Idiopathic REM sleep behavior disorder as a long-term predictor of neurodegenerative disorders

EPMA Journal

Volumn 2, Issue 4, 2011, Pages 451-458

  Fulda, Stephany ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Dementia with Lewy bodies; Long term prediction; Multiple system atrophy; Parkinson's disease; Prevention; REM sleep behavior disorder

Indexed keywords

CLINICAL FEATURE; DEGENERATIVE DISEASE; DIFFUSE LEWY BODY DISEASE; DISEASE ASSOCIATION; DISEASE COURSE; HUMAN; PARASOMNIA; PARKINSON DISEASE; PATIENT ASSESSMENT; PREDICTION; PRIORITY JOURNAL; REM SLEEP; REVIEW; SHY DRAGER SYNDROME;

EID: 84855288174     PISSN: 18785077     EISSN: 18785085     Source Type: Journal    
DOI: 10.1007/s13167-011-0096-8     Document Type: Review

References (89)

1. American Academy of Sleep Medicine. The international classification of sleep disorders: diagnostic and coding manual. 2nd ed. Westchester: American Academy of Sleep Medicine; 2005.
2. Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep. 1986; 9: 293-308.
3. Schenck CH, Lee SA, Bornemann MAC, Mahowald MW. Potentially lethal behaviors associated with rapid eye movement sleep behavior disorder: review of the literature and forensic implications. J Forensic Sci. 2009; 54: 1475-84.
4. Gagnon J-F, Postuma RB, Montplaisir J. Update on the pharmacology of REM sleep behavior disorder. Neurology. 2006; 67: 742-7.
5. Aurora RN, Zak RS, Maganti RK, Auerbach SH, Casey KR, Chowdhuri S, et al. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med. 2010; 6: 85-95.
6. Schuld A, Kraus T, Haack M, Hinze-Selch D, Pollmächer T. Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder. J Sleep Res. 1999; 8: 321-2.
7. Boeve BF, Silber MH, Ferman TJ. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med. 2003; 4: 281-4.
8. Kunz D, Bes F. Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation. Mov Disord. 1999; 14: 507-11.
9. Kunz D, Mahlberg R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J Sleep Res. 2010; 19: 591-6.
10. Iranzo A, Santamaria J, Tolosa E. The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases. Sleep Med Rev. 2009; 13: 385-401.
11. Hoque R, Chesson AL. Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis. J Clin Sleep Med. 2010; 6: 79-83.
12. Morrison I, Frangulyan R, Riha RL. Beta-blockers as a cause of violent rapid eye movement sleep behavior disorder: a poorly recognized but common cause of violent parasomnias. Am J Med. 2011; 124: e11.
13. Teman PT, Tippmann-Peikert M, Silber MH, Slocumb NL, Auger RR. Idiopathic rapid-eye-movement sleep disorder: associations with antidepressants, psychiatric diagnoses, and other factors, in relation to age of onset. Sleep Med. 2009; 10: 60-5.
14. Fantini ML, Postuma RB, Montplaisir J, Ferini-Strambi L. Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder. Brain Res Bull. 2006; 70: 386-90.
15. Miyamoto T, Miyamoto M, Iwanami M, Hirata K. Olfactory dysfunction in Japanese patients with idiopathic REM sleep behavior disorder: comparison of data using the university of Pennsylvania smell identification test and odor stick identification test for Japanese. Mov Disord. 2010; 25: 1524-6.
16. Miyamoto T, Miyamoto M, Iwanami M, Hirata K, Kobayashi M, Nakamura M, et al. Olfactory dysfunction in idiopathic REM sleep behavior disorder. Sleep Med. 2010; 11: 458-61.
17. Miyamoto T, Miyamoto M, Iwanami M, Suzuki K, Inoue Y, Hirata K. Odor identification test as an indicator of idiopathic REM sleep behavior disorder. Mov Disord. 2009; 24: 268-73.
18. Stiasny-Kolster K, Clever S-C, Möller JC, Oertel WH, Mayer G. Olfactory dysfunction in patients with narcolepsy with and without REM sleep behaviour disorder. Brain. 2007; 130: 442-9.
19. Postuma RB, Lang AE, Massicotte-Marquez J, Montplaisir J. Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. Neurology. 2006; 66: 845-51.
