Fukushima Daiichi Nuclear Power Plant accident: Facts, environmental contamination, possible biological effects, and countermeasures

Journal of Clinical Biochemistry and Nutrition

Volumn 50, Issue 1, 2012, Pages 2-8

  Anzai, Kazunori ^a   Ban, Nobuhiko ^b   Ozawa, Toshihiko ^c   Tokonami, Shinji ^d  

^a NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOKYO HEALTHCARE UNIVERSITY   (Japan)

^c YOKOHAMA COLLEGE OF PHARMACY   (Japan)

^d HIROSAKI UNIVERSITY   (Japan)

Author keywords

Environmental contamination; Fukushima nuclear power plant; Low dose effect; Nuclear accident; Radiation mitigator; Reactive oxygen species

Indexed keywords

HYDROGEN; RADIOACTIVE MATERIAL;

EARTHQUAKE; ENVIRONMENTAL IMPACT; EXPLOSION; GENERATOR; HUMAN; JAPAN; NUCLEAR ACCIDENT; NUCLEAR POWER PLANT; RADIATION EXPOSURE; RADIOACTIVE CONTAMINATION; REVIEW; TSUNAMI;

EID: 84855370030     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.D-11-00021     Document Type: Review

References (40)

1. Cox M. Special Report: Fukushima Daiichi after the Earthquake and Tsunami. Nuclear News 2011; 17-18.
2. Tokonami S. Measures against Nuclear Accident at TEPCO Fukushima Daiichi Nuclear Power Plant: activities carried out by Hirosaki University. Proc of the 3rd Int Symp on Radiat Emerg Med in Hirosaki Univ, in press.
3. Hosoda M, Tokonami S, Sorimachi A, et al. The time variation of dose rate artificially increased by the Fukushima nuclear crisis. Sci Rep 2011; 1: 87.
4. Boiteux S. Repair of ionizing radiation induced base damage: role of DNA glycosylases. In: Ozawa T, Tatsumi K and Hori T, eds. Biodefence Mechanisms Against Environmental Stress, Tokyo: Kodansha-Springer, 1998; 107-114.
5. Ozawa T. Generation of active oxygen by environmental factors; radiation, Tanpakushitsu Kakusan Koso 1988; 33: 2811-2817.
6. Bielski BHJ, Gebski JM. Vol III. In: Pryor WA, ed. Free Radicals in Biology. New York: Academic Press, 1977; 1-51.
7. Michelson AM, McCord JM, Fridovich I. Superoxide and Superoxide Dismutase, New York: Academic Press, 1977; 19-60.
8. International Commission on Radiological Protection. The 2007 recommendations of the international commission on radiological protection. ICRP publication 103. Ann ICRP 2007; 37: 1-332.
9. Preston DL, Ron E, Tokuoka S, et al. Solid cancer incidence in atomic bomb survivors: 1958-1998. Radiat Res 2007; 168: 1-64. (Pubitemid 351292925)
10. Doll R, Wakeford R. Risk of childhood cancer from fetal irradiation. Br J Radiol 1997; 70: 130-139. (Pubitemid 27091013)
11. Committee Examining Radiation Risks of Internal Emitters. report of the Committee Examining Radiation Risks of Internal Emitters (CERRIE), 2004. Retrieved from http://www.cerrie.org
12. Romanenko A, Morimura K, Wanibuchi H, et al. Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation. Cancer Sci 2003; 94: 328-333. (Pubitemid 36626363)
13. Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature 2001; 411: 366-374. (Pubitemid 32467046)
14. Nikjoo H, O'Neill P, Wilson WE, Goodhead DT. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat Res 2001; 156: 577-583. (Pubitemid 33027531)
15. Rothkamm K, Kühne M, Jeggo PA, Löbrich M. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA doublestrand breaks. Cancer Res 2001; 61: 3886-3893. (Pubitemid 32720946)
16. Lloyd DC, Edwards AA, Leonard A, et al. Chromosomal aberrations in human lymphocytes induced in vitro by very low doses of X-rays. Int J Radiat Biol 1992; 61: 335-343.
17. Morgan WF, Sowa MB. Non-targeted effects of ionizing radiation: implications for risk assessment and the radiation dose response profile. Health Phys 2009; 97: 426-432.
