메뉴 건너뛰기




Volumn 46, Issue 1, 2012, Pages 410-418

Measuring in vitro biotransformation rates of super hydrophobic chemicals in rat liver S9 fractions using thin-film sorbent-phase dosing

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MATRIXES; COMMERCIAL CHEMICALS; DOSING SYSTEMS; ENVIRONMENTAL BEHAVIOR; ETHYLENE VINYL ACETATES; HYDROPHOBIC CHEMICALS; IN-VITRO; PROTEIN CONCENTRATIONS; PROTEIN CONTENTS; RAT LIVERS; SOLVENT FREE; SUBSTRATE CONCENTRATIONS; SUPERHYDROPHOBIC;

EID: 84855313371     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es203338h     Document Type: Article
Times cited : (18)

References (49)
  • 1
    • 33847026208 scopus 로고    scopus 로고
    • A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms
    • Arnot, J. A.; Gobas, F. A. P. C. A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms Environ. Rev. 2006, 14, 257-297
    • (2006) Environ. Rev. , vol.14 , pp. 257-297
    • Arnot, J.A.1    Gobas, F.A.P.C.2
  • 2
    • 77249087741 scopus 로고    scopus 로고
    • Use of quantitative structure activity relationships (QSARs) in the categorization of discrete organic substances on Canada's Domestic Substances List (DSL)
    • Robinson, P.; MacDonald, D.; Davidson, N.; Okonski, A.; Sene, A. Use of quantitative structure activity relationships (QSARs) in the categorization of discrete organic substances on Canada's Domestic Substances List (DSL) Environ. Inf. Arch 2004, 2, 122-130
    • (2004) Environ. Inf. Arch , vol.2 , pp. 122-130
    • Robinson, P.1    MacDonald, D.2    Davidson, N.3    Okonski, A.4    Sene, A.5
  • 4
    • 34447503810 scopus 로고    scopus 로고
    • Food web-specific biomagnification of persistent organic pollutants
    • Kelly, B. C.; Ikonomou, M. G.; Blair, J. D.; Morin, A. E.; Gobas, F. A. P. C. Food web-specific biomagnification of persistent organic pollutants Science 2007, 317, 236-239
    • (2007) Science , vol.317 , pp. 236-239
    • Kelly, B.C.1    Ikonomou, M.G.2    Blair, J.D.3    Morin, A.E.4    Gobas, F.A.P.C.5
  • 6
    • 33747630506 scopus 로고    scopus 로고
    • In-vitro-in-vivo extrapolation of quantitative hepatic biotransformation data for fish-I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models
    • Nichols, J. W.; Schultz, I. R.; Fitzsimmons, P. N. In-vitro-in-vivo extrapolation of quantitative hepatic biotransformation data for fish-I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models Aquat. Toxicol. 2006, 78, 74-90
    • (2006) Aquat. Toxicol. , vol.78 , pp. 74-90
    • Nichols, J.W.1    Schultz, I.R.2    Fitzsimmons, P.N.3
  • 7
    • 34248207703 scopus 로고    scopus 로고
    • Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykis s) and rat and its application in bioaccumulation assessment
    • Han, X.; Nabb, D. L.; Mingoia, R. T.; Yang, C. H. Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykis s) and rat and its application in bioaccumulation assessment Environ. Sci. Technol. 2007, 41, 3269-3276
    • (2007) Environ. Sci. Technol. , vol.41 , pp. 3269-3276
    • Han, X.1    Nabb, D.L.2    Mingoia, R.T.3    Yang, C.H.4
  • 8
    • 44149100223 scopus 로고    scopus 로고
    • In vitro biotransformation of surfactants in fish. Part I: Linear alkylbenzene sulfonate (C12-LAS) and alcohol ethoxylate (C13EO8)
