Down-regulation of CXCR7 inhibits the growth and lung metastasis of human hepatocellular carcinoma cells with highly metastatic potential

Experimental and Therapeutic Medicine

Volumn 3, Issue 1, 2012, Pages 117-123

  Xue, Tong Chun ^a   Chen, Rong Xin ^a   Han, Dan ^a   Chen, Jie ^a   Xue, Qiong ^a   Gao, Dong Mei ^a   Sun, Rui Xia ^a   Tang, Zhao You ^a   Ye, Sheng Long ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Chemokine receptor; CXCR7; Hepatocellular carcinoma; Lung; Metastasis

Indexed keywords

CHEMOKINE RECEPTOR CXCR7; GELATINASE A; GELATINASE B; SMALL INTERFERING RNA; SMALL INTERFERING RNA 286; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; LUNG METASTASIS; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; RNA INTERFERENCE; TISSUE MICROARRAY;

EID: 84855411854     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2011.358     Document Type: Article

References (27)

1. Parkin DM, Bray F, Ferlay J and Pisani P: Estimating the world cancer burden: Globocan 2000. Int J Cancer 94: 153-156, 2001.
2. Ben-Baruch A: Organ selectivity in metastasis: regulation by chemokines and their receptors. Clin Exp Metastasis 25: 345-356, 2008.
3. Kakinuma T and Hwang ST: Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol 79: 639-651, 2006.
4. Balabanian K, Lagane B, Infantino S, et al: The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem 280: 35760-35766, 2005.
5. Burns JM, Summers BC, Wang Y, et al: A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med 203: 2201-2213, 2006.
6. Boldajipour B, Mahabaleshwar H, Kardash E, et al: Control of chemokine-guided cell migration by ligand sequestration. Cell 132: 463-473, 2008.
7. Wang J, Shiozawa Y, Wang Y, et al: The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem 283: 4283-4294, 2008.
8. Iwakiri S, Mino N, Takahashi T, et al: Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I non-small cell lung cancer. Cancer 115: 2580-2593, 2009.
9. Zheng K, Li HY, Su XL, et al: Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells. J Exp Clin Cancer Res 29: 31, 2010.
10. Tian J, Tang ZY, Ye SL, et al: New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis. Br J Cancer 81: 814-821, 1999.
11. Stordeur P, Poulin LF, Craciun L, et al: Cytokine mRNA quantification by real-time PCR. J Immunol Methods 259: 55-64, 2002.
12. Ji XN, Ye SL, Li Y, et al: Contributions of lung tissue extracts to invasion and migration of human hepatocellular carcinoma cells with various metastatic potentials. J Cancer Res Clin Oncol 129: 556-564, 2003.
13. Hujanen ES and Terranova VP: Migration of tumor cells to organ-derived chemoattractants. Cancer Res 45: 3517-3521, 1985.
14. Muller A, Homey B, Soto H, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56, 2001.
15. Dalby B, Cates S, Harris A, et al: Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications. Methods 33: 95-103, 2004.
16. Jacob K, Webber M, Benayahu D and Kleinman HK: Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone. Cancer Res 59: 4453-4457, 1999.
17. Simon R, Mirlacher M and Sauter G: Tissue microarrays. Methods Mol Med 97: 377-389, 2004.
18. Lugli A, Spichtin H, Maurer R, et al: EphB2 expression across 138 human tumor types in a tissue microarray: high levels of expression in gastrointestinal cancers. Clin Cancer Res 11: 6450-6458, 2005.
19. Wu X, Fan J, Wang X, et al: Downregulation of CCR1 inhibits human hepatocellular carcinoma cell invasion. Biochem Biophys Res Commun 355: 866-871, 2007.
20. Begum NA, Shibuta K, Mori M and Barnard GF: Reduced expression of the CXCR4 receptor mRNA in hepatocellular carcinoma and lack of inducibility of its ligand α-chemokine hIRH/SDF1α/PBSF in vitro. Int J Oncol 14: 927-934, 1999.
21. Mitra P, De A, Ethier MF, et al: Loss of chemokine SDF-1alpha-mediated CXCR4 signalling and receptor internalization in human hepatoma cell line HepG2. Cell Signal 13: 311-319, 2001.
22. Schimanski CC, Bahre R, Gockel I, et al: Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4. Br J Cancer 95: 210-217, 2006.
23. Xiang ZL, Zeng ZC, Tang ZY, et al: Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival. BMC Cancer 9: 176, 2009.
24. Valentin G, Haas P and Gilmour D: The chemokine SDF1a coordinates tissue migration through the spatially restricted activation of Cxcr7 and Cxcr4b. Curr Biol 17: 1026-1031, 2007.
25. Miao Z, Luker KE, Summers BC, et al: CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci USA 104: 15735-15740, 2007.
26. Jones SW, Brockbank SM, Mobbs ML, et al: The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover. Osteoarthritis Cartilage 14: 597-608, 2006.
27. Rajagopal S, Kim J, Ahn S, et al: Beta-arrestin - but not G protein-mediated signaling by the 'decoy' receptor CXCR7. Proc Natl Acad Sci USA 107: 628-632, 2010.