Topical grape seed proanthocyandin extract reduces sunburn cells and mutant p53 positive epidermal cell formation, and prevents depletion of langerhans cells in an acute sunburn model

Photomedicine and Laser Surgery

Volumn 30, Issue 1, 2012, Pages 20-25

  Yuan, Xiao Ying ^a,b   Liu, Wei ^a,b   Hao, Jian Chun ^a,b   Gu, Wei Jie ^a,b   Zhao, Yan Shuang ^a,b  

^a AIR FORCE GENERAL HOSPITAL   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL CELLS; GRAPE SEEDS; ISCHEMIA-REPERFUSION INJURY; LANGERHANS CELLS; MINIMAL ERYTHEMA DOSE; PHOTOPROTECTION; PREVENTIVE AGENTS; PROANTHOCYANIDINS; SIMULATED RADIATION; ULTRAVIOLET IRRADIATIONS; UV IRRADIATION;

CELLULAR MANUFACTURING; FRUITS; IRRADIATION; ULTRAVIOLET RADIATION;

CELLS;

CD1 ANTIGEN; GRAPE SEED EXTRACT; GRAPE SEED PROANTHOCYANIDINS; PROANTHOCYANIDIN; PROTEIN P53; SUNSCREEN; T6 ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LANGERHANS CELL; MALE; MIDDLE AGED; MUTATION; PATHOLOGY; RADIATION EXPOSURE; SKIN; SUNBURN; TOPICAL DRUG ADMINISTRATION; ULTRAVIOLET RADIATION; VITIS;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; ANTIGENS, CD1; FEMALE; GRAPE SEED EXTRACT; HUMANS; IMMUNOHISTOCHEMISTRY; LANGERHANS CELLS; MALE; MIDDLE AGED; MUTATION; PROANTHOCYANIDINS; SKIN; SUNBURN; SUNSCREENING AGENTS; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS; VITIS; YOUNG ADULT;

EID: 84855466016     PISSN: 15495418     EISSN: None     Source Type: Journal    
DOI: 10.1089/pho.2011.3043     Document Type: Article

References (23)

1. Young, A. (1990). Cumulative effects of ultraviolet radiation on the skin: cancer and photoaging. Semin. Dermatol. 9, 25-31. (Pubitemid 20171868)
2. Yamakoshi, J., Otsuka, F., Sano, A., et al. (2003). Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin-rich extract from grape seeds. Pigment Cell Res. 16, 629-638. (Pubitemid 37466294)
3. Steenvoorden, D., and Beijersbergen van Henegouwen, G. (1997). Cysteine derivatives protect against UV-induced reactive intermediates in human keratinocytes: the role of glutathione synthesis. Photochem. Photobiol. 66, 665-671. (Pubitemid 127470148)
4. Bagchi, D., Garg, A., Krohn, R., Bagchi, M., Tran, M., and Stohs, S. (1997). Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res. Commun. Mol. Pathol. Pharmacol. 95, 179-189. (Pubitemid 27147562)
5. Bagchi, D., Garg, A., Krohn, R., et al. (1998). Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. Gen. Pharmacol. 30, 771-776.
6. Pataki, T., Bak, I., Kovacs, P., Bagchi, D., Das, D., and Tosaki, A. (2002). Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. Am. J. Clin. Nutr. 75, 894-899. (Pubitemid 34441258)
7. Banerjee, B., and Bagchi, D. (2001). Beneficial effects of a novel IH636 grape seed proanthocyanidin extract in the treatment of chronic pancreatitis. Digestion 63, 203-206. (Pubitemid 32429736)
8. Akhtar, S., Meeran, S., Katiyar, N., and Katiyar, S. (2009). Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin- like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors. Clin. Cancer Res. 15, 821-831.
9. Ye, X., Krohn, R., Liu, W., et al. (1999). The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol. Cell Biochem. 196, 99-108. (Pubitemid 29338784)
10. Daniels, F.J., Brophy, D., and Lobitz, W.J. (1961). Histochemical responses of human skin following ultraviolet irradiation. J. Invest. Dermatol. 37, 351-357.
11. Young, A. (1987). The sunburn cell. Photodermatol. 4, 127-134. (Pubitemid 17151700)
12. Liu, W., Lai, W., Wang, X., et al. (2006). Skin phototyping in a Chinese female population: analysis of four hundred and four cases from four major cities of China. Photodermatol. Photoimmunol. Photomed. 22, 184-188. (Pubitemid 44088995)
13. Elmets, C., Singh, D., Tubesing, K., Matsui, M., Katiyar, S., and Mukhtar, H. (2001). Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J. Am. Acad. Dermatol. 44, 425-432. (Pubitemid 32199961)
14. Vayalil, P., Mittal, A., Hara, Y., Elmets, C., and Katiyar, S. (2004). Green tea polyphenols prevent ultraviolet lightinduced oxidative damage and matrix metalloproteinases expression in mouse skin. J. Invest. Dermatol. 122, 1480-1487. (Pubitemid 38757231)
15. Cohen, J. (1993). Apoptosis. Immunol. Today 14, 126-130.
16. Greenblatt, M., Bennett, W., Hollstein, M., and Harris, C. (1994). Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54, 4855-4478.
17. Baadsgaard, O. (1991). In vivo ultraviolet irradiation of human skin results in profound perturbation of the immune system. Relevance to ultraviolet-induced skin cancer. Arch. Dermatol. 127, 99-109.
18. Shreedhar, V., Giese, T., Sung, V.W., and Ullrich, S.E. (1998). A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression.J. Immunol.160, 3783-3789. (Pubitemid 28176081)
19. Araneo, B.A., Dowell, T., Moon, H.B., and Daynes, R.A. (1989). Regulation of murine lymphokine production in vivo. Ultraviolet radiation exposure depresses IL-2 and enhances IL-4 production by T cells through an IL-1-dependent mechanism. J. Immunol. 143, 1737-1744. (Pubitemid 19241182)
20. Wang, L., Saito, K., Toda, M., et al. (2010). UV irradiation after immunization induces type 1 regulatory T cells that suppress Th2-type immune responses via secretion of IL-10. Immunobiology 215, 124-132.
21. Nair, N., Mahajan, S., Chawda, R., Kandaswami, C., Shanahan, T.C., and Schwartz, S.A. (2002). Grape seed extract activates Th1 cells in vitro. Clin. Diagn. Lab Immunol. 9, 470-476. (Pubitemid 34226048)
22. Sharma, S., and Katiyar, S. (2006). Dietary grape-seed proanthocyanidin inhibition of ultraviolet B-induced immune suppression is associated with induction of IL-12. Carcinogenesis 27, 95-102. (Pubitemid 43025248)
23. Tanaka, K., Hasegawa, J., Asamitsu, K., and Okamoto, T. (2007). Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB. Eur. J. Pharmacol. 565, 212-219. (Pubitemid 46782762)