    • Dyer, S. D.; Bernhard, M. J.; Cowan-Ellsberry, C.; Perdu-Durand, E.; Demmerle, S.; Cravedi, J. P. In vitro biotransformation of surfactants in fish. Part I: Linear alkylbenzene sulfonate (C12-LAS) and alcohol ethoxylate (C13EO8) Chemosphere. 2008, 72, 850-862
    • (2008) Chemosphere. , vol.72 , pp. 850-862
    • Dyer, S.D.1    Bernhard, M.J.2    Cowan-Ellsberry, C.3    Perdu-Durand, E.4    Demmerle, S.5    Cravedi, J.P.6
  • 10
    • 66649121198 scopus 로고    scopus 로고
    • Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): Comparison of basal-level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment
    • Han, X.; Nabb, D. L.; Yang, C. H.; Snajdr, S. I.; Mingoia, R. T. Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): Comparison of basal-level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment Environ. Toxicol. Chem. 2009, 28, 481-488
    • (2009) Environ. Toxicol. Chem. , vol.28 , pp. 481-488
    • Han, X.1    Nabb, D.L.2    Yang, C.H.3    Snajdr, S.I.4    Mingoia, R.T.5
  • 11
    • 79960496457 scopus 로고    scopus 로고
    • Protein and lipid binding parameters in rainbow trout (Oncorhynchus mykiss) blood and liver fractions to extrapolate from an in vitro metabolic degradation assay to in vivo bioaccumulation potential of hydrophobic organic chemicals
    • Escher, B. I.; Cowan-Ellsberry, C. E.; Dyer, S.; Embry, M. R.; Erhardt, S.; Halder, M.; Kwon, J. H.; Johanning, K.; Oosterwijk, M. T. T.; Rutishauser, S.; Segner, H.; Nichols, J. Protein and lipid binding parameters in rainbow trout (Oncorhynchus mykiss) blood and liver fractions to extrapolate from an in vitro metabolic degradation assay to in vivo bioaccumulation potential of hydrophobic organic chemicals Chem. Res. Toxicol. 2011, 24, 1134-1143
    • (2011) Chem. Res. Toxicol. , vol.24 , pp. 1134-1143
    • Escher, B.I.1    Cowan-Ellsberry, C.E.2    Dyer, S.3    Embry, M.R.4    Erhardt, S.5    Halder, M.6    Kwon, J.H.7    Johanning, K.8    Oosterwijk, M.T.T.9    Rutishauser, S.10    Segner, H.11    Nichols, J.12
  • 12
    • 71549140069 scopus 로고    scopus 로고
    • Optimization of an isolated perfused rainbow trout liver model: Clearance studies with 7-ethoxycoumarin
    • Nichols, J. W.; Hoffman, A. D.; Fitzsimmons, P. N. Optimization of an isolated perfused rainbow trout liver model: Clearance studies with 7-ethoxycoumarin Aquat. Toxicol. 2009, 95, 182-194
    • (2009) Aquat. Toxicol. , vol.95 , pp. 182-194
    • Nichols, J.W.1    Hoffman, A.D.2    Fitzsimmons, P.N.3
  • 13
    • 0017335453 scopus 로고
    • Prediction of hepatic extraction ratio from in-vitro measurement of intrinsic clearance
    • Rane, A.; Wilkinson, G. R.; Shand, D. G. Prediction of hepatic extraction ratio from in-vitro measurement of intrinsic clearance J.Pharmacol. Exp. Ther. 1977, 200, 420-424
    • (1977) J.Pharmacol. Exp. Ther. , vol.200 , pp. 420-424
    • Rane, A.1    Wilkinson, G.R.2    Shand, D.G.3
  • 14
    • 0028342648 scopus 로고
    • Utility of in-vitro drug metabolism data in predicting in-vivo metabolic clearance
    • Houston, J. B. Utility of in-vitro drug metabolism data in predicting in-vivo metabolic clearance Biochem. Pharmacol. 1994, 47, 1469-1479
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 1469-1479
    • Houston, J.B.1
  • 15
    • 0032733974 scopus 로고    scopus 로고
    • Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in-vitro half-life approach and nonspecific binding to microsomes
