Cysteine Derivatives Protect Against UV-Induced Reactive Intermediates in Human Keratinocytes: The Role of Glutathione Synthesis

Photochemistry and Photobiology

Volumn 66, Issue 5, 1997, Pages 665-671

  Steenvoorden, David P T ^a,b   Van Beijersbergen Henegouwen, Gerard M J ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BUTHIONINE SULFOXIMINE; CYSTEINE; DRUG DERIVATIVE; GLUTATHIONE; SCAVENGER;

ARTICLE; BIOLOGY; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; HUMAN; KERATINOCYTE; METABOLISM; RADIATION EXPOSURE; ULTRAVIOLET RADIATION;

BUTHIONINE SULFOXIMINE; CELLS, CULTURED; CYSTEINE; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; KERATINOCYTES; PHOTOBIOLOGY; ULTRAVIOLET RAYS;

EID: 0031263266     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1997.tb03204.x     Document Type: Article

References (29)

1. Urbach, F. (1989) Potential effects of altered solar ultraviolet radiation on human skin cancer. Photochem. Photobiol. 50, 507-513.
2. Black, H. S. (1987) Potential involvement of free radical reactions in ultraviolet light-mediated cutaneous damage. Photochem. Photobiol. 46, 213-221.
3. Clement-Lacroix, P., L. Michel, A. Moysan, P. Morliere and L. Dubertret (1996) UVA-induced immune suppression in human skin: protective effect of vitamin E in human epidermal cells in vitro. Br. J. Dermatol. 134, 77-84.
4. Wamer, W. G. and R. R. Wei (1997) In vitro photooxidation of nucleic acids by ultraviolet A radiation. Photochem. Photobiol. 65, 560-563.
5. Miyachi, Y. (1995) Photoaging from an oxidative standpoint. J. Dermatol. Sci. 9, 79-86.
6. Van den Broeke, L. T. and G. M. J. Beijersbergen van Henegouwen (1993) Thiols as potential UV radiation protectors. An in vitro study. J. Photochem. Photobiol. B Biol. 17, 279-286.
7. Biaglow, J. E., M. E. Varnes, E. P. Clark and E. R. Epp (1983) The role of thiols in cellular response to radiation and drugs. Radiat. Res. 95, 437-455.
8. Prutz, W. A. (1989) Chemical repair in irradiated DNA solutions containing thiols and/or disulphides. Further evidence for disulphide radical anions acting as electron donors. Int. J. Radiat. Biol. 56, 21-33.
9. Meister, A. (1991) Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol. Ther. 51, 155-194.
10. Connor, M. J. and L. A. Wheeler (1987) Depletion of cutaneous glutathione by ultraviolet radiation. Photochem. Photobiol. 46, 239-245.
11. Shindo, Y., E. Witt, D. Han and L. Packer (1994) Dose-response effects of acute ultraviolet irradiation on antioxidants and molecular markers of oxidation in murine epidermis. J. Invest. Dermatol. 104, 470-475.
12. Tyrrell, R. M. and M. Pidoux (1988) Correlation between endogenous glutathione content and sensitivity of cultured human skin cells to radiation at defined wavelengths in the solar ultraviolet range. Photochem. Photobiol. 47, 405-412.
13. Kobayashi, S., M. Takehana and C. Tohyama (1996) Glutathione isopropyl ester reduces UVB-induced skin damage in hairless mice. Photochem. Photobiol. 63, 106-110.
14. Karg, E., A. Tunek, H. Broetell, A. Hallberg, E. Rosengren and H. Rorsman (1990) Glutathione in human melanoma cells: effects of cysteine, cysteine esters and glutathione isopropyl ester. J. Dermatol. Sci. 1, 39-46.
15. Butterworth, M., D. G. Upshall, M. Hobbs and G. M. Cohen (1993) Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteine isopropylester and other cysteine precursors. Biochem. Pharmacol. 45, 1769-1774.
16. Steenvoorden, D. P. T. and G. M. J. Beijersbergen van Henegouwen (1996) Cysteine derivatives as prodrugs for UV-protection. In Abstracts, 12th Int. Congress on Photobiology, 1-6 September 1996, p. 213. Vienna, Austria.
17. Garmyn, G. and H. Degreef (1997) Suppression of UVB-induced c-fos and c-jun expression in human keratinocytes by N-acetylcysteine. J. Photochem. Photobiol. B Biol. 37, 125-130.
18. Renzing, J., S. Hansen and D. P. Lane (1996) Oxidative stress is involved in the UV-activation of p53. J. Cell Sci. 109, 1105-1112.
19. Van den Broeke, L. T. and G. M. J. Beijersbergen van Henegouwen (1995) Topically applied N-acetylcysteine as a protector against UVB-induced systemic immunosuppression. J. Photochem. Photobiol. B Biol. 27, 61-65.
20. Van den Broeke, L. T. and G. M. J. Beijersbergen van Henegouwen (1994) UV radiation protection efficacy of cysteine derivatives, studies with UVA-induced binding of 8-MOP and CPZ to rat epidermal biomacromolecules in vivo. Int. J. Radiat. Biol. 67, 411-420.
21. Rheinwald, J. G. and H. Green (1975) Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6, 331-344.
22. Anderson, M. E. (1985) Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113, 548-555.
23. Schoonderwoerd, S. A., G. M. J. Beijersbergen van Henegouwen, K. C. M. Persons, S. Caffieri and F. Dall'Aqua (1991) Photobinding of 8-methoxypsoralen, 4,6,4′-trimethylangelicin and chlorpromazin to Wistar rat epidermal biomacromolecules in vivo. J. Photochem. Photobiol. B Biol. 10, 257-268.
24. Nishiuch, Y., M. Sasaki, M. Nakayasu and A. Oikawa (1976) Cytotoxicity of cysteine in culture media. In Vitro 12, 635-638.
25. Anderson, M. E. and A. Meister (1983) Transport and direct utilization of γ-glutamylcyst(e)ine for glutathione synthesis. Proc. Natl. Acad. Sci. USA 80, 707-711.
26. Anderson, M. E., F. Powrie, R. Puri and A. Meister (1985) Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione. Arch. Biochem. Biophys. 239, 538-548.
27. Perchellet, E. M., E. A. Maatta, N. L. Abney and J.-P. Perchellet (1987) Effects of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione and ornithine decarboxylase induction in isolated mouse epidermal cells with 12-O-tetradecanoylphorbol-13-acetate. J. Cell. Physiol. 131, 64-73.
28. Wellner, V. P., M. E. Anderson, R. N. Puri, G. L. Jensen and A. Meister (1984) Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts. Proc. Natl. Acad. Sci. USA 81, 4732-1735.
29. Uhlig, S. and A. Wendel (1990) Glutathione enhancement in various mouse organs and protection by glutathione-isopropylester against liver injury. Biochem. Pharmacol. 39, 1877-1881.