Mutational analyses of the influenza A virus polymerase subunit PA reveal distinct functions related and unrelated to RNA polymerase activity

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Liang, Yuhong ^a,b   Danzy, Shamika ^a   Dao, Luan Danh ^a,c   Parslow, Tristram G ^a   Liang, Yuying ^a,d  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c The Arcas Group   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA A VIRUS POLYMERASE SUBUNIT PA; INFLUENZA A VIRUS POLYMERASE SUBUNIT PB1; INFLUENZA A VIRUS POLYMERASE SUBUNIT PB2; RNA POLYMERASE; UNCLASSIFIED DRUG; DNA DIRECTED RNA POLYMERASE; PA PROTEIN, INFLUENZA VIRUSES; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN; VIRUS RNA;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CODON; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA FLANKING REGION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; LIFE CYCLE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHENOTYPE; PROMOTER REGION; PROTEIN ENGINEERING; RNA SYNTHESIS; TRANSACTIVATION; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS MUTATION; VIRUS PARTICLE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL NUCLEUS; CHEMICAL STRUCTURE; CHEMISTRY; DOG; GENETIC TRANSFECTION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; TRANSGENIC ORGANISM; VIRULENCE;

INFLUENZA A VIRUS;

ANIMALS; CELL NUCLEUS; CELLS, CULTURED; DNA MUTATIONAL ANALYSIS; DNA-DIRECTED RNA POLYMERASES; DOGS; HUMANS; INFLUENZA A VIRUS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; ORGANISMS, GENETICALLY MODIFIED; RNA REPLICASE; RNA, VIRAL; TRANSFECTION; VIRAL PROTEINS; VIRULENCE;

EID: 84855419686     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029485     Document Type: Article

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