Neutralization of LINGO-1 during in vitro differentiation of neural stem cells results in proliferation of immature neurons

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Lööv, Camilla ^a   Fernqvist, Maria ^a   Walmsley, Adrian ^b   Marklund, Niklas ^a   Erlandsson, Anna ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; BETAIII TUBULIN; MEMBRANE PROTEIN; NOGO 66 RECEPTOR INTERACTING PROTEIN 1; UNCLASSIFIED DRUG; LINGO1 PROTEIN, MOUSE; NERVE PROTEIN; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL DIVISION; CELL LEVEL; CELL MATURATION; CELL PROLIFERATION; CELL SHAPE; CELL TYPE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO DEVELOPMENT; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEURAL STEM CELL; NEUROBLAST; NONHUMAN; PROTEIN LOCALIZATION; ANIMAL; C57BL MOUSE; CELL COUNT; CELL DIFFERENTIATION; CELL SURVIVAL; CYTOLOGY; GENE EXPRESSION REGULATION; HUMAN; IMMUNOLOGY; METABOLISM; NERVE CELL;

ANIMALS; ANTIBODIES, NEUTRALIZING; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; NEURONS;

EID: 84855312691     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029771     Document Type: Article

References (44)

1. Gritti A, Parati EA, Cova L, Frolichsthal P, Galli R, et al. (1996) Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor. J Neurosci 16: 1091-1100.
2. Johe KK, Hazel TG, Muller T, Dugich-Djordjevic MM, McKay RD, (1996) Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev 10: 3129-3140.
3. Doetsch F, Petreanu L, Caille I, Garcia-Verdugo JM, Alvarez-Buylla A, (2002) EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 36: 1021-1034.
4. Reynolds BA, Weiss S, (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255: 1707-1710.
5. Androutsellis-Theotokis A, Leker RR, Soldner F, Hoeppner DJ, Ravin R, et al. (2006) Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442: 823-826.
6. Lai K, Kaspar BK, Gage FH, Schaffer DV, (2003) Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci 6: 21-27.
7. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, et al. (1997) Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278: 477-483.
8. Glaser T, Perez-Bouza A, Klein K, Brustle O, (2005) Generation of purified oligodendrocyte progenitors from embryonic stem cells. Faseb J 19: 112-114.
9. Hirabayashi Y, Itoh Y, Tabata H, Nakajima K, Akiyama T, et al. (2004) The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development 131: 2791-2801.
10. Muroyama Y, Kondoh H, Takada S, (2004) Wnt proteins promote neuronal differentiation in neural stem cell culture. Biochem Biophys Res Commun 313: 915-921.
11. Pozniak CD, Pleasure SJ, (2006) A tale of two signals: Wnt and Hedgehog in dentate neurogenesis. Sci STKE 2006: pe5.
12. Lie DC, Colamarino SA, Song HJ, Desire L, Mira H, et al. (2005) Wnt signalling regulates adult hippocampal neurogenesis. Nature 437: 1370-1375.
13. Munji RN, Choe Y, Li G, Siegenthaler JA, Pleasure SJ, (2011) Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors. J Neurosci 31: 1676-1687.
14. Panhuysen M, Vogt Weisenhorn DM, Blanquet V, Brodski C, Heinzmann U, et al. (2004) Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region. Mol Cell Neurosci 26: 101-111.
15. Erlandsson A, Enarsson M, Forsberg-Nilsson K, (2001) Immature neurons from CNS stem cells proliferate in response to platelet-derived growth factor. J Neurosci 21: 3483-3491.
16. Erlandsson A, Morshead CM, (2006) Exploiting the properties of adult stem cells for the treatment of disease. Curr Opin Mol Ther 8: 331-337.
17. Erlandsson A, Brannvall K, Gustafsdottir S, Westermark B, Forsberg-Nilsson K, (2006) Autocrine/Paracrine platelet-derived growth factor regulates proliferation of neural progenitor cells. Cancer Res 66: 8042-8048.
18. Mi S, Lee X, Shao Z, Thill G, Ji B, et al. (2004) LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci 7: 221-228.
19. Ji B, Li M, Wu WT, Yick LW, Lee X, et al. (2006) LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury. Mol Cell Neurosci 33: 311-320.
20. Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, et al. (2007) NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. J Neurosci 27: 220-225.
21. Mi S, Hu B, Hahm K, Luo Y, Kam Hui ES, et al. (2007) LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat Med 13: 1228-1233.
22. Zhang Z, Xu X, Zhang Y, Zhou J, Yu Z, et al. (2009) LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension. J Biol Chem 284: 15717-15728.
23. Mi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, et al. (2005) LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci 8: 745-751.
24. Fu QL, Hu B, Wu W, Pepinsky RB, Mi S, et al. (2008) Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection. Invest Ophthalmol Vis Sci 49: 975-985.
25. Llorens F, Gil V, Iraola S, Carim-Todd L, Marti E, et al. (2008) Developmental analysis of Lingo-1/Lern1 protein expression in the mouse brain: interaction of its intracellular domain with Myt1l. Dev Neurobiol 68: 521-541.
26. Mathis C, Schroter A, Thallmair M, Schwab ME, (2010) Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cereb Cortex 20: 2380-2390.
27. Satoh J, Tabunoki H, Yamamura T, Arima K, Konno H, (2007) TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. Neuropathol Appl Neurobiol 33: 99-107.
28. Inoue H, Lin L, Lee X, Shao Z, Mendes S, et al. (2007) Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A 104: 14430-14435.
29. Mi S, Miller RH, Tang W, Lee X, Hu B, et al. (2009) Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells. Ann Neurol 65: 304-315.
30. Llorens F, Gil V, del Rio JA, (2011) Emerging functions of myelin-associated proteins during development, neuronal plasticity, and neurodegeneration. FASEB J 25: 463-475.
31. Mi S, (2008) Troy/Taj and its role in CNS axon regeneration. Cytokine Growth Factor Rev 19: 245-251.
32. Rudick RA, Mi S, Sandrock AW Jr, (2008) LINGO-1 antagonists as therapy for multiple sclerosis: in vitro and in vivo evidence. Expert Opin Biol Ther 8: 1561-1570.
33. Walmsley AR, Mir AK, (2007) Targeting the Nogo-A signalling pathway to promote recovery following acute CNS injury. Curr Pharm Des 13: 2470-2484.
34. Mi S, Sandrock A, Miller RH, (2008) LINGO-1 and its role in CNS repair. Int J Biochem Cell Biol 40: 1971-1978.
35. Lv J, Xu RX, Jiang XD, Lu X, Ke YQ, et al. (2010) Passive immunization with LINGO-1 polyclonal antiserum afforded neuroprotection and promoted functional recovery in a rat model of spinal cord injury. Neuroimmunomodulation 17: 270-278.
36. Bandtlow C, Dechant G, (2004) From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits. Sci STKE 2004: pe24.
37. Hou T, Shi Y, Cheng S, Yang X, Li L, et al. (2010) Nogo-A expresses on neural stem cell surface. Int J Neurosci 120: 201-205.
38. Li X, Fu QL, Jing XL, Liao XX, Zeng AH, et al. (2009) Myelin-associated glycoprotein inhibits the neuronal differentiation of neural progenitors. Neuroreport 20: 708-712.
39. Gao Y, Wang B, Xiao Z, Chen B, Han J, et al. (2010) Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells. Stem Cells Dev 19: 53-60.
40. Wang B, Xiao Z, Chen B, Han J, Gao Y, et al. (2008) Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway. PLoS One 3: e1856.
41. Gao Y, Xiao Z, Chen B, Wang B, Han J, et al. (2009) Effect of different regions of Nogo-A on the differentiation of neural progenitors. Neurosci Lett 458: 132-135.
42. Martin I, Andres CR, Vedrine S, Tabagh R, Michelle C, et al. (2009) Effect of the oligodendrocyte myelin glycoprotein (OMgp) on the expansion and neuronal differentiation of rat neural stem cells. Brain Res 1284: 22-30.
43. Bai Y, Markham K, Chen F, Weerasekera R, Watts J, et al. (2008) The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics 7: 15-34.
44. Bourikas D, Mir A, Walmsley AR, (2010) LINGO-1-mediated inhibition of oligodendrocyte differentiation does not require the leucine-rich repeats and is reversed by p75(NTR) antagonists. Mol Cell Neurosci 45: 363-369.