20. Ferini-Strambi L, Di Gioia MR, Castronovo V, Oldani A, Zucconi M, Cappa SF. Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): does the idiopathic form of RBD really exist? Neurology. 2004; 62: 41-5.
21. Massicotte-Marquez J, Décary A, Gagnon J-F, Vendette M, Mathieu A, Postuma RB, et al. Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder. Neurology. 2008; 70: 1250-7.
22. Terzaghi M, Sinforiani E, Zucchella C, Zambrelli E, Pasotti C, Rustioni V, et al. Cognitive performance in REM sleep behaviour disorder: a possible early marker of neurodegenerative disease? Sleep Med. 2008; 9: 343-51.
23. Fantini ML, Gagnon J-F, Petit D, Rompré S, Décary A, Carrier J, et al. Slowing of electroencephalogram in rapid eye movement sleep behavior disorder. Ann Neurol. 2003; 53: 774-80.
24. Iranzo A, Isetta V, Molinuevo JL, Serradell M, Navajas D, Farre R, et al. Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorder. Sleep Med. 2011; 11: 534-9.
25. Ferini-Strambi L, Oldani A, Zucconi M, Smirne S. Cardiac autonomic activity during wakefulness and sleep in REM sleep behavior disorder. Sleep. 1996; 19: 367-9.
26. Lanfranchi PA, Fradette L, Gagnon J-F, Colombo R, Montplaisir J. Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder. Sleep. 2007; 30: 1019-25.
27. Postuma RB, Lanfranchi PA, Blais H, Gagnon J-F, Montplaisir JY. Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder. Mov Disord. 2010; 25: 2304-10.
28. Kashihara K, Imamura T, Shinya T. Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease. Parkinsonism Relat Disord. 2010; 16: 252-5.
29. Miyamoto T, Miyamoto M, Inoue Y, Usui Y, Suzuki K, Hirata K. Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Neurology. 2006; 67: 2236-8.
30. Miyamoto T, Miyamoto M, Iwanami M, Hirata K. Cardiac (123)I-MIBG accumulation in Parkinson's disease differs in association with REM sleep behavior disorder. Parkinsonism Relat Disord. 2011; 17: 219-20.
31. Miyamoto T, Miyamoto M, Suzuki K, Nishibayashi M, Iwanami M, Hirata K. 123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder. Sleep. 2008; 31: 717-23.
32. Eisensehr I, Linke R, Noachtar S, Schwarz J, Gildehaus FJ, Tatsch K. Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controls. Brain. 2000; 123: 1155-60.
33. Iwanami M, Miyamoto T, Miyamoto M, Hirata K, Takada E. Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder. Sleep Med. 2010; 11: 361-5.
34. Stockner H, Iranzo A, Seppi K, Serradell M, Gschliesser V, Sojer M, et al. Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder. Mov Disord. 2009; 24: 1906-9.
35. Unger MM, Möller JC, Stiasny-Kolster K, Mankel K, Berg D, Walter U, et al. Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT. Mov Disord. 2008; 23: 596-9.
36. Plazzi G, Corsini R, Provini F, Pierangeli G, Martinelli P, Montagna P, et al. REM sleep behavior disorders in multiple system atrophy. Neurology. 1997; 48: 1094-7.
37. Tachibana N, Kimura K, Kitajima K, Shinde A, Kimura J, Shibasaki H. REM sleep motor dysfunction in multiple system atrophy: with special emphasis on sleep talk as its early clinical manifestation. J Neurol Neurosurg Psychiatr. 1997; 63: 678-81.
38. Iranzo A, Santamaría J, Rye DB, Valldeoriola F, Martí MJ, Muñoz E, et al. Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. Neurology. 2005; 65: 247-52.
39. Köllensperger M, Geser F, Seppi K, Stampfer-Kountchev M, Sawires M, Scherfler C, et al. Red flags for multiple system atrophy. Mov Disord. 2008; 23: 1093-9.
40. Vetrugno R, Provini F, Cortelli P, Plazzi G, Lotti EM, Pierangeli G, et al. Sleep disorders in multiple system atrophy: a correlative video-polysomnographic study. Sleep Med. 2004; 5: 21-30.
41. Olson EJ, Boeve BF, Silber MH. Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain. 2000; 123: 331-9.
42. Gagnon JF, Bédard MA, Fantini ML, Petit D, Panisset M, Rompré S, et al. REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease. Neurology. 2002; 59: 585-9.
