Intraepithelial γ/δ T cells in duodenal mucosa are related to the immune state and survival time in AIDS

Journal of Virology

Volumn 70, Issue 6, 1996, Pages 3545-3550

  Nilssen, Dag E ^a,d   Müller, Fredrik ^b   Øktedalen, Olav ^d   Frøland, Stig S ^c   Fausa, Olav ^c   Halstensen, Trond S ^a,e   Brandtzaeg, Per ^a  

^a Institute of Pathology   (Norway)

^b Department of Laboratory Services Bacteriology Norwegian Veterinary Institute   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

^e NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; NEOPTERIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL SURVIVAL; DUODENUM MUCOSA; EPITHELIUM CELL; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; INTESTINE MUCOSA; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; SURVIVAL TIME; T LYMPHOCYTE ACTIVATION;

EID: 0030011639     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.6.3545-3550.1996     Document Type: Article

References (51)

1. Aukrust, P., S. S. Frøland and F. Müller. 1992. Raised scrum neopterin levels in patients with primary hypogammagtobulinaemia; correlation to other immunological parameters and to clinical and histological features. Clin. Exp. Immunol. 89:211-216.
2. + lymphocyte subsets during HIV infection. Clin. Exp. Immunol. 75:206-210.
3. Balk, S. P., E. C. Ebert, R. L. Blumenthal, F. V. McDermott, K. W. Wucherpfennig, S. B. Landau, and R. S. Blumberg. 1991. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science 253:1411-1415.
4. Bartlett, J. G., P. C. Bielitsos, and C. L. Sears. 1992. AIDS enteropathy. Clin. Infect. Dis. 15:726-735.
5. 2-microglobulin in acquired immunodeficiency syndrome (AIDS) patients. Clin. Chem. 29:1560.
6. Born, W., M. P. Happ, A. Dallas, C. Reudon, R. Kubo, T. Shinnick, P. Brennan, and R. O'Brien. 1990. Recognition of heat shock proteins and γ/δ cell function. Immunol. Today 11:40-43.
7. Bosnes, V., E. Qvigstad, K. E. A. Lundin, and E. Thorsby. 1990. Recognition of particular HLA-DQ heterodimer by a human γ/δ T cell clone. Eur. J. Immunol. 20:1429-1433.
8. Brandtzaeg, P., T. S. Halstensen, H. Scott, L. M. Sollid, and K. Valnes. 1989. Epithelial homing of γδ T cells. Nature (London) 341:113-114.
9. Brenner, M. B., J. McLean, D. P. Dialynas, J. L. Strominger, J. A. Smith, F. L. Owen, J. G. Seidman, S. Ip, F. Rosen, and M. S. Krangel. 1986. Identification of a putative second T-cell receptor. Nature (London) 322:145-149.
10. Brinchmann, J. E., F. Vartdal, G. Gaudernack, G. Markussen, S. Funderud, J. Ugelstad, and E. Thorsby. 1988. Direct immunomagnctic quantification of lymphocyte subsets in blood. Clin. Exp. Immunol. 71:182-186.
11. Brinchmann, J. E., F. Vartdal, and E. Thorsby. 1989. T lymphocyte subset changes in human immunodeficiency virus infection. J. Acquired Immun. Detic. Syndr. 2:398-403.
12. Carbonari, M., M. Cherchi, and R. Paganelli. 1990. Relative increase of T cells expressing the gamma/delta rather than the alpha/beta receptor in ataxia-tclangicctasia. N. Engl. J. Med. 322:73-76.
13. Ciccone, E., O. Viale, C. Bottino, D. Pende, N. Migone, G. Casorali, G. Tambussi, A. Moretta, and L. Moretta. 1988. Antigen recognition by human T cell receptor γ-positive lymphocytes. J. Exp. Med. 167:1517-1522.
14. Ciccone, E., O. Viale, D. Pende, M. Malnati, G. B. Ferrara, S. Barocci, A. Moretta, and L. Moretta. 1989. Specificity of human T lymphocytes expressing a γ/δ T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a γ/δ clone. Eur. J. Immunol. 19:1267-1271.