    • Obach, R. S. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in-vitro half-life approach and nonspecific binding to microsomes Drug Metab. Dispos. 1999, 27, 1350-1359
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 1350-1359
    • Obach, R.S.1
  • 16
    • 4143108324 scopus 로고    scopus 로고
    • Substrate depletion approach for determining in-vitro metabolic clearance: Time dependencies in hepatocyte and microsomal incubations
    • Jones, H. M.; Houston, J. B. Substrate depletion approach for determining in-vitro metabolic clearance: Time dependencies in hepatocyte and microsomal incubations Drug Metab. Dispos. 2004, 32, 973-982
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 973-982
    • Jones, H.M.1    Houston, J.B.2
  • 17
    • 33646421123 scopus 로고    scopus 로고
    • Predictions of the in-vivo clearance of drugs from rate of loss using human liver microsomes for phase i and phase II biotransformations
    • Mohutsky, M. A.; Chien, J. Y.; Ring, B. J.; Wrighton, S. A. Predictions of the in-vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations Pharm. Res. 2006, 23, 654-662
    • (2006) Pharm. Res. , vol.23 , pp. 654-662
    • Mohutsky, M.A.1    Chien, J.Y.2    Ring, B.J.3    Wrighton, S.A.4
  • 18
    • 0015387181 scopus 로고
    • Some problems in Michaelis-Menten kinetic analysis of benzpyrene hydroxylase in hepatic microsomes from polycyclic hydrocarbon-pretreated animals
    • Hansen, A. R.; Fouts, J. R. Some problems in Michaelis-Menten kinetic analysis of benzpyrene hydroxylase in hepatic microsomes from polycyclic hydrocarbon-pretreated animals Chem. Biol. Interact. 1972, 5, 167-182
    • (1972) Chem. Biol. Interact. , vol.5 , pp. 167-182
    • Hansen, A.R.1    Fouts, J.R.2
  • 20
    • 0016426608 scopus 로고
    • Relationship between fluorescence and conformation of eNAD+ bound to dehydrogenases
    • Luisi, P. L.; Baici, A.; Bonner, F. J; Aboderin, A. A. Relationship between fluorescence and conformation of eNAD+ bound to dehydrogenases Biochemistry 1975, 14, 362-368
    • (1975) Biochemistry , vol.14 , pp. 362-368
    • Luisi, P.L.1    Baici, A.2    Bonner, F.J.3    Aboderin, A.A.4
  • 21
    • 67349172147 scopus 로고    scopus 로고
    • Development of a dynamic delivery method for in-vitro bioassays
    • Kwon, J. H.; Wuethrich, T.; Mayer, P.; Escher, B. I. Development of a dynamic delivery method for in-vitro bioassays Chemosphere 2009, 76, 83-90
    • (2009) Chemosphere , vol.76 , pp. 83-90
    • Kwon, J.H.1    Wuethrich, T.2    Mayer, P.3    Escher, B.I.4
  • 22
    • 0035146956 scopus 로고    scopus 로고
    • Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes
    • Easterbrook, J.; Lu, C.; Sakai, Y.; Li, A. P. Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes Drug Metab. Dispos. 2001, 29, 141-144
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 141-144
    • Easterbrook, J.1    Lu, C.2    Sakai, Y.3    Li, A.P.4
  • 23
    • 0031921010 scopus 로고    scopus 로고
    • Evaluation of the selectivity of in-vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities
    • Hickman, D.; Wang, J. P.; Wang, Y.; Unadkat, J. D. Evaluation of the selectivity of in-vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities Drug Metab. Dispos. 1998, 26, 207-215
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 207-215
    • Hickman, D.1    Wang, J.P.2    Wang, Y.3    Unadkat, J.D.4
  • 24
    • 78049388321 scopus 로고    scopus 로고
