Author keywords

Butter; Peroxisome proliferator activated receptor gamma; Soy protein; Steatosis; Sterol regulatory element binding protein

Indexed keywords

BETA CONGLYCININ; BINDING PROTEIN; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; CASEIN; CD36 ANTIGEN; DRINKING WATER; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; SAFFLOWER OIL; SOYBEAN PROTEIN; STARCH; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUCROSE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BUTTER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; ENERGY YIELD; FATTY LIVER; GENE TARGETING; LIPID DIET; MALE; MOUSE; NONHUMAN; PHYSICAL ACTIVITY; PROTEIN INTAKE;

ANIMALS; ANTIGENS, PLANT; DIET, HIGH-FAT; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; FATTY LIVER; GLOBULINS; LIVER; MALE; MICE; MICE, INBRED STRAINS; NUCLEAR PROTEINS; POSTPRANDIAL PERIOD; PPAR GAMMA; SAFFLOWER OIL; SEED STORAGE PROTEINS; SOYBEAN PROTEINS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SUCROSE; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

CARTHAMUS TINCTORIUS; MUS;

EID: 84855480055     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.11.006     Document Type: Article

References (40)

1. Clark J.M., Brancati F.L., Diehl A.M. Nonalcoholic fatty liver disease. Gastroenterology 2002, 122:1649-1657.
2. Bacon B.R., Farahvash M.J., Janney C.G., Neuschwander-Tetri B.A. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994, 107:1103-1109.
3. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002, 346:1221-1231.
4. Donnelly K.L., Smith C.I., Schwarzenberg S.J., Jessurun J., Boldt M.D., Parks E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005, 115:1343-1351.
5. Horton J.D., Shimomura I. Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr Opin Lipidol 1999, 10:143-150.
6. Uyeda K., Yamashita H., Kawaguchi T. Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage. Biochem Pharmacol 2002, 63:2075-2080.
7. Reddy J.K., Mannaerts G.P. Peroxisomal lipid metabolism. Annu Rev Nutr 1994, 14:343-370.
8. Gavrilova O., Haluzik M., Matsusue K., Cutson J.J., Johnson L., Dietz K.R., et al. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem 2003, 278:34268-34276.
9. Nakatani T., Kim H.J., Kaburagi Y., Yasuda K., Ezaki O. A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver: relationship to anti-obesity. J Lipid Res 2003, 44:369-379.
10. Surwit R.S., Kuhn C.M., Cochrane C., McCubbin J.A., Feinglos M.N., Diet-induced type II diabetes in C57BL/6J mice. Diabetes 1988, 37:1163-1167.
11. Gregoire F.M., Zhang Q., Smith S.J., Tong C., Ross D., Lopez H., et al. Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice. Am J Physiol Endocrinol Metab 2002, 282:E703-E713.
12. Kim S., Sohn I., Ahn J.I., Lee K.H., Lee Y.S. Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model. Gene 2004, 340:99-109.
13. Inoue M., Ohtake T., Motomura W., Takahashi N., Hosoki Y., Miyoshi S., et al. Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun 2005, 336:215-222.
14. Nagata R., Nishio Y., Sekine O., Nagai Y., Maeno Y., Ugi S., et al. Single nucleotide polymorphism (-468 Gly to A) at the promoter region of SREBP-1c associates with genetic defect of fructose-induced hepatic lipogenesis. J Biol Chem 2004, 279:29031-29042. [corrected].
15. Yamazaki T., Nakamori A., Sasaki E., Wada S., Ezaki O. Fish oil prevents sucrose-induced fatty liver but exacerbates high-safflower oil-induced fatty liver in ddY mice. Hepatology 2007, 46:1779-1790.
16. Velasquez M.T., Bhathena S.J. Role of dietary soy protein in obesity. Int J Med Sci 2007, 4:72-82.
17. Saito T., Kohno M., Tsumura K., Kugimiya W., Kito M. Novel method using phytase for separating soybean beta-conglycinin and glycinin. Biosci Biotechnol Biochem 2001, 65:884-887.
18. Ferrannini E. The theoretical bases of indirect calorimetry: a review. Metabolism 1988, 37:287-301.