15. Comans-Bitter, W. M., J. J. M. van Dongen, and H. J. Neijens. 1989. Expression of the classical T cell receptor (TCR-αβ) and the alternative T cell receptor (TCR-γδ) in athymic children and normal children, abstr. 36-9. In Proceedings of the 7th International Congress of Immunology, Berlin. Gustav Fischer Verlag, Stuttgart, Germany.
16. De Paoli, P., D. Gennari, P. Martelli, G. Basaglia, M. Crovatto, S. Battistin, and G. Santini. 1991. A subset of γ/δ lymphocytes is increased during HIV-1 infection. Clin. Exp. Immunol. 83:187-191.
17. De Paoli, P., D. Gennari, P. Martelli, V. Cavarzerani, R. Comoretto, and G. Santini. 1990. γδ T cell receptor-bearing lymphocytes during Epstein-Barr virus infection. J. Infect. Dis. 161:1013-1016.
18. Ellakany, S., T. L. Whiteside, R. R. Schade, and D. H. van Thiel. 1987. Analysis of intestinal lymphocyte suhpopulations in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. Am. J. Clin. Pathol. 87:356-364.
19. Erle, D. J. 1995. Scratching the surface. Curr. Biol. 5:252-254.
20. Falini, B., L. Flenghi, S. Pileri, P. Pelicci, M. Fagioli, M. F. Martelli, L. Moretta, and E. Ciccone. 1989. Distribution of T cells bearing different forms of the T cell receptor γ/δ in normal and pathological human tissues. J. Immunol. 143:2480-2488.
21. Finkel, T. H., and N. K. Banda. 1994. Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells? Curr. Opin. Immunol. 6:605-611.
22. Greene, W. C. 1993. AIDS and the immune system. Sci. Am. 269:98-105.
23. Greipp, P. R., J. A. Katzmann, W. M. O'Fallon, and R. A. Kyle. 1988. Value of β2-microglobulin level and plasma cell labeling indices as prognostic factors in patients with newly diagnosed myeloma. Blood 72:219-223.
24. Haas, W., P. Pereira, and S. Tonegawa. 1993. Gamma/delta cells. Annu. Rev. Immunol. 11:637-685.
25. + CDS and Vδ1/Jδ1 phenotypes arc increased in coeliac disease. Scand. J. Immunol. 30:665-672.
26. + lymphocytes in AIDS and p24-antigenemic HlV-1-infected patients. Clin. Immunol. Immunopathol. 69:248-250.
27. Hohlfeld, R., A. G. Engel, K. Ii, and M. C. Harper. 1991. Polymyositis mediated by T lymphocytes that express the γδ receptor. N. Engl. J. Med. 324:877-881.
28. Huitfeldt, H., and P. Brandtzaeg. 1985. Various keratin antibodies produce immunohistochemical staining of human myocardium and myometrium. Histochemistry 83:381-389.
29. Hvas, J., J. R. Oksenberg, R. Fernando, L. Steinman, and C. C. A. Bernard. 1993. γδ T cell receptor repertoire in brain lesions of patients with multiple sclerosis. J. Neuroimmunol. 46:225-234.
30. Janeway, C. A., Jr., B. Jones, and A. Hayday. 1988. Specificity and function of T cells bearing γδ receptors. Immunol. Today 9:73-76.
31. Jarry, A., A. Cortez, and E. Rene. 1990. Infected cells and immune cells in the gastrointestinal tract of AIDS patients. An immunohistochemical study of 127 cases. Histopathology 16:133-140.
32. Keystone, E. C., C. Rittershaus, N. Wood, K. M. Snow, J. Flatow, J. C. Purvis, L. Poplonski, and P. C. Rung. 1991. Elevation of a 78 T cell subset in peripheral blood and synovial fluid of patients with rheumatoid arthritis. Clin. Exp. Immunol. 84:78-82.
33. Klein, J. R., and M. Hamad. 1995. γδ T cells, antigen recognition and intestinal immunity. Immunol. Today 16:108-109.
34. Lim, S. G., A. Cordez, C. A. Lee, M. A. Johnson, C. Elias, and W. Poulter. 1993. Loss of mucosal CD4 lymphocytes is an early feature of HIV infection. Clin. Exp. Immunol. 92:448-454.