    • Effect of regular organic solvents on cytochrome P450-mediated metabolic activities in rat liver microsomes
    • Li, D.; Han, Y.; Meng, X.; Sun, X.; Yu, Q.; Li, Y.; Wan, L.; Huo, Y.; Guo, C. Effect of regular organic solvents on cytochrome P450-mediated metabolic activities in rat liver microsomes Drug Metab. Dispos. 2010, 38, 1922-1925
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 1922-1925
    • Li, D.1    Han, Y.2    Meng, X.3    Sun, X.4    Yu, Q.5    Li, Y.6    Wan, L.7    Huo, Y.8    Guo, C.9
  • 25
    • 0033168907 scopus 로고    scopus 로고
    • Establishing and controlling dissolved concentrations of hydrophobic organics by partitioning from a solid phase
    • Mayer, P.; Wernsing, J.; Tolls, J.; de Maagd, P. G. J.; Sijm, D. T. H. M. Establishing and controlling dissolved concentrations of hydrophobic organics by partitioning from a solid phase Environ. Sci. Technol. 1999, 33, 2284-2290
    • (1999) Environ. Sci. Technol. , vol.33 , pp. 2284-2290
    • Mayer, P.1    Wernsing, J.2    Tolls, J.3    De Maagd, P.G.J.4    Sijm, D.T.H.M.5
  • 26
    • 0035887812 scopus 로고    scopus 로고
    • Partition controlled delivery of hydrophobic substances in toxicity tests using poly(dimethylsiloxane) (PDMS) films
    • Brown, R. S.; Akhtar, P.; Akerman, J.; Hampel, L.; Kozin, I. S.; Villerius, L. A.; Klamer, H. J. C. Partition controlled delivery of hydrophobic substances in toxicity tests using poly(dimethylsiloxane) (PDMS) films Environ. Sci. Technol. 2001, 35, 4097-4102
    • (2001) Environ. Sci. Technol. , vol.35 , pp. 4097-4102
    • Brown, R.S.1    Akhtar, P.2    Akerman, J.3    Hampel, L.4    Kozin, I.S.5    Villerius, L.A.6    Klamer, H.J.C.7
  • 27
    • 0037955749 scopus 로고    scopus 로고
    • Partition-controlled delivery of toxicants: A novel in-vivo approach for embryo toxicity testing
    • Kiparissis, Y.; Akhtar, P.; Hodson, P. V.; Brown, R. S. Partition-controlled delivery of toxicants: A novel in-vivo approach for embryo toxicity testing Environ. Sci. Technol. 2003, 37, 2262-2266
    • (2003) Environ. Sci. Technol. , vol.37 , pp. 2262-2266
    • Kiparissis, Y.1    Akhtar, P.2    Hodson, P.V.3    Brown, R.S.4
  • 28
    • 54749136995 scopus 로고    scopus 로고
    • Passive dosing of soil invertebrates with polycyclic aromatic hydrocarbons: Limited chemical activity explains toxicity cutoff
    • Mayer, P.; Holmstrup, M. Passive dosing of soil invertebrates with polycyclic aromatic hydrocarbons: Limited chemical activity explains toxicity cutoff Environ. Sci. Technol. 2008, 42, 7516-7521
    • (2008) Environ. Sci. Technol. , vol.42 , pp. 7516-7521
    • Mayer, P.1    Holmstrup, M.2
  • 29
    • 75149178322 scopus 로고    scopus 로고
    • Passive dosing for producing defined and constant exposure of hydrophobic organic compounds during in-vitro toxicity tests
    • Smith, K. E. C.; Oostingh, G. J.; Mayer, P. Passive dosing for producing defined and constant exposure of hydrophobic organic compounds during in-vitro toxicity tests Chem. Res. Toxicol. 2010, 23, 55-65
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 55-65
    • Smith, K.E.C.1    Oostingh, G.J.2    Mayer, P.3
  • 31
    • 0036891948 scopus 로고    scopus 로고
    • The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties
    • Austin, R. P.; Barton, P.; Cockroft, S. L.; Wenlock, M. C.; Riley, R. J. The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties Drug Metab. Dispos. 2002, 30, 1497-1503
