Intraepithelial γδ t cells remain increased in the duodenum of aids patients despite antiretroviral treatment

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Nilssen, Dag E ^a,b   Brandtzaeg, Per ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b AKERSHUS UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD3 ANTIGEN; CD8 ANTIGEN; DIDANOSINE; IMMUNOGLOBULIN; INDINAVIR; LAMIVUDINE; NELFINAVIR; STAVUDINE; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; ZIDOVUDINE; LYMPHOCYTE ANTIGEN RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADAPTIVE IMMUNITY; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG WITHDRAWAL; DUODENUM; DUODENUM BIOPSY; FEMALE; GENE EXPRESSION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INTRAEPITHELIAL LYMPHOCYTE; LYMPHOCYTE COUNT; MALE; RETROSPECTIVE STUDY; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; ADOLESCENT; AGED; CASE CONTROL STUDY; CHILD; DRUG EFFECT; IMMUNOLOGY; INTESTINE MUCOSA; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; UPREGULATION;

ANIMALIA;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADOLESCENT; ADULT; AGED; ANTI-RETROVIRAL AGENTS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DUODENUM; FEMALE; HUMANS; INTESTINAL MUCOSA; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; UP-REGULATION; YOUNG ADULT;

EID: 84855361096     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029066     Document Type: Article

References (41)