18. Wakeford R. And now, Fukushima. J Radiol Prot 2011; 31: 167-176.
19. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources and effects of ionizing radiation. UNSCEAR 2008 Report to the General Assembly with Scientific Annexes. Volume II, Scientific Annex D: health effects due to radiation from the chernobyl accident. New York: United Nations, 2011.
20. Nair RR, Rajan B, Akiba S, et al. Background radiation and cancer incidence in Kerala, India-Karanagappally cohort study. Health Phys 2009; 96: 55-66.
21. Brizel DM. Pharmacologic approaches to radiation protection. J Clin Oncol 2007; 25: 4084-4089. (Pubitemid 47492952)
22. Nomoto K, Yokokura T, Tsuneoka K, Shikita M. Radioprotection of mice by a single subcutaneous injection of heat-killed Lactobacillus casei after irradiation. Radiat Res 1991; 125: 293-297.
23. Satyamitra M, Uma Devi P, Murase H, Kagiya VT. In vivo postirradiation protection by a vitamin E analog, α-TMG. Radiat Res 2003; 160: 655-661. (Pubitemid 37521708)
24. Ueno M, Inano H, Onoda M, et al. Modification of mortality and tumorigenesis by tocopherol-mono-glucoside (TMG) administered after X irradiation in mice and rats. Radiat Res 2009; 172: 519-524.
25. Anzai K, Ikota N, Ueno M, Nyui M, Kagiya TV. Heat-treated mineral-yeast as a potent post-irradiation radioprotector. J Radiat Res (Tokyo) 2008; 49: 425-430. (Pubitemid 352030607)
26. Burdelya LG, Krivokrysenko VI, Tallant TC, et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 2008; 320: 226-230. (Pubitemid 351521417)
27. Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML. Melatonin and radioprotection from genetic damage: in vivo/in vitro studies with human volunteers. Mutat Res 1996; 371: 221-228.
28. Vijayalaxmi, Meltz ML, Reiter RJ, Herman TS, Kumar KS. Melatonin and protection from whole-body irradiation: survival studies in mice. Mutat Res 1999; 425: 21-27.
29. Koc M, Taipi S, Erin Buyukokurglu M, Bakan N. The effect of melatonin against oxdative damage during total-body irradiation in rats. Radiat Res 2003; 160: 251-255. (Pubitemid 36897506)
30. Vijayalaxmi, Reiter RJ, Tan DX, Herman TS, Thomas CR Jr. Melatonin as a radioprotective agent: a review. Int J Radiat Oncol Biol Phys 2004; 59: 639-653.
31. Manda K, Ueno M, Anzai K. AFMK, a melatonin metabolite, attenuates X-ray- induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res 2007; 42: 386-393. (Pubitemid 46581663)
32. Shirazi A, Ghobadi G, Ghazi-Khansari M. A radiobiological review on melatonin: a novel radioprotector. J Radiat Res (Tokyo) 2007; 48: 263-272. (Pubitemid 47105598)
33. Korkmaz A, Tan DX, Reiter RJ. Melatonin; an established radioprotective agent against Japan's nuclear disaster. TAF Prev Med Bull 2011; 10: 127-129.
34. Reiter RJ, Tan DX, Korkmaz A, Manchester LC. The disaster in Japan: utility of melatonin in providing protection against ionizing radiation. J Pineal Res 2011; 50: 357-358.
35. Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007; 13: 688-694. (Pubitemid 46889750)
36. Qian L, Cao F, Cui J, et al. The potential cardioprotective effects of hydrogen in irradiated mice. J Radiat Res (Tokyo) 2010; 51: 741-747.
37. Zhao L, Zhou C, Zhang J, et al. Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice. Int J Biol Sci 2011; 7: 297-300.
38. Kang KM, Kang YN, Choi IB, et al. Effects of drinking hydrogen-Rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res 2011; 1: 11.
39. Terasaki Y, Ohsawa I, Terasaki M, et al. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol 2011; 301: L415-L426.
40. Inano H, Onoda M, Inafuku N, et al. Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 2000; 21: 1835-1841.