Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III

Journal of Immunology

Volumn 188, Issue 1, 2012, Pages 394-403

  Wenzel, Michael ^a   Wunderlich, Michael ^a   Besch, Robert ^b   Poeck, Hendrik ^a,c   Willms, Simone ^a   Schwantes, Astrid ^d   Kremer, Melanie ^a   Sutter, Gerd ^a,d   Endres, Stefan ^a   Schmidt, Andreas ^a   Rothenfusser, Simon ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d PAUL EHRLICH INSTITUT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; AIM2 INFLAMMASOME; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CASPASE ACTIVATING AND RECRUITMENT DOMAIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; ASC PROTEIN; ATM PROTEIN; CAFFEINE; CASPASE 8; CASPASE 9; DNA DIRECTED RNA POLYMERASE III; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HELICASE; INFLAMMASOME; INTERFERON RECEPTOR; INTERFERON REGULATORY FACTOR 3; INTERFERON TYPE 1 RECEPTOR; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN BAX; PROTEIN P53; RETINOID ACID INDUCED GENE 1 LIKE HELICASE; SERINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS DNA;

AIM2 GENE; APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; CELL DEATH; CONTROLLED STUDY; CYTOSOL; DNA DAMAGE; GENE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MITOCHONDRIAL APOPTOSIS; MITOCHONDRION; MODIFIED VACCINIA VIRUS ANKARA; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; VACCINIA VIRUS; VIRUS CELL INTERACTION;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-2-ASSOCIATED X PROTEIN; CASPASE 8; CELL CYCLE PROTEINS; CYTOSOL; DNA DAMAGE; DNA, VIRAL; DNA-BINDING PROTEINS; HEK293 CELLS; HUMANS; INFLAMMASOMES; INTERFERONS; MACROPHAGES; MICE; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA POLYMERASE III; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; VACCINIA; VACCINIA VIRUS;

EID: 84855362156     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100523     Document Type: Article

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