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1497-1503
    • Austin, R.P.1    Barton, P.2    Cockroft, S.L.3    Wenlock, M.C.4    Riley, R.J.5
  • 32
    • 23944451585 scopus 로고    scopus 로고
    • A unified model for predicting human hepatic, metabolic clearance from in-vitro intrinsic clearance data in hepatocytes and microsomes
    • Riley, R. J.; McGinnity, D. F.; Austin, R. P. A unified model for predicting human hepatic, metabolic clearance from in-vitro intrinsic clearance data in hepatocytes and microsomes Drug Metab. Dispos. 2005, 33, 1304-1311
    • (2005) Drug Metab. Dispos. , vol.33 , pp. 1304-1311
    • Riley, R.J.1    McGinnity, D.F.2    Austin, R.P.3
  • 33
  • 34
    • 40849096159 scopus 로고    scopus 로고
    • Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations
    • Gertz, M.; Kilford, P. J.; Houston, J. B.; Galetin, A. Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations Drug Metab. Dispos. 2008, 36, 535-542
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 535-542
    • Gertz, M.1    Kilford, P.J.2    Houston, J.B.3    Galetin, A.4
  • 35
    • 43649103530 scopus 로고    scopus 로고
    • A fugacity approach for assessing the bioaccumulation of hydrophobic organic compounds from estuarine sediment
    • Golding, C. J.; Gobas, F. A. P. C; Birch, G. E. A fugacity approach for assessing the bioaccumulation of hydrophobic organic compounds from estuarine sediment Environ. Toxicol. Chem. 2008, 27, 1047-1054
    • (2008) Environ. Toxicol. Chem. , vol.27 , pp. 1047-1054
    • Golding, C.J.1    Gobas, F.A.P.C.2    Birch, G.E.3
  • 36
    • 61349198771 scopus 로고    scopus 로고
    • Assessing exposure of sediment biota to organic contaminants by thin-film solid phase extraction
    • Meloche, L. M.; deBruyn, A. M. H.; Otton, S. V.; Ikonomou, M. G.; Gobas, F. A. P. C Assessing exposure of sediment biota to organic contaminants by thin-film solid phase extraction Environ. Toxicol. Chem. 2009, 28, 247-253
    • (2009) Environ. Toxicol. Chem. , vol.28 , pp. 247-253
    • Meloche, L.M.1    Debruyn, A.M.H.2    Otton, S.V.3    Ikonomou, M.G.4    Gobas, F.A.P.C.5
  • 37
    • 34547092951 scopus 로고    scopus 로고
    • Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems
    • Van, L. M.; Hargreaves, J. A.; Lennard, M. S.; Tucker, G. T.; Rostami-Hodjegan, A. Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems Eur. J. Pharm. Sci. 2007, 32, 8-16
    • (2007) Eur. J. Pharm. Sci. , vol.32 , pp. 8-16
    • Van, L.M.1    Hargreaves, J.A.2    Lennard, M.S.3    Tucker, G.T.4    Rostami-Hodjegan, A.5
  • 40
    • 0014411520 scopus 로고
    • Differences in kinetics of benzpyrene hydroxylation by hepatic drug-metabolizing enzymes from phenobarbital and 3-methylcholanthrene-treated rats
    • Alvares, A. P.; Schilling, G. R.; Kuntzman, R. Differences in kinetics of benzpyrene hydroxylation by hepatic drug-metabolizing enzymes from phenobarbital and 3-methylcholanthrene-treated rats Biochem. Biophys. Res. Commun. 1968, 30, 588-593
    • (1968) Biochem. Biophys. Res. Commun. , vol.30 , pp. 588-593
    • Alvares, A.P.1    Schilling, G.R.2    Kuntzman, R.3
  • 41
    • 0015751048 scopus 로고
    • Properties of benzpyrene hydroxylase in liver, intestinal-mucosa and adrenal of untreated and 3-methylcholanthrene-treated rats