43. De Cock VC, Vidailhet M, Leu S, Texeira A, Apartis E, Elbaz A, et al. Restoration of normal motor control in Parkinson's disease during REM sleep. Brain. 2007; 130: 450-6.
44. Wetter TC, Trenkwalder C, Gershanik O, Högl B. Polysomnographic measures in Parkinson's disease: a comparison between patients with and without REM sleep disturbances. Wien Klin Wochenschr. 2001; 113: 249-53.
45. Diederich NJ, Vaillant M, Mancuso G, Lyen P, Tiete J. Progressive sleep "destructuring" in Parkinson's disease. A polysomnographic study in 46 patients. Sleep Med. 2005; 6: 313-8.
46. Kumru H, Santamaria J, Tolosa E, Valldeoriola F, Muñoz E, Marti MJ, et al. Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations. Ann Neurol. 2004; 56: 599-603.
47. Postuma RB, Gagnon JF, Vendette M, Charland K, Montplaisir J. REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features. J Neurol Neurosurg Psychiatr. 2008; 79: 1117-21.
48. Kumru H, Santamaria J, Tolosa E, Iranzo A. Relation between subtype of Parkinson's disease and REM sleep behavior disorder. Sleep Med. 2007; 8: 779-83.
49. Gagnon J-F, Fantini ML, Bédard M-A, Petit D, Carrier J, Rompré S, et al. Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia. Neurology. 2004; 62: 401-6.
50. Vendette M, Gagnon J-F, Décary A, Massicotte-Marquez J, Postuma RB, Doyon J, et al. REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. Neurology. 2007; 69: 1843-9.
51. Iranzo A, Molinuevo JL, Santamaría J, Serradell M, Martí MJ, Valldeoriola F, et al. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol. 2006; 5: 572-7.
52. Boeve BF, Silber MH, Ferman TJ, Lucas JA, Parisi JE. Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Mov Disord. 2001; 16: 622-30.
53. Ferman TJ, Smith GE, Boeve BF, Ivnik RJ, Petersen RC, Knopman D, et al. DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology. 2004; 62: 181-7.
54. Boeve BF, Silber MH, Ferman TJ, Kokmen E, Smith GE, Ivnik RJ, et al. REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. Neurology. 1998; 51: 363-70.
55. Ferman TJ, Boeve BF, Smith GE, Silber MH, Kokmen E, Petersen RC, et al. REM sleep behavior disorder and dementia: cognitive differences when compared with AD. Neurology. 1999; 52: 951-7.
56. Boeve BF, Silber MH, Parisi JE, Dickson DW, Ferman TJ, Benarroch EE, et al. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology. 2003; 61: 40-5.
57. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005; 65: 1863-72.
58. Sforza E, Krieger J, Petiau C. REM sleep behavior disorder: clinical and physiopathological findings. Sleep Med Rev. 1997; 1: 57-69.
59. Weyer A, Minnerop M, Abele M, Klockgether T. REM sleep behavioral disorder in pure autonomic failure (PAF). Neurology. 2006; 66: 608-9.
60. Arnulf I, Merino-Andreu M, Bloch F, Konofal E, Vidailhet M, Cochen V, et al. REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy. Sleep. 2005; 28: 349-54.
61. Gagnon J-F, Petit D, Fantini ML, Rompré S, Gauthier S, Panisset M, et al. REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease. Sleep. 2006; 29: 1321-5.
62. Boeve BF, Lin S-C, Strongosky A, Dickson DW, Wszolek ZK. Absence of rapid eye movement sleep behavior disorder in 11 members of the pallidopontonigral degeneration kindred. Arch Neurol. 2006; 63: 268-72.
63. Gagnon J-F, Postuma RB, Mazza S, Doyon J, Montplaisir J. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurol. 2006; 5: 424-32.
64. Dauvilliers Y, Rompré S, Gagnon J-F, Vendette M, Petit D, Montplaisir J. REM sleep characteristics in narcolepsy and REM sleep behavior disorder. Sleep. 2007; 30: 844-9.
65. Mayer M-E. Motor dyscontrol in sleep of narcoleptic patients (a lifelong development?). J Sleep Res. 1993; 2: 143-8.
66. Nightingale S, Orgill JC, Ebrahim IO, de Lacy SF, Agrawal S, Williams AJ. The association between narcolepsy and REM behavior disorder (RBD). Sleep Med. 2005; 6: 253-8.