1. Virgin HW, Walker BD, (2010) Immunology and the elusive AIDS vaccine. Nature 464: 224-231.
2. Broliden K, Haase AT, Ahuja SK, Shearer GM, Andersson J, (2009) Introduction: Back to basics: mucosal immunity and novel HIV vaccine concepts. J Intern Med 265: 5-17.
3. Shacklett BL, Critchfield JW, Ferre AL, Hayes TL, (2009) Mucosal T-cell responses to HIV: responding at the front lines. J Intern Med 265: 58-66.
4. Hirbod T, Kaul R, Reichard C, Kimani J, Ngugi E, et al. (2008) HIV-neutralizing immunoglobulin A and HIV-specific proliferation are independently associated with reduced HIV acquisition in Kenyan sex workers. AIDS 22: 727-735.
5. Masopust D, (2009) Developing an HIV cytotoxic T-lymphocyte vaccine: issues of CD8 T-cell quantity, quality and location. J Intern Med 265: 125-137.
6. Pennington DJ, Silva-Santos B, Hayday AC, (2005) γ/δ T cell development - having the strength to get there. Curr Opin Immunol 17: 108-115.
7. Ciofani M, Zúñiga-Pflücker JC, (2010) Determining γδ versus αß T cell development. Nat Rev Immunol 10: 657-663.
8. Bonneville M, O'Brien RL, Born WK, (2010) γδ T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol 10: 467-478.
9. Halstensen TS, Scott H, Brandtzaeg P, (1989) Intraepithelial T cells of the TCRγ/δ+ CD8- and Vδ1/Jδ1+ phenotypes are increased in coeliac disease. Scand J Immunol 30: 665-672.
10. Bhagat G, Naiyer AJ, Shah JG, Harper J, Jabri B, et al. (2008) Small intestinal CD8+TCRγδ+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Invest 118: 281-293.
11. Nilssen DE, Halstensen TS, Frøland SS, Fausa O, Brandtzaeg P, (1993) Distribution and phenotypes of duodenal intraepithelial γ/δ T cells in patients with various types of primary B-cell deficiency. Clin Immunol Immunopathol 68: 301-310.
12. Nilssen DE, Aukrust P, Frøland SS, Müller F, Fausa O, et al. (1993) Duodenal intraepithelial γ/δ T cells and soluble CD8, neopterin and β2-microglobulin in serum of IgA-deficient subjects with or without IgG subclass deficiency. Clin Exp Immunol 94: 91-98.
13. Nilssen DE, Müller F, Øktedalen O, Frøland SS, Fausa O, et al. (1996) Intraepithelial γ/δ T cells in duodenal mucosa are related to the immune state and survival time in AIDS. J Virol 70: 3545-3550.
14. Nilssen DE, Øktedalen O, Brandtzaeg P, (2004) Intestinal B cell hyperactivity in AIDS is controlled by highly active antiretroviral therapy. Gut 53: 487-493.
15. Brinchmann JE, Vartdal F, Thorsby E, (1989) T lymphocyte subset changes in human immunodeficiency virus infection. J Acquired Immune Defic Syndr 2: 398-403.
16. Pabst R, Russel MW, Brandtzaeg P, (2008) Tissue distribution of lymphocytes and plasma cells and the role of the gut. Trends Immunol 29: 206-208.
17. Snijders F, Meenan J, van den Blink B, van Deventer SJ, ten Kate FJ, (1996) Duodenal intraepithelial and lamina propria T lymphocytes in human immunodeficiency virus-infected patients with and without diarrhoea. Scand J Gastroenterol 31: 1176-1181.
18. Brandtzaeg P, Halstensen TS, Scott H, Sollid LM, Valnes K, et al. (1989) Epithelial homing of γδ T cells? Nature 341: 113-114.
19. Brandtzaeg P, Farstad IN, Helgeland L, (1998) Phenotypes of T cells in the gut. In: MacDonald TT, editors. Mucosal T cells Chemical Immunology 71: 1-26.
20. Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, et al. (2010) Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med 207: 553-564.
21. Burgers WA, Riou C, Mlotshwa M, Maenetje P, de Assis Rosa D, et al. (2009) Association of HIV-specific and total CD8+ T memory phenotypes in subtype C HIV-1 infection with viral set point. J Immunol 182: 4751-4761.
22. Ciccone EJ, Read SW, Mannon PJ, Yao MD, Hodge JN, et al. (2010) Cycling of gut mucosal CD4+ T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels. Mucosal Immunol 3: 172-181.
23. Hayday AC, (2009) γ/δ cells and the lymphoid stress-surveillance response. Immunity 31: 184-196.
24. Martin B, Hirota K, Cua DJ, Stockinger B, Veldhoen M, (2009) Interleukin-17-producing γδ T cells selectively expand in response to pathogen products and environmental signals. Immunity 31: 321-330.
25. Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, et al. (2009) Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity. Immunity 31: 331-341.
26. Chennupati V, Worbs T, Liu X, Malinarich FH, Schmitz S, et al. (2010) Intra- and intercompartmental movement of γδ T cells: intestinal intraepithelial and peripheral γδ T cells represent exclusive nonoverlapping populations with distinct migration characteristics. J Immunol 185: 5160-5168.
27. Bhalla RB, Safai B, Mertelsmann R, Schwartz MK, (1983) Abnormally high concentrations of β2-microglobulin in acquired immunodeficiency syndrome (AIDS) patients. Clin Chem 29: 1560.
28. Schneider T, Zippel T, Schmidt W, Pauli G, Heise W, et al. (1997) Abnormal predominance of IgG in HIV-spesific antibodies produced by short-term cultured duodenal biopsy specimens from HIV-infected patients. J AIDS Hum Retrovir 16: 333-339.
29. Schneider T, Zippel T, Schmidt W, Pauli G, Heise W, et al. (1998) Increased immunoglobulin G production by short term cultured duodenal biopsy samples from HIV-infected patients. Gut 42: 357-361.
30. Klatt NR, Harris LD, Vinton CL, Sung H, Briant JA, et al. (2010) Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunol 3: 387-398.
31. Prendergast A, Prado JG, Kang YH, Chen F, Riddell LA, et al. (2010) HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells. AIDS 24: 491-502.
32. Klatt NR, Brenchley JM, (2010) Th17 cell dynamics in HIV infection. Curr Opin HIV AIDS 5: 135-140.
33. Petermann F, Rothhammer V, Claussen MC, Haas JD, Blanco LR, et al. (2010) γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity 33: 351-363.
34. Bernardes SS, Borges IK, Lima JE, Milanez PdeA, Conchon-Costa I, et al. (2010) Involvement of regulatory T cells in HIV immunopathogenesis. Curr HIV Res 8: 340-346.
35. Sachdeva M, Fischl MA, Pahwa R, Sachdeva N, Pahwa S, (2010) Immune exhaustion occurs concomitantly with immune activation and decrease in regulatory T cells in viremic chronically HIV-1-infected patients. J Acquir Immune Defic Syndr 54: 447-454.
36. Kanwar B, Favre D, McCune JM, (2010) Th17 and regulatory T cells: implications for AIDS pathogenesis. Curr Opin HIV AIDS 5: 151-157.
37. Loke P, Favre D, Hunt PW, Leung JM, Kanwar B, et al. (2010) Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers. Blood 115: e20-32 (erratum in: Blood 2010, 116: 2402).
38. Fenoglio D, Poggi A, Catellani S, Battaglia F, Ferrera A, et al. (2009) Vδ1 T lymphocytes producing IFN-γ and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans. Blood 113: 6611-6618.
39. Huitfeldt H, Brandtzaeg P, (1985) Various keratin antibodies produce immunohistochemical staining of human myocardium and myometrium. Histochemistry 83: 381-389.
40. Selby WS, Janossy G, Bofill M, Jewell DP, (1983) Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease. Clin Exp Immunol 52: 219-228.
41. Brinchmann JE, Vartdal F, Gaudernack G, Markussen G, Funderud S, et al. (1988) Direct immunomagnetic quantification of lymphocyte subsets in blood. Clin Exp Immunol 71: 182-186.