    • Zampaglione, N. G.; Mannering, G. J. Properties of benzpyrene hydroxylase in liver, intestinal-mucosa and adrenal of untreated and 3-methylcholanthrene- treated rats J. Pharmacol. Exp. Ther. 1973, 185, 676-685
    • (1973) J. Pharmacol. Exp. Ther. , vol.185 , pp. 676-685
    • Zampaglione, N.G.1    Mannering, G.J.2
  • 42
    • 0025719330 scopus 로고
    • The use of 2,4,5,2′,4′,5′-hexachlorobiphenyl (6-CB) as an unmetabolizable lipophilic model-compound
    • Muhlebach, S.; Wyss, P. A.; Bickel, M. H. The use of 2,4,5,2′, 4′,5′-hexachlorobiphenyl (6-CB) as an unmetabolizable lipophilic model-compound Pharmacol. Toxicol. 1991, 69, 410-415
    • (1991) Pharmacol. Toxicol. , vol.69 , pp. 410-415
    • Muhlebach, S.1    Wyss, P.A.2    Bickel, M.H.3
  • 43
    • 0018564937 scopus 로고
    • Inhibition of benzo(a)pyrene and benzo(a)pyrene 7,8-dihydrodiol metabolism by benzo(a)pyrene quinones
    • Shen, A. L.; Fahl, W. E.; Wrighton, S. A.; Jefcoate, C. R. Inhibition of benzo(a)pyrene and benzo(a)pyrene 7,8-dihydrodiol metabolism by benzo(a)pyrene quinones Cancer Res. 1979, 39, 4123-4129
    • (1979) Cancer Res. , vol.39 , pp. 4123-4129
    • Shen, A.L.1    Fahl, W.E.2    Wrighton, S.A.3    Jefcoate, C.R.4
  • 44
    • 0020403845 scopus 로고
    • The kinetics of benzo(a)pyrene anti-7,8-dihydrodiol 9,10-epoxide formation from benzo(a)pyrene and regulatory membrane effects
    • Fahl, W. E. The kinetics of benzo(a)pyrene anti-7,8-dihydrodiol 9,10-epoxide formation from benzo(a)pyrene and regulatory membrane effects Arch. Biochem. Biophys. 1982, 216, 581-592
    • (1982) Arch. Biochem. Biophys. , vol.216 , pp. 581-592
    • Fahl, W.E.1
  • 45
    • 0019966037 scopus 로고
    • Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene-induced rat-liver microsomes
    • Keller, G. M.; Turner, C. R.; Jefcoate, C. R. Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene- induced rat-liver microsomes Mol. Pharmacol. 1982, 22, 451-458
    • (1982) Mol. Pharmacol. , vol.22 , pp. 451-458
    • Keller, G.M.1    Turner, C.R.2    Jefcoate, C.R.3
  • 46
    • 0035213044 scopus 로고    scopus 로고
    • Two-phase partitioning bioreactors in fermentation technology
    • Malinowski, J. J. Two-phase partitioning bioreactors in fermentation technology Biotechnol. Adv. 2001, 19, 525-538
    • (2001) Biotechnol. Adv. , vol.19 , pp. 525-538
    • Malinowski, J.J.1
  • 48
    • 0034827302 scopus 로고    scopus 로고
    • Influence of microsomal concentration on apparent intrinsic clearance: Implications for scaling in vitro data
    • Kalvass, J. C.; Tess, D. A.; Giragossian, C.; Linhares, M. C.; Maurer, T. S. Influence of microsomal concentration on apparent intrinsic clearance: Implications for scaling in vitro data Drug Metab. Dispos. 2001, 29, 1332-1336
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1332-1336
    • Kalvass, J.C.1    Tess, D.A.2    Giragossian, C.3    Linhares, M.C.4    Maurer, T.S.5
  • 49
    • 0038515137 scopus 로고    scopus 로고
    • Quantitative structure activity relationships for predicting the bioaccumulation of POPs in terrestrial food-webs
    • Gobas, F. A. P. C; Kelly, B. C.; Arnot, J. A. Quantitative structure activity relationships for predicting the bioaccumulation of POPs in terrestrial food-webs QSAR Comb. Sci. 2003, 22, 329-336
    • (2003) QSAR Comb. Sci. , vol.22 , pp. 329-336
    • Gobas, F.A.P.C.1    Kelly, B.C.2    Arnot, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.