LINGO-1-mediated inhibition of oligodendrocyte differentiation does not require the leucine-rich repeats and is reversed by p75NTR antagonists

Molecular and Cellular Neuroscience

Volumn 45, Issue 4, 2010, Pages 363-369

  Bourikas, Dimitris ^a   Mir, Anis ^a   Walmsley, Adrian Robert ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Leucine rich repeats; LINGO 1; Myelin basic protein; Oligodendrocyte differentiation; P75NTR

Indexed keywords

MEMBRANE PROTEIN; MYELIN BASIC PROTEIN; NEUROTROPHIN RECEPTOR P75; PROTEIN LINGO 1; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DEMYELINATING DISEASE; HUMAN; HUMAN CELL; MULTIPLE SCLEROSIS; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DOMAIN; REMYELINIZATION;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELL SEPARATION; FLOW CYTOMETRY; HUMANS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MYELIN BASIC PROTEINS; NERVE TISSUE PROTEINS; OLIGODENDROGLIA; RATS; RECEPTOR, NERVE GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

RATTUS;

EID: 77957969034     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2010.07.009     Document Type: Article

References (26)

1. de Castro F., Bribian A. The molecular orchestra of the migration of oligodendrocyte precursors during development. Brain Res. Rev. 2005, 49:227-241.
2. Dowling P., Ming X., Raval S., Husar W., Casaccia-Bonnefil P., Chao M., Cook S., Blumberg B. Up-regulated p75NTR neurotrophin receptor on glial cells in MS plaques. Neurology 1999, 53:1676-1682.
3. Franklin R.J.M., Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat. Rev. Neurosci. 2008, 9:839-855.
4. Jeffery N.D., Blakemore W.F. Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. Brain 1997, 120:27-37.
5. Ladiwala U., Lachance C., Simoneau S.J., Bhakar A., Barker P.A., Antel J.P. p75 neurotrophin receptor expression on adult human oligodendrocytes: signaling without cell death in response to NGF. J. Neurosci. 1998, 18:1297-1304.
6. Lee X., Yang Z., Shao Z., Rosenberg S.S., Levesque M., Pepinsky R.B., Qiu M., Miller R.H., Chan J.R., Mi S. NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. J. Neurosci. 2007, 27:220-225.
7. Liang X., Draghi N.A., Resh M.D. Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes. J. Neurosci. 2004, 24:7140-7149.
8. Louis J.C., Muir D., Varon S. Autocrine inhibition of mitotic activity in cultured oligodendrocyte-type-2 astrocyte (O-2A) precursor cells. Glia 1992, 6:30-38.
9. Martin R., McFarland H.F., McFarlin D.E. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 1992, 10:153-187.
10. McLaurin J., Trudel G.C., Shaw I.T., Antel J.P., Cashman N.R. A human glial hybrid cell line differentially expressing genes subserving oligodendrocyte and astrocyte phenotype. J. Neurobiol. 1995, 26:283-293.
11. Mi S., Lee X., Shao Z., Thill G., Ji B., Relton J., Levesque M., Allaire N., Perrin S., Sands B., Crowell T., Cate R.L., McCoy J.M., Pepinsky R.B. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat. Neurosci. 2004, 7:221-228.
12. Mi S., Miller R.H., Lee X., Scott M.L., Shulag-Morskaya S., Shao Z., Chang J., Thill G., Levesque M., Zhang M., Hession C., Sah D., Trapp B., He Z., Jung V., McCoy J.M., Pepinsky R.B. LINGO-1 negatively regulates myelination by oligodendrocytes. Nat. Neurosci. 2005, 8:745-751.
13. Mi S., Hu B., Hahm K., Luo Y., Kam Hui E.S., Yuan Q., Wong W.M., Wang L., Su H., Chu T.H., Guo J., Zhang W., So K.F., Pepinsky B., Shao Z., Graff C., Garber E., Jung V., Wu E.X., Wu W. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat. Med. 2007, 13:1228-12233.
14. Mi S., Miller R.H., Tang W., Lee X., Hu B., Wu W., Zhang Y., Shields C.B., Zhang Y., Miklasz S., Shea D., Mason J., Franklin R.J., Ji B., Shao Z., Chédotal A., Bernard F., Roulois A., Xu J., Jung V., Pepinsky B. Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells. Ann. Neurol. 2009, 65:304-315.
15. Mosyak L., Wood A., Dwyer B., Buddha M., Johnson M., Aulabaugh A., Zhong X., Presman E., Benard S., Kelleher K., Wilhelm J., Stahl M.L., Kriz R., Gao Y., Cao Z., Ling H.P., Pangalos M.N., Walsh F.S., Somers W.S. The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. J. Biol. Chem. 2006, 281:36378-36390.
16. Park J.B., Yiu G., Kaneko S., Wang J., Chang J., He X.L., Garcia K.C., He Z. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron 2005, 45:345-351.
17. Patrikios P., Stadelmann C., Kutzelnigg A., Rauschka H., Schmidbauer M., Laursen H., Sorensen P.S., Brück W., Lucchinetti C., Lassmann H. Remyelination is extensive in a subset of multiple sclerosis patients. Brain 2006, 129:3165-3172.
18. Pignot V., Hein A.E., Barske C, Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J. Neurochem. 2003, 85:717-728.
19. Shao Z., Browning J.L., Lee X., Scott M.L., Shulga-Morskaya S., Allaire N., Thill G., Levesque M., Sah D., McCoy J.M., Murray B., Jung V., Pepinsky R.B., Mi S. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron 2005, 45:353-359.
20. Smith K.J., Blakemore W.F., McDonald W.I. Central remyelination restores secure conduction. Nature 1979, 280:395-396.
21. Umemori H., Kadowaki Y., Hirosawa K., Yoshida Y., Hironaka K., Okano H., Yamamoto T. Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination. J. Neurosci. 1999, 19:1393-1397.
22. Wang K.C., Kim J.A., Sivasankaran R., Segal R., He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 2002, 420:74-78.
23. White R., Gonsior C., Krämer-Albers E.M., Stöhr N., Hüttelmaier S., Trotter J. Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granules. J. Cell Biol. 2008, 181:579-586.
24. Wolf R.M., Wilkes J.J., Chao M.V., Resh M.D. Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation. J. Neurobiol. 2001, 49:62-78.
25. Wong S.T., Henley J.R., Kanning K.C., Huang K.H., Bothwell M., Poo M.M. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat. Neurosci. 2002, 5:1302-1308.
26. Yamashita T., Tohyama M. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat. Neurosci. 2003, 6:461-467.