Relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determine their cytotoxicity

Journal of Biological Chemistry

Volumn 287, Issue 1, 2012, Pages 233-244

  Rekdal, Øystein ^a,b   Haug, Bengt Erik ^c   Kalaaji, Manar ^a   Hunter, Howard N ^d   Lindin, Inger ^a   Israelsson, Ingrid ^a   Solstad, Terese ^a   Yang, Nannan ^a   Brandl, Martin ^a,e   Mantzilas, Dimitrios ^f   Vogel, Hans J ^d  

^a UNIVERSITY OF TROMSØ   (Norway)

^b LYTIX BIOPHARMA AS   (Norway)

^c UNIVERSITY OF BERGEN   (Norway)

^d UNIVERSITY OF CALGARY   (Canada)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^f UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PEPTIDES; AMPHIPATHIC; ANTI-TUMOR ACTIVITIES; BLUE SHIFT; CANCER CELL LINES; CYTOTOXIC ACTIVITIES; HELICAL STRUCTURES; HYDROPHOBIC ENVIRONMENT; L-SERINE; MEMBRANE SURFACE; MEMBRANE-ACTIVE PEPTIDES; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; RELEASE EXPERIMENTS; SPATIAL POSITIONS; STRUCTURAL STUDIES;

AMINO ACIDS; CELL CULTURE; DICHROISM; EXPERIMENTS; HYDROPHOBICITY; LIPOSOMES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; PHOSPHOLIPIDS; POLYPEPTIDES;

CYTOTOXICITY;

1 PALMITOYL 2 OLEOYL SN GLYCERO 3 PHOSPHO LEVO SERINE; 2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; ALANINE; AMPHIPATHIC HELICAL 21 MER PEPTIDE; CATION; LIPOSOME; MEMBRANE PROTEIN; PHOSPHATIDYLCHOLINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CANCER CELL; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; MICELLE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 84855275544     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.279281     Document Type: Article

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