Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells

European Journal of Pharmacology

Volumn 675, Issue 1-3, 2012, Pages 15-21

  Chen, Li Min ^a,b   Lin, Zhi Ying ^a,b   Zhu, Yuan Gui ^a,b   Lin, Nan ^a,b   Zhang, Jing ^a,b   Pan, Xiao Dong ^a,b   Chen, Xiao Chun ^a,b  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b Medical University   (China)

Author keywords

Amyloid precursor protein; Amyloidgenesis; BACE1; Ginsenoside; PPAR

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; BETA SECRETASE 1; GINSENOSIDE RG 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; DRUG STRUCTURE; ENZYME ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE; CENTRAL NERVOUS SYSTEM AGENTS; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION; GINSENOSIDES; HUMANS; MICE; NERVE TISSUE PROTEINS; NEURONS; PEPTIDE FRAGMENTS; PPAR GAMMA; PROMOTER REGIONS, GENETIC; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 84855435177     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.11.039     Document Type: Article

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