35. Lundqvist, C., V. Baranov, S. Teglund, S. Hammarström, and M.-L. Hammarström. 1994. Cytokine profile and ultrastructure of intrapitheual γδ T cells in chronically inflamed human gingiva suggest a cytotoxic effector function. J. Immunol. 153:2302-2312.
36. + peripheral lymphocyte subset. J. Exp. Med. 171:1171-1188.
37. Modlin, R. L., C. Pirmez, F. M. Hofman, V. Torigian, K. Uyemura, T. H. Rea, B. R. Bloom, and M. B. Brenner. 1989. Lymphocytes bearing antigen-specific 78 T-cell receptors accumulate in human infectious disease lesions. Nature (London) 339:544-548.
38. 2-microglohulin in serum of IgA-deficient subjects with or without IgG subclass deficiency. Clin. Exp. Immunol. 94:91-98.
39. Nilssen, D. E., P. Brandtzaeg, S. S. Frøland, and O. Fausa. 1992. Subclass composition and J-chain expression of the 'compensatory' gastrointestinal IgG cell population in selective IgA deficiency. Clin. Exp. Immunol. 87:237-245.
40. Nilssen, D. E., T. S. Halstensen, S. S. Freland, O. Fausa, and P. Brandtzaeg. 1993. Distribution and phenotypes of duodenal intraepithelial γ/δ T cells in patients with various types of primary B-cell deficiency. Clin. Immunol. Immunopathol. 68:301-310.
41. Porcelli, S., M. B. Brenner, and H. Band. 1991. Biology of the human 78 T-cell receptor. Immunol. Rev. 120:137-183.
42. Roussilhon, C., M. Agrapart, J.-J. Ballet, and A. Bensussan. 1990. T lymphocytes bearing the γδ T cell receptor in patients with acute Plasmodium falcipanim malaria. J. Infect. Dis. 162:283-285.
43. Selby, W. S., G. Janossy, M. Bofill, and D. P. Jewell. 1983. Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease. Clin. Exp. Immunol. 52:219-228.
44. Spencer, J., P. G. Isaacson, T. C. Diss, and T. T. MacDonald. 1989. Expression of disulfide-linked and non-disulfide-linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes. Eur. J. Immunol. 19:1335-1338.
45. Strannegård, Ö., J. Björkander, K. Hellstrand, A. Pacsa, S. Hermodsson, and L. A. Hanson. 1987. Interferon and β2-microglohulin in patients with common variable immunodeficiency or selective IgA deficiency. Int. Arch. Allergy Appl. Immunol. 84:217-222.
46. Strominger, J. 1989. The γ/δ T cell receptor and class 1b MHC-related proteins: enigmatic molecules of immune recognition. Cell 57:895-898.
47. Ullrich, R., M. Zeitz, W. Heise, M. L'Age, K. Ziegler, C. Bergs, and E. O. Riecken. 1990. Mucosal atrophy is associated with loss of activated T cells in the duodenal mucosa of human immunodeficiency virus (HIV)-infected patients. Digestion 46:302-307.
48. Van Dongen, J. J. M., R. de Groot, W. M. Comans-Bitter, and H. J. Neijens. 1991. T cell receptor 78 expression in healthy children and children with ataxia telangiectasia, p. 305-306. In H. M. Chapel, R. J. Levinsky, A. D. B. Webster (ed.), Progress in immune deficiency III. Royal Society of Medicine Services Ltd., London.
49. Van Kerckhove, C., G. J. Russell, K. Deusch, K. Reich, A. K. Bhan, H. DerSimonian, and M. B. Brenner. 1992. Oligoclonality of human intestinal intraepithelial T cells. J. Exp. Med. 175:57-63.
50. Vecchi, M., L. Crosti, E. Berti, D. Agape, A. Cerri, and R. De Franchis. 1992. Increased jejunal intraepithelial lymphocytes bearing γ/δ T-cell receptor in dermatitis herpetiformis. Gastroenterology 102:1499-1505.
51. Wachter, H., D. Fuchs, A. Hausen, G. Reibnegger, and E. R. Werner. 1989. Neopterin as a marker for activation of cellular immunity: immunologic basis and clinical application. Adv. Clin. Chem. 27:81-141.