67. Schenck CH, Mahowald MW. Motor dyscontrol in narcolepsy: rapid-eye-movement (REM) sleep without atonia and REM sleep behavior disorder. Ann Neurol. 1992; 32: 3-10.
68. Iranzo A, Graus F, Clover L, Morera J, Bruna J, Vilar C, et al. Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis. Ann Neurol. 2006; 59: 178-81.
69. Tan A, Salgado M, Fahn S. Rapid eye movement sleep behavior disorder preceding Parkinson's disease with therapeutic response to levodopa. Mov Disord. 1996; 11: 214-6.
70. Uchiyama M, Isse K, Tanaka K, Yokota N, Hamamoto M, Aida S, et al. Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology. 1995; 45: 709-12.
71. Turner RS, D'Amato CJ, Chervin RD, Blaivas M. The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. Neurology. 2000; 55: 1730-2.
72. Tison F, Wenning GK, Quinn NP, Smith SJ. REM sleep behaviour disorder as the presenting symptom of multiple system atrophy. J Neurol Neurosurg Psychiatr. 1995; 58: 379-80.
73. Schenck CH, Mahowald MW, Anderson ML, Silber MH, Boeve BF, Parisi JE. Lewy body variant of Alzheimer's disease (AD) identified by postmortem ubiquitin staining in a previously reported case of AD associated with REM sleep behavior disorder. Biol Psychiatr. 1997; 42: 527-8.
74. Wright BA, Rosen JR, Buysse DJ, Reynolds CF, Zubenko GS. Shy-Drager syndrome presenting as a REM behavioral disorder. J Geriatr Psychiatry Neurol. 1990; 3: 110-3.
75. Claassen DO, Josephs KA, Ahlskog JE, Silber MH, Tippmann-Peikert M, Boeve BF. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology. 2010; 75: 494-9.
76. Boeve BF, Dickson DW, Olson EJ, Shepard JW, Silber MH, Ferman TJ, et al. Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep Med. 2007; 8: 60-4.
77. Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder. Neurology. 1996; 46: 388-93.
78. Schenck C, Bundlie S, Mahowald M. REM sleep behaviour disorder (RBD) delayed emergence of parkinsonism and/or dementia in 65% of older men initially diagnosed with idiopathic RBD, and an analysis of the maximum and minimum tonic and/or phasic electromyographic abnormalities found during REM sleep. Sleep. 2003; 26(Abstract Suppl): A316.
79. Tippman-Peikert M, Olson EJ, Boeve B, Silber MH. Idiopathic REM sleep behavior disorder: a follow-up of 39 patients. Sleep. 2006; 29(Abstract Suppl): A272.
80. Iranzo A, Molinuevo J, Santamaria J, Serradell M, Marti M, Valledeoriola F, et al. Sixty-four percent of patients with idiopathic REM sleep behavior disorder developed a neurological disorder after a mean clinical follow-up of seven years. Sleep. 2008; 31(Abstract Suppl): A280.
81. Postuma RB, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology. 2009; 72: 1296-300.
82. Iranzo A, Ratti PL, Casanova-Molla J, Serradell M, Vilaseca I, Santamaria J. Excessive muscle activity increases over time in idiopathic REM sleep behavior disorder. Sleep. 2009; 32: 1149-53.
83. Fantini ML, Farini E, Ortelli P, Zucconi M, Manconi M, Cappa S, et al. Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. Sleep. 2011; 34: 619-25.
84. Miyamoto T, Orimo S, Miyamoto M, Hirata K, Adachi T, Hattori R, et al. Follow-up PET studies in case of idiopathic REM sleep behavior disorder. Sleep Med. 2010; 11: 100-1.
85. Postuma RB, Gagnon JF, Rompré S, Montplaisir JY. Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease. Neurology. 2010; 74: 239-44.
86. Iranzo A, Lomeña F, Stockner H, Valldeoriola F, Vilaseca I, Salamero M, et al. Decreased striatal dopamine transporters uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol. 2010; 9: 1070-7.
87. Postuma RB, Gagnon J-F, Vendette M, Desjardins C, Montplaisir JY. Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder. Ann Neurol. 2011; 69: 811-8.
88. Ahlskog JE. Beating a dead horse: dopamine and Parkinson disease. Neurology. 2007; 69: 1701-11.
89. Savica R, Rocca WA, Ahlskog JE. When does Parkinson disease start? Arch Neurol. 2010; 67: 798-801.