19. Weir J.B. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949, 109:1-9.
20. Chitturi S., Abeygunasekera S., Farrell G.C., Holmes-Walker J., Hui J.M., Fung C., et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002, 35:373-379.
21. Koonen D.P., Jacobs R.L., Febbraio M., Young M.E., Soltys C.L., Ong H., et al. Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes 2007, 56:2863-2871.
22. Magnusson B., Asp L., Bostrom P., Ruiz M., Stillemark-Billton P., Linden D., et al. Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins. Arterioscler Thromb Vasc Biol 2006, 26:1566-1571.
23. Matsusue K., Kusakabe T., Noguchi T., Takiguchi S., Suzuki T., Yamano S., et al. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab 2008, 7:302-311.
24. Iritani N., Hosomi H., Fukuda H., Tada K., Ikeda H. Soybean protein suppresses hepatic lipogenic enzyme gene expression in Wistar fatty rats. J Nutr 1996, 126:380-388.
25. Aoyama T., Fukui K., Takamatsu K., Hashimoto Y., Yamamoto T. Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice (yellow KK). Nutrition 2000, 16:349-354.
26. Moriyama T., Kishimoto K., Nagai K., Urade R., Ogawa T., Utsumi S., et al. Soybean beta-conglycinin diet suppresses serum triglyceride levels in normal and genetically obese mice by induction of beta-oxidation, downregulation of fatty acid synthase, and inhibition of triglyceride absorption. Biosci Biotechnol Biochem 2004, 68:352-359.
27. Kohno M., Hirotsuka M., Kito M., Matsuzawa Y. Decreases in serum triacylglycerol and visceral fat mediated by dietary soybean beta-conglycinin. J Atheroscler Thromb 2006, 13:247-255.
28. Martinez-Villaluenga C., Bringe N.A., Berhow M.A., Gonzalez de Mejia E. Beta- conglycinin embeds active peptides that inhibit lipid accumulation in 3T3-L1 adipocytes in vitro. J Agric Food Chem 2008, 56:10533-10543.
29. Mochizuki Y., Maebuchi M., Kohno M., Hirotsuka M., Wadahama H., Moriyama T., et al. Changes in lipid metabolism by soy beta-conglycinin-derived peptides in HepG2 cells. J Agric Food Chem 2009, 57:1473-1480.
30. Martinez-Villaluenga C., Rupasinghe S.G., Schuler M.A., Gonzalez de Mejia E. Peptides from purified soybean beta-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain. FEBS J 2010, 277:1481-1493.
31. Nakajima S., Hira T., Eto Y., Asano K., Hara H. Soybean beta 51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells. Regul Pept 2010, 159:148-155.
32. Yamazaki T, Shiraishi S, Kishimoto K, Miura S, Ezaki O. An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat. J Nutr Biochem, in press.
33. Matsusue K., Haluzik M., Lambert G., Yim S.H., Gavrilova O., Ward J.M., et al. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 2003, 111:737-747.
34. Zhang Y.L., Hernandez-Ono A., Siri P., Weisberg S., Conlon D., Graham M.J., et al. Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J Biol Chem 2006, 281:37603-37615.
35. Miller C.W., Ntambi J.M. Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc Natl Acad Sci U S A 1996, 93:9443-9448.
36. Bengoechea-Alonso M.T., Ericsson J. SREBP in signal transduction: cholesterol metabolism and beyond. Curr Opin Cell Biol 2007, 19:215-222.
37. Tachibana N., Iwaoka Y., Hirotsuka M., Horio F., Kohno M. Beta-conglycinin lowers very-low-density lipoprotein-triglyceride levels by increasing adiponectin and insulin sensitivity in rats. Biosci Biotechnol Biochem 2010, 74:1250-1255.
38. Ministry of Health, Labour and Welfare The National Health and Nutrition survey in Japan, 2007 (in Japanese) 2010, Daiich Shuppan Publishing, Tokyo.
39. Brooks J.R., Morr C.V. Current aspects of soy protein fractionation and nomenclature. J Am Oil Chem Soc 1985, 62:1347-1354.
40. Food and Drug Administration Food labeling: health claims; soy protein and coronary heart disease. Food and Drug Administration, HHS. Final rule. Fed Regist 1999, 64:57700-57733.